Digital Commons Network^™

Comparing Biological Parametersof Rrparian Outfalls And Associated Rio Grande Main Channel In Valencia County New Mexico, Mollie Hanttula

Shared Knowledge Conference

Aridland rivers in the southwestern United States often experience times of intermittent drying where portions of the main river channel are no longer flowing. This is true for the Middle Rio Grande in New Mexico, often through the summer months. This study is centered around the portion of the Middle Rio Grande that flows through Valencia County, New Mexico and the outfalls which flow from the agricultural ditches, that parallel the Rio Grande. Where an outfall is a channel of water that flows from the irrigation ditch, through the bosque, and into the Rio Grande. This research will compare aquatic …

Tracing Transmission Of Sin Nombre Virus And Discovery Of Infection In Multiple Rodent Species, Samuel Goodfellow

Shared Knowledge Conference

Orthohantaviruses are a family of negative-sense, single-stranded segmented RNA viruses that can cause hantavirus cardiopulmonary syndrome (HCPS) throughout North, Central and South America. Transmission of these viruses is primarily through exposure to droppings from infected rodents. Sin Nombre virus (SNV), found in North America, is primarily carried, and transmitted, by deer mice (Peromyscus maniculatus) and has a ~36% case fatality rate in humans. New Mexico has the highest number of human SNV cases in the United States making it important to understand the distribution and genetics of SNV within this region. In August 2020, amidst the severe acute respiratory syndrome …

20211027_Hslic's Biomedical Informatics Seminar Series Presents- Joseph A. Cook, Phd, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

Integrin Activation Is An Essential Component Of Sars-Cov-2 Infection, Peter Simons, Derek A. Rinaldi, Virginie Bondu, Alison M. Kell, Steven Bradfute, Diane S. Lidke, Tione Buranda

Pathology Research and Scholarship

SARS-CoV-2 infection depends on binding its spike (S) protein to angiotensin-converting enzyme 2 (ACE2). The S protein expresses an RGD motif, suggesting that integrins may be co-receptors. Here, we UV-inactivated SARS-CoV-2 and fluorescently labeled the envelope membrane with octadecyl rhodamine B (R18) to explore the role of integrin activation in mediating cell entry and productive infection. We used flow cytometry and confocal microscopy to show that SARS-CoV-2^R18 particles engage basal-state integrins. Furthermore, we demonstrate that Mn2+, which induces integrin extension, enhances cell entry of SARS-CoV-2^R18. We also show that one class of integrin antagonist, which binds to …

Data Sharing Workshop, Lori D. Sloane

Posters and Presentations

Learning Objectives:

• Identify the key elements of planning clinical research data management
• Outline steps needed to develop a data collection plan
• Locate standards, validated instruments, and coding schemes for research
• Describe and implement the different components of a data management plan
• Introduction to OpenRefine data tool

A Neutrosophic Folding On A Neutrosophic Fundamental Group, M. Abu-Saleem

Neutrosophic Sets and Systems

No abstract provided.

Tet2 And Dnmt3a Mutations Exert Divergent Effects On Dna Repair And Sensitivity Of Leukemia Cells To Parp Inhibitors, Silvia Maifrede, Bac Viet Le, Margaret Nieborowska-Skorska, Konstantin Golovine, Katherine Sullivan-Reed, Wangisa M B Dunuwille, Joseph Nacson, Michael Hulse, Kelsey Keith, Jozef Madzo, Lisa Beatrice Caruso, Zachary Gazze, Zhaorui Lian, Antonella Padella, Kumaraswamy N. Chitrala, Boris A. Bartholdy, Ksenia Matlawska-Wasowska, Daniela Di Marcantonio, Giorgia Simonetti, Georg Greiner, Stephen M Sykes, Peter Valent, Elisabeth M. Paietta, Martin S. Tallman, Hugo F. Fernandez, Mark R. Litzow, Mark D. Minden, Jian Huang, Giovanni Martinelli, George S. Vassiliou, Italo Tempera, Katarzyna Piwocka, Neil Johnson, Grant A. Challen, Tomasz Skorski

Pediatrics Research and Scholarship

Somatic variants in TET2 and DNMT3A are founding mutations in hematological malignancies that affect the epigenetic regulation of DNA methylation. Mutations in both genes often co-occur with activating mutations in genes encoding oncogenic tyrosine kinases such as FLT3ITD, BCR-ABL1, JAK2V617F , and MPLW515L , or with mutations affecting related signaling pathways such as NRASG12D and CALRdel52 . Here, we show that TET2 and DNMT3A mutations exert divergent roles in regulating DNA repair activities in leukemia cells expressing these oncogenes. Malignant TET2-deficient cells displayed downregulation of BRCA1 and LIG4, resulting in reduced activity of BRCA1/2-mediated homologous recombination (HR) and DNA-PK-mediated non-homologous …

Unm Medicine Fall 2021, University Of New Mexico, Health Sciences Center, School Of Medicine

School of Medicine Alumni Magazine

No abstract provided.

Unm Medicine, The University Of New Mexico School Of Medicine Alumni Magazine, Fall 2020, Ashley Salazar, Bridgette Wagner Jones, Alexandria Sanchez, Elizabeth Sandlin, David A. Andrade, Supreetha Gubbala, Tenisha Marques, Ruth Morgan, Paige R. Penland, Michael E. Richards, C Nathaniel Roybal, Maggie Schold, Michele W. Sequeria, Jett Loe, Raymond Mares, José Rodriguez, Alan Stone

School of Medicine Alumni Magazine

No abstract provided.

Health, Exercise & Sports Sciences 2021 Apr Self-Study & Documents, University Of New Mexico

UNM Academic Program Review

UNM Health, Exercise & Sports Sciences APR self-study report and review team report for Fall 2021, fulfilling requirements of the Higher Learning Commission.

Optical Sciences & Engineering 2021 Apr Self-Study & Documents, University Of New Mexico

UNM Academic Program Review

UNM Optical Sciences & Engineering APR self-study report and addendum for Fall 2021, fulfilling requirements of the Higher Learning Commission. OSE was postponed in Fall 2020 following the emergence of the coronavirus, as such their self-study is from Fall 2020. The 2021 addendum serves to update this document.

Ethics Of Ai In Pathology: Current Paradigms And Emerging Issues, Chhavi Chauhan, Rama R. Gullapalli

Pathology Research and Scholarship

Deep learning has rapidly advanced artificial intelligence (AI) and algorithmic decision-making (ADM) paradigms, affecting many traditional fields of medicine, including pathology, which is a heavily data-centric specialty of medicine. The structured nature of pathology data repositories makes it highly attractive to AI researchers to train deep learning models to improve health care delivery. Additionally, there are enormous financial incentives driving adoption of AI and ADM due to promise of increased efficiency of the health care delivery process. AI, if used unethically, may exacerbate existing inequities of health care, especially if not implemented correctly. There is an urgent need to harness …

Trade-Offs In Growth And Development: A Life History Approach, Anna Medendorp Rautman

Anthropology ETDs

Life history theory (LHT) is the conceptualization of tradeoffs in resources allocation. Plasticity, the ability of phenotypes to vary in response to environmental cues, is integral to LHT. Prior to completed maturation, resources are distributed towards maintenance or somatic maturation, a combination of growth and development (G&D). This dissertation presents an examination of intragroup variation in the G&D of the dental and skeletal systems within a sample of 20th century White females to consider whether they provide evidence for tradeoffs within the subadult interval. In a series of individual research chapters, I consider the following: 1) how does the relative …

Heterogeneity Of Circulating Tumor Cell Neoplastic Subpopulations Outlined By Single-Cell Transcriptomics, Christine M. Pauken, Shelby Ray Kenney, Kathryn J. Brayer, Yan Guo, Ursa A. Brown-Glaberman, Dario Marchetti

Pathology Research and Scholarship

Fatal metastasis occurs when circulating tumor cells (CTCs) disperse through the blood to initiate a new tumor at specific sites distant from the primary tumor. CTCs have been classically defined as nucleated cells positive for epithelial cell adhesion molecule and select cytokeratins (EpCAM/CK/DAPI), while negative for the common lymphocyte marker CD45. The enumeration of CTCs allows an estimation of the overall metastatic burden in breast cancer patients, but challenges regarding CTC heterogeneity and metastatic propensities persist, and their decryption could improve therapies. CTCs from metastatic breast cancer (mBC) patients were captured using the RareCyte

A Compendium Of Inorganic Photochemistry: Synthetic And Spectroscopic Discoveries, Sebastian B. Vittardi

Chemistry and Chemical Biology ETDs

This dissertation reports and examines contributions made in the advancement of inorganic photochemistry. Empirically driven assessments are allotted to the interplay between ligand sets, excited states, and photochemistry observed in metal complexes. A methodical spectroscopic examination is provided for oligothiophene-sensitized lanthanides. Their excited state dynamics were elucidated by femtosecond pump-probe spectroscopy and used to develop a model explaining their wavelength-dependent dual functionality. Iron (II) cyanide and isocyanides are evaluated to identify the efficacy of strong-field ligands in promoting charge-transfer excited states. Fundamentals of ligand field theory helped conceptualize the synthetically tunable parameters and effects transposed to their absorption dynamics. Transition …

Risk Of Hemolytic Uremic Syndrome Related To Treatment Of Escherichia Coli O157 Infection With Different Antimicrobial Classes, Rajal K. Mody, Robert M. Hoekstra, Magdalena Kendall Scott, John Dunn, Kirk Smith, Melissa Tobin-D'Angelo, Beletshachew Shiferaw, Katie Wymore, Paula Clogher, Amanda Palmer, Nicole Comstock, Kari Burzlaff, Sarah Lathrop, Sharon Hurd, Patricia M. Griffin

Pathology Research and Scholarship

Treatment of Shiga toxin-producing Escherichia coli O157 (O157) diarrhea with antimicrobials might alter the risk of hemolytic uremic syndrome (HUS). However, full characterization of which antimicrobials might affect risk is lacking, particularly among adults. To inform clinical management, we conducted a case-control study of residents of the FoodNet surveillance areas with O157 diarrhea during a 4-year period to assess antimicrobial class-specific associations with HUS among persons with O157 diarrhea. We collected data from medical records and patient interviews. We measured associations between treatment with agents in specific antimicrobial classes during the first week of diarrhea and development of HUS, adjusting …

Mitochondrial Proteins In Mediating Colon Cancer And Potential Theraputics, Kunlun Yin

Chemistry and Chemical Biology ETDs

Cancer is one of the biggest threatens to human health. Many people died because of various types of cancer. Colon cancer is one of the leading causes of new incidence and mortality in the whole world. It is important to understand the mechanism of tumorigenesis and development. Based on the mechanisms, we may develop new therapeutics to improve survival rate. In Chapter 2, we discussed the PINK1 function in suppression colon cancer. We found that PINK1 deficiency can promote colon cancer, and PINK1 overexpression suppressed tumor growth in vivo and in vitro. PINK1 can activate its substrate P53, which activates …

Molecular Classification Improves Risk Assessment In Adult Bcr-Abl1-Negative B-All, Elisabeth Paietta, Kathryn G. Roberts, Victoria Wang, Zhaohui Gu, Georgina A N Buck, Deqing Pei, Cheng Cheng, Ross L. Levine, Omar Abdel-Wahab, Zhongshan Cheng, Gang Wu, Chunxu Qu, Lei Shi, Stanley Pounds, Cheryl L. Willman, Richard Harvey, Janis Racevskis, Jan Barinka, Yanming Zhang, Gordon W. Dewald, Rhett P. Ketterling, David Alejos, Hillard M. Lazarus, Selina M. Luger, Letizia Foroni, Bela Patel, Adele K. Fielding, Ari Melnick, David I. Marks, Anthony V. Moorman, Peter H. Wiernik, Jacob M. Rowe, Martin S. Tallman, Anthony H. Goldstone, Charles G. Mullighan, Mark R. Litzow

Pathology Research and Scholarship

Genomic classification has improved risk assignment of pediatric, but not adult B-lineage acute lymphoblastic leukemia (B-ALL). The international UKALLXII/ECOG-ACRIN E2993 (#NCT00002514) trial accrued 1229 adolescent/adult patients with BCR-ABL1- B-ALL (aged 14 to 65 years). Although 93% of patients achieved remission, 41% relapsed at a median of 13 months (range, 28 days to 12 years). Five-year overall survival (OS) was 42% (95% confidence interval, 39, 44). Transcriptome sequencing, gene expression profiling, cytogenetics, and fusion polymerase chain reaction enabled genomic subtyping of 282 patient samples, of which 264 were eligible for trial, accounting for 64.5% of E2993 patients. Among patients with outcome …

Global Population Divergence Of A Cosmopolian Desert Plant, Victor Ryan Alfaro

Biology ETDs

Genetic and phenotypic variation can have different patterns within a species if it has populations with contrasting histories. Populations can have discrete differences that are shaped by different evolutionary scenarios, but within each population, range, or region, traits and association with fitness can also be affected by both edaphic and landscape variation. For my dissertation, I surveyed and experimentally analyzed variation and adaptive potential in Sahara mustard (Brassica tournefortii), a desert annual that has endemic, invasive, and agricultural populations in Africa, Asia, and the Americas. Although my multi-trait analysis generated complex results, my findings can be applied to …

The Interaction And Progression Of Adolescent Substance Use And Co-Occurring Mental Health Problems And Social Support: A Latent Growth Modeling Approach, Jeremiah D. Simmons

Psychology ETDs

Background: Few studies have examined a reciprocal parallel process longitudinal trajectory of adolescent substance use and mental health problems simultaneously, and none have described this parallel process for adolescents receiving outpatient substance use treatment. No studies have examined how social support may account for deviations outside the overall trajectories for substance use or mental health problems. Method: Secondary data analysis examined a longitudinal parallel process latent growth model between mental health and substance use problems among adolescents who received outpatient substance use treatment. Results: Findings suggest that mental health and substance use problems are associated both initially and longitudinally, and …

Uba2 Variants Underlie A Recognizable Syndrome With Variable Aplasia Cutis Congenita And Ectrodactyly, Rhonda E Schnur, Sairah Yousaf, James Liu, Wendy K Chung, Lindsay Rhodes, Michael Marble, Regina M Zambrano, Nara Sobreira, Parul Jayakar, Mary Ella Pierpont, Matthew J Schultz, Pavel N Pichurin, Rory J Olson, Gail E Graham, Matthew Osmond, Gustavo A Contreras-García, Karina A Campo-Neira, Camilo A Peñaloza-Mantilla, Mark Flage, Srikar Kuppa, Karina Navarro, Maria J Guillen Sacoto, Ingrid M Wentzensen, Maria I Scarano, Jane Juusola, Carlos E Prada, Robert B Hufnagel

Pediatrics Research and Scholarship

PURPOSE: The human chromosome 19q13.11 deletion syndrome is associated with a variable phenotype that includes aplasia cutis congenita (ACC) and ectrodactyly as specific features. UBA2 (ubiquitin-like modifier-activating enzyme 2) lies adjacent to the minimal deletion overlap region. We aimed to define the UBA2-related phenotypic spectrum in humans and zebrafish due to sequence variants and to establish the mechanism of disease.

METHODS: Exome sequencing was used to detect UBA2 sequence variants in 16 subjects in 7 unrelated families. uba2 loss of function was modeled in zebrafish. Effects of human missense variants were assessed in zebrafish rescue experiments.

RESULTS: Seven human UBA2 …

Hybridization Between Deep Learning Algorithms And Neutrosophic Theory In Medical Image Processing: A Survey, Nn Mostafa, K Ahmed, I El-Henawy

Neutrosophic Sets and Systems

No abstract provided.

Canonical Nf-Κb Promotes Lung Epithelial Cell Tumour Growth By Downregulating The Metastasis Suppressor Cd82 And Enhancing Epithelial-To-Mesenchymal Cell Transition, Eugenia Roupakia, Evangelia Chavdoula, Georgia Karpathiou, Giannis Vatsellas, Dimitrios Chatzopoulos, Angeliki Mela, Jennifer M. Gillette, Katharina Kriegsmann, Mark Kriegsmann, Anna Batistatou, Anna Goussia, Kenneth B. Marcu, Emmanouil Karteris, Apostolos Klinakis, Evangelos Kolettas

Pathology Research and Scholarship

BACKGROUND: The development of non-small cell lung cancer (NSCLC) involves the progressive accumulation of genetic and epigenetic changes. These include somatic oncogenic

METHODS: Human NSCLC cells were used to knock-down RelA/p65 (RelA/p65

RESULTS: RelA/p65

CONCLUSIONS: Canonical NF-κB signalling promotes NSCLC, in part, by downregulating the metastasis suppressor CD82/KAI1 which inhibits cell migration, EMT and tumour growth.

Wagon Tracks Volume 35, Issue 3 (May 2021)

Wagon Tracks

2 On the Cover: The Trail to Santa Fe by Ron Kil
4 Insights from your President
5 Joanne’s Jottings
2,5-6,9, 15,30 Trail News
7-9 Roots Run Deep on the Santa Fe Trail by Marcia Fox
10-14, 23-20 Diary of William Baskerville, Jr., on the Santa Fe Trail, 1854 by Joy L. Poole
16-17 2021 Symposium
31 In Memoriam: Davy Mitchell, Robbie Roberts
31 Chapter Reports 33 Membership Information
36 American Solar Car Challenge

Current Advances In Transfusion Medicine 2020: A Critical Review Of Selected Topics By The Aabb Clinical Transfusion Medicine Committee, Elizabeth S. Allen, Claudia S. Cohn, Sara Bakhtary, Nancy M. Dunbar, Thomas Gniadek, Courtney K. Hopkins, Jessica Jacobson, Parvez M. Lokhandwala, Ryan A. Metcalf, Colin Murphy, Micah T. Prochaska, Jay S. Raval, Hua Shan, Emily K. Storch, Monica B. Pagano

Pathology Research and Scholarship

BACKGROUND: The AABB Clinical Transfusion Medicine Committee (CTMC) compiles an annual synopsis of the published literature covering important developments in the field of transfusion medicine (TM), which has been made available as a manuscript published in Transfusion since 2018.

METHODS: CTMC committee members reviewed original manuscripts including TM-related topics published electronically (ahead) or in print from December 2019 to December 2020. The selection of topics and manuscripts was discussed at committee meetings and chosen based on relevance and originality. Next, committee members worked in pairs to create a synopsis of each topic, which was then reviewed by two additional committee …

Rheumatic Heart Disease In The United States: Forgotten But Not Gone: Results Of A 10 Year Multicenter Review., Sarah R De Loizaga, Lindsay Arthur, Bhawna Arya, Brian Beckman, Wubishet Belay, Cole Brokamp, Nak Hyun Choi, Sean Connolly, Soham Dasgupta, Tavenner Dibert, Marylou M Dryer, Lakshmi R Gokanapudy Hahn, Elizabeth Anne Greene, Daphney Kernizan, Omar Khalid, Jennifer Klein, Ryan Kobayashi, Subhrajit Lahiri, Raymond P Lorenzoni, Andrea Otero Luna, Jennifer Marshall, Theodore Millette, Lily Moore, Babu Muhamed, Meghna Murali, Kinjal Parikh, Amy Sanyahumbi, Divya Shakti, Elizabeth Stein, Sanket Shah, Hannah Wilkins, Mcallister Windom, Scott Wirth, Meghan Zimmerman, Andrew F Beck, Nicholas Ollberding, Craig Sable, Andrea Beaton

Pediatrics Research and Scholarship

Background Recent evaluation of rheumatic heart disease (RHD) mortality demonstrates disproportionate disease burden within the United States. However, there are few contemporary data on US children living with acute rheumatic fever (ARF) and RHD. Methods and Results Twenty-two US pediatric institutions participated in a 10-year review (2008-2018) of electronic medical records and echocardiographic databases of children 4 to 17 years diagnosed with ARF/RHD to determine demographics, diagnosis, and management. Geocoding was used to determine a census tract-based socioeconomic deprivation index. Descriptive statistics of patient characteristics and regression analysis of RHD classification, disease severity, and initial antibiotic prescription according to community …

Longitudinal Assessment Of Cytokine Expression And Plasminogen Activation In Hantavirus Cardiopulmonary Syndrome Reveals Immune Regulatory Dysfunction In End-Stage Disease, Peter Simons, Yan Guo, Virginie Bondu, Susan L. Tigert, Michelle Harkins, Samuel Goodfellow, Cana Tompkins, Devon Chabot-Richards, Xuexian O. Yang, Laura Gonzalez Bosc, Steven Bradfute, Daniel A. Lawrence, Tione Buranda

Pathology Research and Scholarship

Pathogenic New World orthohantaviruses cause hantavirus cardiopulmonary syndrome (HCPS), a severe immunopathogenic disease in humans manifested by pulmonary edema and respiratory distress, with case fatality rates approaching 40%. High levels of inflammatory mediators are present in the lungs and systemic circulation of HCPS patients. Previous studies have provided insights into the pathophysiology of HCPS. However, the longitudinal correlations of innate and adaptive immune responses and disease outcomes remain unresolved. This study analyzed serial immune responses in 13 HCPS cases due to Sin Nombre orthohantavirus (SNV), with 11 severe cases requiring extracorporeal membrane oxygenation (ECMO) treatment and two mild cases. We …

The Emerging Role Of Suppressors Of Cytokine Signaling (Socs) In The Development And Progression Of Leukemia, Esra'a Keewan, Ksenia Matlawska-Wasowska

Pediatrics Research and Scholarship

Cytokines are pleiotropic signaling molecules that execute an essential role in cell-to-cell communication through binding to cell surface receptors. Receptor binding activates intracellular signaling cascades in the target cell that bring about a wide range of cellular responses, including induction of cell proliferation, migration, differentiation, and apoptosis. The Janus kinase and transducers and activators of transcription (JAK/STAT) signaling pathways are activated upon cytokines and growth factors binding with their corresponding receptors. The SOCS family of proteins has emerged as a key regulator of cytokine signaling, and SOCS insufficiency leads to constitutive activation of JAK/STAT signaling and oncogenic transformation. Dysregulation of …

Neutrosophic Statistics Applied In Social Science, Adrián Alejandro Alvaracín Jarrín, David Santiago Proaño Tamayo, Salomón Alejandro Montecé Giler, Juan Carlos Arandia Zambrano, Dante Manuel Macazana

Neutrosophic Sets and Systems

"Obesity is a chronic, non-contagious disease to which attention has been paid worldwide at all times, but current studies are focused on childhood and adolescent obesity after the Covid-19 pandemic. The reason lies in the fact that the younger the child, the greater the risk of developing complications during his life. That is why it is established as a problem to be analyzed from various points of view. Consequently, this study aims to develop a causal analysis of the determinants of childhood and adolescent obesity in post-COVID-19 Ecuador using Neutrosophic Cognitive Maps from a hermeneutical point of view. The authors …

Neutrosophic Statistical Analysis Of Arthrofibrosis Of The Knee Rehabilitation, Sara Guerrón Enríquez, Zuly Ribel Nazate Chugá, Ruth Isabel Tavera, María Clemencia Villareal Gel, Darvin Manuel Ramírez Guerra

Neutrosophic Sets and Systems

This research aims at deepening the validation of knee arthrofibrosis rehabilitation techniques. It begins with a bibliographic review and an initial diagnosis that justifies the need to investigate these issues, and aspects that give consistency to them. We designed both a pre-test and a post-test, where the patient is physically examined, as well as a questionnaire is applied about the degree of pain or degree of independence. In the study we proposed to the patients to answer questions about the pain degree in form of intervals rather than single values, this allows us to assess most accurately what patients feel, …