Digital Commons Network^™

Syndromic Gastrointestinal Panel Diagnostic Tests Have Changed Our Understanding Of The Epidemiology Of Yersiniosis-Foodborne Diseases Active Surveillance Network, 2010-2021, Logan C. Ray, Daniel C. Payne, Joshua Rounds, Rosalie T. Trevejo, Elisha Wilson, Kari Burzlaff, Katie N. Garman, Sarah Lathrop, Tamara Rissman, Katie Wymore, Sophia Wozny, Siri Wilson, Louise K. Francois Watkins, Beau B. Bruce, Daniel L. Weller

Pathology Research and Scholarship

BACKGROUND: In the US, yersinosis was understood to predominantly occur in winter and among Black or African American infants and Asian children. Increased use of culture-independent diagnostic tests (CIDTs) has led to marked increases in yersinosis diagnoses.

METHODS: We describe differences in the epidemiology of yersiniosis diagnosed by CIDT versus culture in 10 US sites, and identify determinants of health associated with diagnostic method.

RESULTS: Annual reported incidence increased from 0.3/100 000 in 2010 to 1.3/100 000 in 2021, particularly among adults ≥18 years, regardless of race and ethnicity, and during summer months. The proportion of CIDT-diagnosed infections increased from …

A Cost-Effectiveness Analysis Of Telehealth Vs. Office-Based Delivery Of Buprenorphine At The Addiction And Substance Abuse Program (Asap) Clinic - University Of New Mexico Hospital: A Societal Perspective, Rana Alkhafaji

Pharmaceutical Sciences ETDs

This study evaluates the cost-effectiveness of office-based versus telehealth delivery of buprenorphine treatment for opioid use disorder (OUD). A retrospective chart review of 135 patients at the University of New Mexico Hospital's Addiction and Substance Abuse Program compared retention rates and costs between the two settings. Retention was defined as continuous treatment for at least six months. No statistically significant difference in retention rates was found, with 51% for office-based and 42% for telehealth. However, office-based treatment had higher total costs, with an incremental cost-effectiveness ratio of $3,750 per 1% increase in retention. The findings suggest telehealth is a cost-effective …

New Insights Into T Lymphocyte-Mediated Immunity To Toxoplasma Gondii, Claire Marie Doherty

Biology ETDs

With nearly a third of the global population infected with the protozoan, Toxoplasma gondii, this parasite sits at a unique, immune-mediated interface of health and disease. In healthy individuals, Toxoplasma results in a chronic yet asymptomatic infection of the central nervous system. This quiescent infection is the result of parasite exploitation of host immune barriers, yet Toxoplasma can quickly become an opportunistic pathogen when immunity is disrupted by illness or immunosuppressive therapies. During the HIV-AIDS pandemic, it was observed that once latent Toxoplasma infections became the cause of severe, even fatal, disease in the absence of an intact T …

Formulation, Characterization, And In Vivo Immunogenicity Evaluation Of Heat-Stabilized Dissolvable Polymeric Microneedles, Aidan Lane Leyba

Biomedical Engineering ETDs

Since its introduction, vaccination has improved health outcomes tremendously. However, modern vaccination efforts are still difficult to implement, particularly in developing countries with warm climates. This includes complex and expensive cold-chain management of vaccines to maintain stability, a lack of medical personnel to administer parental vaccines, and needle phobia. As an alternative, dissolvable microneedles have recently been studied for their simple and painless application. In this thesis, I present a novel manufacturing process for polymer-based dissolvable microneedles, loaded with virus-like particles vaccines conjugated to TRIO or Sialokinin peptides to target malaria and arboviruses, respectively. We have performed multiple characterization studies …

Recognizing Strokes In The Pacu In Adult Versus Pediatric Patients, Juliet Velhagen, Thomas Ferrer, Ricardo Falcon, Tim Petersen, Codruta Soneru

Brain & Behavioral Health Research Day

This poster discusses strokes in the post-anesthesia care unit in both adult and pediatric patients. We discuss stroke incidence, post-anesthesia stroke symptoms to be aware of, what symptoms overlap between adult and pediatric patients, and the importance of early stroke recognition.

To Infinity & Beyond: From Citation Analysis To Understanding Open Access Publishing, Robyn Gleasner, Robinson Lewis Worley

Posters and Presentations

The University of New Mexico Health Sciences Library and Informatics Center conducted a citation analysis to determine where faculty are publishing and open access publishing trends. The actions based on the results of this analysis including gaps in the collection, acquisitions decisions, and emerging publishing trends will be shared.

Choclo Virus (Chov) Recovered From Deep Metatranscriptomics Of Archived Frozen Tissues In Natural History Biorepositories, Paris S Salazar-Hamm, William L Johnson, Robert A Nofchissey, Jacqueline R Salazar, Publio Gonzalez, Samuel M Goodfellow, Jonathan L Dunnum, Steven B Bradfute, Blas Armién, Joseph A Cook, Daryl B Domman, Darrell L Dinwiddie

Pediatrics Research and Scholarship

BACKGROUND: Hantaviruses are negative-stranded RNA viruses that can sometimes cause severe disease in humans; however, they are maintained in mammalian host populations without causing harm. In Panama, sigmodontine rodents serve as hosts to transmissible hantaviruses. Due to natural and anthropogenic forces, these rodent populations are having increased contact with humans.

METHODS: We extracted RNA and performed Illumina deep metatranscriptomic sequencing on Orthohantavirus seropositive museum tissues from rodents. We acquired sequence reads mapping to Choclo virus (CHOV, Orthohantavirus chocloense) from heart and kidney tissue of a two-decade old frozen museum sample from a Costa Rican pygmy rice rat (Oligoryzomys costaricensis) collected …

Unm Pathology, Pathfinder Winter 2024, Unm Department Of Pathology

Newsletters

No abstract provided.

Unm Health Sciences Center Data Book 2023-24, University Of New Mexico - Health Sciences Center

Health Sciences Center Databook (1990-ongoing)

No abstract provided.

University Of New Mexico Health Sciences Center Discovery Research Annual Report 2024, Michael Haederle, Claire Hannon, Nicole San Roman, Jett Loe, Sara Mota, Sarah Head

Research Annual Reports

Annual research report from the University of New Mexico Health Sciences Center.

Neutrosophic Evaluation Of Healthcare System Resilience, Elsy Labrada González, Marcia Alexandra Silva Mata, Carlos Valverde González, Juan Antonio Arrunátegui Aguirre

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Modeling Of Healthcare Resource Allocation, Olivia Elizabeth Altamirano Guerrero, Neyda De Las Mercedes Hernández Bandera, Lexter Iván Mihalache Bernal, José Sergio Puig Espinosa

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Approaches To Epidemic And Pandemic Response, Daniel Alejandro Arroyo Zumarraga, María Fernanda Cueva Moncayo, Enrique Rodríguez Reyes, Rodolfo González Ortega

Neutrosophic Sets and Systems

No abstract provided.

Smart Applications And Resource Management In Internet Of Things, Zeinab Akhavan

Computer Science ETDs

Internet of Things (IoT) technologies are currently the principal solutions driving smart cities. These new technologies such as Cyber Physical Systems, 5G and data analytic have emerged to address various cities' infrastructure issues ranging from transportation and energy management to healthcare systems. An IoT setting primarily consists of a wide range of users and devices as a massive network interacting with different layers of the city infrastructure resulting in generating sheer volume of data to enable smart city services. The goal of smart city services is to create value for the entire ecosystem, whether this is health, education, transportation, energy, …

Intersections Of Health And Religion: Experiences And Perceptions Of Muslim Refugee Women In The Us Regarding Communication With Healthcare Providers, Sumaira Abrar

Communication ETDs

Delivering healthcare to Muslim refugee patients in a healthcare environment necessitates a profound understanding of their cultural and religious beliefs. The healthcare provider faces intricate hurdles in facilitating effective communication due to the diverse social, cultural, migration, and religious backgrounds within this population. Moreover, bridging the healthcare communication gap often involves grappling with gender-specific expectations aligned with how patients perceive healthcare delivery. To effectively navigate these challenges and enhance patient-provider communication, it is essential for providers to comprehend cultural norms, be well-versed in religious values and restrictions, and grasp the significance of self-care practices and connections to traditional and cultural …

Targeting Translation And The Cell Cycle Inversely Affects Ctc Metabolism But Not Metastasis, Tetiana Y. Bowley, Seth D. Merkley, Irina V. Lagutina, Mireya C. Ortiz, Margaret Lee, Bernard Tawfik, Dario Marchetti

Pathology Research and Scholarship

Melanoma brain metastasis (MBM) is significantly associated with poor prognosis and is diagnosed in 80% of patients at autopsy. Circulating tumor cells (CTCs) are "seeds" of metastasis and the smallest functional units of cancer. Our multilevel approach has previously identified a CTC RPL/RPS gene signature directly linked to MBM onset. We hypothesized that targeting ribogenesis prevents MBM/metastasis in CTC-derived xenografts. We treated parallel cohorts of MBM mice with FDA-approved protein translation inhibitor omacetaxine with or without CDK4/CDK6 inhibitor palbociclib, and monitored metastatic development and cell proliferation. Necropsies and IVIS imaging showed decreased MBM/extracranial metastasis in drug-treated mice, and RNA-Seq on …

Early Antibody Treatment, Inflammation, And Risk Of Post-Covid Conditions, Kelly A. Gebo, Sonya L. Heath, Yuriko Fukuta, Xianming Zhu, Sheriza Baksh, Allison G. Abraham, Feben Habtehyimer, David Shade, Jessica Ruff, Malathi Ram, Oliver Laeyendecker, Reinaldo E. Fernandez, Eshan U. Patel, Owen R. Baker, Shmuel Shoham, Edward R. Cachay, Judith S. Currier, Jonathan M. Gerber, Barry Meisenberg, Donald N. Forthal, Laura L. Hammitt, Moises A. Huaman, Adam Levine, Giselle S. Mosnaim, Bela Patel, James H. Paxton, Jay S. Raval, Catherine G. Sutcliffe, Shweta Anjan, Thomas Gniadek, Seble Kassaye, Janis E. Blair, Karen Lane, Nichol A. Mcbee, Amy L. Gawad, Piyali Das, Sabra L. Klein, Andrew Pekosz, Evan M. Bloch, Daniel Hanley, Arturo Casadevall, Aaron A R Tobian, David J. Sullivan

Pathology Research and Scholarship

Approximately 20% of individuals infected with SARS-CoV-2 experienced long-term health effects, as defined PCC. However, it is unknown if there are any early biomarkers associated with PCC or whether early intervention treatments may decrease the risk of PCC. In a secondary analysis of a randomized clinical trial, this study demonstrates that among outpatients with SARS-CoV-2, increased IL-6 at time of infection is associated with increased odds of PCC. In addition, among individuals treated early, within 5 days of symptom onset, with COVID-19 convalescent plasma, there was a trend for decreased odds of PCC after adjusting for other demographic and clinical …

New Mexico Health Care Workforce Committee 2023 Annual Report, University Of New Mexico - Health Sciences Center

New Mexico Health Care Workforce Committee (2013-ongoing)

No abstract provided.

Hsc Connects Newsletter - September 15, 2023, Unm Hsc Communications

HSC Connects Newsletters

Weekly newsletter of the UNM Health Sciences Center.

Monitoring Health Disparities In Healthcare-Associated Infection Surveillance: A Society For Healthcare Epidemiology Of America (Shea) Research Network (Srn) Survey, Caitlin L. Mcgrath, Latania K. Logan, Valerie M. Deloney, Lorry G. Rubin, Karen A. Ravin, Martha Muller, Allison H. Bartlett, Annabelle De St Maurice, W Matthew Linam, Carolyn Caughell, Lynn Ramirez-Avila, Shea Pediatric Leadership Council Steering Committee

Pediatrics Research and Scholarship

We investigated whether and how infection prevention programs monitor for health disparities as part of healthcare-associated infection (HAI) surveillance through a survey of healthcare epidemiology leaders. Most facilities are not assessing for disparities in HAI rates. Professional society and national guidance should focus on addressing this gap.

Evidence-Based Public Health Practice: Searching For Evidence, Lisa M. Acuff, Jonathan Eldredge, Alexis Ellsworth-Kopkowski, Gale G. Hannigan

Educational Resources

No abstract provided.

Transfusion Reactions Associated With Covid-19 Convalescent Plasma In Outpatient Clinical Trials, Moises A. Huaman, Jay S. Raval, James H. Paxton, Giselle S. Mosnaim, Bela Patel, Shweta Anjan, Barry R. Meisenberg, Adam C. Levine, Christi E. Marshall, Anusha Yarava, Aarthi G. Shenoy, Sonya L. Heath, Judith S. Currier, Yuriko Fukuta, Janis E. Blair, Emily S. Spivak, Joann R. Petrini, Patrick B Broderick, William Rausch, Marieelena Cordisco, Jean Hammel, Benjamin Greenblatt, Valerie C Cluzet, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L. Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S Zand, Edward R. Cachay, Seble G. Kassaye, Malathi Ram, Ying Wang, Piyali Das, Karen Lane, Nichol A Mcbee, Amy L Gawad, Nicky Karlen, Daniel E Ford, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, Stephan Ehrhardt, Bryan Lau, Sheriza N. Baksh, David M. Shade, Arturo Casadevall, Daniel F. Hanley, Jiangda Ou, Thomas J. Gniadek, Alyssa Ziman, Shmuel Shoham, Kelly A. Gebo, Evan M. Bloch, Aaron A R Tobian, David J. Sullivan, Jonathan M. Gerber

Pathology Research and Scholarship

BACKGROUND: COVID-19 convalescent plasma (CCP) is an important therapeutic option for outpatients at high risk of hospitalization from SARS-CoV-2 infection. We assessed the safety of outpatient CCP transfusions administered during clinical trials.

STUDY DESIGN AND METHODS: We analyzed data pertaining to transfusion-related reactions from two randomized controlled trials in the U.S. that evaluated the efficacy of CCP versus control plasma in various ambulatory settings. Multivariable logistic regression was used to assess whether CCP was associated with transfusion reactions, after adjusting for potential confounders.

RESULTS: The combined study reported 79/1351 (5.9%) adverse events during the transfusion visit, with the majority 62/1351 …

Volume 20, Issue 1

Medical Muse

No abstract provided.

Volume 18, Issue 1

Medical Muse

No abstract provided.

Single-Valued Pentapartitioned Neutrosophic Weighted Hyperbolic Tangent Similarity Measure To Determine The Most Significant Environmental Risks During The Covid-19 Pandemic, Priyanka Majumder, Arnab Paul, Surapati Pramanik

Neutrosophic Sets and Systems

No abstract provided.

Examining The Effects Of Iron-Oxide Nanoparticles On Primary Gingival Keratinocytes For The Prevention Of Oral Disease, Jennifer C. Carranza

Dental Hygiene ETDs

Oral plaque biofilm has been identified as the primary contributor to dental conditions such as dental caries and periodontal disease that promotes a diverse and pervasive collection of microbial species to inhabit the oral cavity. Disrupting the plaque matrix early could help combat this global disease burden. This study evaluated the effect of IONPs on primary gingival keratinocytes.

Purpose: This study aimed to examine existing research regarding nanoparticles and determine if IONPs affect the PGK cell membranes with preliminary research to find the maximum lysis possible with PGK cells.

Methods: IONP core/shell syntheses were performed. Considering keratinocyte characteristics, examining data …

Investigation Of Orthohantavirus Genetics In Rodent Reservoirs And Clinical Samples, Samuel Melvin Goodfellow

Biomedical Sciences ETDs

Orthohantaviruses are negative-sense, single stranded RNA viruses with trisegmented genomes that can cause severe disease in humans and are carried by several host reservoirs throughout the world. In the United States, Sin Nombre orthohantavirus (SNV) is the primary cause of hantavirus cardiopulmonary syndrome (HCPS) with a fatality rate of ~36% and the highest cases occuring in the southwest region. The primary SNV host reservoir is thought to be the western deer mouse, Peromyscus maniculatus, however it has been shown that other rodents can carry different orthohantaviruses. We designed a pan-orthohantavirus detection tool to survey several small mammal populations throughout New …

Heterochiral Dna Nanotechnology For Biomedical Applications, Tracy L. Mallette

Biomedical Engineering ETDs

In the past 30 years, there have been major advancements on how to treat and diagnose disease because of the improvement and increase in accessibility of sequencing technology. Nucleic acid-based therapeutics can manipulate protein expression. Likewise, pathogens can be identified and detected with single nucleotide specificity. However, the underlying oligonucleotide technology requires protection against natural defense systems that have evolved to destroy foreign nucleic acids. Many chemical modifications that can protect nucleotides also have significant cytotoxic side effects and must be carefully designed into the strands. A novel way to protect against nuclease-mediated degradation is through the use of mirror-image, …

Effects Of Childhood Health And Adversity On Women’S Estrous And Extended Sexuality In Romantic Relationships, Tran Dinh

Psychology ETDs

Variations in childhood conditions may favor different strategies of investment in pair-bonds and reproduction. The current study followed 213 romantically-involved women up to four times across the ovulatory cycle. Analyses find that childhood health and adversity moderate hormone-dependent changes in women’s sexual interests, oxytocin responses, and mate preferences. In light of proposed paternity assurance functions of extended (non-conceptive) sexuality, results suggest women with poorer, compared to better, childhood conditions prioritize bond formation but invest less in maintaining or bolstering partner investment. The estrous (conceptive) sexuality of women with poor childhood health may reflect greater investments in current reproduction, even when …

The Effect Of Sodium Bicarbonate On Acute Kidney Injury Markers During Physical Work In The Heat, Abdulaziz Abdulrahman A. Masoud, Fabiano Amorim, Christine Mermier, Michael Deyhle, Zidong Li

Health, Exercise, and Sports Sciences ETDs

Sodium bicarbonate supplementation (NaHCO₃) before physical work in the heat may reduce the risk of developing acute kidney injury (AKI). Purpose: To determine the effects of NaHCO₃ supplementation before a prolonged bout of physical work in the heat on AKI markers and kidney function. Method: A randomized, cross-over, double blinded design was conducted on 8 participants (3 females) who consumed NaHCO₃ (0.2 g/kg body weight) or placebo (CON) before prolonged (120 minutes) moderate intensity (~65% of maximal heart rate) physical work in the heat [40℃ and 23% relative humidity (RH)]. Blood and urine samples were collected …