Digital Commons Network^™

Decreased Incidence Of Infections Caused By Pathogens Transmitted Commonly Through Food During The Covid-19 Pandemic - Foodborne Diseases Active Surveillance Network, 10 U.S. Sites, 2017-2020, Logan C. Ray, Jennifer P. Collins, Patricia M. Griffin, Hazel J. Shah, Michelle M. Boyle, Paul R. Cieslak, John Dunn, Sarah Lathrop, Suzanne Mcguire, Tamara Rissman, Elaine J. Scallan Walter, Kirk Smith, Melissa Tobin-D'Angelo, Katie Wymore, Joanna Zablotsky Kufel, Beverly J. Wolpert, Robert Tauxe, Daniel C. Payne

Pathology Research and Scholarship

Foodborne illnesses are a substantial and largely preventable public health problem; before 2020 the incidence of most infections transmitted commonly through food had not declined for many years. To evaluate progress toward prevention of foodborne illnesses in the United States, the Foodborne Diseases Active Surveillance Network (FoodNet) of CDC's Emerging Infections Program monitors the incidence of laboratory-diagnosed infections caused by eight pathogens transmitted commonly through food reported by 10 U.S. sites.* FoodNet is a collaboration among CDC, 10 state health departments, the U.S. Department of Agriculture's Food Safety and Inspection Service (USDA-FSIS), and the Food and Drug Administration. This report …

20210922_Learn More About Time Management To Help You Reach Your Goals, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

A Protocol For A Comprehensive Monitoring And Evaluation Framework With A Compendium Of Tools To Assess Quality Of Project Echo (Extension For Community Healthcare Outcomes) Implementation Using Mixed Methods, Developmental Evaluation Design, Smita Ghosh, Brenna M. Roth, Irene Massawe, Emmanuel Mtete, Jacob Lusekelo, Eve Pinsker, Steven Seweryn, Patrick K. Moonan, Bruce B. Struminger

Project ECHO Bibliography

Introduction: The United States Centers for Disease Control and Prevention (CDC), through U.S. President's Emergency Plan for AIDS Relief (PEPFAR), supports a third of all people receiving HIV care globally. CDC works with local partners to improve methods to find, treat, and prevent HIV and tuberculosis. However, a shortage of trained medical professionals has impeded efforts to control the HIV epidemic in Sub-Saharan Africa and Asia. The Project Extension for Community Healthcare Outcomes (ECHO^TM) model expands capacity to manage complex diseases, share knowledge, disseminate best practices, and build communities of practice. This manuscript describes a practical protocol for …

Risk Of Hemolytic Uremic Syndrome Related To Treatment Of Escherichia Coli O157 Infection With Different Antimicrobial Classes, Rajal K. Mody, Robert M. Hoekstra, Magdalena Kendall Scott, John Dunn, Kirk Smith, Melissa Tobin-D'Angelo, Beletshachew Shiferaw, Katie Wymore, Paula Clogher, Amanda Palmer, Nicole Comstock, Kari Burzlaff, Sarah Lathrop, Sharon Hurd, Patricia M. Griffin

Pathology Research and Scholarship

Treatment of Shiga toxin-producing Escherichia coli O157 (O157) diarrhea with antimicrobials might alter the risk of hemolytic uremic syndrome (HUS). However, full characterization of which antimicrobials might affect risk is lacking, particularly among adults. To inform clinical management, we conducted a case-control study of residents of the FoodNet surveillance areas with O157 diarrhea during a 4-year period to assess antimicrobial class-specific associations with HUS among persons with O157 diarrhea. We collected data from medical records and patient interviews. We measured associations between treatment with agents in specific antimicrobial classes during the first week of diarrhea and development of HUS, adjusting …

Mitochondrial Proteins In Mediating Colon Cancer And Potential Theraputics, Kunlun Yin

Chemistry and Chemical Biology ETDs

Cancer is one of the biggest threatens to human health. Many people died because of various types of cancer. Colon cancer is one of the leading causes of new incidence and mortality in the whole world. It is important to understand the mechanism of tumorigenesis and development. Based on the mechanisms, we may develop new therapeutics to improve survival rate. In Chapter 2, we discussed the PINK1 function in suppression colon cancer. We found that PINK1 deficiency can promote colon cancer, and PINK1 overexpression suppressed tumor growth in vivo and in vitro. PINK1 can activate its substrate P53, which activates …

20210920_Display To Celebrate Curanderas Y Parteras, Healers In New Mexico, Robyn Gleasner

HSLIC Blog Post

No abstract provided.

Civil Procedure Update 2021: New Mexico Annual Judicial Conclave, Verónica C. Gonzales

Faculty Scholarship

These materials are part of a presentation on civil procedure given to magistrate, district, appellate, and tribal court judges, justices, and staff attorneys in New Mexico courts. These materials include the language of approved and proposed amendments to the state and federal rules of civil procedure as well as summaries of relevant appellate cases issued by the New Mexico Supreme Court and Court of Appeals, the Supreme Court of the United States, and the Supreme Court of the Navajo Nation between May 1, 2021 to September 1, 2021.

Molecular Classification Improves Risk Assessment In Adult Bcr-Abl1-Negative B-All, Elisabeth Paietta, Kathryn G. Roberts, Victoria Wang, Zhaohui Gu, Georgina A N Buck, Deqing Pei, Cheng Cheng, Ross L. Levine, Omar Abdel-Wahab, Zhongshan Cheng, Gang Wu, Chunxu Qu, Lei Shi, Stanley Pounds, Cheryl L. Willman, Richard Harvey, Janis Racevskis, Jan Barinka, Yanming Zhang, Gordon W. Dewald, Rhett P. Ketterling, David Alejos, Hillard M. Lazarus, Selina M. Luger, Letizia Foroni, Bela Patel, Adele K. Fielding, Ari Melnick, David I. Marks, Anthony V. Moorman, Peter H. Wiernik, Jacob M. Rowe, Martin S. Tallman, Anthony H. Goldstone, Charles G. Mullighan, Mark R. Litzow

Pathology Research and Scholarship

Genomic classification has improved risk assignment of pediatric, but not adult B-lineage acute lymphoblastic leukemia (B-ALL). The international UKALLXII/ECOG-ACRIN E2993 (#NCT00002514) trial accrued 1229 adolescent/adult patients with BCR-ABL1- B-ALL (aged 14 to 65 years). Although 93% of patients achieved remission, 41% relapsed at a median of 13 months (range, 28 days to 12 years). Five-year overall survival (OS) was 42% (95% confidence interval, 39, 44). Transcriptome sequencing, gene expression profiling, cytogenetics, and fusion polymerase chain reaction enabled genomic subtyping of 282 patient samples, of which 264 were eligible for trial, accounting for 64.5% of E2993 patients. Among patients with outcome …

Pediatric Partnership: Drs. Aaron & Metta Cardon Join Unm Child Neurology Faculty, Michael Haederle

HSC Newsroom

No abstract provided.

20210910_Hslic's Biomedical Informatics Seminar Series Presents- Mary Hill, Mot, Otr.L, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

20210909_Unm Holding Annual Suicide Awareness Week Sept. 12-18, David Lucero

HSLIC Blog Post

No abstract provided.

The Interaction And Progression Of Adolescent Substance Use And Co-Occurring Mental Health Problems And Social Support: A Latent Growth Modeling Approach, Jeremiah D. Simmons

Psychology ETDs

Background: Few studies have examined a reciprocal parallel process longitudinal trajectory of adolescent substance use and mental health problems simultaneously, and none have described this parallel process for adolescents receiving outpatient substance use treatment. No studies have examined how social support may account for deviations outside the overall trajectories for substance use or mental health problems. Method: Secondary data analysis examined a longitudinal parallel process latent growth model between mental health and substance use problems among adolescents who received outpatient substance use treatment. Results: Findings suggest that mental health and substance use problems are associated both initially and longitudinally, and …

Exercise As A Multi-Modal Disease-Modifying Medicine In Systemic Sclerosis: An Introduction By The Global Fellowship On Rehabilitation And Exercise In Systemic Sclerosis (G-Forss), Henrik Pettersson, Helene Alexanderson, Janet L. Poole, Janos Varga, Malin Regardt, Anne-Marie Russell, Yasser Salam, Kelly Jensen, Jennifer Mansour, Tracy Frech, Carol Feghali-Bostwick, Cecília Varjú, Nancy Baldwin, Matty Heenan, Kim Fligelstone, Monica Holmner, Matthew R. Lammi, Mary Beth Scholand, Lee Shapiro, Elizabeth R. Volkmann, Lesley Ann Saketkoo

Pediatrics Research and Scholarship

Systemic sclerosis (SSc) is a heterogeneous multisystem autoimmune disease whereby its main pathological drivers of disability and damage are vascular injury, inflammatory cell infiltration, and fibrosis. These mechanisms result in diffuse and diverse impairments arising from ischemic circulatory dysfunction leading to painful skin ulceration and calcinosis, neurovascular aberrations hindering gastrointestinal (GI) motility, progressive painful, incapacitating or immobilizing effects of inflammatory and fibrotic effects on the lungs, skin, articular and periarticular structures, and muscle. SSc-related impairments impede routine activities of daily living (ADLs) and disrupt three critical life areas: work, family, social/leisure, and also impact on psychological well-being. Physical activity and …

Uba2 Variants Underlie A Recognizable Syndrome With Variable Aplasia Cutis Congenita And Ectrodactyly, Rhonda E Schnur, Sairah Yousaf, James Liu, Wendy K Chung, Lindsay Rhodes, Michael Marble, Regina M Zambrano, Nara Sobreira, Parul Jayakar, Mary Ella Pierpont, Matthew J Schultz, Pavel N Pichurin, Rory J Olson, Gail E Graham, Matthew Osmond, Gustavo A Contreras-García, Karina A Campo-Neira, Camilo A Peñaloza-Mantilla, Mark Flage, Srikar Kuppa, Karina Navarro, Maria J Guillen Sacoto, Ingrid M Wentzensen, Maria I Scarano, Jane Juusola, Carlos E Prada, Robert B Hufnagel

Pediatrics Research and Scholarship

PURPOSE: The human chromosome 19q13.11 deletion syndrome is associated with a variable phenotype that includes aplasia cutis congenita (ACC) and ectrodactyly as specific features. UBA2 (ubiquitin-like modifier-activating enzyme 2) lies adjacent to the minimal deletion overlap region. We aimed to define the UBA2-related phenotypic spectrum in humans and zebrafish due to sequence variants and to establish the mechanism of disease.

METHODS: Exome sequencing was used to detect UBA2 sequence variants in 16 subjects in 7 unrelated families. uba2 loss of function was modeled in zebrafish. Effects of human missense variants were assessed in zebrafish rescue experiments.

RESULTS: Seven human UBA2 …

Chicago's Stay-At-Home Mandate-The Need To Improve On Domestic Violence Prevention And Response, Amy Bonomi, Rashmi Gangamma, Theresa H Cruz

Pediatrics Research and Scholarship

No abstract provided.

Shea Pediatric Leadership Council Commentary: Personal Protective Equipment During Care Of Children With Multisystem Inflammatory Syndrome In Children (Mis-C), Martha L. Muller, Latania K. Logan, Larry K. Kociolek, Judith A. Guzman-Cottrill, Allison H. Bartlett, Joshua K. Schaffzin, Karen A Ravin, Lorry G Rubin, Jason Lake, Carolyn Caughell, Lynn Ramirez-Avila, Shea Pediatric Leadership Council

Pediatrics Research and Scholarship

No abstract provided.

A Comprehensive Framework For Navigating Patient Care In Systemic Sclerosis: A Global Response To The Need For Improving The Practice Of Diagnostic And Preventive Strategies In Ssc, Lesley Ann Saketkoo, Tracy Frech, Cecília Varjú, Robyn Domsic, Jessica Farrell, Jessica K. Gordon, Carina Mihai, Nora Sandorfi, Lee Shapiro, Janet L. Poole, Elizabeth R. Volkmann, Monika Lammi, Kendra Mcanally, Helene Alexanderson, Henrik Pettersson, Faye Hant, Masataka Kuwana, Ami A. Shah, Vanessa Smith, Vivien Hsu, Otylia Kowal-Bielecka, Shervin Assassi, Maurizio Cutolo, Cristiane Kayser, Victoria K. Shanmugam, Madelon C. Vonk, Kim Fligelstone, Nancy Baldwin, Kerri Connolly, Anneliese Ronnow, Beata Toth, Maureen Suave, Sue Farrington, Elana J. Bernstein, Leslie J. Crofford, László Czirják, Kelly Jensen, Monique Hinchclif, Marie Hudson, Matthew R Lammi, Jennifer Mansour, Nadia D. Morgan, Fabian Mendoza, Mandana Nikpour, John Pauling, Gabriela Riemekasten, Anne-Marie Russell, Mary Beth Scholand, Elise Seigart, Tatiana Sofia Rodriguez-Reyna, Laura Hummers, Ulrich Walker, Virginia Steen

Pediatrics Research and Scholarship

Systemic sclerosis (SSc), the most lethal of rheumatologic conditions, is the cause of death in >50% of SSc cases, led by pulmonary fibrosis followed by pulmonary hypertension and then scleroderma renal crisis (SRC). Multiple other preventable and treatable SSc-related vascular, cardiac, gastrointestinal, nutritional and musculoskeletal complications can lead to disability and death. Vascular injury with subsequent inflammation transforming to irreversible fibrosis and permanent damage characterizes SSc. Organ involvement is often present early in the disease course of SSc, but requires careful history-taking and vigilance in screening to detect. Inflammation is potentially reversible provided that treatment intensity quells inflammation and other …

Myeloid/Lymphoid Neoplasms With Flt3 Rearrangement, Guilin Tang, Wayne Tam, Nicholas J. Short, Prithviraj Bose, David Wu, Stephanie N. Hurwitz, Adam Bagg, Heesun J. Rogers, Eric D. Hsi, Andres E. Quesada, Wei Wang, Roberto N. Miranda, Carlos E. Bueso-Ramos, L Jeffrey Medeiros, Valentina Nardi, Robert P. Hasserjian, Daniel A. Arber, Attilio Orazi, Kathryn Foucar, Sa A. Wang

Pathology Research and Scholarship

Myeloid/lymphoid neoplasms (M/LN) with 13q12/FLT3 rearrangement have been suggested as candidates for possible inclusion in the World Health Organization classification group of M/LN with eosinophilia (M/LN-eo). We report 12 patients with confirmed FLT3 rearrangement, six with t(12;13)/ETV6-FLT3; one with ins(13;22)/BCR-FLT3; and five with an unconfirmed partner gene located on chromosome bands 2p16, 3q27, 5q15, 5q35, and 7q36. Disease presentations were heterogeneous, including lymphoblastic leukemia/lymphoma, myeloid sarcoma, chronic eosinophilic leukemia, chronic myelomonocytic leukemia, and myelodysplastic syndrome. However, some common features were observed, such as extramedullary involvement (n = 7, 58%), associated eosinophilia in blood, bone marrow, or tissue (n = 8, …

Unm Hslic Organizational Chart 2021, Sally Bowler-Hill

HSLIC Organizational Charts

No abstract provided.

Uptake Of Co-Testing With Hpv And Cytology For Cervical Screening: A Population-Based Evaluation In The United States, Jack Cuzick, Ruofei Du, Rachael Adcock, Walter Kinney, Nancy Joste, Ruth M. Mcdonald, Kevin English, Salina M. Torres, Debbie Saslow, Cosette M. Wheeler

Pathology Research and Scholarship

OBJECTIVES: Human papillomavirus (HPV) testing for cervical screening has been shown to increase the yield of precancerous disease and reduce the incidence of cervical cancer more than cytology alone. Here we document the state-wide uptake of co-testing with HPV and cytology in women aged 30-64 years as recommended by national and international bodies.

METHODS: Registry-based study of all screening cytology and HPV tests in New Mexico from 2008 to 2019 among women aged 21-64 years, with a focus on cytology negative tests to distinguish co-testing from reflex HPV testing to triage equivocal or mildly abnormal cytology.

RESULTS: A total of …

Adherence To National Guidelines On Cervical Screening: A Population-Based Evaluation From A Statewide Registry, Philip E. Castle, Walter K. Kinney, Lu Chen, Jane J. Kim, Steven Jenison, Giovanna Rossi, Huining Kang, Jack Cuzick, Cosette M. Wheeler, New Mexico Hpv Pap Registry Steering Committee

Pathology Research and Scholarship

In 2012, national recommendations for cervical-cancer screening of women aged 30-64 years were quinquennial human papillomavirus and cytology co-testing or triennial cytology. Data from a state-wide surveillance program in New Mexico demonstrated 65.2% (95% confidence interval [95%CI]= 64.6%% to 65.7%) of women screened in 2019 had negative co-test within the last 3 years. Percentages of women screened in 2013, 2016, and 2019 with a prior negative co-test more than 5 and up to 7 years ago were 2.6% (95% CI = 2.2% to 2.9%), 2.1% (95% CI = 1.9% to 2.2%), and 6.5% (95% CI = 6.2% to 6.8%), respectively …

20210829_Upcoming Workshops, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

Hybridization Between Deep Learning Algorithms And Neutrosophic Theory In Medical Image Processing: A Survey, Nn Mostafa, K Ahmed, I El-Henawy

Neutrosophic Sets and Systems

No abstract provided.

2-Additive Choquet Similarity Measures For Multi-Period Medical Diagnosis In Single-Valued Neutrosophic Set Setting, Murat Olgun, Ezgı Turkarslan, Mehmet Unver, Jun Ye

Neutrosophic Sets and Systems

No abstract provided.

An Introduction To Refined Neutrosophic Number Theory, Mohammad Abobala, Muritala Ibrahim

Neutrosophic Sets and Systems

No abstract provided.

On The Characterization Of Maximal And Minimal Ideals In Several Neutrosophic Rings, Mohammad Abobala

Neutrosophic Sets and Systems

No abstract provided.

An Efficient Framework For Drug Product Selection – Dps According To Neutrosophic Bwm, Mabac And Promethee Ii Methods, Muhammad Edmerdash, Waleed Khedr, Ehab Rushdy

Neutrosophic Sets and Systems

No abstract provided.

The Neutrosophic Integrals By Parts, Yaser Ahmad Alhasan

Neutrosophic Sets and Systems

No abstract provided.

Types Of System Of The Neutrosophic Linear Equations And Cramer’S Rule, Yaser Ahmad Alhasan

Neutrosophic Sets and Systems

No abstract provided.

Canonical Nf-Κb Promotes Lung Epithelial Cell Tumour Growth By Downregulating The Metastasis Suppressor Cd82 And Enhancing Epithelial-To-Mesenchymal Cell Transition, Eugenia Roupakia, Evangelia Chavdoula, Georgia Karpathiou, Giannis Vatsellas, Dimitrios Chatzopoulos, Angeliki Mela, Jennifer M. Gillette, Katharina Kriegsmann, Mark Kriegsmann, Anna Batistatou, Anna Goussia, Kenneth B. Marcu, Emmanouil Karteris, Apostolos Klinakis, Evangelos Kolettas

Pathology Research and Scholarship

BACKGROUND: The development of non-small cell lung cancer (NSCLC) involves the progressive accumulation of genetic and epigenetic changes. These include somatic oncogenic

METHODS: Human NSCLC cells were used to knock-down RelA/p65 (RelA/p65

RESULTS: RelA/p65

CONCLUSIONS: Canonical NF-κB signalling promotes NSCLC, in part, by downregulating the metastasis suppressor CD82/KAI1 which inhibits cell migration, EMT and tumour growth.