Digital Commons Network^™

Integrin Activation Is An Essential Component Of Sars-Cov-2 Infection, Peter Simons, Derek A. Rinaldi, Virginie Bondu, Alison M. Kell, Steven Bradfute, Diane S. Lidke, Tione Buranda

Pathology Research and Scholarship

SARS-CoV-2 infection depends on binding its spike (S) protein to angiotensin-converting enzyme 2 (ACE2). The S protein expresses an RGD motif, suggesting that integrins may be co-receptors. Here, we UV-inactivated SARS-CoV-2 and fluorescently labeled the envelope membrane with octadecyl rhodamine B (R18) to explore the role of integrin activation in mediating cell entry and productive infection. We used flow cytometry and confocal microscopy to show that SARS-CoV-2^R18 particles engage basal-state integrins. Furthermore, we demonstrate that Mn2+, which induces integrin extension, enhances cell entry of SARS-CoV-2^R18. We also show that one class of integrin antagonist, which binds to …

Data Sharing Workshop, Lori D. Sloane

Posters and Presentations

Learning Objectives:

• Identify the key elements of planning clinical research data management
• Outline steps needed to develop a data collection plan
• Locate standards, validated instruments, and coding schemes for research
• Describe and implement the different components of a data management plan
• Introduction to OpenRefine data tool

20211013_Last Chance Of The Semester To Attend Pubmed Like A Pro Workshop, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

Tetraspanin Cd82 Regulates S1pr, Chelsea A. Saito-Reis, Victoria D. Balise, Erica M. Pascetti, Magdalena Jiminez, Jennifer M. Gillette

Pathology Research and Scholarship

Hematopoietic stem and progenitor cell (HSPC) mobilization into the blood occurs under normal physiological conditions and is stimulated in the clinic to enable the isolation of HSPCs for transplantation therapies. In the present study, we identify the tetraspanin CD82 as a novel regulator of HSPC mobilization. Using a global CD82 knockout (CD82KO) mouse, we measure enhanced HSPC mobilization after granulocyte-colony stimulating factor (G-CSF) or AMD3100 treatment, which we find is promoted by increased surface expression of the sphingosine 1-phosphate receptor 1 (S1PR

Building Consensus Around The Future Remote Work: One Library’S Study, Sally Bowler-Hill

Posters and Presentations

OBJECTIVE: The purpose of this study was to explore and understand employee perceptions of remote work as a potential option after the library returns to “normal” operations. This survey was used to develop the library’s telecommuting and remote work guideline.

METHODS: An 8-question, web-based survey was sent to all library faculty and staff, asking their opinions about working remotely after the COVID-19 pandemic. The study was declared minimal risk by our institutional IRB. The questions included multiple choice and free-text responses about how often employees wanted to work remotely; what tasks they believed could be done productively from home; what …

Question Formulation Skills Building Among Dental Hygiene Students: Randomized Controlled Trial, Jonathan Eldredge, Christine N. Nathe

Posters and Presentations

No abstract provided.

20211011_Indigenous Peoples’ Day. Five Learnings Honoring The Healing Power Of Two-Spirit Identity, Jonathan Pringle, University Of New Mexico Health Sciences Library And Informatics Center

HSLIC Blog Post

Blog Post. To request access to this blog post, please contact [email protected].

10-12-2021 Hsc Committee Meeting Agenda, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Identification Of The Most Significant Risk Factor Of Covid-19 In Economy Using Cosine Similarity Measure Under Svpns-Environment, Priyanka Majumder, Suman Das, Rakhal Das, Binod Chandra Tripathy

Neutrosophic Sets and Systems

No abstract provided.

Neutrogeometry & Antigeometry Are Alternatives And Generalizations Of The Non-Euclidean Geometries, Florentin Smarandache

Neutrosophic Sets and Systems

No abstract provided.

20211005_Pubmed's Single Citation Matcher And The Mesh Database Links Removed From Hslic's Homepage, Robyn Gleasner

HSLIC Blog Post

No abstract provided.

20211004_Black Men In White Coats Screening And Discussion, Amy Weig-Pickering

HSLIC Blog Post

No abstract provided.

Pulling Back The Curtain: A Follow-Up Report From The Aba Criminal Justice Section Women In Criminal Justice Task Force, Maryam Ahranjani

Faculty Scholarship

In an era when women’s hard-fought and hard-earned participation in the workforce is in peril, the ABA Criminal Justice Section’s Women in Criminal Justice Task Force (TF) continues its groundbreaking work of documenting challenges in hiring, retention and promotion of women criminal lawyers. Pulling Back the Curtain follows up on the initial findings of the TF. The findings are published in the Berkeley Journal of Criminal Law and the ABA Criminal Justice magazine. This report describes the results of a subsequent survey of diverse criminal lawyers and judges conducted at the end of 2020. The survey posed questions related to …

Tet2 And Dnmt3a Mutations Exert Divergent Effects On Dna Repair And Sensitivity Of Leukemia Cells To Parp Inhibitors, Silvia Maifrede, Bac Viet Le, Margaret Nieborowska-Skorska, Konstantin Golovine, Katherine Sullivan-Reed, Wangisa M B Dunuwille, Joseph Nacson, Michael Hulse, Kelsey Keith, Jozef Madzo, Lisa Beatrice Caruso, Zachary Gazze, Zhaorui Lian, Antonella Padella, Kumaraswamy N. Chitrala, Boris A. Bartholdy, Ksenia Matlawska-Wasowska, Daniela Di Marcantonio, Giorgia Simonetti, Georg Greiner, Stephen M Sykes, Peter Valent, Elisabeth M. Paietta, Martin S. Tallman, Hugo F. Fernandez, Mark R. Litzow, Mark D. Minden, Jian Huang, Giovanni Martinelli, George S. Vassiliou, Italo Tempera, Katarzyna Piwocka, Neil Johnson, Grant A. Challen, Tomasz Skorski

Pediatrics Research and Scholarship

Somatic variants in TET2 and DNMT3A are founding mutations in hematological malignancies that affect the epigenetic regulation of DNA methylation. Mutations in both genes often co-occur with activating mutations in genes encoding oncogenic tyrosine kinases such as FLT3ITD, BCR-ABL1, JAK2V617F , and MPLW515L , or with mutations affecting related signaling pathways such as NRASG12D and CALRdel52 . Here, we show that TET2 and DNMT3A mutations exert divergent roles in regulating DNA repair activities in leukemia cells expressing these oncogenes. Malignant TET2-deficient cells displayed downregulation of BRCA1 and LIG4, resulting in reduced activity of BRCA1/2-mediated homologous recombination (HR) and DNA-PK-mediated non-homologous …

Unm Medicine Fall 2021, University Of New Mexico, Health Sciences Center, School Of Medicine

School of Medicine Alumni Magazine

No abstract provided.

Unm Medicine, The University Of New Mexico School Of Medicine Alumni Magazine, Fall 2020, Ashley Salazar, Bridgette Wagner Jones, Alexandria Sanchez, Elizabeth Sandlin, David A. Andrade, Supreetha Gubbala, Tenisha Marques, Ruth Morgan, Paige R. Penland, Michael E. Richards, C Nathaniel Roybal, Maggie Schold, Michele W. Sequeria, Jett Loe, Raymond Mares, José Rodriguez, Alan Stone

School of Medicine Alumni Magazine

No abstract provided.

Health, Exercise & Sports Sciences 2021 Apr Self-Study & Documents, University Of New Mexico

UNM Academic Program Review

UNM Health, Exercise & Sports Sciences APR self-study report and review team report for Fall 2021, fulfilling requirements of the Higher Learning Commission.

Growth Rates Of Infants Randomized To Continuous Positive Airway Pressure Or Intubation After Extremely Preterm Birth, Ariel A. Salas, Waldemar A. Carlo, Barbara T. Do, Edward F. Bell, Abhik Das, Krisa P. Van Meurs, Brenda B. Poindexter, Seetha Shankaran, Noelle Younge, Kristi L. Watterberg, Rosemary D. Higgins, Eunice Kennedy Shriver National Institute Of Child Health And Human Development Neonatal Research Network

Pediatrics Research and Scholarship

OBJECTIVE: To evaluate the effects of early treatment with continuous positive airway pressure (CPAP) on nutritional intake and in-hospital growth rates of extremely preterm (EPT) infants.

STUDY DESIGN: EPT infants (24

RESULTS: Growth data were analyzed for 810 of 1316 infants enrolled in SUPPORT (414 in the intervention group, 396 in the control group). The median gestational age was 26 weeks, and the mean birth weight was 839 g. Baseline characteristics, total nutritional intake, and in-hospital comorbidities were not significantly different between the 2 groups. In a regression model, growth rates between birth and 36 weeks of PMA, as well …

Optical Sciences & Engineering 2021 Apr Self-Study & Documents, University Of New Mexico

UNM Academic Program Review

UNM Optical Sciences & Engineering APR self-study report and addendum for Fall 2021, fulfilling requirements of the Higher Learning Commission. OSE was postponed in Fall 2020 following the emergence of the coronavirus, as such their self-study is from Fall 2020. The 2021 addendum serves to update this document.

Ethics Of Ai In Pathology: Current Paradigms And Emerging Issues, Chhavi Chauhan, Rama R. Gullapalli

Pathology Research and Scholarship

Deep learning has rapidly advanced artificial intelligence (AI) and algorithmic decision-making (ADM) paradigms, affecting many traditional fields of medicine, including pathology, which is a heavily data-centric specialty of medicine. The structured nature of pathology data repositories makes it highly attractive to AI researchers to train deep learning models to improve health care delivery. Additionally, there are enormous financial incentives driving adoption of AI and ADM due to promise of increased efficiency of the health care delivery process. AI, if used unethically, may exacerbate existing inequities of health care, especially if not implemented correctly. There is an urgent need to harness …

Trade-Offs In Growth And Development: A Life History Approach, Anna Medendorp Rautman

Anthropology ETDs

Life history theory (LHT) is the conceptualization of tradeoffs in resources allocation. Plasticity, the ability of phenotypes to vary in response to environmental cues, is integral to LHT. Prior to completed maturation, resources are distributed towards maintenance or somatic maturation, a combination of growth and development (G&D). This dissertation presents an examination of intragroup variation in the G&D of the dental and skeletal systems within a sample of 20th century White females to consider whether they provide evidence for tradeoffs within the subadult interval. In a series of individual research chapters, I consider the following: 1) how does the relative …

Servitudes Done "Proper"Ly: Propriety, Not Contract Law, Elizabeth Elia

Faculty Scholarship

The law of servitudes has changed dramatically in the last hundred years. Legal scholars have been successful in documenting these changes in case law, but less successful in articulating a unified set of principles that guide the current law of servitudes. One explanation that received significant attention is the idea that efficient recording systems in the United States have liberated property owners from the constraints of traditional property laws disfavoring servitudes and have allowed these owners the broader freedoms of contract law. However, this explanation, and the sweeping common law reforms that flow from it, have not resonated with courts. …

New Mexico Health Care Workforce Committee 2021 Annual Report, University Of New Mexico - Health Sciences Center

New Mexico Health Care Workforce Committee (2013-ongoing)

Each year the New Mexico Health Care Workforce Committee studies the supply and distribution of health care providers in order to provide a report to the Legislature by October 1. The committee also makes recommendations for improving recruitment and retention of providers in New Mexico's rural and underserved areas.

Providing Real-Time Resources In Support Of Lgbtq+ And Hiv+ Populations As Information Experts On The Echo Hub Team: A Case Report., Laura Menard, Chelsea Misquith

Project ECHO Bibliography

Background: Project ECHO (Extension for Community Healthcare Outcomes) is a telehealth initiative that aims to reduce disparities in delivery of health care by leveraging technology and local expertise to provide guidance on specialized subjects to health care providers across the world. In 2018, a new ECHO hub convened in Indianapolis with a focus on health care for individuals in the lesbian, gay, bisexual, trans, and queer (LGBTQ+) populations. This ECHO iteration was one of the first of its kind and would soon be followed by a new human immunodeficiency virus (HIV) ECHO as well.

Case Presentation: In a novel approach, …

Piloting A Diversity, Equity, And Inclusion Needs Assessment To Explore Patron Perceptions At A University Health Science Library, Jane Morgan-Daniel, Lauren E. Adkins, Michele R. Tennant, Hannah F. Norton, Chloe Hough, Mary E. Edwards, Matthew Daley, Melissa L. Rethlefsen

Publications

Objective: A diversity, equity, and inclusion (DEI) needs assessment was conducted at a health sciences library. The objectives were to (1) quantitatively assess patrons’ attitudes towards the existing DEI climate in the library and (2) qualitatively identify contextual factors influencing patrons’ perceptions. The purpose was to better understand patrons’ views of the DEI climate in order to identify potential gaps, strengths, and areas of improvement within the library.

Population: The assessment was led by a DEI Team at the University of Florida’s Health Science Center Libraries (HSCL). HSCL serves the university’s six health science colleges from two sites, Gainesville and …

Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report On 30 Patients, Hasan Hashem, Giorgia Bucciol, Seza Ozen, Sule Unal, Ikbal Ok Bozkaya, Nurten Akarsu, Mervi Taskinen, Minna Koskenvuo, Janna Saarela, Dimana Dimitrova, Dennis D. Hickstein, Amy P. Hsu, Steven M. Holland, Robert Krance, Ghadir Sasa, Ashish R. Kumar, Ingo Müller, Monica Abreu De Sousa, Selket Delafontaine, Leen Moens, Florian Babor, Federica Barzaghi, Maria Pia Cicalese, Robbert Bredius, Joris Van Montfrans, Valentina Baretta, Simone Cesaro, Polina Stepensky, Neven Benedicte, Despina Moshous, Guillaume Le Guenno, David Boutboul, Jignesh Dalal, Joel P. Brooks, Elif Dokmeci, Jasmeen Dara, Carrie L. Lucas, Sophie Hambleton, Keith Wilson, Stephen Jolles, Yener Koc, Tayfun Güngör, Caroline Schnider, Fabio Candotti, Sandra Steinmann, Ansgar Schulz, Chip Chambers, Michael Hershfield, Amanda Ombrello, Jennifer A. Kanakry, Isabelle Meyts

Pediatrics Research and Scholarship

PURPOSE: Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency, lymphoproliferation, immune cytopenias, and bone marrow failure (BMF). Tumor necrosis factor (TNF-α) blockade is the treatment of choice for the vasculopathy, but often fails to reverse refractory cytopenia. We aimed to study the outcome of hematopoietic cell transplantation (HCT) in patients with DADA2.

METHODS: We conducted a retrospective study on the outcome of HCT in patients with DADA2. The primary outcome was overall survival (OS).

RESULTS: Thirty DADA2 patients …

'That Name Is Dead To Me': Reforming Name Change Laws To Protect Transgender And Nonbinary Youth, Sarah Steadman

Faculty Scholarship

For transgender and some nonbinary youth, living under a chosen name is a first step toward becoming their authentic selves. For these youth, a name change is powerful; it allows them to choose a name that matches their gender identity. They consider their birth name to be a distressing “dead” name - one that they cannot relate to and need to bury.

Using one’s chosen name decreases suicidality among transgender youth who face many challenges, including family rejection and other severe mental health stressors. Transgender and nonbinary youth can only require others to use their chosen names after obtaining a …

Economics 2021 Apr Self-Study & Documents, University Of New Mexico

UNM Academic Program Review

UNM Economics APR self-study report for Fall 2021, fulfilling requirements of the Higher Learning Commission.

Heterogeneity Of Circulating Tumor Cell Neoplastic Subpopulations Outlined By Single-Cell Transcriptomics, Christine M. Pauken, Shelby Ray Kenney, Kathryn J. Brayer, Yan Guo, Ursa A. Brown-Glaberman, Dario Marchetti

Pathology Research and Scholarship

Fatal metastasis occurs when circulating tumor cells (CTCs) disperse through the blood to initiate a new tumor at specific sites distant from the primary tumor. CTCs have been classically defined as nucleated cells positive for epithelial cell adhesion molecule and select cytokeratins (EpCAM/CK/DAPI), while negative for the common lymphocyte marker CD45. The enumeration of CTCs allows an estimation of the overall metastatic burden in breast cancer patients, but challenges regarding CTC heterogeneity and metastatic propensities persist, and their decryption could improve therapies. CTCs from metastatic breast cancer (mBC) patients were captured using the RareCyte

10-12-2021 Hsc Committee Notice, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.