Digital Commons Network^™

Ulcerative Colitis: Novel Epithelial Insights Provided By Single Cell Rna Sequencing, Joao M. Serigado, Jennifer Foulke-Abel, William C. Hines, Joshua A. Hanson, Julie In, Olga Kovbasnjuk

Pathology Research and Scholarship

Ulcerative Colitis (UC) is a chronic inflammatory disease of the intestinal tract for which a definitive etiology is yet unknown. Both genetic and environmental factors have been implicated in the development of UC. Recently, single cell RNA sequencing (scRNA-seq) technology revealed cell subpopulations contributing to the pathogenesis of UC and brought new insight into the pathways that connect genome to pathology. This review describes key scRNA-seq findings in two major studies by Broad Institute and University of Oxford, investigating the transcriptomic landscape of epithelial cells in UC. We focus on five major findings: (1) the identification of BEST4 + cells, …

Serenity Mesa Youth Recovery Center - Addiction And Adolescents, Jennifer Weiss-Burke

Brain & Behavioral Health Research Day

Serenity Mesa Youth Recovery Center is a transitional living treatment facility located in Albuquerque. Serenity Mesa provides 90-days of treatment, life skills, high school education, and career readiness for young people (ages 14-21) who are looking to get help for their substance abuse issues. Serenity Mesa is one of the only treatment centers in NM providing services to youth. Our goal is to meet each young person where they are at and try and build treatment goals around their individual needs, taking into account their living situation, family supports, substance abuse, mental health issues, age, education, and job skills. Working …

Knowledge Graph Analytics Platform With Lincs And Idg For Parkinson's Disease Target Illumination, Jeremy Yang, Chris Gessner, Joel Duerksen, Daniel Biber, Jessica Binder, Murat Ozturk, Brian Foote, Robin Mcentire, Kyle Stirling, Ying Ding, David Wild

Brain & Behavioral Health Research Day

NIH programs LINCS, “Library of Integrated Network-based Cellular Signatures”, and IDG, “Illuminating the Druggable Genome”, have generated rich open access datasets for the study of the molecular basis of health and disease. LINCS provides experimental genomic and transcriptomic evidence. IDG provides curated knowledge for illumination and prioritization of novel protein drug target hypotheses. Together, these resources can support a powerful new approach to identifying novel drug targets for complex diseases. Integrating LINCS and IDG, we built the Knowledge Graph Analytics Platform (KGAP) for identification and prioritization of drug target hypotheses, via open source package kgap_lincs-idg. We investigated results for Parkinson’s …

Creating A Quality Life For People With Brain Injuries Using Neuroplasticity, Mindfulness Meditation, Mindfulness-Based Stress Reduction, Ken Collins

Brain & Behavioral Health Research Day

Ken Collins has lived with his brain injury for 45 years and has worked with people with brain injuries since 1983. He is an advocate of developing home and community-based services for people with brain injuries. In 1986-88 he was a VISTA Volunteer and helped develop the first transitional living program for people with brain injuries in the U.S. Ken is currently employed as Executive Director, Hozho Center for Personal Enhancement in Gallup, New Mexico where he supervises staff and provides independent living services to Veterans, Navajo's and Zuni's with brain injuries in McKinley County.

Pilot And Feasibility Study Of Universal Screening For Opioid Use Disorder And Co-Occurring Depression And/Or Post-Traumatic Stress Disorder In Primary Care Settings In New Mexico, Cristina Murray-Krezan, Alex Dopp, Lina Tarhuni, Mary D. Carmody, Kirsten Becker, Jessica Anderson, Miriam Komaromy, Lisa S. Meredith, Katherine Watkins, Katherine Wagner, Kimberly Page

Brain & Behavioral Health Research Day

Study Rationale: We implemented a feasibility/pilot study to assess identification of opioid use disorder (OUD) and co-occurring mental health disorders (depression and post-traumatic stress disorder; co-MHD) in 4 primary care (PC) clinics. The main goals were to: 1) assess the feasibility of implementing universal screening for probable OUD, depression, and PTSD in PC clinics to inform recruitment for a planned clinical trial (2) assess pilot measures for detecting probable OUD and co-MHD (“observed”) by comparing to electronic health record diagnoses (EHR, “expected”).

Methods: Two sources of data were accessed, and prevalence estimates were calculated and compared on: aggregate data from …

Hslic Annual Report Fy2021-22, University Of New Mexico Health Sciences Library And Informatics Center

HSLIC Annual Reports

No abstract provided.

نيوتروسوفيك أوفرسيت ، نيوتروسوفيك أونديرست ، وإزاحة نيوتروسوفيك [Neutrosophic Overset, Neutrosophic Underset, And Neutrosophic Offset], Florentin Smarandache, Riad K Al-Hamido (Translator From English To Arabic)), Khaled Adnan Alabdullah (Translator From English To Arabic)

Branch Mathematics and Statistics Faculty and Staff Publications

تم تعريف Neutrosophic Over-/ Under- / Off-Set and -Logic لأول مرة بواسطة Smarandache في عام 1995 ونشر في عام 2007. وهي مختلفة تمامًا عن المجموعات / المنطق / الاحتمالات الأخرى. قام بتمديد مجموعة العدلات على التوالي إلى Neutrosophic Overset {عندما يكون بعض مكونات neutrosophic> 1} ، Neutrosophic Underset {عندما يكون بعض مكونات neutrosophic <0} ، وإلى إزاحة Neutrosophic {عندما تكون بعض مكونات العدلات خارج الفاصل الزمني [0 ، 1] ، أي بعض مكونات العدلات> 1 ومكونات أخرى نيوتروسوفيك <0}. هذا ليس مفاجئًا فيما يتعلق بالمجموعة / المنطق الغامض الكلاسيكي ، أو المجموعة / المنطق الغامض الحدسي ، أو الاحتمال الكلاسيكي / غير الدقيق ، حيث لا يُسمح بالقيم خارج الفاصل الزمني [0 ، 1] ، نظرًا لأن عالمنا الحقيقي به العديد من الأمثلة و تطبيقات المكونات الزائدة / السفلية / البعيدة عن العدلات

Neutrosophic Over-/Under-/Off-Set and -Logic were defined for the first time by Smarandache in 1995 and published in 2007. They are totally different from other sets/logics/probabilities. He extended the neutrosophic set respectively to Neutrosophic Overset {when some neutrosophic component is > 1}, Neutrosophic Underset {when …

Collected Papers (On Neutrosophics Theory And Applications), Volume Xii, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

This twelfth volume of Collected Papers includes 86 papers comprising 976 pages on Neutrosophic Theory and Applications, published between 2013-2021 in the international journal and book series NSS by the author alone or in collaboration with the following 112 co-authors (alphabetically ordered) from 21 countries.

Snap-Ed Nm Evaluation: Policy, System, And Environment Evaluation 2018-2022, Theresa H. Cruz, Erica Landrau-Cribbs, Camille Velarde, Yvonnie Vitanzos

Reports & Documents

No abstract provided.

Health Literacy Book Club Kits: Bifold Brochures, Allison B. Cruise, Kristin R. Proctor, Amy E. Weig-Pickering

Projects

The Health Sciences Library and Informatics Center (HSLIC) created ten Reading Is Healthy Book Club Kits and made them available for checkout to public libraries and community organizations in New Mexico. Each kit includes eight copies of a book club selection along with discussion questions and health literacy materials.

The goals of this project are to encourage conversations around health and wellness topics, destigmatize the discussion of health topics, and increase health literacy in our communities. This aligns with HSLIC’s strategic goal to empower our communities to engage with health information.

These bifold brochures were create by HSLIC staff as …

State Ballot Initiatives And Federal Preemption: How Colorado Voters Have Changed Cooperative Federalism In Wildlife Management, Lucas O'Brien

Natural Resources Journal

In United States wildlife management, there is a notion that the federal government manages land while states manage wildlife. While it is true that states have historically held authority over wildlife, federal agencies often also have the authority, and often an obligation, to manage and conserve wildlife. This overlapping jurisdiction has led to the frequent preemption of state wildlife laws and management tactics by federal statutes or objectives, eroding state authority in this area over the past century. In the 2020 election, Colorado voters passed Proposition 114, a state ballot initiative that requires Colorado Parks and Wildlife to reintroduce wolves …

More Than A Rake: Toward A Statutory Solution For Wildfire Threats To Department Of Defense Installations, Steven L. Spencer Ii Major

Natural Resources Journal

Over the past four decades, the average area annually burned in wildfires in the United States has roughly quadrupled. Larger, more powerful wildfires increasingly threaten inhabited areas as well as vital infrastructure, including many installations of the United States Armed Forces. This article first introduces readers to what wildfire is and the unique challenges it creates to the environment, health and, specifically, to the Department of Defense (DoD). Next, it discusses the dominant approaches to addressing the wildfire threat, prescribed fire and mechanical treatment. It then summarizes the primary laws, policies and partners involved in wildfire policy in the United …

Waste: One Woman’S Fight Against America’S Dirty Secret By Catherine Coleman Flowers (The New Press, 2020), Deanna Warren

Natural Resources Journal

No abstract provided.

Case Note: Federal Indian Law – Tribal Criminal Jurisdiction – Indian Civil Rights Act – Tribal Sovereignty – United States V. Cooley, Sarah A. Sadlier, Mnikȟówožu Lakȟóta

Tribal Law Journal

In United States v. Cooley, a Ninth Circuit panel denied a petition for rehearing en banc, holding that a tribal officer, who was not cross-deputized, could neither search nor detain a non-Indian on a federal or state highway right-of-way through the reservation unless that individual had committed an “apparent” crime in the officer’s presence. Narrowly defining tribal police authority, the panel ruled that the officer conducted an extra-jurisdictional search and seizure. In arriving at this conclusion, the panel refused to recognize that the Tribe’s sovereignty affords its law enforcement agencies the authority to investigate those who imperil public order on …

Bad Men Among The Whites Claims In The Mni Wiconi Age, Julie Combs, Cherokee Nation

Tribal Law Journal

In a series of nine treaties with Native Nations in the late 1860s, the United States promised to reimburse Indigenous people for wrongs committed by “bad men among the whites, or among other people subject to the authority of the United States.” In the century and half that followed the signing of these nine treaties, “bad men among the whites” claims have been litigated in the Federal Circuit with some success by Indigenous plaintiffs, and courts have shaped the meaning of the clause and the remedies a successful plaintiff may receive. This comment explores the Bad Men clause in the …

Hegemonic Instability? India’S Himalayan Hegemony In Theoretical And Historical Perspective, Philip Hultquist Ph.D., Prakash Adhikari Ph.D.

Himalayan Research Papers Archive

Is India the regional hegemon of South Asia? If so, what kind of hegemon is it? India has long been considered the regional hegemon of South Asia, primarily based on relative power considerations alone. We critique this material basis for hegemony. Hegemons must act to establish their hegemony, and smaller states must acquiesce to some degree to establish the relationship. We follow the literature to identify three strands of behavioral definitions of regional hegemony—leadership, domination, and sphere of influence—each drawing on different theoretical foundations, liberalism, realism, and imperialism, respectively. India has demonstrated characteristics of each, depending on the period and …

Snap-Ed Focus Groups With Adults, Theresa H. Cruz, Erica Landrau-Cribbs, Camille Velarde, Yvonnie Vitanzos

Reports & Documents

No abstract provided.

We Need To Make A Plan A Journey And Guide To Project Management, Robyn M. Gleasner

Publications

This book chapter (from Project Management in Technical Services: Practical Tips and Case Studies) out­lines how project management and planning came to fruition for the Resources, Archives, and Discovery Unit (RAD) at the University of New Mexico Health Sciences Library & Informatics Center (UNM HSLIC). It also demonstrates how project management can help achieve the goals of projects by showing specific examples from projects such as the integrated library system migration, fourth floor shift to make room for a new classroom, and other inventory and shelf management projects as well as offering lessons learned along the way.

No “Box To Be Checked”: Environmental Justice In Modern Legal Practice, Clifford J. Villa

Faculty Scholarship

For nearly thirty years, environmental justice has been part of our civic conversation and included in the mission of federal agencies. But while public attention to environmental justice has waxed and waned over time, environmental justice principles have endured and developed into rules of law. This development may be expected to continue and accelerate with recent events such as the nationwide outcry after the police killing of George Floyd in 2020, the disparate impacts of COVID-19 on people of color, and the express priorities of the Biden administration. This paper seeks to help legal practitioners and other interested parties comprehend …

Affirmed Or Delegated? Finding Inherent Tribal Civil Power To Issue Protection Orders Against All Persons In Light Of Spurr V. Pope, Kelly Gaines Stoner, Cherokee Ancestry, Lauren Van Schilfgaarde, Cochiti Pueblo

Tribal Law Journal

Federal courts have wreaked havoc on tribal jurisdiction by injecting incertitude over their most basic authority, including the authority to issue and enforce civil protection orders. This jurisdictional incertitude causes not just legal disruption, but also further compromises the safety of Native people who are disproportionately victimized, especially by gender-based forms of violence. While Congress has been slow to remedy the onslaught of judicial limitations on tribal jurisdiction, Congress has at least remedied tribal authority to issue and enforce protection orders in 18 U.S.C. § 2265(e). However, even in this remedy, jurisdictional incertitude remains.

Spatially Distributed Infection Increases Viral Load In A Computational Model Of Sars-Cov-2 Lung Infection, Melanie E. Moses, Steven Hofmeyr, Judy L. Cannon, Akil Andrews, Rebekah Gridley, Monica Hinga, Kirtus Leyba, Abigail Pribisova, Vanessa Surjadidjaja, Humayra Tasnim, Stephanie Forrest

Pathology Research and Scholarship

A key question in SARS-CoV-2 infection is why viral loads and patient outcomes vary dramatically across individuals. Because spatial-temporal dynamics of viral spread and immune response are challenging to study in vivo, we developed Spatial Immune Model of Coronavirus (SIMCoV), a scalable computational model that simulates hundreds of millions of lung cells, including respiratory epithelial cells and T cells. SIMCoV replicates viral growth dynamics observed in patients and shows how spatially dispersed infections can lead to increased viral loads. The model also shows how the timing and strength of the T cell response can affect viral persistence, oscillations, and control. …

Randomized Controlled Trial Of Early Outpatient Covid-19 Treatment With High-Titer Convalescent Plasma, David J. Sullivan, Kelly A. Gebo, Shmuel Shoham, Bryan Lau, Aarthi G G Shenoy, Giselle S. Mosnaim, Thomas J. Gniadek, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L. Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S. Raval, Seble G. Kassaye, E Colin Foster, Michael Roth, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. Mcbee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Stephan Ehrhardt, Sheriza N. Baksh, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, Arturo Casadevall, Aaron A R Tobian, Daniel F. Hanley, Evan M. Bloch, Valerie C. Cluzet

Pathology Research and Scholarship

BACKGROUND: The efficacy of polyclonal high titer convalescent plasma to prevent serious complications of COVID-19 in outpatients with recent onset of illness is uncertain.

METHODS: This multicenter, double-blind randomized controlled trial compared the efficacy and safety of SARS-CoV-2 high titer convalescent plasma to placebo control plasma in symptomatic adults ≥18 years positive for SARS-CoV-2 regardless of risk factors for disease progression or vaccine status. Participants with symptom onset within 8 days were enrolled, then transfused within the subsequent day. The measured primary outcome was COVID-19-related hospitalization within 28 days of plasma transfusion. The enrollment period was June 3, 2020 to …

The Power Of Outdoor Learning Experiences: A Narrative Inquiry, Vincent M. Case

Language, Literacy, and Sociocultural Studies ETDs

Outdoor learning experiences offer schools an initial avenue to address global community issues, including climate change, natural resource depletion, disconnection from nature, and the current global coronavirus pandemic. This narrative inquiry study, grounded in the theoretical work of Vygotsky, Cajete, Brody, and Kahn, seeks to understand how children’s perceptions of their outdoor learning experiences provide insights into their learning processes. This study’s findings suggest that regardless of the location (mountains, home, school campuses, local natural areas), students say that they: experience positive affect and enjoyment; observe through their senses to explore, discover, inquire, change their behavior, and build deeper relationships …

Arginine-Rich Polypeptides Are Potent Inhibitors Of Human Papillomavirus Infection And Powerful Tools To Investigate Viral Attachment And Entry, Jesse Mckay Young

Biomedical Sciences ETDs

HPV is the most common sexually transmitted infection. It is estimated that 80% of sexually active adults will contract an HPV infection. Thus, there is a significant need for low-cost and easily distributable HPV antivirals that can be used alongside vaccines to combat infection. Herein I have identified protamine sulfate (PS) as a potent microbicide against HPV infection. PS was agnostic to genotype and efficacious pre and post HPV exposure. PS application topically reduced HPV internalization by altering epidermal growth factor receptor (EGFR) signaling and suppressed EGFR-stimulated HPV entry. Our preliminary data also suggest that heparin binding epidermal growth factor …

Soil Moisture Dependent Runoff In A Dryland Region: An Investigation Of The Role Of Antecedent Conditions, Monitoring, And Modeling Strategies, Gerhard Schoener

Civil Engineering ETDs

Approximately 30% of the Earth’s land surface is characterized as arid or semiarid, including much of the western United States. Accurate runoff predictions are important for informed watershed management, particularly in rapidly urbanizing areas. Infiltration excess overland flow is the dominant mechanism for runoff generation in many dryland basins, and event-based infiltration or loss models are commonly used to estimate runoff. However, predictions are associated with considerable uncertainty due to the role antecedent soil moisture, an initial condition that must be set by the modeler. The objectives of my research were to (1) evaluate the impact of antecedent soil moisture …

20211217_Hslic Door Window Decorating Contest, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

Systems And Methods For Scalable Retinal Screening Programs, Jeremy Richard Benson

Computer Science ETDs

This dissertation addresses gaps in artificial intelligence-based computer vision tasks in the medical image processing field. We demonstrate effective methods for standardizing and augmenting digital fundus photographs so that robust convolutional neural network-based systems can perform high-throughput disease classification and generalize to never-before-seen data from novel camera technologies, scaling with the changing hardware landscape, as well as keeping up with vast amount of incoming data from the ever-increasing population. We also tackle the problem of discovering relevant samples in an unlabeled cohort of image data, thus widening the bottleneck to all downstream supervised machine learning tasks.

Energetic Tradeoffs, Infection, And Immunity In Wild Chimpanzees Of Uganda And Tanzania, Sarah Renee Phillips

Anthropology ETDs

Infectious disease is a primary source of mortality for most mammal species, but scientists have little understanding of factors driving variation in infection and immunity between individuals, populations, and species in the wild. Life history theory provides an evolutionary framework for delineating distribution of available energy to competing physiological demands, including growth, reproduction, and maintenance. Early life reproduction should be favored over late life survival, but, in long-lived species, reproductive success is strongly tied to survival to old age. Slower pace of reproduction could allow investment in immunity, reducing risk of morbidity and mortality to infectious disease. Additionally, several host …

Synthetic Aperture Optical Imaging Interferometric Microscopy With Improved Image Quality, Preyom K. Dey

Electrical and Computer Engineering ETDs

The resolution limit of optical microscopy can be extended by using Imaging Interferometric Microscopy (IIM), which uses a low numerical aperture (NA) objective lens to achieve resolution equivalent to that of a high-NA objective lens with multiple sub-images. Along with the resolution enhancement challenge, IIM often suffers from poor image quality. In this dissertation, several image quality improvement methods are proposed and verified with simulation and experimental results. Next, techniques to extend the resolution limit of IIM to ≤ 100nm using a low-NA objective lens are demonstrated. An experimental technique of using a grating coupler on …

Moderate Prenatal Ethanol Exposure, Sex, And Housing Modify Spatial Navigation Behavior And Hippocampal Cell Firing In Adult Rodents, Christy Magcalas

Psychology ETDs

Prenatal alcohol exposure (PAE) is associated with structural and physiological changes that impact the central nervous system and can result in persistent negative consequences in a broad spectrum of cognitive and behavioral domains including deficits in spatial learning and memory and behavioral flexibility. The current study focuses on examining the behavioral and mechanistic consequences of PAE, sex and housing. Rats were tested in the Morris Water Task where they were trained to navigate to a goal location and tested in a pool shift manipulation. There were no significant differences between PAE treatment, sex, or housing groups during training, but there …