Digital Commons Network^™

20211215_Dr. Eldredge Receives Hsc Faculty Research Excellence Award, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

Comparison Of The Transcriptomic Signatures In Pediatric And Adult Cml, Minyoung Youn, Stephanie M. Smith, Alex Gia Lee, Hee-Don Chae, Elizabeth Spiteri, Jason Erdmann, Ilana Galperin, Lara Murphy Jones, Michele Donato, Parveen Abidi, Henrique Bittencourt, Norman Lacayo, Gary Dahl, Catherine Aftandilian, Kara L. Davis, Jairo A. Matthews, Steven M. Kornblau, Min Huang, Nathan Sumarsono, Michele S. Redell, Cecilia H. Fu, I-Ming Chen, Todd A. Alonzo, Elizabeth Eklund, Jason Gotlib, Purvesh Khatri, E Alejandro Sweet-Cordero, Nobuko Hijiya, Kathleen M. Sakamoto

Pathology Research and Scholarship

Children with chronic myeloid leukemia (CML) tend to present with higher white blood counts and larger spleens than adults with CML, suggesting that the biology of pediatric and adult CML may differ. To investigate whether pediatric and adult CML have unique molecular characteristics, we studied the transcriptomic signature of pediatric and adult CML CD34+ cells and healthy pediatric and adult CD34+ control cells. Using high-throughput RNA sequencing, we found 567 genes (207 up- and 360 downregulated) differentially expressed in pediatric CML CD34+ cells compared to pediatric healthy CD34+ cells. Directly comparing pediatric and adult CML CD34+ cells, 398 genes (258 …

Wagon Tracks Volume 35, Issue 4 (August 2021)

Wagon Tracks

Contents

2 On the Cover: Cheyenne Horse Guard by Ron Kil

4 Insights from your President

5 Joanne’s Jottings

2, 6-11 Trail News

12-16 2021 SFTA Symposium

29-30 Book Reviews: David C. Beyreis, Blood in the Borderlands; Conflict, Kinship, and the Bent Family, 1821-1920. Reviewed by John Porter Bloom. Richard L. Miller, John P. Slough: The Forgotten Civil War General. Reviewed by Leo Oliva. Lee M. Cullimore, To Make a Fortune in Missouri: Meredith Miles Maramduke 1791-1864. Reviewed by Rich Lawson.

31-36 Chapter Reports

33 Membership Form

36 Calendar

Cardiovascular Diseases Risk Analysis Using Distance-Based Similarity Measure Of Neutrosophic Sets, Norzieha Mustapha, Suriana Alias, Roliza Md Yasin, Ilyani Abdullah, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

Selection A Suitable Supplier For Enhancing Supply Chain Management Under Neutrosophic Environment, Hager Hosny, Ibrahim El-Henawey, Samah Abo-Elhadid

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Fuzzy Boundary Value Problem Under Generalized Hukuhara Differentiability, Bassem A. Kamal, A. A. Salama, M. Shokry, Magdi S. El-Azab, Galal I. El-Baghdady

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Sets And Systems, Vol. 47, 2021, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

Practice Development Trajectories Of Experienced Nurses: Adaptive Experts, Routine Experts, And Non-Experts, Dee Mulcahy

Nursing ETDs

This qualitative study examined practice development among experienced, acute care nurses (n = 9) with at least 10 years of experience. Using an interpretive biographical approach, with participants’ written practice narratives and in-depth interviews, the study focused on how the work environment and life experiences influenced or impeded practice development. Participants were classified as routine- or adaptive experts (n = 3 of each type) with one intermediate case and two not readily classifiable. Antecedents to becoming a nurse included family influences, personal interests, altruistic values, and financial need. Experience was necessary but not sufficient for adaptive expertise. Compared …

Decreasing Water Supply And Community Health In New Mexico: A Reason For Change, Chelsea Whitney

Climate Change and Public Health Preparedness

No abstract provided.

Statistical Development Of The Neutrosophic Lognormal Model With Application To Environmental Data, Zahid Khan, Adnan Amin, Sajjad Ahmad Khan, Muhammad Gulistan

Neutrosophic Sets and Systems

No abstract provided.

Effects Of Inclusive Social Skills Training On Preschoolers, Lauren E. Weiss

Special Education ETDs

Social interventions for children with disabilities are generally conducted in small groups and outside of the classroom; therefore, little is known about inclusive and classwide social interventions in early childhood educational settings. This study evaluated the effects of inclusive social skills training (ISST), a program delivered remotely to inclusive preschool classrooms via direct instruction, video modeling, rehearsal, and feedback, to teach social skills. Educators rated preschoolers' social skills in a nonequivalent pretest-posttest design and evaluated the social validity of ISST. I examined the differences in scores. A significant interaction effect was detected in the program group between abilities. Overall, educators …

What Does Social Entrepreneurship Mean To Change Agents In New Mexico? A Phenomenographic Approach To Understanding Social Entrepreneurship, Audriana Stark

Organization, Information and Learning Sciences ETDs

Social entrepreneurship has been identified as a solution to some of the world’s most pressing problems, including health, education, and environmental issues. Despite the rise in literature about social entrepreneurship, there is still a lack of understanding how place-based social entrepreneurship is being conceived and experienced by practitioners. Therefore, this study uses a phenomenographic approach to understand what social entrepreneurship means to change agents in New Mexico, a place characterized by social and economic challenges, as well as an abundance of natural and cultural resources. The findings revealed five distinct categories of description for social entrepreneurship including: Category 1. No …

Windblown Transport Of Toxic Metals In Airborne Particulate Matter Near The Jackpile-Paguate Uranium Mine On Laguna Pueblo, New Mexico, Savannah S. Larosa-Lopresti

Earth and Planetary Sciences ETDs

Abandoned uranium mines across the U.S. disproportionately affect indigenous communities who suffer numerous intergenerational health consequences from chronic exposure to toxic metal mixtures. The Jackpile-Paguate Uranium Mine on Laguna Pueblo in west-central New Mexico was designated a Superfund Site in 2013 and exposure risks from inhalation of toxic metals in airborne particulate matter are of concern for the local tribal communities. This research aims to examine atmospheric parameters driving windblown transport of respirable particulate matter in the region, to determine concentrations of heavy metals including U, V, Pb, and As due to the link with potential health risks, and to …

20211207_Clinicalkey Resources Available, Robyn Gleasner

HSLIC Blog Post

No abstract provided.

Efficacy And Safety Of Low-Dose Versus High-Dose Hydrocortisone To Treat Hypotension In Neonates: A Protocol For A Systematic Review And Meta-Analysis, Katelyn Sushko, Nada Al-Rawahi, Kristi L. Watterberg, John Van Den Anker, Catherine Litalien, Jacques Lacroix, Abdul Razak, Samira Samiee-Zafarghandy

Pediatrics Research and Scholarship

BACKGROUND: Impaired adrenal function is a well-described entity in critically ill term and preterm neonates with systemic hypotension. The standard treatment for neonatal hypotension includes volume expanders and vasopressors. Recent evidence supports the use of glucocorticoids for the primary or rescue treatment of neonatal hypotension associated with impaired adrenal function. However, inconsistency regarding the prescribed dosing regimen to provide the best balance between efficacy and safety in this vulnerable population remains an area of concern.

METHODS: We will conduct a systematic review and meta-analysis to evaluate low-dosing compared with high-dosing regimens of hydrocortisone for the treatment of hypotension in critically …

Telehealth During The Covid-19 Pandemic: A Cross-Sectional Survey Of Registered Dietitian Nutritionists, Mary Rozga, Deepa Handu, Kathryn Kelley, Elizabeth Yakes Jimenez, Hannah Martin, Marsha Schofield, Alison Steiber

Pediatrics Research and Scholarship

During the current coronavirus disease 2019 (COVID-19) pandemic, health care practices have shifted to minimize virus transmission, with unprecedented expansion of telehealth. This study describes self-reported changes in registered dietitian nutritionist (RDN) practice related to delivery of nutrition care via telehealth shortly after the onset of the COVID-19 pandemic in the United States. This cross-sectional, anonymous online survey was administered from mid-April to mid-May 2020 to RDNs in the United States providing face-to-face nutrition care prior to the COVID-19 pandemic. This survey included 54 questions about practitioner demographics and experience and current practices providing nutrition care via telehealth, including billing …

Subcutaneous Testosterone Is Effective And Safe As Gender-Affirming Hormone Therapy In Transmasculine And Gender-Diverse Adolescents And Young Adults: A Single Center's 8-Year Experience, Sarah E. Laurenzano, Ron S. Newfield, Euyhyun Lee, Maja Marinkovic

Pediatrics Research and Scholarship

Purpose: To describe our Center's 8-year experience with subcutaneous testosterone (SC-T) as gender-affirming hormone therapy (GAHT) in transmasculine and gender-diverse (TM/GD) youth. Methods: An Institutional Review Board (IRB)-approved retrospective study for 119 TM/GD subjects who started SC-T at age 13-19 and received SC-T for >6 months between 2012 and 2020. Results: SC-T was typically started at 25-50 mg biweekly and dose was escalated at provider's discretion. Over 96% of subjects were on 100-320 mg monthly (divided weekly or biweekly) at last follow-up. There was an overall increase in mean total and free testosterone (T) over the dose range (p …

Genomes For Kids: The Scope Of Pathogenic Mutations In Pediatric Cancer Revealed By Comprehensive Dna And Rna Sequencing, Scott Newman, Joy Nakitandwe, Chimene A Kesserwan, Elizabeth M Azzato, David A Wheeler, Michael Rusch, Sheila Shurtleff, Dale J Hedges, Kayla V Hamilton, Scott G Foy, Michael N Edmonson, Andrew Thrasher, Armita Bahrami, Brent A Orr, Jeffery M Klco, Jiali Gu, Lynn W Harrison, Lu Wang, Michael R Clay, Annastasia Ouma, Antonina Silkov, Yanling Liu, Zhaojie Zhang, Yu Liu, Samuel W Brady, Xin Zhou, Ti-Cheng Chang, Manjusha Pande, Eric Davis, Jared Becksfort, Aman Patel, Mark R Wilkinson, Delaram Rahbarinia, Manish Kubal, Jamie L Maciaszek, Victor Pastor, Jay Knight, Alexander M Gout, Jian Wang, Zhaohui Gu, Charles G Mullighan, Rose B Mcgee, Emily A Quinn, Regina Nuccio, Roya Mostafavi, Elsie L Gerhardt, Leslie M Taylor, Jessica M Valdez, Stacy J Hines-Dowell, Alberto S Pappo, Giles Robinson, Liza-Marie Johnson, Ching-Hon Pui, David W Ellison, James R Downing, Jinghui Zhang, Kim E Nichols

Pediatrics Research and Scholarship

Genomic studies of pediatric cancer have primarily focused on specific tumor types or high-risk disease. Here, we used a three-platform sequencing approach, including whole-genome sequencing (WGS), whole-exome sequencing (WES), and RNA sequencing (RNA-seq), to examine tumor and germline genomes from 309 prospectively identified children with newly diagnosed (85%) or relapsed/refractory (15%) cancers, unselected for tumor type. Eighty-six percent of patients harbored diagnostic (53%), prognostic (57%), therapeutically relevant (25%), and/or cancer-predisposing (18%) variants. Inclusion of WGS enabled detection of activating gene fusions and enhancer hijacks (36% and 8% of tumors, respectively), small intragenic deletions (15% of tumors), and mutational signatures revealing …

Clinical Follow-Up Practices After Cervical Cancer Screening By Co-Testing: A Population-Based Study Of Adherence To U.S. Guideline Recommendations, Rebecca B. Perkins, Rachael Adcock, Vicki Benard, Jack Cuzick, Alan Waxman, Jean Howe, Stephanie Melkonian, Janis Gonzales, Charles Wiggins, Cosette M. Wheeler

Pathology Research and Scholarship

Failure to follow-up women after abnormal cervical screening could lead to cervical cancers, yet little is known about adherence to recommended follow-up after abnormal co-testing [cytology and high-risk human papillomavirus (hrHPV) testing]. We documented clinical management following cervical screening by co-testing in a diverse population-based setting. A statewide surveillance program for cervical screening, diagnosis, and treatment was used to investigate all cytology, hrHPV and biopsy reports in the state of New Mexico from January 2015 through August 2019. Guideline-adherent follow-up after co-testing required 1) biopsy within 6 months for low-grade cytology if positive for hrHPV, for high-grade cytology irrespective of …

Burden Of Mycoplasma Genitalium And Bacterial Coinfections In A Population-Based Sample In New Mexico, Anne Hammer, Patti E. Gravitt, Rachael Adcock, Nicole Patterson, Jack Cuzick, Cosette M. Wheeler

Pathology Research and Scholarship

In this population-based US study, the overall prevalence of Mycoplasma genitalium was 1.95% (95% confidence interval [CI], 1.62%-2.34%), declining from 6.12% (95% CI, 4.72%-7.92%) in women aged 21 to 24 years to 0.48% (95% CI, 0.25%-0.94%) in women aged 40 to 64 years. The prevalence of coinfections with Chlamydia trachomatis and Trichomonas vaginalis was low.

An Exploration Of Unintended Effects Of Education Policies In The United States, Kevin Estes

Economics ETDs

The work in this dissertation examines unintended consequences from various public policies in education. The first policy examined is the adoption of the four-day school week schedule by public-school districts across the United States. Concerns over the additional weekend night for students are explored by examining teen traffic safety within the school district before and after adoption of the four-day schedule. The second policy examined is the usage of academic probation by universities. Student responses to being placed on academic probation vary, and financial implications for the student are a potential mechanism behind these responses. Student responses segmented by Pell …

Examining Psilocybin And Lsd Consumption Through A Geographical Lens, Nicole Sarah Caruana

Geography ETDs

n recent years, the study of psychedelic science has reemerged across a variety of fields. Psilocybin and LSD (Lysergic Acid Diethylamide) are two psychedelic substances receiving an influx of attention for their success treating issues such as depression, post-traumatic stress, and addiction. Psilocybin and LSD are still widely used despite their classification as illegal Schedule I substance. This study aims to learn more about current users with the following questions guiding this research: What are barriers limiting psilocybin and LSD consumption? What are the motivations behind use? What impacts are psilocybin and LSD having on users lives? I used Qualitative …

The Nursing Baccalaureate Dual Enrollment Model: Outcomes For A Community College And University Partnership, Jenny B. Landen

Nursing ETDs

The partnership model in which universities collaborate with community colleges for the prelicensure Bachelor of Science (BSN) education has been identified by the National Academy of Medicine (NAM) as one of five viable academic progression models for nursing. The current literature lacks evidence on the success of these academic progression models for replication and improvement in an effort to increase the BSN-educated workforce. This retrospective descriptive study explored the differences in demographic and academic characteristics of the prelicensure BSN graduates and the differences in program outcomes from a partnership model in New Mexico which included three universities and five community …

Request For Modification 21-019 To Resource Conservation And Recovery Act (Rcra) Facility Operating Permit, Sandia National Laboratories/New Mexico (Snl/Nm), Sandia National Laboratories/Nm Snl

Facilities-Units

The Department of Energy/National Nuclear Security Administration (DOE/NNSA) and Sandia National Laboratories, New Mexico (SNL/NM) have requested modifications to the Resource Conservation and Recovery Act Facility Operating Permit (Permit) for Sandia National Laboratories/New Mexico. The requested modifications consist of revisions to the Mixed Waste Landfill (MWL) Long-Term Monitoring and Maintenance Plan (LTMMP), which is incorporated by reference into Permit Attachment M, "Long-Term Monitoring and Maintenance Plan for Solid Waste Management Units and Areas of Concern Granted Corrective Action Complete with Controls." The MWL is also known as Solid Waste Management Unit (SWMU) 76.

The DOE/NNSA and SNL/NM propose to make …

An Investigation Of Phosphorus Removal By Purple Bacteria In Dairy Wastewater Lagoons, Lauren M. Gomez, Andrew J. Schuler, Jose M. Cerrto, David T. Hanson

Civil Engineering ETDs

The objective of this study was to determine whether the polyphosphate metabolism in purple photosynthetic bacteria (PPB) is similar to that of wastewater polyphosphate-accumulating organisms (PAOs) such as Accumulibacter. Dairy lagoon samples were studied in continuous and batch laboratory tests to evaluate whether cyclic light and dark conditions for PPB are similar to aerobic and anaerobic conditions for PAOs in domestic wastewater treatment systems. 16s rRNA gene amplicon sequencing indicated the presence of the purple sulfur bacterium Thiolamprovum (53.92%) in one lagoon source, and Thiodictyon (3.50%) in a second lagoon. Phosphorus contents were at least 0.7% higher than the …

Ipedition Fall 2021, The Unm Hsc Inter-Professional Education Team

The IPE Newsletters

No abstract provided.

Glomerular Disease In Temporal Association With Sars-Cov-2 Vaccination: A Series Of 29 Cases, Tiffany N. Caza, Clarissa A. Cassol, Nidia Messias, Andrew Hannoudi, Randy S. Haun, Patrick D. Walker, Rebecca M. May, Regan M. Seipp, Elizabeth J. Betchick, Hassan Amin, Mandolin S. Ziadie, Michael Haderlie, Joy Eduwu-Okwuwa, Irina Vancea, Melvin Seek, Essam B. Elashi, Ganesh Shenoy, Sayeed Khalillullah, Jesse A. Flaxenburg, John Brandt, Matthew J. Diamond, Adam Frome, Eugene H. Kim, Gregory Schlessinger, Erlandas Ulozas, Janice L. Weatherspoon, Ethan Thomas Hoerschgen, Steven L. Fabian, Sung Yong Bae, Bilal Iqbal, Kanwalijit K. Chouhan, Zeina Karam, James T. Henry, Christopher P. Larsen

Pediatrics Research and Scholarship

Background: Immune responses to vaccination are a known trigger for a new onset of glomerular disease or disease flare in susceptible individuals. Mass immunization against SARS-CoV-2 in the COVID-19 pandemic provides a unique opportunity to study vaccination-associated autoimmune kidney diseases. In the recent literature, there are several patient reports demonstrating a temporal association of SARS-CoV-2 immunization and kidney diseases.

Methods: Here, we present a series of 29 cases of biopsy-proven glomerular disease in patients recently vaccinated against SARS-CoV-2 and identified patients who developed a new onset of IgA nephropathy, minimal change disease, membranous nephropathy, ANCA-associated GN, collapsing glomerulopathy, or diffuse …

11-30-2021 Hsc Committee Agenda, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Nuanced Networks: How Social Relationships And Power Influence Participation In Private Lands Conservation Programs, Ellen Loechner

Geography ETDs

Because the majority of land in the Midwestern United States is privately owned, the responsibility for creating and maintaining space for wildlife conservation falls upon private landowners. Numerous state and federal agencies and non-governmental organizations (NGOs) host private lands conservation programs that offer landowners financial and technical support to complete conservation projects on their property (Echols, Front, and Cummins 2019). While the individual motivations and priorities of a landowner may inform how they use and manage their property, a landowner’s ability to connect with the agricultural and conservation communities may determine if they have the opportunity to participate in these …

Microrna Analysis Of Human Stroke Brain Tissue Resected During Decompressive Craniectomy/Stroke-Ectomy Surgery, Andrew P. Carlson, William Mckay, Jeremy S. Edwards, Radha Swaminathan, Karen S. Santacruz, Ron L. Mims, Howard Yonas, Tamara Roitbak

Pathology Research and Scholarship

BACKGROUND: Signaling pathways mediated by microRNAs (miRNAs) have been identified as one of the mechanisms that regulate stroke progression and recovery. Recent investigations using stroke patient blood and cerebrospinal fluid (CSF) demonstrated disease-specific alterations in miRNA expression. In this study, for the first time, we investigated miRNA expression signatures in freshly removed human stroke brain tissue.

METHODS: Human brain samples were obtained during craniectomy and brain tissue resection in severe stroke patients with life-threatening brain swelling. The tissue samples were subjected to histopathological and immunofluorescence microscopy evaluation, next generation miRNA sequencing (NGS), and bioinformatic analysis.

RESULTS: miRNA NGS analysis detected …