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High-Throughput Genomic/Proteomic Studies: Finding Structure And Meaning By Similarity, George Sidney Davidson Jul 2010

High-Throughput Genomic/Proteomic Studies: Finding Structure And Meaning By Similarity, George Sidney Davidson

Biology ETDs

The post-genomic challenge was to develop high-throughput technologies for measuring genome scale mRNA expression levels. Analyses of these data rely on computers in an unprecedented way to make the results accessible to researchers. My research in this area enabled the first compendium of microarray experiments for a multi-cellular eukaryote, Caenorhabditis elegans. Prior to this research approximately 6% of the C. elegans genome had been studied, and little was known about global expression patterns in this organism. Here I cluster data from 553 different microarray experiments and show that the results are stable, statistically significant and highly enriched for specific biological …

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Always Read The Introduction: Integrating Regulatory And Coding Sequence Evolution In Yeast, Annette M. Evangelisti Jul 2010

Always Read The Introduction: Integrating Regulatory And Coding Sequence Evolution In Yeast, Annette M. Evangelisti

Biology ETDs

We analyze duplicate genes in a yeast, Saccharomyces cerevisiae with the aim of determining a genes history and to observe that gene in its genomic context. In Chapter 2 we show that the fate of a duplicate gene pair is in part determined by its genome location. Moreover, we show that for two classes of duplicate genes, resulting from either small-scale duplication or whole-genome duplication, this fate can often be assessed by measuring the patterns of asymmetry in the sequence divergence of the genes in question. In Chapter 3 we study duplicate genes in the context of their local environments …

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Female Perception Of Testeronized Male Facial Images: Evidence Of A Co-Evolutionary Tradeoff Responsive To Conditions For Both Competition And Cooperation, Melissa L. Franklin Jul 2010

Female Perception Of Testeronized Male Facial Images: Evidence Of A Co-Evolutionary Tradeoff Responsive To Conditions For Both Competition And Cooperation, Melissa L. Franklin

Biology ETDs

Theorists and researchers who examine the evolutionary ecology of mating dynamics consider two primary forces, intrasexual and intersexual, as important pressures of selection. Bilateral symmetry and, more controversially, hormone markers in many species, impart information that has been found to influence some aspects of intersexual selection. Both symmetry, as a sign of developmental stability, and hormone markers (i.e., testosteronized traits as cues of immunocompetence) have been classically treated as signals of genetic fitness (Moller & Swaddle, 1997; Hamilton & Zuk, 1982), although neither are consistently shown to correlate with increased mating success. Indeed, results between studies on either trait independently …

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Edward Abbey's Bottle: An Essay On Trash And Treasure, Thomas Bowen Jul 2010

Edward Abbey's Bottle: An Essay On Trash And Treasure, Thomas Bowen

New Mexico Historical Review

No abstract provided.

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Book Reviews Jul 2010

Book Reviews

New Mexico Historical Review

No abstract provided.

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Mechanisms Of Augmented Coronary Artery Constriction Following Exposure To Diesel Exhaust, Tom W. Cherng Jul 2010

Mechanisms Of Augmented Coronary Artery Constriction Following Exposure To Diesel Exhaust, Tom W. Cherng

Biomedical Sciences ETDs

Numerous epidemiology studies demonstrate that acute increases in air pollutants correlate with an increase in cardiovascular disease-related mortality. The pollutant diesel exhaust (DE) has been shown to impair both flow-mediated and agonist-induced dilation of the brachial artery, used as a surrogate for coronary artery function. It is speculated that enhanced sensitivity to the endogenous vasoconstrictor ET-1 impairs cardiac blood flow and contributes to the immediate onset of myocardial ischemia and infarction in humans following DE exposure. In addition, impaired endothelium-dependent dilation can be improved with the restoration of nitric oxide (NO) synthase (NOS) activity. We therefore sought to determine the …

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The Role Of Bcl-2 Modifying Factor (Bmf) In Airway Epithelial Cell Death, Amelia H. T. Unione Jul 2010

The Role Of Bcl-2 Modifying Factor (Bmf) In Airway Epithelial Cell Death, Amelia H. T. Unione

Biomedical Sciences ETDs

One of the components that obstruct the airway in asthma is the sudden and increased secretion of mucus from metaplastic mucous cells in small airways. Because previous studies have shown that the resolution of mucous cell metaplasia (MCM) during prolonged exposure of mice to allergen is mediated by IFN gamma and the Bcl-2 family of proteins, we investigated the regulation and the role of a pro-apoptotic BH3 domain-only protein, Bmf, in airway epithelial cells (AECs) treated with IFN gamma. We hypothesize that Bmf is crucial for IFN gamma-induced cell death. Our findings show that IFN gamma suppressed Bmf expression in …

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- Immunosupression Of T-Dependent Antibody Responses By Polycyclic Aromatic Hydrocarbons And Arsenic In Spleen Cells From C57bl/6j Mice, Qian Li Jul 2010

- Immunosupression Of T-Dependent Antibody Responses By Polycyclic Aromatic Hydrocarbons And Arsenic In Spleen Cells From C57bl/6j Mice, Qian Li

Biomedical Sciences ETDs

Polycyclic aromatic hydrocarbons (PAHs) and arsenic are both toxic contaminants that are widely distributed in the environment. Previous studies have shown that certain levels of PAHs and arsenic exposure individually can lead to immune suppression and carcinogenesis. Co-exposures to these two classes of chemicals are commonly seen in the environment. However, no previous studies have evaluated the immunotoxicity following simultaneous exposure to both arsenic and PAHs. Therefore, the purpose of this study was to define the immunotoxicity of selected PAHs and arsenic in a murine spleen cell system, and to elucidate possible toxicological mechanisms. Spleen cells were isolated from male …

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Changes In C-Myb Activity During Proliferation, Anita M. Quintana Jul 2010

Changes In C-Myb Activity During Proliferation, Anita M. Quintana

Biomedical Sciences ETDs

c-myb encodes a transcription factor and is the cellular parent of the v-myb oncogene, which causes acute myeloid leukemia in chickens and mice. Truncation or deletion can unmask the oncogenic potential of the human c-myb gene and recent reports have established that the human c-myb locus is subject to translocation and duplication in human pediatric T-ALL. c-Myb is expressed in all proliferating hematopoietic progenitor cells and has been implicated in some solid tumors, such as breast and colon. Evidence suggests that c-Myb activity is cell type specific and cell cycle dependent. For example, c-Myb interacts with cyclin D1 and CDK6 …

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Characterization Of Subspecies B1 Human Adenovirus Orf E3-10.9k, Kathryn Marie Frietze Jul 2010

Characterization Of Subspecies B1 Human Adenovirus Orf E3-10.9k, Kathryn Marie Frietze

Biomedical Sciences ETDs

Subspecies B1 human adenoviruses (HAdVs) are important causes of acute respiratory disease in pediatric and military recruit populations. Although extensive epidemiological data document the genetic diversity of these human pathogens, little is known about the relevance of this genetic diversity on the pathogenesis and fitness of subspecies B1 HAdVs. Additionally, the unique molecular biology of these pathogens is understudied compared to the species C HAdV serotypes 2 and 5. One of the uniquely diverse regions of the HAdV genomes is the early region 3 (E3) transcription unit. These genes are implicated in pathogenesis, host-species specificity, and the modulation of the …

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Nuances In A Panethnic Southwest Landscape, Angelica Solares Jul 2010

Nuances In A Panethnic Southwest Landscape, Angelica Solares

Architecture and Planning ETDs

Urban landscapes of places with large immigrant populations are transformed as immigrants bring a different use of space with them. Mexican immigrants throughout the southwestern United States have physically transformed the landscape, and these trans-formed places often result in spaces that foster socialization and assert cultural identity. This thesis proposes that a three-stage cycle of spatial production exists in Mexicano communities in the United States, and describes the authors three-stage cycle of spatial production model in detail. The cycle begins with the formation of an enclave, followed by the transformation of the urban landscape which then results in one of …

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Identification Of Man-Made Hazards In Aneth Chapter, Navajo Nation, Utah, Eugenia L. Quintana Jul 2010

Identification Of Man-Made Hazards In Aneth Chapter, Navajo Nation, Utah, Eugenia L. Quintana

Architecture and Planning ETDs

Identification of man-made hazards is an initial step in planning recommendations for mitigation of man-made hazards. This project entailed a participatory process that engaged the local community in identifying man-made hazards specific to Aneth. The man-made hazards have challenged the community in managing potential damages, physical, environmental and economic losses due to pollution and contamination from man-made hazards. The development of this professional project has revealed some pathways to environmental protection for the Aneth Chapter, which could be the first Navajo Nation Chapter to move towards the development of a plan for mitigation of man-made hazards based upon the identification …

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An Examination Of Communicative Dialectical Tensions And Paradoxes Encountered By Native American Researchers In The Field And In The Academy, Lorenda Belone Jul 2010

An Examination Of Communicative Dialectical Tensions And Paradoxes Encountered By Native American Researchers In The Field And In The Academy, Lorenda Belone

Communication ETDs

This study investigated the communicative dialectical tensions and paradoxical situations faced by Native researchers in the academy and in research with their own communities or with other Native communities. Thematic analysis was conducted on narratives from 12 semi-structured interviews from participants across the country. Three major themes emerged regarding communicative struggles for the participants when conducting research with Native communities: a dialectic of insider/outsider; challenge of developing positive communication; and concerns of appropriate and inappropriate behavior. Four major themes emerged with regards to communication challenges for the participants while working in the academy: insider-outsider dialectic, paradox of walking the talk, …

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Identifying Comedy: The Linguistic Properties Of Humor, Aaron Frale Jun 2010

Identifying Comedy: The Linguistic Properties Of Humor, Aaron Frale

Theatre & Dance ETDs

This dissertation is a method to label comedy with a linguistic model. Comedy is defined via an audience's laughter. The first part presents anecdotal evidence and certain factors of comedy. Time and Cultural awareness play into the understanding of comedy. Time can situate the humor in a piece of writing. Cultural understanding can unlock the laughter in a joke. The second section breaks down comedy into a linguistic model. Expression, meaning, and context are the different parts of comedy. Each part has impact on humor. An audience understanding these three parts is critical to the concept of "comedy equals a …

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Quantitative Structure-Property Relationships For Predicting Group Iib Metal Binding By Organic Ligands, Aliyar Mousavi Jun 2010

Quantitative Structure-Property Relationships For Predicting Group Iib Metal Binding By Organic Ligands, Aliyar Mousavi

Chemistry and Chemical Biology ETDs

Mercury (Hg), cadmium (Cd), and zinc (Zn) in the environment are all of toxicological and environmental concern, and the pollution of natural waters by any of these three elements is most serious. Mercury is the most environmentally concerning of the three because of the neurotoxin species monomethylmercury produced in aquatic systems through the methylation of Hg2+ by aquatic microorganisms. An important chemical process in natural waters that limits the availability of mercury for methylation is the binding of Hg(II) by natural organic matter (NOM). These associations are exceptionally strong, and as NOM is ubiquitous in aquatic environments, estimating equilibrium …

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U.S. Press Representation Of The Southern Sudanese Civil War, 1983-2005, Abdissa Zerai Jun 2010

U.S. Press Representation Of The Southern Sudanese Civil War, 1983-2005, Abdissa Zerai

Communication ETDs

The study examines how the U.S. print news media discursively represented the civil war that raged from 1983-2005 between southern Sudan and the central government in the north over the tenures of three successive war-time Sudanese administrations. The study was situated within the broader theoretical umbrella of cultural studies. However, the theory of representation and postcolonial theory served as the principal theoretical frames for the study. Employing critical discourse analysis, with framing as a strategy, the study focused on five U.S. print news media outlets (three national newspapers and two national newsmagazines): The New York Times, The Washington Post, The …

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Spatial Spread Of Infectious Diseases, Aaron Mora Jun 2010

Spatial Spread Of Infectious Diseases, Aaron Mora

Mathematics & Statistics ETDs

In this thesis we do a comparative study of diffusive models with non-diffusive models, looking at the effect movements in the form of simple diffusion have on the spreading of infectious diseases. This study is undertaken within the context of the SI and SIR models, two of the most fundamental models for the propagation of infectious diseases. The diffusive SI and SIR models are supplemented with no flux boundary conditions to insure meaningful comparison of the populations predictions. In addition, we use a one dimensional spatial domain for computational simplicity. The comparison of the SI (and SIR) model with its …

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White Matter Integrity In Alcohol Dependence And Remission Using Tract-Based Spatial Statistics, Mollie Monnig Jun 2010

White Matter Integrity In Alcohol Dependence And Remission Using Tract-Based Spatial Statistics, Mollie Monnig

Psychology ETDs

The effects of alcohol on white matter integrity were investigated in a sample of 12 individuals with current alcohol dependence or abuse (AUD-C), 9 individuals with alcohol dependence in remission (AUD-R) for at least one year, and 16 healthy control (HC) participants matched to alcohol groups on age, sex, and smoking status. Magnetic resonance imaging (MRI) and neuropsychological data were collected. Diffusion tensor imaging (DTI) data was analyzed using tract-based spatial statistics (TBSS). Using a standard white matter atlas, fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were quantified for three corpus callosum ROIs and …

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Accelerating Recovery Of Behavioral And Cognitive Functions Via Single Intracerebral Injection Of Matrigel Containing Neurotrophic Factors After Somatosensory Contusion In Adult Rats, Nariman Arfai Jun 2010

Accelerating Recovery Of Behavioral And Cognitive Functions Via Single Intracerebral Injection Of Matrigel Containing Neurotrophic Factors After Somatosensory Contusion In Adult Rats, Nariman Arfai

Psychology ETDs

Unilateral sensorimotor contusion injury results in contralateral hindlimb paralysis as well as behavioral & cognitive deficits in rats. In response to cortical injury, adult neural stem cells (NSC) in the subventricular zone (SVZ) proliferate, and generate new neurons & glia that migrate towards injured areas. Thus, they may potentially be harnessed for neural repair. After cortical injury, the number of migratory NSCs to lesioned sites has been shown to be significantly lower than the overall cell loss in rats. To address this issue, in-vitro & in-vivo studies have shown that various growth factors (GF) enhance the rate of proliferation, differentiation …

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The Effect Of A 36-Session Cardiac Rehabilitation Program On The Framingham Risk Score, Veronica Gonzales Jun 2010

The Effect Of A 36-Session Cardiac Rehabilitation Program On The Framingham Risk Score, Veronica Gonzales

Health, Exercise, and Sports Sciences ETDs

Cardiac Rehabilitation is widely used in the United States to help individuals who have had a cardiac event that is approved by insurance companies. Factors that lead to the development of cardiovascular disease are lack of exercise, tobacco use, obesity, high blood pressure, high cholesterol levels, and diet comprised of high consumption of saturated fats, salt, refined carbohydrates, and low levels of fruits and vegetables (World Health Organization, 2008). The purpose of this study is to examine the effectiveness of a cardiac rehabilitation program in modifying the patients Framingham risk score after 36 sessions of cardiac rehabilitation. This is a …

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A Framework For The Development Of Virtual Robotic Games, Paul Ng Jun 2010

A Framework For The Development Of Virtual Robotic Games, Paul Ng

Electrical and Computer Engineering ETDs

Multiple robotic experiments are inherently high in operating costs. As the number of agents increase, resources in time, cost, and physical space becomes a limiting factor in experimentation. This thesis presents a framework that addresses these problems by virtual reality. The computer gaming industry has made unparalleled advances in computer graphics and dynamic and kinematic modeling. This progress provides a realism that is utilized in virtual robot experiments with close comparability of results with its real-world counterpart. Developing the Virtual Robotic Games framework with the integration of a video game engine produces a testbed for multi-agent experiments while reducing the …

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Constructing, Consuming, And Complicating The Human-Nature Binary: Communication Practices In Forest Environmental Education, Elizabeth Dickinson Jun 2010

Constructing, Consuming, And Complicating The Human-Nature Binary: Communication Practices In Forest Environmental Education, Elizabeth Dickinson

Communication ETDs

This project combines interdisciplinary conversations within the field of communication to examine environmental meaning systems and communication practices in the context of forest environmental education. Due to concerns over children's environmental alienation, there has been a continued push toward place-based environmental education. One such venture is the North Carolina Educational State Forest system (NCESF), where educators bring K-12 students into forests to help them reconnect with nature, expand environmental knowledge, and tackle what has been recently termed "nature-deficit disorder." When students visit the sites, rangers deliver structured lessons on ecosystems and forest management to children and chaperones--lessons that must adhere …

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Unesco Adds Three Sites In Mexico To Its Biosphere-Reserve Network, Ladb Staff Jun 2010

Unesco Adds Three Sites In Mexico To Its Biosphere-Reserve Network, Ladb Staff

SourceMex

No abstract provided.

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Water Resources Assessment Of The Cimarron River And Evaluation Of Water Quality Characteristics At The Maxwell National Wildlife Refuge, Bruce M. Thomson, Abdul-Mehdi Ali Jun 2010

Water Resources Assessment Of The Cimarron River And Evaluation Of Water Quality Characteristics At The Maxwell National Wildlife Refuge, Bruce M. Thomson, Abdul-Mehdi Ali

Water Resources Field Methods Reports

During the second week of June 2010, the UNM Masters of Water Resources students, staff, and collaborators studied the Cimarron River watershed from its head waters above Eagle Nest Lake to its confluence with the Canadian River near Taylor Springs, NM, and the Maxwell National Wildlife Refuge(NWR)near Maxwell, NM. The investigation included measuring flows and water quality characteristics at 34 surface water sites in the two study areas. The main objectives of the study were to conduct a river assessment of the Cimarron River and evaluate water quality characteristics and playa lake sediment chemistry at the Maxwell NWR. It is …

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El Salvador Turns Wary Eye Toward Up-River Guatemala Gold Mine, Benjamin Witte-Lebhar May 2010

El Salvador Turns Wary Eye Toward Up-River Guatemala Gold Mine, Benjamin Witte-Lebhar

NotiCen

No abstract provided.

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Peru: Camisea Gas Pipeline Inaugurate After 20 Years, Notisur Writers May 2010

Peru: Camisea Gas Pipeline Inaugurate After 20 Years, Notisur Writers

NotiEn: An Analytical Digest About Energy Issues in Latin America

Twenty years after the Camisea natural-gas fields in the Peruvian department of Cuzco were discovered, President Alejandro Toledo has inaugurated the pipeline that will bring the gas from the interior to Lima and the Pacific coast. The president and his ministers say the revenues generated by the sale and distribution of gas will be an economic windfall for Peru and will revolutionize energy consumption for the country's citizens. But as the Toledo government celebrates the pipeline opening as a historic moment in the economic life of Peru, environmental and indigenous groups say the project will do significant harm to the …

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South American Leaders Propose Massive Trans-Amazonian Gas Pipeline From Venezuela Through Brazil And Argentina, Notisur Writers May 2010

South American Leaders Propose Massive Trans-Amazonian Gas Pipeline From Venezuela Through Brazil And Argentina, Notisur Writers

NotiEn: An Analytical Digest About Energy Issues in Latin America

Venezuelan President Hugo Chavez has pledged to build a natural-gas pipeline that would stretch from his country to Argentina. He has met with Argentine President Nestor Kirchner and Brazilian President Luiz Inacio Lula da Silva to begin a preliminary-planning process for the megapipeline, although energy-industry analysts have expressed doubts about the economic viability of such a gigantic project and environmental groups have fears that its construction would damage the Amazonian ecosystem. The project would run between 8,000 km and 10,000 km and would supposedly require an investment of US$20 billion, though cost estimates have varied widely.

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Congregational Development Research Study Executive Summary, Richard L. Wood May 2010

Congregational Development Research Study Executive Summary, Richard L. Wood

Sociology Faculty and Staff Publications

The Congregational Development Research Study (CDRS) examines the impact of faith-based community organizing on organizational development in its primary institutional sponsors— religious congregations. That is, we study whether and how congregational development results from the particular form of civic engagement sometimes known as congregation-based, institutional, or broad-based organizing, and termed here faith-based community organizing.'

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Massive Oil Spill In Gulf Of Mexico Could Have Short- And Long-Term Implications For Mexico's State-Run Oil Company Pemex, Ladb Staff May 2010

Massive Oil Spill In Gulf Of Mexico Could Have Short- And Long-Term Implications For Mexico's State-Run Oil Company Pemex, Ladb Staff

SourceMex

No abstract provided.

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A Sample Of Rural And Global Health Issues, Carol J. Bett, Barbara Cechanowicz, Demetrius Chapman, Stephen Hernandez, Hannelore Kriegor, Melanie Mayo, Loyce Phoenix, Conrad Rios, Teresa Sellstrom, Max Veltman May 2010

A Sample Of Rural And Global Health Issues, Carol J. Bett, Barbara Cechanowicz, Demetrius Chapman, Stephen Hernandez, Hannelore Kriegor, Melanie Mayo, Loyce Phoenix, Conrad Rios, Teresa Sellstrom, Max Veltman

Global, Rural, & Cultural Health Book Series

The challenges faced by local, national, and global communities in an ever-changing world have continued to grow as we complete the first decade of the 21st century. The doctoral students writing this book undertook the effort with advocacy for disenfranchised populations in mind. This compilation illuminates the challenges and gaps in access to health care confronted by a wide range of people, from overweight children, lesbians, and Native Americans to individuals in rural communities in Papua New Guinea. As the reader can readily see, we are a group of students with wide-ranging experiences and interests.

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