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Sex Vs Gender In A Forensic Anthropological Analysis, Erik M. Schulz Jan 2021

Sex Vs Gender In A Forensic Anthropological Analysis, Erik M. Schulz

Nebraska Anthropologist

This paper will be discussing the topic of gender identification in a forensic anthropology outcome. The purpose will be to see if a forensic anthropologist should determine the gender of an individual or just biological sex when talking about identifying a body. To support this argument, the following topics will be evaluated: looking at the current methods used for identifying sex of an individual, looking at reconstruction and modification practices, looking at documentation aspects in a forensic report, biological profile make up, and cultural significance. The conclusion will state that anthropologists should make a case for sex, but that gender …


About The Authors Jan 2021

About The Authors

Honors in Practice Online Archive

No abstract provided.


“Movies, Tv Shows, And Memes . . . Oh My!”: An Honors Education Through Popular Culture And Critical Pedagogy, Evan W. Faidley Jan 2021

“Movies, Tv Shows, And Memes . . . Oh My!”: An Honors Education Through Popular Culture And Critical Pedagogy, Evan W. Faidley

Honors in Practice Online Archive

Entertainment media and popular culture often overdramatize the college experience. An honors colloquium engages students in scholarly research and discourse involving thematic elements of academic life in popular culture. An interdisciplinary approach to race, class, the professoriate, Greek life, and foreign experience is espoused. Through a lens of critical social theory, students deconstruct misinformed “stories most often told” to reconstruct more cogent understandings of college life and student experience. With a curriculum designed to advance social justice through equitizing education and amending cultural perceptions, this colloquium helps develop self-motivated, self-regulated, and engaged learners.


Editor’S Introduction, Ada Long Jan 2021

Editor’S Introduction, Ada Long

Honors in Practice Online Archive

This journal of the plague year has attracted a record number of submissions, creating the thickest volume of Honors in Practice since its inception in 2005. The inclusion of essays in response to a Call for Papers about COVID- 19 is no doubt responsible for some of this torrent of submissions, but research essays have also come in at a greater rate than before, not to mention the “Brief Ideas about What Works in Honors.” As you will see, the essays on the pandemic’s effects on honors mostly make the best of a fraught and frustrating year for honors administrators, …


Meditations In An Emergency: Collaborating Online In Narratives Of Illness And Care, Jayda Coons Jan 2021

Meditations In An Emergency: Collaborating Online In Narratives Of Illness And Care, Jayda Coons

Honors in Practice Online Archive

This article describes a collaborative writing project involving narratives of health and caregiving. An interdisciplinary seminar titled “Narratives of Illness and Care” examines literary and medical narratives to better understand disease, therapeutic communication, empathy, and the social determinants of health. During the COVID-19 crisis, however, the instructor adapted course structure and curricular assignments to help students make meaningful connections with their immediate circumstance. The author reflects on the significance of the project during a time of global upheaval and suggests changes for future iterations.


Tough Talks: Student-Led Programs To Facilitate Civil Discourse, Leah Horton, Doug Corbitt, Booker White Jan 2021

Tough Talks: Student-Led Programs To Facilitate Civil Discourse, Leah Horton, Doug Corbitt, Booker White

Honors in Practice Online Archive

These student-led, co-curricular programs are designed to give honors students the opportunity to learn and practice civil discourse through difficult conversations. Issues such as race, religion, politics, gender, and sexual orientation are carefully curated to help students practice and hone their dialogue skills outside the classroom where grades are not a factor. A brave spaces ideology provides the foundation for shared pools of meaning, encouraging students to move from certainty to curiosity with the shared understanding that discomfort is an opportunity for growth. By teaching students how to engage in controversy with civility, Tough Talks support an honors ethos of …


“To Seek A Newer World”: Honors In Virtual Reality, Betsy Greenleaf Yarrison Jan 2021

“To Seek A Newer World”: Honors In Virtual Reality, Betsy Greenleaf Yarrison

Honors in Practice Online Archive

Honors education was never intended to be a virtual offering; it takes intimate, three-dimensional, communal, and intellectual interaction among faculty and students to tackle wicked problems. The COVID-19 crisis forced honors educators into an extreme reboot, extracting courses from comfortable working spaces and relocating them to strange new platforms for remote, computer-mediated instruction. For many faculty, the 2020 pandemic introduced online instruction for the first time. Toward this end, many novices were able to brilliantly reimagine and re-engineer their courses while others struggled. In this essay, the author points out that higher education has always adapted new technologies, asserting that …


A View Of Health As A Human Right: A Snapshot From An Honors Program, Peter Longo, Satoshi Machida, John Falconer Jan 2021

A View Of Health As A Human Right: A Snapshot From An Honors Program, Peter Longo, Satoshi Machida, John Falconer

Honors in Practice Online Archive

This study examines implications of a rights-based perspective among honors students through the lens of healthcare. Students (n = 71) surveyed in April 2019 were asked to consider issues relating to health entitlement and government responsibility. Perspectives on local, regional, national, and global access to health care; state and national government fiscal responsibility; and rights-based approaches to health entitlement were elicited. Data indicate a propensity for understanding health as a human right among honors students. Probit regressions show a more inclusive stance on healthcare policy and a general preference toward a universal healthcare system. Acknowledging that innovative curricula can help …


Targeted Metabolomics Analysis Of Postoperative Delirium, Bridget A. Tripp, Simon T. Dillon, Min Yuan, John M. Asara, Sarinnapha M. Vasunilashorn, Tamara G. Fong, Eran D. Metzger, Sharon K. Inouye, Zhongcong Xie, Long H. Ngo, Edward R. Marcantonio, Towia A. Libermann, Hasan H. Otu Jan 2021

Targeted Metabolomics Analysis Of Postoperative Delirium, Bridget A. Tripp, Simon T. Dillon, Min Yuan, John M. Asara, Sarinnapha M. Vasunilashorn, Tamara G. Fong, Eran D. Metzger, Sharon K. Inouye, Zhongcong Xie, Long H. Ngo, Edward R. Marcantonio, Towia A. Libermann, Hasan H. Otu

Department of Electrical and Computer Engineering: Faculty Publications

Postoperative delirium is the most common complication among older adults undergoing major surgery. The pathophysiology of delirium is poorly understood, and no blood-based, predictive markers are available. We characterized the plasma metabolome of 52 delirium cases and 52 matched controls from the Successful Aging after Elective Surgery (SAGES) cohort (N= 560) of patients ≥ 70 years old without dementia undergoing scheduled major non-cardiac surgery. We applied targeted mass spectrometry with internal standards and pooled controls using a nested matched case-control study preoperatively (PREOP) and on postoperative day 2 (POD2) to identify potential delirium risk and disease markers. Univariate analyses identifed …


A Routine Electroencephalography Monitoring System For Automated Sports-Related Concussion Detection, Amirsalar Mansouri, Patrick Ledwidge, Khalid Sayood, Dennis L. Molfese Jan 2021

A Routine Electroencephalography Monitoring System For Automated Sports-Related Concussion Detection, Amirsalar Mansouri, Patrick Ledwidge, Khalid Sayood, Dennis L. Molfese

Department of Electrical and Computer Engineering: Faculty Publications

Cases of concussions in the United States keep increasing and are now up to 2 million to 3 million incidents per year. Although concussions are recoverable and usually not life-threatening, the degree and rate of recovery may vary depending on age, severity of the injury, and past concussion history. A subsequent concussion before full recovery may lead to more-severe brain damage and poorer outcomes. Electroencephalography (EEG) recordings can identify brain dysfunctionality and abnormalities, such as after a concussion. Routine EEG monitoring can be a convenient method for reducing unreported injuries and preventing long-term damage, especially among groups with a greater …


An Efficient And Coherent Pipeline For Graduate Student And Postdoctoral Scholar Educational Development, Daniel Mann, Matthew Mahavongtrakul, Ashley Hooper Jan 2021

An Efficient And Coherent Pipeline For Graduate Student And Postdoctoral Scholar Educational Development, Daniel Mann, Matthew Mahavongtrakul, Ashley Hooper

To Improve the Academy: A Journal of Educational Development

As higher education shifts toward a culture of evidence-based teaching practices, future faculty are seeking opportunities to develop their pedagogical knowledge and skills. Many centers for teaching and learning (CTLs) have not proportionally grown in resources to meet the demand for graduate student and postdoctoral scholar programming (e.g., teaching certificates and pedagogy seminars). This article presents a model of a wide-ranging, coherent pipeline of educational development for graduate students and postdoctoral scholars managed by a CTL with modest staffing.


Leveraging Collaboration And Peer Support To Initiate And Sustain A Faculty Development Program, Anneris Coria-Navia, Scott Moncrieff Jan 2021

Leveraging Collaboration And Peer Support To Initiate And Sustain A Faculty Development Program, Anneris Coria-Navia, Scott Moncrieff

To Improve the Academy: A Journal of Educational Development

In today’s impoverished higher education fiscal climate, especially considering the enormous financial implications to higher education of accommodating the changes required by the coronavirus pandemic, “nonessential” though highly important programs, such as centers for teaching and learning (CTLs), are very likely to be underfunded. In this study, we illustrate how underfunded programs can leverage peer collaboration and support to initiate productive, formal systems of assistance for faculty by describing a number of such programs developed by and/or coordinated by our CTL. Moreover, we propose that sustainable programs, especially at small liberal arts institutions, must include a strong component of peer …


Queer Refugee Experience: An Inquiry Into The Studies Of Transnationalism And Its Relationship To The Livelihood Of Syrian Refugees Who Identify As Lgbtq+ And Have Migrated To Turkey, Anne Frances Bennett Jan 2021

Queer Refugee Experience: An Inquiry Into The Studies Of Transnationalism And Its Relationship To The Livelihood Of Syrian Refugees Who Identify As Lgbtq+ And Have Migrated To Turkey, Anne Frances Bennett

UReCA: The NCHC Journal of Undergraduate Research and Creative Activity

Critical research titled Queer Refugee Experience: An Inquiry into the Studies of Transnationalism and its Relationship to the Livelihood of Syrian Refugees who Identify as LGBTQ+ and have Migrated to Turkey by Anne Frances Bennett in UReCA: The NCHC Undergraduate Journal of Research and Creative Activity, 2021, pages 101-122.

First paragraph

This paper will explore the missing elements of the studies of transnationalism by analyzing the vulnerable identities, inclusive exclusions, and states of exception of LGBTQ+, Syrian refugees migrating to Turkey. Since the Syrian Refugee Crisis began, masses of migrants have escaped to Turkey in search of freedom, especially those …


Adolescent Literature & Intersectional Oppression, Zacharia Jefferson Macneal Cross Jan 2021

Adolescent Literature & Intersectional Oppression, Zacharia Jefferson Macneal Cross

UReCA: The NCHC Journal of Undergraduate Research and Creative Activity

Critical essay titled Adolescent Literature & Intersectional Oppression by Zacharia Jefferson Macneal Cross in UReCA: The NCHC Undergraduate Journal of Research and Creative Activity, 2021, pages 73-78.

First paragraph

Healing Historical Trauma in The Marrow Thieves

In this essay I examine how Cherrie Dimaline’s The Marrow Thieves acknowledges and works through the struggles of Native Americans, allowing the characters a way through their seemingly impossible survival and clearing a path to heal their historical trauma. The ability to dream is a key element of this processing of trauma, as well as the very thing that they are hunted for.


Raw And Pure Education In The Society, Iwasan D. Kejawa Jan 2021

Raw And Pure Education In The Society, Iwasan D. Kejawa

Department of Educational Administration: Dissertations, Theses, and Student Research

What does education mean to individuals in the world today? Education is a way one can attain or improve his or her ability to lead and survive in the society of ours. Without educational training of the mind, it may be impossible to realize the importance of adaptability of living in the environment. Without education, It may also be difficult to embellish the use of both the mental and physical attributes possessed by individual beings.

What really is education? Education is the training of the mind to perform desire functions or to perpetuate the modality of obtaining an end or …


Recent Advances In Supramolecular Affinity Separations: Affinity Chromatography And Related Methods, Ashley G. Woolfork, Sazia Iftekhar, Susan Ovbude, Kyungah Suh, Sadia Sharmeen, Isaac Kyei, Jacob Jones, David S. Hage Jan 2021

Recent Advances In Supramolecular Affinity Separations: Affinity Chromatography And Related Methods, Ashley G. Woolfork, Sazia Iftekhar, Susan Ovbude, Kyungah Suh, Sadia Sharmeen, Isaac Kyei, Jacob Jones, David S. Hage

David Hage Publications

Contents

1 Introduction

2 Supports for Affinity Chromatography

 2.1 Natural Supports and Related Materials

 2.2 Inorganic Supports

 2.3 Synthetic Supports

 2.4 Magnetic Beads and Particles

 2.5 Smart Materials

 2.6 Nanomaterials

 2.7 Support Formats

3 Immobilization Methods

 3.1 Non-Covalent Immobilization

 3.2 Covalent Immobilization

4 Binding Agents Used in Affinity Chromatography

 4.1 Biological Agents as Affinity Ligands

4.1.1 Immunoaffinity Chromatography

4.1.2 Immunoglobulin-Binding Proteins

4.1.3 Lectins

4.1.4 Enzymes

4.1.5 Serum Proteins

4.1.6 Biotin, Avidin, and Streptavidin

4.1.7 Carbohydrates

4.1.8 Lipids

4.1.9 Nucleic Acids

 4.2 Non-Biological Agents as Affinity Ligands

4.2.1 Boronates and Related Mixed Ligands

4.2.2 Dye-Ligands

4.2.3 Immobilized Metal-Ion Chelates

4.2.4 Molecularly …


Analysis Of Drinking Water Disinfection Options, Bryce Carlen Jan 2021

Analysis Of Drinking Water Disinfection Options, Bryce Carlen

Department of Environmental Studies: Undergraduate Student Theses

This thesis utilizes existing research to provide a framework that can be used for community and disaster planning. It analyses the critical process of water disinfection for drinking water. It focuses on chemical, distillation, and ultraviolet treatments in both centralized and point-of-use treatment. This thesis aims to provide a method for communities to determine the optimal water treatment, utilizing a framework based on weighted criteria. The decision-making framework is an easy-to-use and flexible process that communities can tailor for their specific needs to find the optimal treatment relative to their needs. In this study’s generalized example, ultraviolet treatment and distillation …


Audit Of Waste Collected Over One Week From Superior Dental Health Of Lincoln, Bryclin Alstrom Jan 2021

Audit Of Waste Collected Over One Week From Superior Dental Health Of Lincoln, Bryclin Alstrom

Department of Environmental Studies: Undergraduate Student Theses

A waste audit of Superior Dental Health of Lincoln was conducted in order to propagate the implementation of sustainable waste management practices within the company. Differentiating between hazardous waste and solid waste is necessary for environmentally friendly waste management and ceasing the spread of infectious pathogens. The audit identified nine different materials contributing to the biomedical waste stream of the company. Of which, personal protective equipment (PPE) is of major concern due to the financial commitment necessary to acquire / dispose of these products, as well as the strain in supply due to the current COVID-19 pandemic. The results of …


Long-Term Impacts Of 2019 Flood Experiences On Nebraskans’ Climate Change Perceptions, Caitlin Kingsley Jan 2021

Long-Term Impacts Of 2019 Flood Experiences On Nebraskans’ Climate Change Perceptions, Caitlin Kingsley

Department of Environmental Studies: Undergraduate Student Theses

This study examines climate change perceptions in Nebraskans who experienced or witnessed flooding in March 2019. The purpose is to determine the impacts of 2019 flood experiences on Nebraskans’ climate change perceptions. The objectives are to determine the influence of flood proximity on changes in climate change perceptions, determine whether 2019 flooding had long-term impacts on Nebraskans’ climate change perceptions, and determine the influence of personal background factors on perceptions. A three-phase interview was utilized to collect background information, climate change perceptions, 2019 flood experiences, and relationships between 2019 flood experiences and climate change perceptions. Background information and climate change …


Mental Health Incorporation In Nebraskan Recovery Plans Following The 2019 Midwestern Floods, Isabelle Murray Jan 2021

Mental Health Incorporation In Nebraskan Recovery Plans Following The 2019 Midwestern Floods, Isabelle Murray

Department of Environmental Studies: Undergraduate Student Theses

In March 2019, Nebraska was hit with major floods that caused extensive damage throughout the state. Nebraskans spent the following months recovering from many aspects of the natural disaster. One aspect of emergency response and the act of recovery that is commonly overlooked is the mental health of individuals following the traumatic events. The purpose of this thesis is to evaluate the level of incorporation of mental health care and services in recovery plans following natural disasters. The qualitative analysis of recovery plans focused on Nebraska and the county-level response to the 2019 Midwestern floods. The objectives were to identify …


Mitigation Strategies For Municipal Solid Waste Generation In Lincoln, Justine Mileski Jan 2021

Mitigation Strategies For Municipal Solid Waste Generation In Lincoln, Justine Mileski

Department of Environmental Studies: Undergraduate Student Theses

This study was completed to explore mitigation solutions to Municipal Solid Waste (MWS) in the City of Lincoln. Due to population growth, especially in urban environments, waste generation is an increasingly difficult problem that requires complex solutions. This work is done to explore efficacy of various mitigation strategies such as recycling and composting of waste. This study will be conducted utilizing data found in the City of Lincoln Solid Waste Plan 2040 and applying it to the EPA Policy and Program Impact Estimator. Specifically, withing the EPA Policy and Program Impact Estimator, curbside collection and pay-as-you-throw (PAYT) programming will be …


Regenerative Agriculture’S Potential Carbon Storage In Nebraska Soils, Jenna Mccoy Jan 2021

Regenerative Agriculture’S Potential Carbon Storage In Nebraska Soils, Jenna Mccoy

Department of Environmental Studies: Undergraduate Student Theses

This meta-analysis investigates the possible carbon sequestration of no-till and cover crop practices on Nebraska farmlands. These management practices are part of regenerative agriculture, a farming method designed to mitigate and adapt to climate change. As climate change is expected to significantly reduce yields in Nebraska, sequestering carbon in farmlands offers a way to adapt to climate change impacts and lower the concentration of carbon dioxide in the atmosphere. However, changing management practices is difficult and is driven primarily by economics. This study aims to determine how much carbon these practices can sequester in Nebraska soil each year by evaluating …


Designing A Mobile App And Online Directory To Increase The Visibility Of Environmental Organizations In A Community, Kayla Vondracek Jan 2021

Designing A Mobile App And Online Directory To Increase The Visibility Of Environmental Organizations In A Community, Kayla Vondracek

Department of Environmental Studies: Undergraduate Student Theses

Concern for environmental degradation, natural resource depletion, and public health has long been a necessary part of a strongly developed and sophisticated society. Humans are primarily responsible for the depletion of the natural environment as it supplies the commodities required to ensure the long-term survival of civilizations. As cultures continue to evolve, so does the practice of land stewardship and protection of resources. With the necessary expansion of industry and housing needed to support a rising human population, the management of natural resources, pollution control, and the environment has become increasingly important to people worldwide. Bernstein and Szuster (2019) suggest …


Sparking Awareness In Lincoln Electronic Waste Trends And Habits: A Student Behavioral Analysis, Zowie Vincent Jan 2021

Sparking Awareness In Lincoln Electronic Waste Trends And Habits: A Student Behavioral Analysis, Zowie Vincent

Department of Environmental Studies: Undergraduate Student Theses

Nebraska is recognized as one of the few states that have not established any laws or practices managing electronic waste. Along with no e-waste management laws, there is also a lack of studies discussing the behavioral trends and habits towards electronic devices and how to dispose of them once they are unable to function. Continuing to ignore the choice of recycling electronics results in further damage towards the environment, human and animal health, as well as an economic opportunity of a growing market. This study focuses on the trends and habits of electronic consumption, usage, and disposal amongst students at …


The Garden Oasis: Observations In A Southern California Garden, Chris Tankersley Jan 2021

The Garden Oasis: Observations In A Southern California Garden, Chris Tankersley

Department of Entomology: Distance Master of Science Projects

A garden can be a special place of relaxation and a corridor from which one can connect with the natural world and observe the complex relationships among the many organisms that make it their home. These organisms include a vast array of insects that contribute to the diversity of even the smallest garden. We purchased an unassuming house in a quiet Southern California suburban neighborhood that included about half an acre of property made up of mostly lawn and a dense menagerie of backyard shrubs and trees on a steep hillside, along with a pond that was in desperate need …


Results Of Our 2020 Court Review Membership Survey, Court Review Editors Jan 2021

Results Of Our 2020 Court Review Membership Survey, Court Review Editors

Court Review: Journal of the American Judges Association

At the end of the calendar year 2020, the Court Review co-editors solicited feedback about the publication. A link to a survey was emailed to the American Judges Association membership (approximately 1400 members) and was included within the printed and online editions of Court Review. The questions in the survey asked about experiences as a reader and contributing author of Court Review.

We received 81 responses; however, 13 respondents only answered the first question (i.e., how long have you been receiving Court Review?) and are therefore not included in the responses below (n=68). Although we would have preferred …


Of Pigs And Men: The Best-Laid Plans For Prevention And Control Of Swine Fevers, Jishu Shi, Lihua Wang, David Scott Mcvey Jan 2021

Of Pigs And Men: The Best-Laid Plans For Prevention And Control Of Swine Fevers, Jishu Shi, Lihua Wang, David Scott Mcvey

School of Veterinary and Biomedical Sciences: Faculty Publications

John Steinbeck drew the title of his novel “Of Mice and Men” from a line in a Robert Burns poem “To a mouse”: “The best-laid plans of mice and men/Go often awry.” Unlike John Steinbeck who used the title to mirror the characters who were struggling during the Great Depression to the mouse whose nest was accidentally destroyed by the poet (Burns 1785), we chose this line to emphasize that the best-laid plan can go wrong in infectious disease control and prevention. Here, we will discuss the contributing factors behind the global successes and failures in the prevention and control …


Impact Of The Histidine‐Containing Phosphocarrier Protein Hpr On Carbon Metabolism And Virulence In Staphylococcus Aureus, Linda Pätzold, Anne-Christine Brausch, Evelyn-Laura Bielefeld, Lisa Zimmer, Greg A. Somerville, Markus Bischoff, Rosmarie Gaupp Jan 2021

Impact Of The Histidine‐Containing Phosphocarrier Protein Hpr On Carbon Metabolism And Virulence In Staphylococcus Aureus, Linda Pätzold, Anne-Christine Brausch, Evelyn-Laura Bielefeld, Lisa Zimmer, Greg A. Somerville, Markus Bischoff, Rosmarie Gaupp

School of Veterinary and Biomedical Sciences: Faculty Publications

Carbon catabolite repression (CCR) is a common mechanism pathogenic bacteria use to link central metabolism with virulence factor synthesis. In gram‐positive bacteria, catabolite control protein A (CcpA) and the histidine‐containing phosphocarrier protein HPr (encoded by ptsH) are the predominant mediators of CCR. In addition to modulating CcpA activity, HPr is essential for glucose import via the phosphotransferase system. While the regulatory functions of CcpA in Staphylococcus aureus are largely known, little is known about the function of HPr in CCR and infectivity. To address this knowledge gap, ptsH mutants were created in S. aureus that either lack the open reading …


An Evaluation Of The Anti-Carcinogenic Response Of Major Isothiocyanates In Non-Metastatic And Metastatic Melanoma Cells, Melina Mitsiogianni, Sotiris Kyriakou, Ioannis Anestopoulos, Dimitrios T. Trafalis, Maria V. Deligiorgi, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidi Jan 2021

An Evaluation Of The Anti-Carcinogenic Response Of Major Isothiocyanates In Non-Metastatic And Metastatic Melanoma Cells, Melina Mitsiogianni, Sotiris Kyriakou, Ioannis Anestopoulos, Dimitrios T. Trafalis, Maria V. Deligiorgi, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidi

School of Veterinary and Biomedical Sciences: Faculty Publications

Malignant melanoma is one of the most deadly types of solid cancers, a property mainly attributed to its highly aggressive metastatic form. On the other hand, different classes of isothiocy- anates, a class of phytochemicals, present in cruciferous vegetables have been characterized by considerable anti-cancer activity in both in vitro and in vivo experimental models. In the current study, we investigated the anti-cancer response of five isothiocyanates in an in vitro model of melanoma consisting of non-metastatic (A375, B16F-10) and metastatic (VMM1, Hs294T) malignant melanoma as well as non-melanoma epidermoid carcinoma (A431) and non-tumorigenic melanocyte-neighboring keratinocyte (HaCaT) cells. Our aim …


Inhibition Of Zika Virus Replication By G-Quadruplex-Binding Ligands, Prativa Majee, Aryamav Pattnaik, Bikash R. Sahoo, Uma Shankar, Asit K. Pattnaik, Amit Kumar, Debasis Nayak Jan 2021

Inhibition Of Zika Virus Replication By G-Quadruplex-Binding Ligands, Prativa Majee, Aryamav Pattnaik, Bikash R. Sahoo, Uma Shankar, Asit K. Pattnaik, Amit Kumar, Debasis Nayak

School of Veterinary and Biomedical Sciences: Faculty Publications

Zika virus (ZIKV), a mosquito-transmitted Flavivirus, emerged in the last decade causing serious diseases and affecting human health globally. Currently, no licensed vaccines or antivirals are available to combat ZIKV, although several vaccine candidates are in the pipeline. In recent years, the presence of non-canon- ical G-quadruplex (GQ) secondary structures in viral genomes has ignited significant attention as potential targets for anti- viral strategy. In this study, we identified several novel conserved potential GQ structures by analyzing published ZIKV genome sequences using an in-house algorithm. Bio- physical and biochemical analysis of the RNA sequences con- taining these potential GQ sequences …