Digital Commons Network^™

Covid-19 And Headache-Related Disability, Lauren Thaxter

Electronic Theses and Dissertations

Migraine is a common nervous system disorder that is a leading cause of disability worldwide, and approximately half of individuals with migraine report their migraine attacks cause substantial impairment in activities. A bidirectional relationship exists between migraine and psychological symptoms, and comorbid psychological symptoms compound migraine-related disability. Due to COVID-19 pandemic response procedures, many university students experienced institutional closures and corresponding increases in depression, stress, and anxiety, with the most prominent worries being about one's own health and the health of loved ones. The present study aimed to explore the relationship between COVID-19 status (pre-COVID vs. during COVID) and headache-related …

Design And Identification Of Organic Molecules As Agonists Of The Gabab Receptor And As Difluoro-C-Glycosylated Derivatives Of Flavonoids Using Molecular Modeling, Reem Alkhodier

Electronic Theses and Dissertations

The use of molecular modeling in pharmaceutical research is continuously growing. This growth is a result of the increasing number of experimental structures, the development of sophisticated modeling methods, and the improvement in computer performance by using GPUs and cloud computing. Nowadays, molecular modeling is routinely used in drug discovery to investigate biological processes and molecular properties. Herein, we use molecular modeling to investigate the behaviors of compounds with unique scaffolds.

Baclofen is the only marketed GABAB receptor agonist that is used for spasticity disorders, and it has shown promise as an anti-abuse agent. However, it has disadvantages that raise …

Synthesis And Charecterisation Of Methylene Blue Derivatives, Rohit Alluri

Electronic Theses and Dissertations

Since its discovery, the fluorescent dye known as methylene blue has been employed in a variety of scientific disciplines. Methylene blue (MB) for intraoperative fluorescence imaging has only lately been employed. 10-N-carbamoyl linkage modification of Methylene blue helps us in developing compounds with off-to-on fluorescence switch in the presence of near infrared (NIR). Due to its naturally induced photodamage to normal tissues and deeper penetration of lesion regions when compared to UV and visible light, near infrared (NIR) light is considered favorable among the broad radiation range. The previously synthesized derivatives are not completely soluble in water, they require other …

Development Of Hydroxyl Radical Protein Footprinting For Challenging Systems, Zhi Cheng

Electronic Theses and Dissertations

Structural biology plays an important role in modern molecular biosciences. High-resolution hydroxyl radical protein footprinting (HR-HRPF) is a mass spectrometry (MS) based method for analyzing protein topography at a spatial resolution from peptide up to the individual amino acids. Fast photochemical oxidation of protein (FPOP) is an HRPF technique that generates hydroxyl radicals by UV laser-induced photolysis of hydrogen peroxide. FPOP coupled with MS technology has successfully elucidated protein structure information, protein-protein interaction, and protein allosteric or conformational change. Even though FPOP coupled MS has quickly had a large impact on the field of biopharmaceutical analysis, serious limitations still remain. …

Physiological Corticosterone Attenautes Gp120-Mediated Microglial Activation And Is Associated With Reduced Anxiety-Like Behavior In Gp120-Expressing Mice, Emaya Marie Moss

Electronic Theses and Dissertations

Human immunodeficiency virus (HIV) persists as a global pandemic. Despite the benefits of combinatorial antiretroviral therapies (cART), virotoxic HIV proteins are still detectable within the central nervous system and approximately half of all cART-treated patients contend with neurological impairments. The mechanisms underlying these effects are not known, but likely involve actions of virotoxic HIV proteins including glycoprotein 120 (gp120). Glycoprotein 120 is neurotoxic, in part due to its capacity to activate microglia. Corticosterone, an endogenous anti-inflammatory, has been found to attenuate neuronal death caused by gp120-induced microglial cytokine production in vitro. But, the concentration-dependent effects of corticosterone to influence microglial …

Biopolymer Unfolding As A Process Of Biased Activated Barrier Crossing, Sudeep Adhikari

Electronic Theses and Dissertations

The biopolymer unfolding process can be conceptualized as the thermally activated crossing of a barrier in some energy landscape; the real-world unfolding dynamics are in correspondence with the rate of transit over the barrier. In this dissertation, we report on four projects that exploit this analogy to advance our understanding of so-called pulling experiments, in which a biopolymer chain is encouraged to unfold by direct application of forces to its two ends. Regardless of the specific experimental realization, standard pulling techniques give rise to a biased barrier crossing problem. The applied force has the effect of tilting the energy landscape. …

Student Success: Do First-Time, Full Time (Ftft) Students At The University Of Mississippi Enrolled In Intermediate Math (Ds 099) Earn Higher Grades In College Algebra (Math 121) Than Those Students Who Enrolled Directly In College Algebra?, Martina Brewer-Mister

Electronic Theses and Dissertations

Critics of developmental studies suggest that remedial courses may negatively influence a student’s program selection, persistence, and completion because remedial classes do not count toward graduation requirements (Long & Boatman, 2013). They have also found that over half of the students referred to remediation do not complete the courses (Clayton, Crosta, & Belfield, 2014; Bailey, Jeong, & Cho, 2010). The number is even lower for minority students (Bailey, 2010).

Using pre-existing data collected from the Office of Institutional Research, Effectiveness, and Planning at the University of Mississippi, an independent sample t-test and correlation analysis were conducted to examine the outcomes …

Spectroscopic Investigations Of Newly Developed Materials For Light Harvesting, Energy Conversion, And Bioimaging, Austin L. Dorris

Electronic Theses and Dissertations

A multitude of spectroscopic techniques were employed in the making of this dissertation to investigate materials with environmental, commercial, optoelectronic, bioimaging, and solar energy conversion applications. Graphene-like materials like biochar represent a field of study in which bioavailable materials are deployed for CO2 and heavy-metal adsorption to combat the detrimental effects of industry on the environment. Vibrational characterization of these materials via Raman spectroscopy is integral in elucidating the structure-function relationship and determining the best approach for material preparation and functionalization. Carbonaceous systems such as cellulose are also studied via Raman spectroscopy to interrogate the viability of cellulose nanocrystals as …

Core Size Conversion And Ligand Effects On Gold Nanomolecules Structure And Properties., Senthilkumar Eswaramoorthy

Electronic Theses and Dissertations

The size, shape and structure of the materials determines its properties in any scale. When the size of the material reaches nanometer scale, it shows a strikingly different property from the bulk. Monodisperse metal nanoparticles are highly desired due to its unique properties which can be explored for targeted applications. The nanoparticles with size less than 3 nm, atomically precise metal nanoparticles can be achieved, whereas nanoparticles in 3-100 nm range are monodisperse in size but not atomically monodisperse. Thiolate protected gold nanoparticles size less than 3 nm forms highly stable atomically precise compounds with distinct number of gold atoms …

First-Year Students' Perceptions Of Innate Intelligence, Ability, And Interest Across Four Stem Domains: A Comparative Structural Equation Model, Savannah Lea Kelly

Electronic Theses and Dissertations

Higher education institutions play a pivotal role in preparing students to acquire the skills necessary to enter the STEM workforce and serve as critical partners in the STEM educational-occupational pipeline. It is imperative that postsecondary institutions encourage equal opportunities for admittance into STEM domains. However, research has consistently demonstrated that gender and racial disparities continue to exist in STEM fields at the postsecondary level, particularly when viewed through the lens of disaggregated disciplinary data. One way to address inequitable attainment across STEM is to evaluate whether students prematurely preclude themselves from STEM participation due to a misalignment between students’ self-perceptions …

Faculty Perceptions Of Open And Affordable Education Resources, Megan Lowe

Electronic Theses and Dissertations

A now-common question regarding whether or not individuals should pursue college degrees is whether college is worth the cost. One of the ways that institutions of higher learning may help students reduce cost of attending college, thereby reducing the financial stresses, is to reduce expenses where possible. One place where institutions of higher learning can reduce expenses for students is course texts and materials. This reduction can be accomplished in several ways, but one way that has gained visibility is the use of open educational resources (OER) and affordable education resources (AER), also known as AOER. This qualitative research study …

Α-Tocopherol Succinate Nano Structured Lipid Carriers For The Ocular Delivery Of The Anticancer Agents And Statistical Modeling Of Release Study Profiles By Linear Mixed Models, Sushrut Marathe

Electronic Theses and Dissertations

Retinoblastoma (RB) is a rare type of cancer that develops quickly from immature retinal cells. Enucleation, external beam radiotherapy, episcleral plaque radiotherapy, and cryotherapy have been the treatment options for the RB.

Paclitaxel (PTX) is an effective antineoplastic medication with a wide range of applications in the treatment of malignant tumors., systemic toxicity, quick elimination, and resistance limit its clinical use. Due to its limited solubility, PTX formulations have proven difficult to develop, necessitating the use of Cremophor® EL and organic solvents. Furthermore, the blood-retinal barrier prevents PTX from penetrating into the ocular tissues. The goal of this work was …

Meaning In Life And Psychological Distress: Examining Veterans And Psychological Adaptation To Civilian Life, Victoria Mccutcheon

Electronic Theses and Dissertations

Veterans’ transition from the military to civilian life can be conceptualized as a cultural transition (i.e., acculturation). This transition means leaving the familiarity and consistency of military life and attempting to integrate one’s values, skills, expectations, and identity as a service member into the dominant civilian culture. The present study seeks to examine the psychological adaptation component of acculturation (i.e., the individual’s feelings and perceptions of being in the new culture) in a veteran sample, as it relates to meaning in life. The existing body of veteran literature has demonstrated that meaning and purpose (a distinct component of meaning) are …

Inevitable Mortality And The Incessant Momentum Of Medicalized Death, Clifford Mckay

Electronic Theses and Dissertations

Atul Gawande, MD, affirms the inevitability of human mortality and the end of life in natural death. He decries current medical delivery’s incessant momentum toward medicalized death and recommends a meaningful conversation between doctor and patient to chart a course of care that supports what is important to the patient. But the tradition of a doctor’s dominance and a patient’s submissiveness disrupts the conversation. New definitions of both doctor and patient, and the intent to respect a patient’s autonomy, will facilitate decision-making and support patients’ values at the end of life, diminishing the momentum of medicalized death.

Using Ab Initio Quantum Mechanical Methods For The Characterization And Isomerization Of Novel Compounds, Kimberley N. Poland

Electronic Theses and Dissertations

Computational quantum chemistry is the branch of chemistry derived from quantum mechanics to calculate structures and properties of molecules utilizing rigorous mathematical equations and approximations. This work focuses on utilizing wavefunction based methods to compute molecular properties such as optimized geometries, harmonic and anharmonic vibrational frequencies, dipole moments, strain energy, and isomerization channels with high degrees of accuracy, allowing for a direct comparison with previous work and experiment. Electronic structure modeling using various \textit{ab intio} methods can provide insight into the characterization and behavior of molecules otherwise unobserved, including, but not limited to, detection in the interestellar medium.

Investigating The Effects Of Absurd Humor And Mortality Salience On Moral Identity, Belongingness, Belief In A Just World, And Meaning In Life, Joshua Semko

Electronic Theses and Dissertations

Background: Humans have a sense of meaning, and people actively create and maintain meaning in their lives. One way humans make meaning is through fluid compensation, which is the automatic process of compensating for a threat to one’s global meaning system by temporarily strengthening other, non-related beliefs. This phenomenon has been thoroughly investigated in response to mortality salience (i.e., reminders of one’s death), but not absurd humor. This is important because little is known about the role of humor in meaning making. More research is needed to determine whether humor is a unique meaning-making process. Further, no studies have investigated …

The Effect Of Pitch Height On Instrument Gender Ratings, Raven Gordon Thompson

Electronic Theses and Dissertations

The purpose of this study was to examine the effect of pitch height on instrument gender ratings. This study’s participants (N=64) consisted of music major (n=32) and non-music major (n=32) students who are enrolled at the University of Mississippi. Using a 5-point semantic rating scale, participants rated the perceived masculinity and femininity of six musical instruments (flute, clarinet, saxophone, trumpet, trombone, tuba) as they are played at the approximate midpoint of their ranges and as they played in ranges that countered their established instrument-sex-stereotype. Specifically, female instruments (flute, clarinet) played in their low ranges while male instruments (trombone, tuba) played …

Finding Aid For The Dorothye Quaye Chapman Reed (Mum00799)Collection

Archives & Special Collections: Finding Aids (alphabetical)

Collection of correspondence, clippings, photographs, writings, and material pertaining to the life and career of Dorothye Quaye Chapman Reed.

Improving Three-Dimensional Instructional Practices Via Professional Development, Alethea Henry

Electronic Theses and Dissertations

The purpose of this applied research study was to improve the use of three-dimensional pedagogy in science classes in chronically low-performing schools. The need to build teacher capacity became evident after the state adopted more rigorous science standards revealing deficits in teachers’ pedagogical content knowledge. This study utilized two elements, three-dimensional professional development and the science cadre, to build teacher capacity as well as foster collaboration and create buy-in throughout the district among science leaders. Data collected and analyzed from classroom observations, student surveys, and teacher interviews revealed improved usage of three-dimensional instruction and increased buy-in throughout the district to …

Development Of Hollow Vaginal Device Using Stereolithography (Sla) 3d Printing For Intravaginal Drug Delivery, Preethi Lakkala

Electronic Theses and Dissertations

Vulvovaginal candidiasis is a condition caused by the polymorphic opportunistic fungus Candida albicans, which involves the first-line treatment with antifungal agents comprising azole groups. An intravaginal drug delivery device is an alternate approach to conventional therapy that transcend multiple daily administrations and systemic side effects associated with oral medications and offers effective drug concentrations at the target site for a sustained period. This study reports, for the first time, the development of a novel hollow vaginal device by exploiting stereolithography (SLA) 3D printing technology to achieve localized and extended delivery of Itraconazole. These devices were fabricated using a shape memory …

Evaluating The Effectiveness Of Mindfulness-Based Group Interventions On Reducing Externalizing Behaviors In Adolescent Populations, Erica Montgomery

Electronic Theses and Dissertations

This study explores the extent of the impact that mindfulness-based interventions, such as mindfulness-based stress reduction techniques, have on externalizing behaviors in adolescents. Specifically, the intended population receiving the intervention will be minority adolescents, ages 9-15, in rural Mississippi who have received disciplinary action from the school or community based on acting out and aggression. The Ohio Youth Rating Scale will be used to collect information from three primary sources: parents, teachers, and participants. Data will be collected at multiple points in the intervention. Based on previous research with similar age groups, outcomes should be favorable for reducing unwanted behaviors.

Do Policies Matter? An Exploratory, Qualitative Study Of The Lived Experiences On Campus Of Transgender And Non-Binary Education Employees, Sarah Clay

Electronic Theses and Dissertations

The student population of American colleges and universities is becoming increasingly diverse. Though the racial and ethnic makeup of a campus population has been given the most attention in diversity and inclusion efforts, there has been a growing focus on LGBTQ issues in recent decades. As a result, institutions of higher learning have been working to develop responsive policies and programs that aim to promote LGBTQ inclusion amongst faculty, staff, and students.

However, the current socio-political climate in the United States is becoming intensely antagonistic toward gender non-conforming people. With gender identity being such a socially and politically divisive issue, …

Down The Stream: The Evolution Of Queer Stream-Of-Consciousness Novels Through The Works Of Virginia Woolf And Ali Smith, Turner Nat Byrd

Electronic Theses and Dissertations

This thesis attempts to understand the evolution of the stream-of-consciousness genre as it applies to, is written by, or centers queer people. Through generous Marxist-feminist readings of the works of Virginia Woolf and Ali Smith—used in this project as exemplars of the genre—it attempts to understand the differences within both the formal and philosophical/political outlook of the two authors. Specifically looking at Woolf’s Mrs. Dalloway and To the Lighthouse and Smith’s Hotel World, The Accidental, and Girl Meets Boy, this project posits that Smith, intentionally or not, has effectively re-written the basic narratives and re-visited the same themes as Woolf, …

The Queer And Trans Ecologies Of Shakespeare's Ocean, Elijah Two Bears

Electronic Theses and Dissertations

This thesis squarely approaches the overlooked theoretical nexus of early modern blue ecologies and LGBTQIA2S+ studies to argue that Shakespeare's ocean is a deeply queer space that inspires both queer and trans effects in his characters, plays, and audiences across time. I argue you can’t fully process Shakespeare’s aquatic environments, and the broader range of his more watery plays, without accounting for the queer destabilization and trans self-fashioning that is inextricably linked with encountering the ocean, whether it is through shipwreck, ship travel, or near-drownings. This project recreates a lost world using whatever small gems of textual and historical evidence …

The N-Terminal Domains Of Voltage Dependent Anion Channels As Novel Members Of The Bcl-2 Family: Their Roles And Interactions With The Bh3 Domain Of The Bcl-2 Family Members, Clement Nana Agyemang

Electronic Theses and Dissertations

VDACs are pore-forming proteins found within the mitochondria's outer membrane (MOM) whose function is to allow the exchange of metabolites such as ATP and ADP in and out of the mitochondria. In apoptotic cells, they allow the release of cytochrome c from the MOM into the cytosol to initiate apoptosis. The Bcl-2 family of proteins regulates mitochondrial-dependent apoptosis by inhibiting or promoting apoptosis through their BH3 domain. Recent studies have demonstrated that VDACs play essential roles in regulating mitochondrial apoptosis through their interactions with the Bcl-2 family. In this study, we proposed that VDACs are part of the Bcl-2 family …

Development And Characterization Of Different Dosage Forms Utilizing Hot-Melt Extrusion Technique, Abdulmajeed Althobaiti

Electronic Theses and Dissertations

Hot melt extrusion (HME) is a promising technique for developing different dosage forms and improving products already on the market. Numerous studies have been published utilizing HME due to its advantages over conventional techniques. It is solvent-free, has few processing steps, continuous processing, and low cost. Furthermore, HME has the flexibility to be coupled with Fused Deposition Modeling (FDM) to develop complex dosage forms for patient-focused drug delivery. The first objective of this research work was to design and develop different dosage forms (capsule-in-capsule, and three-dimensional-printed tablet) of nifedipine/indomethacin fixed-dose combination (FDC) utilizing hot melt extrusion (HME) with or without …

Sustained Delivery Of Carbon Monoxide (Co) Via Organic Co Prodrugs: Pharmacokinetic Studies, Minjia Wang

Electronic Theses and Dissertations

Carbon monoxide (CO) is widely known as poisonous gas. Its role as a signaling molecule (gasotransmitter) with various therapeutic effects is less known. Recent years have seen a surge of interest in CO because of its demonstrated therapeutic effect in treating conditions such as inflammation, drug-induced toxicity, ischemia-reperfusion injury, and kidney injury, among others. In developing CO-based therapeutic agents, one key issue is the availability of pharmaceutically acceptable ways of delivering CO. During the past decade, there has been a large number of experiments in cell culture, animal models, and clinical trials using CO gas incubation/inhalation and heavy metal based …

A History Of Freed Slaves' Homes In Northern Nigeria, 1900-1926, Ajibola A. Abdulrahman

Electronic Theses and Dissertations

This dissertation is about the children rescued from slave traders by the British colonial government in Northern Nigeria in the early twentieth century. The children were first settled in state-owned Freed Slaves Homes located at Zungeru and Borno provinces in 1904. After the state-owned Homes were abolished in 1909, they were moved to the privately-owned Lucy Memorial Freed Slaves’ Home. The study focuses on the experiences of these liberated children within the premises of the Freed Slaves' Homes and in settings outside of these institutions in Northern Nigeria. Drawing on previously unused archival materials obtained from various parts of the …

Formulation Development Of Famotidine Floating Tablets Using Hot-Melt Extrusion Coupled With 3d Printing Technique., Esraa Al Shawakri

Electronic Theses and Dissertations

The main goal of this study is to develop a floating tablet of famotidine using hot melt extrusion coupled (HME) with Fused deposition modeling FDM 3D printing technology. Seventeen different formulations were prepared to obtain printable HME filaments. Hydroxypropyl cellulose (HPL-LF), hydroxypropyl cellulose (HPLC-EF), Hydroxypropyl Methylcellulose (HPMC-E5), and Ethyl Cellulose (EC) were used as polymeric carriers with 10% (w/w) famotidine. Polyethylene Glycol 1500 (PEG-1500) was used as a plasticizer. The resulting physical mixtures were then extruded using an 11 mm twin-screw co-rotating extruder (Thermo Fisher Scientific, Waltham, MA, USA). The HME filaments were then printed using an FDM-3D printer (Prusa …

The Relationship Between Ethnicity, Immigrant Generation, & Delinquency: Examining Youth In Child Protective Services., Erin Leigh Geist

Electronic Theses and Dissertations

Although minority youth are overrepresented in the makeup of the welfare and juvenile justice system, there is a lack of research that examines dually-involved youth. In recent years, there has been an escalation in the number of Hispanic youth that have become involved in the child welfare system, including youth that identify as Hispanic immigrants. This study uses nationally representative data of children receiving welfare services to examine the relationship between ethnicity, immigrant generation, and delinquency. The results of binomial regression models illustrated that there was no effect of Hispanic ethnicity or immigrant generation on delinquency. However, the analysis provided …