Digital Commons Network^™

"The Wild Asleep": A Cultural And Environmental History Of Ramps, Catherine Jessee

Electronic Theses and Dissertations

Ramps, wild onions, or allium tricoccum are a variety of spring ephemeral, or a flowering plant that emerges for a brief period every spring. In working through stereotypical ideas about Appalachian regional identity, I interpret the environmental history of this plant. Incorporating memory, oral histories, and folklore, this thesis complicates wider conceptions of home, community, and boundary. Tapping into an archive of ramps knowledge as it is created, I ask, what can the future of ramps tell us about place, space, and belonging?

Assessing The Effectiveness And Utility Of A Mindfulness-Based Ecological Momentary Intervention In College Students, Jeffrey Pavlacic

Electronic Theses and Dissertations

Mental health problems are common and increasing in college students. Despite the high prevalence rates of mental health problems in college students, a small percentage of students seek treatment. Low treatment seeking is associated with different factors, such as stigma, financial barriers, and emotion dysregulation. Identifying and delivering evidence-based treatments is critical to curtailing mental health problems and promoting psychological well-being in this population. One intervention that offers significant promise is Ecological Momentary Intervention (EMI), which incorporates technology to administer interventions. EMIs are widely applied for heterogeneous psychological problems and effective through different modalities. Mindfulness-based interventions (MBIs) ameliorate psychological distress …

Research News, Publications, 2022, Volume 2, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of April 1 through June 30, 2022.

Research News, Publications, 2022, Volume 1, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of January 1 through March 31, 2022.

Research News, Publications, 2022, Volume 3, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of July 1 through September 30, 2022

The Longitudinal Influence Of Adhd Status And Stimulant Medication On Body Mass Index And Blood Pressure Among Obese Youth, Sophie Kollin

Electronic Theses and Dissertations

Youth with attention-deficit hyperactivity disorder (ADHD) are more vulnerable to developing obesity, as they have significantly higher body mass index (BMI) and are at increased risk of food addiction and binge eating. Stimulant medication use, which is an evidence-based treatment for ADHD, is associated with lower BMI and higher blood pressure among normal weight youth. The purpose of this study was to examine the longitudinal influence of ADHD and stimulant medication use on BMI and blood pressure trajectories among a sample of 456 youth treated in a weight management clinic. Mixed linear modeling examined the main and interactive effects of …

Amphiphilic Janus Polymer Nanoparticles For Pharmaceutical And Biomedical Applications, Mahesh Loku Yaddehige

Electronic Theses and Dissertations

Amphiphilic hybrid polymers have attracted significant interest as biomaterials for both fundamental research and practical clinical applications due to their unique polymer structure and properties relative to the conventional symmetric polymers. Often referred to as “Janus” polymers combine two different polymer segments (hydrophilic and hydrophobic) of varying degrees, sizes, and functionalities to obtain a single amphiphilic or hetero-functional macromolecule with characteristic features. In particular, amphiphilic “Janus” polymers and their self-assemblies have shown apparent success in nanomedicine owing to their ability to provide highly ordered nanoscale multimolecular aggregates, including micelles and vesicles. However, engineering these polymeric materials on a large scale …

Halogen Bond Driven Supramolecular Materials, Dilan Chinthaka Karunathilaka

Electronic Theses and Dissertations

Halogen bonding (XBing) is a type of non-covalent interaction between covalently bound halogen atoms (XB donor), and Lewis bases (XB acceptor). In recent years, it has become a remarkable and adaptable tool to produce interesting molecular architectures and functionalities in organic-based materials. Such applications include liquid crystals, nonlinear optics, photovoltaics, and multicolor displays in the solid phase. Due to this variety of applications, XBing has become an exciting area of study in supramolecular chemistry. Herein are presented synthetic routes and characterization of self-assembling XBing molecules and their resulting materials. First, four different heterocyclic oligomers containing pyrazine, thiophene, and furan have …

Botanical Aphrodisiacs For Women's Health, Hayley N. Prescott

Electronic Theses and Dissertations

Female Sexual Dysfunction (FSD) affects nearly 40% of women in the United States. While males have five FDA approved drugs for ED, there is only one FDA-approved as-needed treatment for premenopausal women with acquired, generalized Hypoactive Sexual Desire Disorder (HSDD), the most prevalent FSD. The lack of approved drugs is largely due to the biopsychosocial complexity of HSDD; however, there are neurobiological underpinnings evident. Due to the lack of safe efficacious treatment options, we hypothesize that botanical species traditionally used as aphrodisiacs may be promising leads, and exert their effects via activation of melanocortin’s, an excitatory circuit implicated in sexual …

Perceptions Of English Learner Support Provided By K-12 Leaders To Educators In Mississippi, Ladonna Thomas

Electronic Theses and Dissertations

The demographic of public schools in America is continuously changing. According to the United States Department of Education (USDE), the English learner population increased in over 25 states from the 2009-2010 school year to the 2014-2015 school year (USDE, 2017). In 2014-15, there were more than 4,800,000 English learners enrolled in schools, accounting for 10% of the total student population (USDE, 2017). With this shifting demographic, educators must be prepared to meet the needs of EL students.

The purpose of this study is to examine educators and instructional leaders’ perceptions of EL instructional support and to highlight the need for …

Implications Of Gender Dysphoria On Gender Schema And Social Cognitive Theories Of Gender Development, Beau Bourgeois

Electronic Theses and Dissertations

This project considers the implications of gender dysphoria under two prominent theories of gender development, gender schema theory (GST) and social cognitive theory (SCT). Gender dysphoria is considered a significant motivator for transgender behavior and is presented in the DSM-5 as the experience of a strong desire, or as primarily affective in nature. GST and SCT differ in a number of ways, most notably in the role affect plays for gender development and behavior motivations. The former places primary emphasis on environmental influences, leaving the role of affect in question, while the latter posits gender behavior and motivation as an …

Late-Stage Diversification Of Select Natural Products €“ New Chemical Entities With Improved Biological Activities, Moneerah J. Alqahtani

Electronic Theses and Dissertations

Owing to their complexity, diverse structures and molecular targets, natural products have contributed, and will continue to contribute, to the development and discovery of new drugs. Although natural products provide numerous active compounds, their complex structures and poor pharmacokinetics make meeting the eligibility criteria for clinical trials unfeasible. In order to improve their drug-likeness, structural modification is an effective tool to generate countless natural product-based molecules with potential therapeutics. This proposal entails synthetic efforts towards late-stage diversification of natural products in two projects.

The first study highlights the multi-factorial nature of Alzheimer’s disease and brings attention to the importance of …

Synthetic Studies On Valuable Fluorinated Building Blocks, Maali Alshammari

Electronic Theses and Dissertations

Fluorine chemistry plays a diverse role in the pharmaceutical, agricultural, and material industries. In fact, around 25% of pharmaceuticals and 40% of agrochemicals contain at least one fluorine atom. The incorporation of fluorine into pharmaceuticals or natural products can increase bioavailability by enhancing lipophilicity, metabolic stability, and overall pharmacokinetics properties. Our laboratory has designed a method to generate difluoroenolates from pentafluoro-gem-diols. This reactivity can be used to produce molecules displaying a difluoromethyl group. The reaction occurs through the release of trifluoroacetate. We improved the design and synthesis of fluorinated derivatives of flavones and measured their antioxidants activities. This work expanded …

Speech Fluency Changes Following Deep Brain Stimulation Of The Subthalamic Nucleus In Parkinson’S Disease: A Meta-Analysis, Emily Morphis

Electronic Theses and Dissertations

Purpose: Speech fluency changes following deep brain stimulation are one aspect that is crucial to consider when exploring treatments for Parkinson’s disease. Deep brain stimulation, specifically of the subthalamic nucleus, has been linked to a decrease in speech fluency despite improved bodily motor control. This acquired dysfluency is referred to as “neurogenic stuttering.” The purpose of the current study is to determine the incidence and severity of speech fluency decline following deep brain stimulation in patients with Parkinson’s disease. A meta-analysis was conducted with 7 studies (239 subjects) that recorded changes in speech fluency. All studies used a quantitative assessment, …

Role Of Astrocytic Insulin-Like Growth Factor 1 In The Regulation Of Behavior, Cognition, And Neuroinflammation, Brayden Thomas

Electronic Theses and Dissertations

Modern medicine has consistently extended life expectancy over recent decades and centuries. Despite this, age-associated cognitive decline and risk of neurodegenerative disease grow in parallel with lifespan, meaning the capacity to live healthier has not mirrored that to live longer. Many studies in both human and rodents have shown the association between age-related cognitive impairment and reduction of insulin-like growth factor-1 (IGF-1) signaling. Additional research has indicated that dysregulated IGF-1 signaling, either systemic or local to the central nervous system (CNS) in cells like neurons and glia, leads to impaired spatial learning and memory in mice. Glia, or glial cells, …

Re-Engineered Metalloproteins And Rationally Designed De Novo Peptides: Towards Artificial Hydrogenases, Pallavi Prasad

Electronic Theses and Dissertations

Metals play a crucial role in biology. Metalloenzymes perform various functions in various life sustaining processes. Global energy crisis is a major challenge that the world is facing. The depleting fossil fuels and increasing carbon footprint calls for a need of alternate clean energy sources. Researchers have been working to help alleviate this challenge for decades. Hydrogen gas comes up as a potential candidate which can be used as a biofuel in a hydrogen fuel cell. Hydrogenase is a metalloenzyme that does a two-electron reversible conversion of protons to hydrogen, making it an excellent hydrogen source. However, this native enzyme …

The Impact Of Blended Classroom Pedagogy On Student Gpa In A Community College Stem Course, Sarah Mattox Holt

Electronic Theses and Dissertations

America is facing a shortage of STEM workers and colleges must meet the demand by educating qualified graduates. However, attrition rates are high in STEM classes, particularly in minority groups. Blended learning has increased in popularity in higher education over recent years and has the potential to improve current teaching practices. Yet, limited research centers on the success of blended learning implemented in a community college STEM course. This quantitative research study (N=1264) was designed to evaluate student success in the blended learning environment versus traditional environment in an introductory community college biology course for science majors. The study indicated …

Development Of Local Depot Formulation For Sustained Systemic Delivery Of Proteins, Pranav Ponkshe

Electronic Theses and Dissertations

Protein therapeutics due to their high potency, high specificity, and desirable profile have gained a lot of traction in the last decade. Though the route of administration is limited to parenteral routes. There are also short half-life and instability issues observed in protein therapeutics making it necessary to develop delivery systems.

In the first chapter interleukin 15 as a cytokine was introduced while the second chapter talks more in detail about the development of a local depot hydrogel formulation for the delivery of recombinant interleukin 15. In vitro stability, and release studies were performed to select the optimum formulation for …

Exploring Non-Covalent Interactions With Quantum Chemical Tools, Morgan Perkins

Electronic Theses and Dissertations

Computational quantum chemistry is an excellent tool for probing properties of all types of chemical systems that are not easily accessible via experimental work. In particular, computational chemistry can be used to develop a better understanding of non-covalent interactions, which are important to a variety of chemical and biological processes. This work focuses primarily on complexes held together by hydrogen and halogen bonding, investigating their relationship to each other and, in a few projects, providing data that can be used for experimental identification of the different configurations. Additionally, comparisons are made between complexes containing first-row elements (e.g. fluorine) and their …

Dye And Redox Shuttle Interactions To Promote Fast Electron Transfer In Dye-Sensitized Solar Cells, Abeysinghe Mudiyanselage Dinesh Bandara Nugegoda

Electronic Theses and Dissertations

Harnessing the sun's power using dye-sensitized solar cells (DSCs) is a possible answer to address the energy challenge. Increasing the performance of DSC devices by increasing the rate of productive electron transfers is critically essential. In this regard, to increase the rate of electron transfers from the redox shuttle to the dye, a strategy of coordinating the redox shuttle through non-covalent interactions such as Lewis acid-Lewis base interactions, π-stacking interactions, and halogen bonding interactions to the dye are considered. DSC devices were fabricated using newly synthesized dyes and redox shuttle pairs to study each strategy. The performance of the devices …

On Airborne Tire Wear Particles Along Roads, Labeling Microplastics With Fluorescent Dyes, Microplastics In Wastewater Treatment Plant And Beach Sand, And Microplastic-Mercury Affinity, Zhiqiang Gao

Electronic Theses and Dissertations

Microplastics (MPs) with sizes of 1 μm to 5 mm that are intentional manufactured or result from fragmentation of large plastic debris are widely recognized as a global pollutant. The distributions and concentrations of MPs in environmental and biological systems as well as their toxicity are not well understood. This dissertation details five studies providing new insight and methods on (1) the occurrence and characteristics of airborne tire wear particles (TWPs) along roads, (2) manufacturing and labeling of MPs with fluorescent dyes, (3) fate of MPs in a secondary wastewater treatment plant (WWTP) at the University of Mississippi, (4) distribution …

Interval Delivery Of 5ht2a Agonists Using Multilayered Polymeric Films, Mehjabeen Hossain

Electronic Theses and Dissertations

There is an urgent unmet medical need to develop therapeutic options for the ~50% of depression patients suffering from treatment-resistant depression, which is difficult to treat with existing psycho- and pharmaco-therapeutic options. Classical psychedelics, such as the 5HT2A agonists, have re-emerged as a treatment paradigm for depression. Recent clinical trials highlight the potential effectiveness of 5HT2A agonists to improve mood and psychotherapeutic growth in treatment-resistant depression patients, even in those who have failed a median of four previous medications in their lifetime. Moreover, microdosing could be a promising way to achieve long-term alleviation of depression symptoms without a hallucinogenic experience. …

Top Ole Miss News Stories Of 2021, Staff Report

University of Mississippi News

Relive a year of accolades and achievements at the university

Study Of How Cancers Spread Promises Treatment Options, Shea Stewart

University of Mississippi News

American Cancer Society funds UM professor's breast cancer research

Ionic Liquid-Solvated Chitosan Nanoparticles As A Novel Method Of Treating Atopic Dermatitis, Leslie Bell

Honors Theses

Atopic dermatitis, or eczema, is an inflammatory skin disease resulting in dry, red, and itchy skin that affects almost 20% of the population of the Western world. This disease creates a physical, emotional, as well as financial burden on those affected, as well as their families. Current treatment options are only somewhat effective, and do not have a long duration of release and therefore efficiency. Furthermore, treatment plans involving corticosteroids need to be closely regulated to monitor side effects such as skin thinning. Other options include topical tacrolimus, emollients, and oral antihistamines, each with varied side effects. This project is …

One Story, Two Authors And Seven Layers, Edwin B. Smith

University of Mississippi News

Gregg Davidson's 'The Manifold Beauty of Genesis One' melds scholarship with faith

December 2, 2021, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Characterization And In Vitro And In Vivo Evaluation Of Tacrolimus-Loaded Poly(Ε-Caprolactone) Nanocapsules For The Management Of Atopic Dermatitis, Guilherme Dos Anjos Camargo, Leandro Ferreira, Diego José Schebelski, Amanda Martinez Lyra

Faculty and Student Publications

Background: Tacrolimus (TAC) is a drug of natural origin used in conventional topical dosage forms to control atopic dermatitis. However, direct application of the drug often causes adverse side effects in some patients. Hence, drug nanoencapsulation could be used as an improved novel therapy to mitigate the adverse effects and enhance bioavailability of the drug. Methods: Physicochemical properties, in vitro drug release experiments, and in vivo anti-inflammatory activity studies were performed. Results: TAC-loaded nanocapsules were successfully prepared by the interfacial deposition of preformed polymer using poly(ε-caprolactone) (PCL). The nanoparticu-late systems presented a spherical shape with a smooth and regular surface, …

Transmission Studies And The Composition Of Prokaryotic Communities Associated With Healthy And Diseased Aplysina Cauliformis Sponges Suggest That Aplysina Red Band Syndrome Is A Prokaryotic Polymicrobial Disease, Matteo Monti, Aurora Giorgi, Cole G. Easson, Deborah J. Gochfeld

Faculty and Student Publications

Aplysina cauliformis, the Caribbean purple rope sponge, is commonly affected by Aplysina Red Band Syndrome (ARBS). This transmissible disease manifests as circular lesions with red margins and results in bare spongin fibers. Leptolyngbya spp. appear to be responsible for the characteristic red coloration but transmission studies with a sponge-derived isolate failed to establish disease, leaving the etiology of ARBS unknown. To investigate the cause of ARBS, contact transmission experiments were performed between healthy and diseased sponges separated by filters with varying pore sizes. Transmission occurred when sponges were separated by filters with pore sizes ≥ 2.5 μm, suggesting a prokaryotic …

Issue 383: November 11-December 2, 2021, The Local Voice

The Local Voice

No abstract provided.