Digital Commons Network^™

Ranking The Biases: The Choice Of Otus Vs. Asvs In 16s Rrna Amplicon Data Analysis Has Stronger Effects On Diversity Measures Than Rarefaction And Otu Identity Threshold, Marlène Chiarello, Mark Mccauley, Sébastien Villéger, Colin R. Jackson

Faculty and Student Publications

Advances in the analysis of amplicon sequence datasets have introduced a methodological shift in how research teams investigate microbial biodiversity, away from sequence identity-based clustering (producing Operational Taxonomic Units, OTUs) to denoising methods (producing amplicon sequence variants, ASVs). While denoising methods have several inherent properties that make them desirable compared to clustering-based methods, questions remain as to the influence that these pipelines have on the ecological patterns being assessed, especially when compared to other methodological choices made when processing data (e.g. rarefaction) and computing diversity indices. We compared the respective influences of two widely used methods, namely DADA2 (a denoising …

Gene Expression Of Stress-Related Biomarkers And Disease Presence In Gene Expression Of Stress-Related Biomarkers And Disease Presence In Crassostrea Virginica, Jaycie Keylon

Honors Theses

Crassostrea virginica, the Eastern oyster, is an environmentally and economically important species along the East coast and in the Gulf of Mexico. Environmentally, oysters are filter feeders, cleaning the water of contaminants. They also provide habitat and shelter for other marine species. Oysters are of significant economic value as seafood to nearby communities as well. Eastern oyster populations have been significantly adversely affected by the parasite Perkinsus marinus, which causes Dermo disease. Dermo affects oysters during times of warm temperatures and high salinities and has the potential to wipe out entire populations of oysters. Throughout this study, the …

Designing A Clinical Study With Dietary Supplements: It's All In The Details, Z. Elizabeth Floyd, David M. Ribnicky, Ilya Raskin, Daniel S. Hsia

Faculty and Student Publications

A successful randomized clinical trial of the effect of dietary supplements on a chosen endpoint begins with developing supporting data in preclinical studies while paying attention to easily overlooked details when planning the related clinical trial. In this perspective, we draw on our experience studying the effect of an ethanolic extract from Artemisia dracunculus L. (termed PMI-5011) on glucose homeostasis as a potential therapeutic option in providing resilience to metabolic syndrome (MetS). Decisions on experimental design related to issues ranging from choice of mouse model to dosing levels and route of administration in the preclinical studies will be discussed in …

The University Is Part Of The Family, J. B. Clark

University of Mississippi News

Four Goulet siblings and two parents spend time together at Ole Miss

Celebrations 2022, University Of Mississippi Writing Project, University Of Mississippi. Office Of Pre-College Programs.

Celebrations: A Literary Magazine

No abstract provided.

Leveraging The Influence Of Power Grid Links In Renewable Energy Power Generation, Wei Wang, Haibo Wang, Bahram Alidaee, Jun Huang, Huijun Yang

Faculty and Student Publications

Smart grid construction provides the basic conditions for grid connection of renewable energy power generation. However, the grid connection of large-scale intermittent renewable energy sources increases the complexity of operational control of power systems. With the increase in intermittent renewable energy grid connections, distribution system operators must optimize and integrate these new participants to ensure the flexibility and stability of smart grids. Dividing the smart grid into logical clusters helps to overcome the problems caused by intermittent renewable energy grid connections. In this study, we propose a 2-step modeling approach that includes both link and leverage analyses to detect the …

Major And Minor Flyer, University Of Mississippi. College Of Liberal Arts

Liberal Arts Publications

A pamphlet listing the 35 majors and 52 minors available through the College of Liberal Arts.

Phytochemical Investigation Of Egyptian Riverhemp: A Potential Source Of Antileukemic Metabolites, Shimaa M. Abdelgawad, Mona H. Hetta, Mohamed A. Ibrahim, Premalatha Balachandran

Faculty and Student Publications

As part of our research group's continuous efforts to find alternative treatments for cancer, the aqueous ethanol extract of Sesbania sesban L. Merr. (SS, Egyptian riverhemp) demonstrated an antileukemic activity against K562 cell line. Bioguided fractionation of SS leaves hydroethanolic extract resulted in the isolation of one new compound (33) named as hederatriol 3-O-β-D-glucuronic acid methyl ester as well as 34 known compounds. Seven compounds ((34), (22), (20), (24), (21), (19), and (35)) showed high antiproliferative effects (IC50 = 22.3, 30.8, 31.3, 33.7, 36.6, 37.5, and 41.5 μM, respectively), while four compounds ((32), (5), (29), and (1)) showed milder activities …

Cryptococcosis In A Patient With Multiple Myeloma Receiving Pomalidomide: A Case Report And Literature Review, Daniel B. Chastain, Sahand Golpayegany, Andrés F. Henao-Martínez, Brittany T. Jackson

Faculty and Student Publications

While overall survival with multiple myeloma (MM) has improved, patients suffer from overwhelming tumor burden, MM-associated comorbidities, and frequent relapses requiring administration of salvage therapies. As a result, this vicious cycle is often characterized by cumulative immunodeficiency stemming from a combination of disease- and treatment-related factors leading to neutropenia, T-cell deficiency, and hypogammaglobulinemia. Infectious etiologies differ based on the duration of MM and treatment-related factors, such as number of previous treatments and cumulative dose of corticosteroids. Herein, we present the case of a patient who was receiving pomalidomide without concomitant corticosteroids for MM and was later found to have cryptococcosis, …

Synthesis Of 3,4,5-Trisubstituted Isoxazoles In Water Via A [3 + 2]-Cycloaddition Of Nitrile Oxides And 1,3-Diketones, Β-Ketoesters, Or Β-Ketoamides, Md Imran Hossain, Md Imdadul H. Khan, Seong Jong Kim, Hoang V. Le

Faculty and Student Publications

Herein we report a method for the synthesis of 3,4,5-trisubstituted isoxazoles in water under mild basic conditions at room temperature via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides. We optimized the reaction conditions to control the selectivity of the production of isoxazoles and circumvent other competing reactions, such as O-imidoylation or hetero [3 + 2]-cycloaddition. The reaction happens fast in water and completes within 1-2 hours, which provides an environmentally friendly access to 3,4,5-trisubstituted isoxazoles, an important class of structures found in numerous bioactive natural products and pharmaceuticals. Additionally, we optimized the reaction conditions to …

Identification Of An Orally Bioavailable, Brain-Penetrant Compound With Selectivity For The Cannabinoid Type 2 Receptor, Meirambek Ospanov, Suresh P. Sulochana, Jason J. Paris, John M. Rimoldi

Faculty and Student Publications

Modulation of the endocannabinoid system (ECS) is of great interest for its therapeutic relevance in several pathophysiological processes. The CB2 subtype is largely localized to immune effectors, including microglia within the central nervous system, where it promotes anti-inflammation. Recently, a rational drug design toward precise modulation of the CB2 active site revealed the novelty of Pyrrolo[2,1-c][1,4]benzodiazepines tricyclic chemotype with a high conformational similarity in comparison to the existing leads. These compounds are structurally unique, confirming their chemo-type novelty. In our continuing search for new chemotypes as selective CB2 regulatory molecules, following SAR approaches, a total of 17 selected (S,E)-11-[2-(arylmethylene)hydrazono]-PBD analogs …

Dual Drug Loaded Lipid Nanocarrier Formulations For Topical Ocular Applications, Ahmed Adel Ali Youssef, Narendar Dudhipala, Soumyajit Majumdar

Faculty and Student Publications

Introduction: Untreated ocular infections can damage the unique fine structures of the eye with possible visual impairments and blindness. Ciprofloxacin (CIP) ophthalmic solution is prescribed as first-line therapy in ocular bacterial infections. Natamycin (NT) ophthalmic suspension is one of the progenitors in ocular antifungal therapy. Nanostructured lipid carriers (NLCs) have been widely examined for ocular penetration enhancement and distribution to deeper ocular tissues. The objective of the current study was to prepare NLCs loaded with a combination of CIP and NT (CIP-NT-NLCs) and embed them in an in-situ gelling system (CIP-NT-NLCs-IG). This novel formulation will target the co-delivery of CIP …

Research News, Publications, 2022, Volume 4, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of October 1 through December 31, 2022

Design, Analysis, And Application Of Flipped Product Chaotic System, Md Sakib Hasan, Partha Sarathi Paul, Anurag Dhungel, Maisha Sadia, Md Razuan Hossain

Faculty and Student Publications

In this paper, a novel method is proposed to build an improved 1-D discrete chaotic map called flipped product chaotic system (FPCS) by multiplying the output of one map with the output of a vertically flipped second map. Two variants, each with nine combinations, are shown with trade-off between computational cost and performance. The chaotic properties are explored using the bifurcation diagram, Lyapunov exponent, Kolmogorov entropy, and correlation coefficient. The proposed schemes offer a wider chaotic range and improved chaotic performance compared to the constituent maps and several prior works of similar nature. Wide chaotic window and improved chaotic complexity …

Cascading Cmos-Based Chaotic Maps For Improved Performance And Its Application In Efficient Rng Design, Partha Sarathi Paul, Maisha Sadia, Md Razuan Hossain, Barry Muldrey, Md Sakib Hasan

Faculty and Student Publications

We present a general framework for improving the chaotic properties of CMOS-based chaotic maps by cascading multiple maps in series. Along with two novel chaotic map topologies, we present the 45 $nm$ designs for four CMOS-based discrete-time chaotic map topologies. With the help of the bifurcation plot and three established entropy measures, namely, Lyapunov exponent, Kolmogorov entropy, and correlation coefficient, we present an extensive chaotic performance analysis on eight unique map circuits (two under each topology) to show that under certain constraints, the cascading scheme can significantly elevate the chaotic performance. The improved chaotic entropy benefits many security applications and …

Uv Exposure Causes Energy Trade-Offs Leading To Increased Chytrid Fungus Susceptibility In Green Tree Frog Larvae, Rebecca L. Cramp, Michel E. B. Ohmer, Craig E. Franklin

Faculty and Student Publications

Levels of ultraviolet (UV) radiation have increased in many parts of the world due to the anthropogenic destruction of the ozone layer. UV radiation is a potent immunosuppressant and can increase the susceptibility of animal hosts to pathogens. UV radiation can directly alter immune function via immunosuppression and photoimmunotolerance; however, UV may also influence pathogen defences by affecting the distribution of energy resources among competing physiological processes. Both defence against UV damage and repair of incurred damage, as well as the maintenance of immune defences and responding to an immune challenge, are energetically expensive. These competing demands for finite energy …

Application Of Artificial Neural Network To Predict The Properties Of Permeable Concrete, Hatem H. Almasaeid, Donia G. Salman

Faculty and Student Publications

The structure of permeable concrete has been the primary reason for its use in construction. Permeable concrete is composed of water, cement, aggregate, and little-to no-fines resulting in the presence of a significant number of voids. This makes permeable concrete an ideal solution to water accumulation issues as it acts as a drainage system. This study employs a feedforward backpropagation artificial neural network model that combines experimental laboratory data from previous studies with appropriate network architectures and training techniques. The purpose of the analysis is to develop a reliable functional relationship, based on water-cement ratio, aggregate-cement ratio, and density parameters, …

Discovery Of New 1h-Pyrazolo[3,4-D]Pyrimidine Derivatives As Anticancer Agents Targeting EgfrWt And EgfrT790m, Ahmed A. Gaber, Mohamed Sobhy, Abdallah Turky, Hanan Gaber Abdulwahab

Faculty and Student Publications

New 1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesised to act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives were assessed for their in vitro anti-proliferative activities against A549 and HCT-116 cancer cells. Compounds 8, 10, 12a, and 12b showed potent anti-proliferative activities. Compound 12b was the most promising member with IC50 values of 8.21 and 19.56 µM against A549 and HCT-116, respectively. Compounds 8, 10, 12a, and 12b were evaluated for their kinase inhibitory activities against wild EGFR (EGFRWT). Compound 12b was the most potent member showing an IC50 value of 0.016 µM. In addition, compound 12b showed noticeable …

Newsletter Winter 2022, Annette Kluck, Margaret Savoie

Newsletters of the Graduate School

No abstract provided.

Does The Contraction History Of The Muscle Dictate Changes In Strength Following Resistance Training?, Zachary William Bell

Electronic Theses and Dissertations

Within-subject training models, whereby researchers apply an exercise condition to one limb, and a separate exercise condition to the opposing limb, have become routine amongst the exercise literature. However, no study has directly tested whether exercising one limb with a high-load condition will influence strength adaptations within the opposing limb, even when the opposite limb is training. Furthermore, muscle post-activation performance enhancement (PAPE) is representing local level changes, however, more research is warranted to understand if this can be differentially impacted with different types (e.g. low load vs. high load) of resistance training. The purpose of this study was to …

"How It Was Made", Bethany Fitts

Electronic Theses and Dissertations

This is a meta-autoethnography describing the researcher’s unfocused, rhizomatic research process throughout the COVID19 pandemic. Themes explored are the COVID19 pandemic, family, death, climate change, queer love, represenation, academia, genre, and religion. The study shows how multiple scales of grief arise during the research process. I locate this method within postcolonial theory of autoethnography that seeks to diversify structures within the academic genre.

Memoria, Historia Y El Feminismo Decolonial: Un Análisis De La Poesía De Cristina Rodríguez Cabral Y Otras Poetas Afrolatinas, Margaree Gabrielle Obioha

Electronic Theses and Dissertations

This study explores the poetic works of Afro-Uruguayan poet Cristina Rodríguez Cabral and other Afro-Uruguayan and Afro-Latina poets and identifies how their works contribute to the body of decolonized feminist literature. The investigation includes the historical context of Black women and Black women poets in Uruguay to set the stage for analyzing the main themes of Rodríguez Cabral’s poetry which include questioning the presentation of Afro-Uruguayan women from a European perspective, the construction of a firm and resilient Afro-Uruguayan woman and the embracing of sisterhood within the African Diaspora. These themes are strongly connected to decolonized feminism in that they …

Electrochemistry, Spectroscopy, And Mass Transport Of Lanthanide Solutes In Bis(Trifluoromethylsulfonyl)Amide-Based Ionic Liquids, Heather Danielle Hamilton

Electronic Theses and Dissertations

In this work, the characterization of lanthanide elements (Dy, Er, Gd, Ho, Tb, Tm, Yb) in various RTIL solvents based on the ubiquitous bis(trifluoromethylsulfonyl)amide anion (Tf2N-) was investigated. The effect of cation structure on the mass transport and electron transfer properties of Yb3+ in [X]-Tf2N RTILs is considered, where [X] is one of six quaternary ammonium cations with varying structure and chemical properties. Cyclic staircase voltammetry (CSV), rotating disk electrode voltammetry (RDEV), and electrochemical impedance spectroscopy (EIS) experiments are used for this purpose. For each RTIL, the dependence of the redox reaction is examined at each of the working electrodes: …

Preparation, Characterization And In-Vitro Release Studies Of Icg-Encapsulated Liposomes, Prateek Uttreja

Electronic Theses and Dissertations

The purpose of the present study was to create Indocyanine Green (ICG) loaded liposomal formulations that were efficient and had controlled drug release. During the Second World War, the photographic dye indocyanine green (ICG) was created. ICG was developed as a medical diagnostic tool for cardiac output tests and for monitoring liver function after receiving FDA approval. The preparation of ICG-encapsulated conventional and PEGylated liposomes containing different types of phosphatidylcholine (PC) such as HSPC, DSPC, DPPC and cholesterol (CH) in the molar ratios of 55:45 and PC:CH: DSPE-PEG2K (polyethylene glycol) in the molar ratio of 55:40:5 respectively was done using …

Effects Of Heterocycles On Biologically Relevant Molecules, Sajith Manjrake Vijayan

Electronic Theses and Dissertations

It is difficult to overstate the importance of heterocycles in many fields of science (including organic, inorganic, pharmaceutical, medicinal, and material science). Due to their remarkable potential for being involved in a vast array of reactions, heterocyclic molecules make up the majority of pharmaceuticals as well as more than half of all natural products. Moreover, nature widely uses heterocycles, and scientists learned to imitate nature by incorporating them into drug molecules to enhance their biological activity. In this research work emphasize the use of heterocycles in biomedical applications.

The first study presents the design, synthesis, and computational evaluation of four …

Inclusive Music Teacher Preparation In The Presbyterian College Of Education At Akropong-Akuapem, Ghana, Samuel Agbenyo

Electronic Theses and Dissertations

For the past three decades, Inclusive Education (IE) has emerged as a crucial educational agenda all over the world. In this study, IE is the practice of including students with disabilities in the general (music) education classroom, where they are educated together with their typically developing peers. Although IE efforts began in Ghana in 1957, some pitfalls have characterized the implementation process over the years, especially regarding music teacher preparation to implement the policies. Studies have reported a state of frustration among stakeholders, notably the elementary school teachers, who feel inadequately prepared to teach within IE settings. In this case …

Resilience Capacity Of School Meal Programs In Southeastern U.S. School Districts During The Covid-19 Pandemic: Findings From Mississippi, Louisiana, And West Virginia, Kritika Gupta

Electronic Theses and Dissertations

Mississippi (MS), Louisiana (LA), and West Virginia (WV) have some of the nation’s highest rates of poverty and health disparities, reflected in high rates of food insecurity. Many of the school districts in these states have greater than 40% of students qualifying for free meals and, under community eligibility, can provide meals free to all children. School meals play an important role in addressing food insecurity in the U.S. and those were severely affected by the COVID-19 pandemic. The ability of social systems (schools) to continue operations during adverse circumstances (pandemic) to ensure the sustained outcome of interest (food security) …

Hiv-1 Tat And Opioids: Implications For Stress-Related Psychopathology, Salahuddin Mohammed

Electronic Theses and Dissertations

The overarching goal of this dissertation was to assess the interaction of HIV-1 Tat protein with opioids like oxycodone and the hypothalamic-pituitary-adrenal (HPA) axis and develop novel therapeutic strategy to restore HPA dysfunction in adult HIV-1 Tat transgenic mice. In the past 3 decades, combined antiretroviral therapeutics (cART) has increased the life expectancy of HIV infected individuals, with a significant decline in the number of deaths. However, due the inability of cART to sufficiently target latent CNS viral reservoirs (predominantly microglia and astrocytes to a lesser extent), approximately 50% of the HIV+ infected population contends with neurological, neuropsychiatric and neuroendocrine …

Exploratory Studies On The Feasibility Of Developing Microneedles Using Hot Melt Extrusion Coupled With Fused Deposition Modeling 3-D Printing, Nikeeta Palande

Electronic Theses and Dissertations

Transdermal drug delivery enables efficient local and systematic drug delivery while offering advantages such as non-invasiveness, patient compliance, and avoidance of first pass metabolism compared to parenteral administration. Due to strong and the multi-layered structure of the skin creates complex barriers which makes the delivery of therapeutic agents across the skin becomes challenging. Microneedles have been shown to deliver drugs through the transdermal route by penetrating the skin’s protective barrier, stratum corneum (SC) and creating a pathway for drug permeation to the dermal tissue. Traditionally, microneedles were fabricated using various types of materials and process such as casting, injection moulding, …

Design Of An Ophthalmic Nanostructured Lipid Carrier Containing Amphotericin B And Nonadecanoic Acid For The Management Of Fungal Keratitis, Vishal Shah

Electronic Theses and Dissertations

Fungal keratitis is a fungal infection of the cornea. Untreated ocular infections can damage the unique, delicate structures of the eye leading to blindness and visual impairments. It primarily affects the corneal epithelium and stroma, although the endothelium and anterior chamber of the eye may get involved in more severe disease. Amphotericin B (AMB) is a macrocyclic polyene that poorly penetrates ocular tissues. However, AMB is a drug of choice used for the treatment of fungal keratitis caused by Candida. Nonadecanoic acid (NDA) is a 19-carbon fatty acid obtained from plants or bacteria which has shown antifungal activity and acts …