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April 7, 2022, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Environment And Co-Occurring Native Mussel Species, But Not Host Genetics, Impact The Microbiome Of A Freshwater Invasive Species (Corbicula Fluminea), Marlène Chiarello, Jamie R. Bucholz, Mark Mccauley, Stephanie N. Vaughn, Garrett W. Hopper, Irene Sánchez González, Carla L. Atkinson, Jeffrey D. Lozier, Colin R. Jackson

Faculty and Student Publications

The Asian clam Corbicula fluminea (Family: Cyneridae) has aggressively invaded freshwater habitats worldwide, resulting in dramatic ecological changes and declines of native bivalves such as freshwater mussels (Family: Unionidae), one of the most imperiled faunal groups. Despite increases in our knowledge of invasive C. fluminea biology, little is known of how intrinsic and extrinsic factors, including co-occurring native species, influence its microbiome. We investigated the gut bacterial microbiome across genetically differentiated populations of C. fluminea in the Tennessee and Mobile River Basins in the Southeastern United States and compared them to those of six co-occurring species of native freshwater mussels. …

Potential Pro-Inflammatory Effect Of Vitamin E Analogs Through Mitigation Of Tetrahydrocannabinol (Thc) Binding To The Cannabinoid 2 Receptor, Anjela Manandhar, Mona H. Haron, Samir A. Ross, Michael L. Klein

Faculty and Student Publications

Vitamin E acetate, which is used as a diluent of tetrahydrocannabinol (THC), has been reported as the primary causative agent of e-cigarette, or vaping, product use-associated lung injury (EVALI). Here, we employ in vitro assays, docking, and molecular dynamics (MD) computer simulations to investigate the interaction of vitamin E with the membrane-bound cannabinoid 2 receptor (CB2R), and its role in modulating the binding affinity of THC to CB2R. From the MD simulations, we determined that vitamin E interacts with both CB2R and membrane phospholipids. Notably, the synchronized effect of these interactions likely facilitates vitamin E acting as a lipid modulator …

Analysis Of Docosanol Using Gc/Ms: Method Development, Validation, And Application To Ex Vivo Human Skin Permeation Studies, Vijay Kumar Shankar, Mei Wang, Srinivas Ajjarapu, Praveen Kolimi

Faculty and Student Publications

Docosanol is the only US Food and Drug Administration (FDA) approved over-the-counter topical product for treating recurrent oral-facial herpes simplex labialis. Validated analytical methods for docosanol are required to demonstrate the bioequivalence of docosanol topical products. A gas chromatography/selected ion monitoring mode mass spectrometry (GC/SIM-MS) method was developed and validated for docosanol determination in biological samples. Docosanol and isopropyl palmitate (internal standard) were separated on a high-polarity GC capillary column with (88% cyanopropy)aryl-polysiloxane employed as the stationary phase. The ions of m/z 83 and 256 were selected to monitor docosanol and isopropyl palmitate, respectively; the total run time was 20 …

Under-Oil Autonomously Regulated Oxygen Microenvironments: A Goldilocks Principle-Based Approach For Microscale Cell Culture, Chao Li, Mouhita Humayun, Glenn M. Walker, Keon Young Park, Bryce Connors, Jun Feng, Molly C. Pellitteri Hahn, Cameron O. Scarlett, Jiayi Li, Yanbo Feng, Ryan L. Clark, Hunter Hefti, Jonathan Schrope, Ophelia S. Venturelli, David J. Beebe

Faculty and Student Publications

Oxygen levels in vivo are autonomously regulated by a supply–demand balance, which can be altered in disease states. However, the oxygen levels of in vitro cell culture systems, particularly microscale cell culture, are typically dominated by either supply or demand. Further, the oxygen microenvironment in these systems is rarely monitored or reported. Here, a method to establish and dynamically monitor autonomously regulated oxygen microenvironments (AROM) using an oil overlay in an open microscale cell culture system is presented. Using this method, the oxygen microenvironment is dynamically regulated via the supply–demand balance of the system. Numerical simulation and experimental validation of …

Evaluation Of The Carotid Artery Using Wavelet-Based Analysis Of The Pulse Wave Signal, Sameh El-Sharo, Amani Al-Ghraibah, Jamal Al-Nabulsi, Mustafa Muhammad Matalgah

Faculty and Student Publications

The use of pulse wave analysis may assist cardiologists in diagnosing patients with vascular diseases. However, it is not common in clinical practice to interpret and analyze pulse wave data and utilize them to detect the abnormalities of the signal. This paper presents a novel approach to the clinical application of pulse waveform analysis using the wavelet technique by decomposing the normal and pathology signal into many levels. The discrete wavelet transform (DWT) decomposes the carotid arterial pulse wave (CAPW) signal, and the continuous wavelet transform (CWT) creates images of the decomposed signal. The wavelet analysis technique in this work …

Math 672: Statistical Methods Ii, Dao Nguyen

GMAS Course Syllabi

No abstract provided.

Three-Dimensional Numerical Modeling Of Flow Hydrodynamics And Cohesive Sediment Transport In Enid Lake, Mississippi, Xiaobo Chao, A. K. M. Azad Hossain, Mohammad Z. Al-Hamdan, Yafei Jia, James V. Cizdziel

Faculty and Student Publications

Enid Lake is one of the largest reservoirs located in Yazoo River Basin, the largest basin in the state of Mississippi. The lake was impounded by Enid Dam on the Yocona River in Yalobusha County and covers an area of 30 square kilometers. It provides significant natural and recreational resources. The soils in this region are highly erodible, resulting in a large amount of fine-grained cohesive sediment discharged into the lake. In this study, a 3D numerical model was developed to simulate the free surface hydrodynamics and transportation of cohesive sediment with a median diameter of 0.0025 to 0.003 mm …

Synthesis Of Alpha Domain Of Metallothionein For Hydrogen Production, Aditya Surakanti

Honors Theses

The world relies on nonrenewable resources for a significant portion of its usable energy, the most common being fossil fuels. Fossil fuels release many unwanted byproducts during their extractions and conversion processes. As a result, this excessive use leads to harsh consequences upon the environment, including rapid global warming, release of numerous water and air pollutants, and it could possibly lead to an increased risk of death in those who are exposed to these toxins. In response to this scenario, the goal of my project is to design an artificial hydrogen catalyst, which can absorb sunlight and oxidize H2O into …

Evaluating Methods Of Preserving Aquatic Invertebrates For Microbiome Analysis, Stephanie N. Vaughn, Colin R. Jackson

Faculty and Student Publications

Research on the microbiomes of animals has increased substantially within the past decades. More recently, microbial analyses of aquatic invertebrates have become of increased interest. The storage method used while collecting aquatic invertebrates has not been standardized throughout the scientific community, and the effects of common storage methods on the microbial composition of the organism is unknown. Using crayfish and dragonfly nymphs collected from a natural pond and crayfish maintained in an aquarium, the effects of two common storage methods, preserving in 95% ethanol and freezing at −20◦C, on the invertebrate bacterial microbiome was evaluated. We found that the bacterial …

Providing Culturally Competent Eldercare For Asian Americans, Britney Ngo

Honors Theses

As the Asian American elderly population continues to grow, it is important to acknowledge cultural factors that may impact their behavior, attitudes, preferences, and decisions in the context of eldercare. Cultural competency acknowledges and considers these factors while providing care that includes biophysical factors of healthcare as well as non-medical dimensions of care such as language and culture.

This thesis seeks to address the applications of providing culturally competent eldercare to Asian Americans and offer future recommendations to care settings that have limited resources by utilizing a multidisciplinary review of literature accompanied by interviews with representatives from On Lok, a …

Three Um Students Named Goldwater Scholars, Staff Report

University of Mississippi News

Record-breaking class of honorees awarded for excellence in STEM studies and research

March 31, 2022, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Protocol: A Scoping Review Of Graduate Student Education, Curriculum Impact, And Interest In Interdisciplinary Research Training, David D. Allen Iii

Faculty and Student Publications

Title: PROTOCOL: A Scoping Review of Graduate Student Education, Curriculum Impact, and Interest in Interdisciplinary Research Training

Background: Alongside traditional graduate education practices, implementing curriculum focused on providing interdisciplinary research training to graduate students may help support their academic development. This additional educational focus can bolster graduate student understanding of methodological practices, develop alternative routes of thinking or approaching a problem/ issue/ topic, may assist in developing student professional socialization skills, and may positively impact student internal motivations, beliefs, and perceptions.

Methods: Our scoping review protocol was developed a priori utilizing the Joanna Briggs Institute guidance, by …

Graduate Student Symposium Expands, Features Keynote By Noted Alumnus, Staff Report

University of Mississippi News

Event draws record number of entries; Forbes '30 Under 30' honoree Sly Spencer Lee shares secrets of success

Scientists To Explore Suicidal Behavior For Brain Awareness Week, Edwin B. Smith

University of Mississippi News

March 23 discussion on Zoom looks at efforts to understand and treat behaviors

Consensus Definition Of Misophonia: A Delphi Study, Susan E. Swedo, David M. Baguley, Damiaan Denys, Laura J. Dixon, Mercede Erfanian, Alessandra Fioretti, Pawel J. Jastreboff, Sukhbinder Kumar, M. Zachary Rosenthal, Romke Rouw, Daniela Schiller, Julia Simner, Eric A. Storch, Steven Taylor, Kathy R. Vander Werff, Cara M. Altimus, Sylvina M. Raver

Faculty and Student Publications

Misophonia is a disorder of decreased tolerance to specific sounds or their associated stimuli that has been characterized using different language and methodologies. The absence of a common understanding or foundational definition of misophonia hinders progress in research to understand the disorder and develop effective treatments for individuals suffering from misophonia. From June 2020 through January 2021, the authors conducted a study to determine whether a committee of experts with diverse expertise related to misophonia could develop a consensus definition of misophonia. An expert committee used a modified Delphi method to evaluate candidate definitional statements that were identified through a …

Machines, Intimacy Topics For Two Hybrid Oxford Science Cafes, Edwin B. Smith

University of Mississippi News

Computer science, neuroscience professors to present during in-person and virtual events

Scholarship Recipients Carry On Late Mba Student's Legacy, Sydney Gibson

University of Mississippi News

Endowment honoring Zach McClendon has served students, young alumni well

Edney Works To Widen The Ladder Of Opportunity For All, J. B. Clark

University of Mississippi News

New assistant vice chancellor has helped increase student access to university

In Silico Tools For Analysis Of Single-Nucleotide Polymorphisms In The Bovine Transferrin Gene, Aarif Ali, Muneeb U. Rehman, Syed Mudasir Ahmad, Tabish Mehraj

Faculty and Student Publications

Dairy cattle with a high milk yield are susceptible to many infectious diseases, such as mastitis. Subclinical mastitis (SCM) is the most prevalent form of mastitis that predominantly affects animal health, and causes adverse effects on the quality and quantity of milk. In dairy animals, subclinical mastitis often remains undetected, as no gross changes in udder characteristics are visible. In the present study, 135 Holstein Friesian dairy animals were selected and screened as healthy (n = 25) and mastitic (n = 110) based on diagnostic tests such as the California mastitis test, pH, electrical conductivity, and somatic cell count. In …

Chemical Composition Analysis, Cytotoxic, Antimicrobial And Antioxidant Activities Of Physalis Angulata L.: A Comparative Study Of Leaves And Fruit, Jayachithra Ramakrishna Pillai, Adil Farooq Wali, Godfred Antony Menezes, Muneeb U. Rehman

Faculty and Student Publications

Physalis angulata L. belongs to the family Solanaceae and is distributed throughout the tropical and subtropical regions. Physalis angulata leaf and fruit extracts were assessed for in vitro anticancer, antioxidant activity, and total phenolic and flavonoid content. The GC-MS technique investigated the chemical composition and structure of bioactive chemicals reported in extracts. The anticancer activity results revealed a decrease in the percentage of anticancer cells’ viability in a concentration-and time-dependent way. We also noticed morphological alterations in the cells, which we believe are related to Physalis angulata extracts. Under light microscopy, we observed that as the concentration of ethanolic extract …

Accomplished Alumna Edith Kelly-Green Boosts Accountancy Scholarship, Bill Dabney

University of Mississippi News

Women's Council founding chair hopes to give recipients head start to success

Daniell Mattern Named Inaugural Stefani-Miller Chair, Edwin B. Smith

University of Mississippi News

No abstract provided.

February 22, 2022, University Of Mississippi. Faculty Senate

Meeting Minutes

Minutes for the February 22, 2022 meeting of the University of Mississippi Faculty Senate.

Racial, Ethnic, And Urban/Rural Differences In Transitions Into Diabetes: Evidence From The Health And Retirement Survey Biomarker And Self-Reported Data, Hyeran Chung, Mary Arends-Kuenning

Journal of Rural Social Sciences

We examine differences in transitions between stages of type 2 diabetes across racial, ethnic, and urban/rural statuses. The individual-level data from the 2006 to 2012 waves of the Health and Retirement Survey (HRS) and county-level data from the 1990-2000 U.S. Censuses, the Dartmouth Atlas of Health Care, and the Inter-university Consortium for Political and Social Research are used to analyze the transition from the stage of prediabetic to diabetic, and the transition from having no diabetes to being prediabetic and diabetic. The HRS includes both biomarker data and self- reported doctors’ diagnoses of diabetes, which allow us to identify people …

Exploring Rural-Urban Differences In Polygenic Associations For Health Among Older Adults In The United States, Trent Davidson, Jason D. Boardman, Lori M. Hunter

Journal of Rural Social Sciences

A complex combination of genes and environment influence health and, as a result, both genes and environment can play a role in shaping health disparities. We consider distinctions in these influences across rural and urban settings, expanding upon work that shows lower genetic associations in rural compared to urban places by studying an older age group and examining more than the typical outcomes of alcohol/substance abuse. Using a sample of 14,994 adults from the 1992 through 2016 waves of the Health andRetirement Study, our results suggest genetic associations for BMI and heart conditions are significantly lower in rural compared to …

The Influence Of Social Determinants Of Health On The Provision Of Postpartum Contraceptives In Medicaid, Irene Nsiah, Nidhi Vij Mali, Marie Barnard, Swarnali Goswami

Faculty and Student Publications

Disparities continue to exist in the timely provision of postpartum contraception. This study aimed to identify prevalence and factors associated with postpartum contraception provision among women enrolled in Medicaid. A retrospective cohort study was conducted using the 2014 National Medicaid data, linked to county‐level social vulnerability index (SVI) data. Women aged 15–44 with a live birth in 2014 were included. Multivariable logistic regression was used to predict 3‐day provision of long‐acting reversible contraception (LARC) and 60‐day provision of most effective or moderately effective contraceptives (MMEC). Overall, 3‐day LARC provision was 0.2% while 60‐day MMEC was 36.3%. Significantly lower odds of …

Phytochemical Screening, In Vitro And In Silico Studies Of Volatile Compounds From Petroselinum Crispum (Mill) Leaves Grown In Saudi Arabia, Ahmed I. Foudah, Mohammad H. Alqarni, Aftab Alam, Mohammad Ayman Salkini

Faculty and Student Publications

The herbal plant Petroselinum crispum (P. crispum) (Mill) is commonly available around the world. In this study, the leaves of the herbal plant P. crispum were collected from the central region of Al-Kharj, Saudi Arabia, to explore their in vitro pharmacological activity. Essential oil from the leaves of P. crispum was isolated using the hydrodistillation method. The composition of P. crispum essential oil (PCEO) was determined using Gas chromatography-mass spectrometry (GC-MS). A total of 67 components were identified, representing approximately 96.02% of the total volatile composi-tion. Myristicin was identified as the principal constituent (41.45%). The in vitro biological activity was …

A Multitarget Approach To Evaluate The Efficacy Of Aquilaria Sinensis Flower Extract Against Metabolic Syndrome, Hee Sung Chae, Olivia Dale, Tahir Maqbool Mir, Bharathi Avula

Faculty and Student Publications

Aquilaria sinensis (Lour.) Spreng is known for its resinous secretion (agarwood), often secreted in defense against injuries. We investigated the effects of A. sinensis flower extract (AF) on peroxisome proliferator-activated receptors alpha and gamma (PPARα and PPARγ), liver X receptor (LXR), glucose uptake, and lipid accumulation (adipogenesis). Activation of PPARα, PPARγ and LXR was determined in hepatic (HepG2) cells by reporter gene assays. Glucose uptake was determined in differentiated muscle (C2C12) cells using 2-NBDG (2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose). Adipogenesis was determined in adipocytes (3T3-L1 cells) by Oil red O staining. At a concentration of 50 µg/mL, AF caused 12.2-fold activation of PPARα and …