Digital Commons Network^™

The Carolina Gay Association, The Southeastern Gay Conferences, And Gay Liberation In The 1970s South, David Hooper Schultz

Electronic Theses and Dissertations

This project explores how the successes and failures of local organizing networks in the South shaped national conversations on the rights of queer Americans. Its starting point is 1970 with the Triangle Gay Alliance’s formation in Raleigh, and it ends in 1978 with the third annual Southeastern Gay Conference and repeal of Miami-Dade County’s nondiscrimination ordinance. Paying close attention to the founding of the Carolina Gay Association in 1975 and the subsequent Southeastern Gay Conferences (SEGCs), the thesis connects the attendance at conferences to locally-organized activist groups from North Carolina to Florida to show that rather than being “lonely hunters” …

Exploring The Impact Of Mississippi Virtual Community College Academy Professional Development For Online Teaching, Terry Woodrow Pollard

Electronic Theses and Dissertations

As online courses and programs continue to grow in number across Mississippi’s community college system, an examination of the system which trains and supports faculty has gone largely unexamined. The aim of this research was to study the impact of the Mississippi Virtual Community College Academy, the state’s online professional development system, on faculty. Structured interviews were conducted with nine faculty in four community colleges across the state to determine conditions that helped or hindered faculty in their implementation of content learned in online professional development courses on credit-bearing courses they would later teach. Analysis of faculty transcripts indicate faculty …

Satisfaction With Campus Involvement And College Student Academic Success, Carissa Pauley

Honors Theses

Previous research has shown there are multiple benefits to overall development and well-being of an individual when they obtain social belongingness (Begen & Turner-Cobb, 2015; Maslow, 1943; Osterman, 2000; Sirgy, 1986). Additionally, social belonging has been shown to have multiple positive effects in the lives of college students (Pittman and Richmond, 2008). The main objective of this study was to help determine whether the satisfaction a college student feels toward the quantity and quality of their social involvement in campus organizations is a predictor of academic success. Participants completed measures assessing academic involvement, satisfaction with The University of Mississippi, quality …

The Effect Of Familiarity On Joint Attention In Children With Asd, Rachel Jenkins

Honors Theses

Joint attention is the ability to share focus on an object with a conversational partner and the awareness that this attention is shared (Moore, Dunham, & Dunham, 2014). Joint attention is an important building block for learning, language, and social development (Mundy & Newell, 2007; Thurm, Lord, Lee, & Newschaffer, 2007). However, previous research has documented that children with autism spectrum disorder (ASD) often have significant deficits and delays in the acquisition of joint attention when compared to typically developing peers of similar chronological ages (Mundy, Sigman, & Kasari, 1994; Osterling & Dawson, 1994; Chiang, Soong, Lin, & Rogers, 2008). …

The Effect Of Histone Deacetylase Inhibitors On Metastatic Breast Cancer Cells In Conjunction With Clinically Relevant Chemotherapeutic Agents, Mary Grace Stewart

Honors Theses

Histone Deacetylases (HDACs) are enzymes charged with the job of loosening DNA packaged around histone proteins. This gives them the opportunity to affect the transcriptional regulation of certain cancer associated genes and proteins, but HDACs are not limited to only DNA modification. They also target non-chromatin proteins in the cytoplasm, and have been closely linked to the many pathways involved in metastatic breast cancer such as apoptosis evasion, cell migration, and angiogenesis. HDAC’s effect on important cytoplasmic proteins could play a huge role in the largely unknown mechanisms of metastatic breast cancer. HDAC inhibitors are a rising class of chemotherapeutic …

Before Disaster Strikes: An Analysis Of Emergency Management Planning, Reagan Moody

Honors Theses

I have always been inspired by the outpouring number of volunteers that arrive to the scene of a natural disaster, ready to help in any way possible. With or without adequate training, these people arrive with warm hearts and helping hands. I admire their valiant efforts, however, it has prompted me to ask the question: If our citizens can respond so quickly in times of adversity, how are city governments preparing spontaneous volunteers for emergency management planning? The intent of this thesis is to properly evaluate the emergency management plans implemented in the cities of Baton Rouge, LA, Spokane, WA, …

Examination Of Communication And Social Media Usage Among Socially Anxious Individuals, Greyson K. Young

Honors Theses

Social anxiety disorder (SAD) affects between 6.8% and 12.1% of the U.S. population. At the core of SAD is the fear of social situations, and in particular, the fear of others’ positive (FPE) and negative (FNE) evaluation. Studies have found that social media and online/indirect communication are commonly used to minimize the experience of stress, anxiety, evaluation, and rejection commonly associated with face-to-face interactions. As such, the aims of the current study were 1) to characterize communication and social media use among socially anxious college students, and 2) to examine associations between social media use and FNE and FPE. The …

Hit Me With Your Best Shot: A Critical Analysis Of The Resistance To Vaccine Utilization, Katherine Coleman Sistrunk

Honors Theses

Vaccines have provided humans protection from infectious diseases for centuries, yet the vaccination rate in the United States fails to come near one-hundred percent, allowing vaccine-preventable diseases to re-emerge in communities across the nation. Vaccines have proven to be a safe and effective method in preventing the spread of infectious disease, but vaccine resistance remains high due to false information perpetuated by anti-vaxxers, greatly impacting the vaccination rate in our country. This thesis, by means of a literature review, provides a critical analysis the resistance to vaccine utilization in the United States to determine what policy recommendations and interventions can …

Influence Of Multidisciplinary Educational Experiences On Engineering And Nutrition Student Perceptions On Collaboration And Soft Skill Development, Caroline Kay Crosby

Honors Theses

Solutions to most real-world challenges require collaborative efforts by multidisciplinary teams to provide the breadth of perspective and expertise needed to create effective solutions. Interprofessional education is a pedagogical practice used to provide students with opportunities to broaden their professional perspective by encouraging students to work as a part of a diverse team to solve complex problems. This process strengthens discipline-specific skill development, problem-solving skills, and appreciation for other disciplines while providing experiences that are attractive to potential employers. Many students are interested in food science, but no food science courses are offered at the university where this study took …

A Marketing Campaign For Hunters’ Home: A Home Of Hope Through Integrated Marketing Communications: Secondary And Primary Research Studying The Target Audience, The Hunting And Conservation Community, To Create An Imc Campaign Focused On Fundraising And Awareness, Josie Corinna Slaughter

Honors Theses

Through research and evaluation of current and experimental nonprofit marketing methodologies and practices designed to raise awareness and attract donors, this project’s purpose is to define and create a marketing campaign for a children’s home, named Hunters’ Home: A Home of Hope, in Namibia. Adopted and unique strategies will be identified to target the audience of hunters to help meet the specific needs of the home, which was founded by Marina Lamprecht, a person widely known and respected by participants in hunting and conservation. To create the marketing campaign, secondary and primary research was conducted. Secondary research was done through …

Investigating The Binding Of Fentanyl And Fentanyl Analogs To The Μ-Opioid Receptor, Marissa Anne Teske

Honors Theses

In 1960, Dr. Paul Janssen of the Janssen Company synthesized fentanyl. It is a rapid-acting analgesic that, unlike similar analgesics around that time, did not have negative cardiovascular effects. Fentanyl, and its derivatives, are strong μ-opioid receptor agonists. Rates of fatal opioid overdoses involving fentanyl have increases rapidly over the past two decades Due to these increasing concerns related to fentanyl and its derivatives, it is important to not only study fentanyl and its known derivatives, but to also study and understand potential new derivatives and how all these compounds interact with the opioid receptors. This study examined the interactions …

The Protective Role Of Estrogen On Hiv-1 Mediated Neurotoxicity, Macklin Licamied

Honors Theses

The prevalence of HIV among men have been in a steady inclination over the last several decades, yet the accelerated infection rate among older women is considerably concerning. Not only does the HIV virus affect the immune system but it also affects the central nervous system. One of its viral proteins, Tat, acts as an excitotoxin and disrupts the cell’s membrane potential by increasing the concentration of Ca2+ inside the cell. This influx of calcium ions leads to apoptosis and secretion of the cell’s contents into the surrounding area. Macrophages, along with other innate immune components, gather and induce the …

Archaeological Investigations At Rowan Oak: Searching For Evidence Of Antebellum Slavery, Arianna Faith Kitchens

Honors Theses

Although best-known as the home of William Faulkner, Rowan Oak and a number of associated outbuildings were built by Robert Sheegog, a wealthy individual who owned multiple plantations and dozens of slaves. Sheegog held seven to nine slaves at Rowan Oak, renting some out to the University of Mississippi for labor-intensive tasks such as constructing the Lyceum and other campus buildings. Although it is known that enslaved individuals lived and worked on the property of Rowan Oak, the location of their housing remains a mystery. Through the use of archaeological survey methods, structural evidence beyond the extant buildings has been …

Time- And Ph- Dependent Proteolysis Of Engineered Proteins By Collagenase, Hunter Berry

Honors Theses

Pleiotropic effects from oral administration of anti-inflammatory drugs limit their effectiveness. The ultimate goal of this project is to develop a novel self-assembling protein-based hydrogel for in situ delivery of NSAIDs at the site of chronic inflammation. Since inflammation causes acidification and activation of collagenases in the inflamed tissue, we have designed the hydrogel to respond to both of these queues to effectively deliver drug at the site. Self-assembly of the protein hydrogel exploits the high affinity and specific interaction between the protein calmodulin (CaM) and its specific binding peptide, M13. The two components of the hydrogel, CCLP and PCLP …

When Words Are Not Enough: The Development Of Human Trafficking In Venezuela Under The Maduro Administration, Holly Prather

Honors Theses

This thesis discusses the role the Maduro administration has played in the development of human trafficking in Venezuela. It does so by employing a qualitative analysis of primary sources such as governmental and NGO reports to determine the links between the Maduro administration and the increase of human trafficking. I argue that the Maduro administration has chosen to employ social policy, the Misiones (Misiones), as the state’s approach to human trafficking instead of enforcing anti-trafficking laws. This, in conjunction with unsound economic policy in response to the 2014 decline in oil prices, gives the Maduro administration a substantial role in …

The Nola Development: Stormwater Management And Green Alternative Designs, Davis P. Odle

Honors Theses

In the design for any development, the management of storm and wastewater is crucial in creating a viable product. The NOLA complex is a development in Oxford, MS that consists of residential as well as commercial units. The stormwater management systems designed for this facility include: an underground storage device, separate ductile iron pipes for the stormwater and wastewater outflows, a rain garden for green alternative storage. The underground storage system is designed for the 500-year storm and to fit under the southwest parking lot on the site. The stormwater outflow pipe will be designed for the 100-year storm, while …

Safety Considerations For The Design Of Modern Elevator Systems, Abhijaya Shrestha

Honors Theses

The main purpose of this work is to perform an analysis on elevator safety considerations in the United States. This report introduces the development of elevators through its history, definitions and commonly used concepts in the elevator industry. Elevators are already an important part of day-to-day life for thousands of people and have significant role to play in the future of urbanization due to increasing population density and decreasing real estate. Elevators not only make vertical transportation convenient, but also play an important role in providing accessibility for people with disabilities; so, its safe and reliable operation is very crucial. …

Lost In Translation: Challenges And Solutions To Language Barriers In Healthcare In Mississippi, Galina Ostrovsky

Honors Theses

Language barriers can impede access to healthcare and compromise quality of care for limited English proficiency (LEP) patients. Although a rights-based framework would suggest and federal mandates require healthcare facilities to provide language access services, multiple factors result in the persistence of language barriers in healthcare. As the literature review shows, these factors include limitations in policy, enforcement, standardization, resources, and ability to recruit and retain professional interpreters. This thesis uses a multi-method case study entailing Mississippi in general and information from two specific sites, a rural Delta county and an urban central county, to assess the issue of language …

A Sustainable Future In The Implementation Of Clinical Pharmacogenomics, Nicholas Keeling

Electronic Theses and Dissertations

Purpose: The sustainability of clinical pharmacogenomics requires further study of clinical education on the topic, its effects on clinical workflow, and the responsibilities of different providers for its delivery. Tools from the discipline of implementation science were utilized herein to help achieve the purposes of the three studies. The broad purpose of this dissertation is to advance the work of clinical pharmacogenomic implementation through a more rigorous convergence with implementation science.

Methods: Three studies constitute the whole of this dissertation. The first is a scoping review that provides a broad characterization of the methods utilized in available peer-revieliterature focusing on …

Continuous Production Of Raloxifene Hydrochloride Loaded Nanostructured Lipid Carriers Using Hot-Melt Extrusion Technology, Derick Muhindo

Electronic Theses and Dissertations

The aim of this study was to utilize a continuous process for the production of Raloxifene Hydrochloride (RX-HCl) loaded NLC formulations for extended drug release using hot-melt extrusion technology coupled with probe sonication, and also to evaluate the in vitro characteristics of the prepared NLCs by particle size, PDI, zeta potential, entrapment efficiency, drug loading, and in vitro drug release profile. Preparation of the NLCs using HME technology involved two main steps, first formation of a pre-emulsion after extrusion and then size reduction of the pre-emulsion using probe sonication to obtain the NLCs. Process parameters for the extrusion process like …

Effect Of Sulfobutyl Ether Β-Cyclodextrins On Oral And Dermal Pharmacokinetics Of Drugs, Vijay Kumar Shankar

Electronic Theses and Dissertations

Silymarin is an extract of Milk Thistle, major constituents are taxifolin, silychristin, silydianin, silybin A, silybin B, isosilybin A and isosilybin B. The in vitro, preclinical and clinical studies have demonstrated silymarin possesses hepatoprotective, anticancer, hypocholesterolemic, cardioprotective effect and dermatological beneficial effect (treatment of UV induced erythema, melanoma, non-melanoma skin cancer, rosacea, melasma, vitiligo and psoriasis) both individually and collectively. Solubility enhancement of silymarin constituent is utmost important to increase bioavailability and to improve drug developability property. The solubility of silymarin in water was enhanced by SBE-β-CD by conventional and heating method, heating method was found to be more efficient …

The Role Of Dunc13 In Ethanol Tolerance, Yusuke Wachi

Electronic Theses and Dissertations

Although the effects of ethanol on presynaptic activity have been studied, the molecular mechanisms and the changes in gene expression which are responsible for inducing ethanol tolerance are unclear. Munc13-1 is an active-zone protein that is essential for presynaptic vesicle fusion. This protein interacts with vesicle fusion machinery at presynaptic active zones in the mammalian brain. The C1 domain of Munc13-1 binds diacylglycerol (DAG), which helps membrane localization of this protein and promotes vesicle fusion, facilitating synaptic vesicle release. Previously, it was shown that ethanol binds to the C1 domain of Munc13-1 in vitro at concentrations below 100 mM (Das …

An Exploration Of Relationships Between Parenting Stress And Primary Headache Disorders, Yelena Louise Johnson

Electronic Theses and Dissertations

Stress is the most commonly reported trigger for headache and stress affects headache both directly through resulting physiological changes and indirectly through its effects on lifestyle and coping behaviors. However one form of stress that has been neglected within headache is parenting. Parenting stress is defined as the imbalance between parents’ perceptions of available resources and their perceived demands of parenthood. Many variables have been established as predictors of parenting stress (e.g. demographic variables child behavior maternal depression) though fewer studies have examined its effects on health. Given that headache and parenthood share similar demographic distributions and risk factors exploration …

Acute Exercise And Creativity: Embodied Cognition Approaches, Emily M. Frith

Electronic Theses and Dissertations

This dissertation manuscript is the culmination of three years of research examining several unique, exercise-induced mechanisms underlying creativity. This collection of work addresses historical and current empirical concepts of creativity in a narrative review, providing recommendations for future research. Several reviews follow this introduction, highlighting the proposed effects of exercise on creativity, putative mechanisms for creativity, and the effects of exercise and embodied manipulations on creative behavior. Multiple experiments utilizing moderate-intensity exercise as a theoretical stimulus for higher-order cognitions were conducted to investigate associations between exercise and creativity, which lead to the final dissertation experiment. The dissertation experiment was the …

Developing Zebrafish As An In Vivo Model To Screen Compounds For Anti-Cancer Activity In Human Breast Cancer, Trisha Dhawan

Electronic Theses and Dissertations

Breast Cancer (BC) is the most frequently diagnosed cancer; 1:8 women are at risk of developing BC in her lifetime. Cancer metastasis causes the majority of deaths in BC patients. Moreover, side effects of traditional chemotherapeutic drugs (TCD) impair the quality of life of these patients. Discovery and development of safe and effective new therapies is imperative for the treatment of BC and targeting metastasis. The goal herein is to further expand the applicability of in vivo xenotransplantation of human BC cells in transgenic zebrafish to screen potential chemotherapeutics for toxicity and efficacy. For xenotransplantation, MCF-7, BT-474, and MDA-MB-231 BC …

Weight Teasing Among Obese Youth: Social Functioning Outcomes Following A Pediatric Weight Management Intervention, Joseph Mitchell Magness

Electronic Theses and Dissertations

The prevalence of excess weight and obesity among children and adolescents in the United States continues to increase. Aside from the different effects weight has on a person’s physical and psychological well-being, obese youth often experience poorer social functioning than normal weight peers. Weight teasing is among those highlighted social difficulties. Pediatric weight management program interventions have been shown to improve health-related quality of life (HRQoL) across domains for obese youth. However, few studies have examined the impact of weight management interventions on social quality of life for those with a history of weight teasing. The present study aimed to …

Pegylated Nanostructured Lipid Carries For Amphotericin B Ocular Delivery, Prit Manish Lakhani

Electronic Theses and Dissertations

The Chapter II focuses on formulation of an optimized and robust amphotericin B ocular formulation with prolonged precorneal residence and ocular tissue concentration at par or superior to the marketed preparations. Additionally, demonstrating stability of amphotericin B formulations in presence of preservative in comparison to marketed preparation, making it an ideal choice of formulation for multi-dosing. As mentioned earlier, we optimized PEGylated nanostructured lipid carriers (PEG-NLC-AmB) for ocular delivery of amphotericin B. The formulations could be autoclaved with at least one-month stability and in vivo ocular biodistribution was statistically insignificantly different compared to AmBisome®. To accomplish the aim, strategies such …

Whistle Before You Work: Defining Paid Labor In The New Deal State, 1938-1947, Thomas Porter

Electronic Theses and Dissertations

This thesis traces the conceptualization of work from the passage of the 1938 Fair Labor Standards Act (FLSA) through the Portal-To-Portal Pay Act of 1947. I argue that the FLSA created a new framework for industrial laborers to define what constituted work. This enables an understanding of work as defined by those in mines and on the industrial plants floor, allowing those who were closest to toil and exertion to create their own definitions. By 1946, Congress heeded to the complaints of the military and capitalists and codified their definition of work and the work week. This restricted the broadly …

Effect Of Solvent Interaction & Soluble Microneedles On Skin Permeability To Drug Molecules, Abhijeet Maurya

Electronic Theses and Dissertations

Skin forms a formidable barrier protecting the human body from external environmental rigors and excessive loss of water; maintaining equilibrium. The barrier properties of the skin can be attributed to its unique macromolecular organization and morphology. As a route for drug administration, skin presents a large surface area and can be used for both systemic and localized targeted drug delivery applications offering several advantages over conventional drug therapy; avoidance of first pass metabolism, patient compliance, sustained or controlled delivery for an extended period, to name a few. However, the organized structure of the skin, since intended to prevent entry of …

Novel Applications Of Hot-Melt Extrusion Technology In Trans-Buccal And Topical Drug Delivery Systems, Nicole Mendonsa

Electronic Theses and Dissertations

As the buccal route of administration can avoid the first pass effect, the bioavailability of drugs that are metabolized in the liver can be increased through this route. Few studies have been conducted using oleic acid as a permeation enhancer in any trans-buccal dosage form. The objective of this study was to develop a buccal tablet using two concentrations of oleic acid for a model drug (Ondansetron) via melt extrusion technology and investigate the effects of oleic acid on the physicochemical properties of the tablet. Formulations consisting of the active drug (ondansetron hydrochloride), polymers and oleic acid were prepared by …