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Npc1161b, An 8-Aminoquinoline Analog, Is Metabolized In The Mosquito And Inhibits Plasmodium Falciparum Oocyst Maturation, Timothy Hamerly, Rebecca E. Tweedell, Bernadette Hritzo, Vincent O. Nyasembe, Babu L. Tekwani, N. P. Dhammika Nanayakkara, Larry A. Walker, Rhoel R. Dinglasan Jan 2019

Npc1161b, An 8-Aminoquinoline Analog, Is Metabolized In The Mosquito And Inhibits Plasmodium Falciparum Oocyst Maturation, Timothy Hamerly, Rebecca E. Tweedell, Bernadette Hritzo, Vincent O. Nyasembe, Babu L. Tekwani, N. P. Dhammika Nanayakkara, Larry A. Walker, Rhoel R. Dinglasan

Faculty and Student Publications

© 2019 by the authors. The goal of this study was to investigate the potential for a cannabidiol-rich cannabis extract (CRCE) to interact with the most common over-the-counter drug and the major known cause of drug-induced liver injury–acetaminophen (APAP)–in aged female CD-1 mice. Gavaging mice with 116 mg/kg of cannabidiol (CBD) [mouse equivalent dose (MED) of 10 mg/kg of CBD] in CRCE delivered with sesame oil for three consecutive days followed by intraperitoneally (i.p.) acetaminophen (APAP) administration (400 mg/kg) on day 4 resulted in overt toxicity with 37.5% mortality. No mortality was observed in mice treated with 290 mg/kg of …

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Pharmacological Evaluation Of Secondary Metabolites And Their Simultaneous Determination In The Arabian Medicinal Plant Plicosepalus Curviflorus Using Hptlc Validated Method, Raha Orfali, Shagufta Perveen, Nasir Ali Siddiqui, Perwez Alam, Tawfeq Abdullah Alhowiriny, Areej Mohammad Al-Taweel, Sami Al-Yahya, Fuad Ameen, Najwa Majrashi, Khulud Alluhayb, Bandar Alghanem, Hayat Shaibah, Shabana Iqrar Khan Jan 2019

Pharmacological Evaluation Of Secondary Metabolites And Their Simultaneous Determination In The Arabian Medicinal Plant Plicosepalus Curviflorus Using Hptlc Validated Method, Raha Orfali, Shagufta Perveen, Nasir Ali Siddiqui, Perwez Alam, Tawfeq Abdullah Alhowiriny, Areej Mohammad Al-Taweel, Sami Al-Yahya, Fuad Ameen, Najwa Majrashi, Khulud Alluhayb, Bandar Alghanem, Hayat Shaibah, Shabana Iqrar Khan

Faculty and Student Publications

© The Author(s) 2019. The present study aimed to identify biologically active secondary metabolites from the rare plant species, Pulsatilla patens subsp. patens and the cultivated P. vulgaris subsp. vulgaris. Chromatographic fractionation of the ethanolic extract of the roots of P. patens subsp. patens resulted in the isolation of two oleanane-type glycosides identified as hederagenin 3-O-β-d-glucopyranoside (2.7 mg) and hederagenin 3-O-β-d-galactopyranosyl-(1→2)-β-d-glucopyranoside (3.3 mg, patensin). HPLC analysis of the methanolic extract of the crude root of P. patens subsp. patens and P. vulgaris subsp. vulgaris revealed the presence of Pulsatilla saponin D (hederagenin 3-O-α-l-rhamnopyranosyl(1→2)-[β-d-glucopyranosyl(1→4)]-α-l-arabinopyranoside). Chromatographic analysis using GC-MS of the silylated …

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Phytochemical Screening Of Pulsatilla Species And Investigation Of Their Biological Activities, Grażyna Łaska, Aneta Sienkiewicz, Marcin Stocki, Jordan K. Zjawiony, Vimal Sharma, Andrzej Bajguz, Alicja Piotrowska-Niczyporuk, Melissa Jacob, Shabana Khan Jan 2019

Phytochemical Screening Of Pulsatilla Species And Investigation Of Their Biological Activities, Grażyna Łaska, Aneta Sienkiewicz, Marcin Stocki, Jordan K. Zjawiony, Vimal Sharma, Andrzej Bajguz, Alicja Piotrowska-Niczyporuk, Melissa Jacob, Shabana Khan

Faculty and Student Publications

© 2019, The Author(s). We previously demonstrated that extracts from Echinacea purpurea material varied substantially in their ability to activate macrophages in vitro and that this variation was due to differences in their content of bacterial components. The purpose of the current study was to identify soil conditions (organic matter, nitrogen, and moisture content) that alter the macrophage activation potential of E. purpurea and determine whether these changes in activity correspond to shifts in the plant-associated microbiome. Increased levels of soil organic matter significantly enhanced macrophage activation exhibited by the root extracts of E. purpurea (p < 0.0001). A change in soil organic matter content from 5.6% to 67.4% led to a 4.2-fold increase in the macrophage activation potential of extracts from E. purpurea. Bacterial communities also differed significantly between root materials cultivated in soils with different levels of organic matter (p < 0.001). These results indicate that the level of soil organic matter is an agricultural factor that can alter the bacterial microbiome, and thereby the activity, of E. purpurea roots. Since ingestion of bacterial preparation (e.g., probiotics) is reported to impact human health, it is likely that the medicinal value of Echinacea is influenced by cultivation conditions that alter its associated bacterial community.

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Schinus Molle: Anatomy Of Leaves And Stems, Chemical Composition And Insecticidal Activities Of Volatile Oil Against Bed Bug (Cimex Lectularius), Camila D. Machado, Vijayasankar Raman, Junaid U. Rehman, Beatriz H.L.N.S. Maia, Emanuelle K. Meneghetti, Valter P. Almeida, Rosi Z. Silva, Paulo V. Farago, Ikhlas A. Khan, Jane M. Budel Jan 2019

Schinus Molle: Anatomy Of Leaves And Stems, Chemical Composition And Insecticidal Activities Of Volatile Oil Against Bed Bug (Cimex Lectularius), Camila D. Machado, Vijayasankar Raman, Junaid U. Rehman, Beatriz H.L.N.S. Maia, Emanuelle K. Meneghetti, Valter P. Almeida, Rosi Z. Silva, Paulo V. Farago, Ikhlas A. Khan, Jane M. Budel

Faculty and Student Publications

© 2019 by the authors The investigation of the constituents that were isolated from Turnera diffusa (damiana) for their inhibitory activities against recombinant human monoamine oxidases (MAO-A and MAO-B) in vitro identified acacetin 7-methyl ether as a potent selective inhibitor of MAO-B (IC50 = 198 nM). Acacetin 7-methyl ether (also known as 5-hydroxy-40, 7-dimethoxyflavone) is a naturally occurring flavone that is present in many plants and vegetables. Acacetin 7-methyl ether was four-fold less potent as an inhibitor of MAO-B when compared to acacetin (IC50 = 50 nM). However, acacetin 7-methyl ether was >500-fold selective against MAO-B over MAO-A as compared …

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Trends In And Predictors Of Carbapenem Consumption Across North American Hospitals: Results From A Multicenter Survey By The Mad-Id Research Network, Nathaniel J. Rhodes, Jamie L. Wagner, Susan L. Davis, John A. Bosso, Debra A. Goff, Michael J. Rybak, Marc H. Scheetz Jan 2019

Trends In And Predictors Of Carbapenem Consumption Across North American Hospitals: Results From A Multicenter Survey By The Mad-Id Research Network, Nathaniel J. Rhodes, Jamie L. Wagner, Susan L. Davis, John A. Bosso, Debra A. Goff, Michael J. Rybak, Marc H. Scheetz

Faculty and Student Publications

This Special Issue is dedicated to the late Dr. Charles (Charlie) D. Hufford, former Professor of Pharmacognosy and Associate Dean for Research and Graduate Studies at University of Mississippi [...].

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Impact Of Hydration Status On Electromyography And Ratings Of Perceived Exertion During The Vertical Jump, Paul T. Donahue, Samuel J. Wilson, Charles C. Williams, Melinda Valliant, John C. Garner Jan 2019

Impact Of Hydration Status On Electromyography And Ratings Of Perceived Exertion During The Vertical Jump, Paul T. Donahue, Samuel J. Wilson, Charles C. Williams, Melinda Valliant, John C. Garner

Faculty and Student Publications

Copyright (c) the author(s). This is an open access article under CC BY license (https://creativecommons.org/licenses/by/4.0/) Background: The vertical jumping task is commonly used to assess lower-body power output in athletic populations, in addition to being commonly used to during investigations of hydration and anaerobic performance. Changes in neuromuscular function during a hypohydrated state have been proposed as a potential mechanism to decreases in anaerobic performance. Objectives: The primary purpose of this investigation was to examine the impact of hydration state on electromyography during the vertical jumping task. Methods: Twenty recreationally trained males were tested in three hydration conditions (hypohydrated, euhydrated, …

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Food Insecurity Is Associated With Poorer Glycemic Control In Patients Receiving Free Versus Fee-Based Care, David H. Holben, Kara A. Brown, Jay H. Shubrook Jan 2019

Food Insecurity Is Associated With Poorer Glycemic Control In Patients Receiving Free Versus Fee-Based Care, David H. Holben, Kara A. Brown, Jay H. Shubrook

Faculty and Student Publications

© 2018 by the American Diabetes Association. This study examined differences in household food security (HFS), household adult food security (HAFS), and indicators of diabetes management between clients using free and fee-for-service clinics for diabetes care and management. The study’s 166 participants (free clinic, n = 41; fee-for-service clinic, n =125) had a mean age of 53 ± 16 years and were primarily Caucasian (n = 147 [91.9%]). Both HFS (P <0.001) and HAFS (P <0.001) differed between the clinic groups, as did A1C (free clinic 8.7 ± 1.7%; fee-for-service 7.8 ± 1.6%; P = 0.005). A1C increased as HFS (r = 0.293, P <0.001) and HAFS (r = 0.288, P = 0.001) worsened.

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The Effects Of Acute Exercise On Episodic Memory Function Among Young University Students: Moderation Considerations By Biological Sex, Lauren Johnson, Paul D. Loprinzi Jan 2019

The Effects Of Acute Exercise On Episodic Memory Function Among Young University Students: Moderation Considerations By Biological Sex, Lauren Johnson, Paul D. Loprinzi

Faculty and Student Publications

© 2019 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License Background: The objective of this study was to evaluate potential sex-specific differences on episodic memory function and determine whether sex moderates the effects of acute exercise on episodic memory. Methods: A randomized controlled intervention was employed. This experiment was conducted among young University students (mean age = 21 years). Both males (n=20) and females (n=20) completed two counterbalanced laboratory visits, with one visit involving a 15-minute bout of moderate-intensity exercise prior to the memory task. The control visit engaged in …

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The Counteracting Effects Of Exercise On High-Fat Diet-Induced Memory Impairment: A Systematic Review, Paul D. Loprinzi, Pamela Ponce, Liye Zou, Hong Li Jan 2019

The Counteracting Effects Of Exercise On High-Fat Diet-Induced Memory Impairment: A Systematic Review, Paul D. Loprinzi, Pamela Ponce, Liye Zou, Hong Li

Faculty and Student Publications

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. The objective of the present review was to evaluate whether exercise can counteract a potential high-fat diet-induced memory impairment effect. The evaluated databases included: Google Scholar, Sports Discus, Embase/PubMed, Web of Science, and PsychInfo. Studies were included if: (1) an experimental/intervention study was conducted, (2) the experiment/intervention included both a high-fat diet and exercise group, and evaluated whether exercise could counteract the negative effects of a high-fat diet on memory, and (3) evaluated memory function (any type) as the outcome measure. In total, 17 articles met the inclusionary criteria. All 17 …

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The Effects Of High-Intensity Interval Exercise And Hypoxia On Cognition In Sedentary Young Adults, Shengyan Sun, Paul D. Loprinzi, Hongwei Guan, Liye Zou, Zhaowei Kong, Yang Hu, Qingde Shi, Jinlei Nie Jan 2019

The Effects Of High-Intensity Interval Exercise And Hypoxia On Cognition In Sedentary Young Adults, Shengyan Sun, Paul D. Loprinzi, Hongwei Guan, Liye Zou, Zhaowei Kong, Yang Hu, Qingde Shi, Jinlei Nie

Faculty and Student Publications

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Background and Objectives: Limited research has evaluated the effects of acute exercise on cognition under different conditions of inspired oxygenation. Thus, the purpose of this study was to examine the effects of high-intensity interval exercise (HIE) under normoxia (inspired fraction of oxygen (FIO2): 0.209) and moderate hypoxia (FIO2: 0.154) on cognitive function. Design: A single-blinded cross-over design was used to observe the main effects of exercise and oxygen level, and interaction effects on cognitive task performance. Methods: Twenty inactive adults (10 males and 10 females, 19–27 years old) performed a cognitive …

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Association Between Habitual Physical Activity On Episodic Memory Strategy Use And Memory Controllability, Paul D. Loprinzi Jan 2019

Association Between Habitual Physical Activity On Episodic Memory Strategy Use And Memory Controllability, Paul D. Loprinzi

Faculty and Student Publications

© 2019 The Author(s). Background:The primary objective of this study was to evaluate the association between habitual physical activity engagement and perceived controllability of memory function. Secondary objectives included the evaluation of physical activity on memory strategy use, and whether the latter mediates the relationship between physical activity on memory controllability. Methods: Two-hundred and nine young adults (M age =25 y) completed a brief survey evaluating physical activity (Physical Activity Vital Signs Questionnaire), memory strategy use (Memory Functioning Questionnaire), and memory controllability (Memory Controllability Inventory). Results: Physical activity was not associated with memory strategy use (β=0.68; 95% CI: -1.25, 2.62; …

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The Effects Of Acute Exercise Intensity On Episodic And False Memory Among Young Adult College Students, Emma K. Dilley, Liye Zou, Paul D. Loprinzi Jan 2019

The Effects Of Acute Exercise Intensity On Episodic And False Memory Among Young Adult College Students, Emma K. Dilley, Liye Zou, Paul D. Loprinzi

Faculty and Student Publications

© 2019 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License Background: Previous experimental work demonstrates that acute exercise may enhance episodic memory performance. However, limited research has examined the extent to which acute exercise influences false episodic memory production, and no studies, to date, have examined whether there is an intensity-specific effect of acute exercise on both true episodic and false episodic memories. Thus, the present experiment evaluated the effects of intensity-specific acute exercise on episodic memory and false episodic memory. Methods: A three-arm, parallel, between-group randomized controlled trial was …

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In Situ Gel Of Triamcinolone Acetonide-Loaded Solid Lipid Nanoparticles For Improved Topical Ocular Delivery: Tear Kinetics And Ocular Disposition Studies, Akshaya Tatke, Narendar Dudhipala, Karthik Yadav Janga, Sai Prachetan Balguri, Bharathi Avula, Monica M. Jablonski, Soumyajit Majumdar Jan 2019

In Situ Gel Of Triamcinolone Acetonide-Loaded Solid Lipid Nanoparticles For Improved Topical Ocular Delivery: Tear Kinetics And Ocular Disposition Studies, Akshaya Tatke, Narendar Dudhipala, Karthik Yadav Janga, Sai Prachetan Balguri, Bharathi Avula, Monica M. Jablonski, Soumyajit Majumdar

Faculty and Student Publications

© 2019 The Authors Objective: The purpose of this systematic review is to summarize the best available evidence on interventions that could be implemented in the college environment to increase HPV vaccination uptake in college students who were not previously vaccinated. Methods: Pubmed, CINAHL, PsycINFO, Cochrane, and EBSCO were searched in December 2017 to identify all literature meeting the following criteria: human subjects, English language, HPV, HPV vaccination, and college. PRISMA recommendations were followed. We focused only on manuscripts that reported vaccine uptake, excluding studies that only reported vaccine intentions. We identified 2989 articles; 101 relevant after screening; nine eligible …

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Investigating Early Childhood Teachers’ Perceptions Of A Preschool Yoga Program, Kenya Wolff, Alicia Stapp Jan 2019

Investigating Early Childhood Teachers’ Perceptions Of A Preschool Yoga Program, Kenya Wolff, Alicia Stapp

Faculty and Student Publications

© The Author(s) 2019. Yoga for young children has become a growing area of interest in early childhood settings across the United States. Evidence suggests that yoga has the ability to improve young children’s physical development, executive functioning, self-regulation, and can aid in decreasing stress and anxiety. While the scope of research on yoga for young children has primarily focused on the experiences and outcomes of the children who participate, far less is known about the experiences and perceptions of teachers who have engaged in such programs with their students. This study utilized a qualitative case study to investigate teachers’ …

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Pituitary Gland Functional Connectivity And Bmi, Paige Rucker, Toshikazu Ikuta Jan 2019

Pituitary Gland Functional Connectivity And Bmi, Paige Rucker, Toshikazu Ikuta

Faculty and Student Publications

The pituitary gland (PG) influences body weight through hormonal releases; however, the relation between body weight and PG’s co-activities with other brain regions remains unclear. Here, we aimed to identify (1) the functional connectivity of the PG and (2) PG functional connectivity associated with body mass index by examining resting state functional magnetic imaging (rsfMRI) data. Using enhanced Nathan Kline Institute-Rockland Sample, PG functional connectivity of 494 individuals was analyzed to assess in voxel-wise fashion. A negative association was found between BMI and PG functional connectivity with the orbitofrontal cortex, hippocampus, putamen and temporal lobe. Our results show PG dysconnectivity …

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Teleneurology Service Provided Via Tablet Technology: 3-Year Outcomes And Physician Satisfaction, Kelly Harper, Megan Mcleod, Summer K. Brown, Georgia Wilson, Maxim Turchan, Emily M. Gittings, Derek Riebau, Mark Baker, Eli Zimmerman, David Charles Jan 2019

Teleneurology Service Provided Via Tablet Technology: 3-Year Outcomes And Physician Satisfaction, Kelly Harper, Megan Mcleod, Summer K. Brown, Georgia Wilson, Maxim Turchan, Emily M. Gittings, Derek Riebau, Mark Baker, Eli Zimmerman, David Charles

Faculty and Student Publications

© James Cook University. Introduction: This study aimed to demonstrate that teleneurology consultations conducted via tablet technology are an efficient and cost-effective means of managing acute neurologic emergencies at community-based hospitals and that utilizing such technology yields high community physician satisfaction. Method: During a 39-month period, Vanderbilt University Medical Center in Tennessee USA, provided teleneurology services to 10 community-based hospitals that lacked adequate neurology coverage. Hospitalists at one community-based hospital were not comfortable treating any patient with a neurologic symptom, resulting in 100% of those patients being transferred. This facility now retains more than 60% of neurology patients. For less …

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Acute Exercise And Mindfulness Meditation On Learning And Memory: Randomized Controlled Intervention, Malina Austin, Paul D. Loprinzi Jan 2019

Acute Exercise And Mindfulness Meditation On Learning And Memory: Randomized Controlled Intervention, Malina Austin, Paul D. Loprinzi

Faculty and Student Publications

© 2019 The Author(s). Background: The purpose of this experiment was to evaluate the potential combined effects of acute exercise and mindfulness mediation on episodic memory. Methods: All data collection occurred in the authors’ laboratory (January to May of 2019). In this three-arm, within-subject design, participants (N=20; Mage=21.6 years) completed three counterbalanced laboratory visits, including Exercise Only, Exercise + Meditation and Control. Learning and memory were assessed from a word-list task. A one-factor repeated-measures ANOVA was computed for two memory outcomes, including the learning outcome (average performance across the 6 trials) and the long-term memory recall (10-minute delay). Results: The …

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The Effects Of Physical Exercise On Parahippocampal Function, P. D. Loprinzi Jan 2019

The Effects Of Physical Exercise On Parahippocampal Function, P. D. Loprinzi

Faculty and Student Publications

© 2019 The Author(s). Objective: The objective of this study was to examine the effects of physical exercise on parahippocampal function. Methods: Studies were identified using electronic databases, including PubMed, PsychInfo, Sports Discus, and Google Scholar. In total, 28 articles met the inclusionary criteria. Among these, 20 were among humans and 8 in animal models. Among the 20 human studies that examined some aspects of the parahippocampal gyrus, 5 evaluated the entorhinal cortex and 1 evaluated the perirhinal cortex. Among the 20 human studies, 3 evaluated neural activity (or BOLD-signal changes), 14 evaluated brain volume (gray or white matter), 2 …

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Southern Register. 2019.1 (Winter 2019), University Of Mississippi. Center For The Study Of Southern Culture Jan 2019

Southern Register. 2019.1 (Winter 2019), University Of Mississippi. Center For The Study Of Southern Culture

Southern Register

No abstract provided.

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Not-For-Profit Entities Best Practices In Presentation And Disclosure, 5th Edition, American Institute Of Certified Public Accountants (Aicpa) Jan 2019

Not-For-Profit Entities Best Practices In Presentation And Disclosure, 5th Edition, American Institute Of Certified Public Accountants (Aicpa)

Accounting Trends and Techniques

No abstract provided.

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The View From Ventress - 2019, University Of Mississippi. College Of Liberal Arts Jan 2019

The View From Ventress - 2019, University Of Mississippi. College Of Liberal Arts

Liberal Arts Newsletters

Cover Story: Arabic Language Flagship. "Here in Oxford, at the University of Mississippi, is one of the best Arabic programs in the country." - John Chappell, Rhodes Scholar finalist and Arabic Flagship graduate

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Change Agents (2019), University Of Mississippi. Office Of Research And Sponsored Programs Jan 2019

Change Agents (2019), University Of Mississippi. Office Of Research And Sponsored Programs

Publications of the ORSP

This publication highlights a few of the significant research efforts at the University of Mississippi during the past year.

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Pharmacy Matters - December 2018/January 2019, University Of Mississippi. School Of Pharmacy Jan 2019

Pharmacy Matters - December 2018/January 2019, University Of Mississippi. School Of Pharmacy

Pharmacy Matters Newsletters

Featured stories: "Pharmacy Student Organization Educates Jackson Children on Health Safety," "UM External Research Funding Surpasses $134 Million in 2017-18," "School of Pharmacy Establishes Anne Marie Liles Memorial Scholarship," "Three Pharmaceutics Graduate Students Advance in Three Minute Thesis Competition"

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Differences In Complete 2 Compete Participant Characteristics: What Can They Tell Us?, Audra Joan Trnovec Jan 2019

Differences In Complete 2 Compete Participant Characteristics: What Can They Tell Us?, Audra Joan Trnovec

Electronic Theses and Dissertations

The majority of C2C students participating at the University of Mississippi (UM) are adult students who face different barriers in their return to higher education than traditional students. These barriers necessitate the review of and changes in student services. To better understand this population, an analysis was conducted of 582 C2C participants who had already acquired some college credit at UM. The purpose of this study is to develop a sustainable program that assists more students to successfully return and complete a degree. The study looked at students’ ages, overall earned credits, gender, overall grade point average, ethnicity, number of …

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Optimization And Characterization Of Hot-Melt Extruded Anti-Inflammatory And Local Anesthetic Bio-Adhesive Semisolid Formulation Using Design Of Experiments (Doe), Rishi Chinmay Thakkar Jan 2019

Optimization And Characterization Of Hot-Melt Extruded Anti-Inflammatory And Local Anesthetic Bio-Adhesive Semisolid Formulation Using Design Of Experiments (Doe), Rishi Chinmay Thakkar

Electronic Theses and Dissertations

Hot melt extrusion is a versatile continuous manufacturing process extensively investigated for its applications with production of oral solid dosage forms, the aim of this study was to venture the applicability of HME in continuous manufacturing of topical semi-solid ointment formulations. Novel combination of a topical corticosteroid (Triamcinolone Acetonide) and local anesthetic (Lidocaine hydrochloride) were selected to be formulated with a water-soluble ointment base consisting of PEG 4000, PEG 1500 and Propylene glycol after performing appropriate drug-excipient compatibility studies. To determine the ratios of the solid to liquid components of the macrogol base, ‘quality by design’ approach was employed by …

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Basketball Officials' Training And Development: Links To Retention, Nathan Ferdinand Jan 2019

Basketball Officials' Training And Development: Links To Retention, Nathan Ferdinand

Electronic Theses and Dissertations

The sharp decline in retention from year-to-year among sport officials is considered a “crisis” among the officiating community and research has attempted to explore the issue by identifying factors that impact retention (Warner et al. 2013). The seven-factor “Referee Retention Scale” (RRS) seeks to predict the likelihood of retention for officials one factor being officials’ ratings of their continuing education (Ridinger et al. 2017). However there is a lack of study for examining the relationships among methods and outcomes of training continuing education and referee retention across sporting contexts. A cross-sectional design was created using an online survey which combined …

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A Mechanistic Study Of The Teratogenic Potential Of 4-O-Methylhonokiol (Mh) On Japanese Medaka (Oryzias Latipes), Santu Kumar Singha Jan 2019

A Mechanistic Study Of The Teratogenic Potential Of 4-O-Methylhonokiol (Mh) On Japanese Medaka (Oryzias Latipes), Santu Kumar Singha

Electronic Theses and Dissertations

An additional goal of this project was to characterize the Wnt/β-catenin signaling pathway to unravel the adverse potential of MH on the cardiovascular system (CVS). Our study suggested that MH-mediated cardiovascular injury may be caused due to upregulation of some major components of the Wnt/β-catenin pathway through expression of excessive pro-inflammatory mediators. Moreover MH decreased expression of ErbB3 and NRG-2 suggesting impaired cardiac structure. MH exposure caused a slow heartbeat blood occlusion absence of blood circulation decreased hatching efficiency and increased mortality in medaka embryos in a concentration- and time-dependent manner. MH might cause blood vessel occlusion by increasing the …

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Institutional Factors That Affect Transfer Student Sucess At A University In The Mid-South Region Of The U.S., Patricia Ann Coats Jan 2019

Institutional Factors That Affect Transfer Student Sucess At A University In The Mid-South Region Of The U.S., Patricia Ann Coats

Electronic Theses and Dissertations

At a four-year university located in the Mid-South region of the United States, students who transfer do so with the likelihood of spending more time and money completing a baccalaureate degree than non-transfer students. This is what research scholar Kevin Dougherty (1992) entitled the Baccalaureate Attainment Gap or the transfer gap. In this companion dissertation, using a multi-method approach, we use the quantitative data of transfer student graduation and retention rates along with qualitative data from interviews conducted with administrative staff about transfer student success. We consider these selected outcomes and administrative staff interviews to be institutional factors that help …

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Food Insecurity And Health Of International Students, Jamie Nichole Benefield Jan 2019

Food Insecurity And Health Of International Students, Jamie Nichole Benefield

Electronic Theses and Dissertations

International college students may be at risk for suffering from food insecurity and poor health. The purposes of this study were to: 1) determine if the household adult food security status (HAFSS) differs between undergraduate and graduate international students (INSTUD) attending the University of Mississippi (UM); 2) establish if a statistically significant relationship exists between health (physical functioning (PF) , role limitations due to physical health (RLPH), role limitations due to emotional problems (RLEP), energy/fatigue (EF), emotional well-being (EWB), social functioning (SF), pain (P), and general health (GH) and HAFSS; 3) assess if health differs between INSTUD living in food …

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Safety Assessment And Chemical Fingerprint Analysis Of Medicinal Plants Commonly Consumed As Herbal Teas; Rooibos (Aspalathus Linearis) And Moringa (Moringa Oleifera), Omer I. Fantoukh Jan 2019

Safety Assessment And Chemical Fingerprint Analysis Of Medicinal Plants Commonly Consumed As Herbal Teas; Rooibos (Aspalathus Linearis) And Moringa (Moringa Oleifera), Omer I. Fantoukh

Electronic Theses and Dissertations

The first chapter discusses the significance of natural products, safety challenges, and quality issues concisely. Specifically, the impact of herb-drug interaction on consumers and the quest for chemical markers for chemical fingerprinting development are provided. Rooibos tea (Aspalathus linearis) is a popular South African herbal tea enjoyed worldwide. Limited reports indicate the potential of rooibos tea to alter the activity of CYP450 isozymes. In chapter two, the phytochemical investigation of A. linearis resulted in the isolation and characterization of 14 phenolic compounds. Safety assessment of the phytochemicals through interaction with CYP, PXR, and P gp was conducted. The …

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