Digital Commons Network^™

Computational And Spectroscopic Studies Of New Sulfur-Containing Dipole-Bound Anions, Nicholas Allen Kruse

Honors Theses

Sulfur and Nitrogen are essential ingredients in both life-supporting and light-harvesting molecules. Their presence also usually leads to the delocalization of electrons and large dipole and quadrupole moments. Such molecules are sometimes able to form negative ions through the electrostatic binding of an excess electron. These so-called multipole-bound (dipole-bound, quadrupole-bound, etc.) anions have been shown to be important in radiation damage in biology and electron transport processes. Here, we present our recent computational and experimental results studying the creation of new multipole-bound anions.

The Long-Term Health And Developmental Impacts Of Children Born At Low Birth Weight, Kathryn Grace Kelly

Honors Theses

The state of Mississippi currently has the highest incidence of low birth weight (LBW) births in the United States. LBW is a negative birth outcome which can lead to suboptimal pediatric health and development. The primary goals of this thesis are to identify the long-term outcomes associated with LBW and to present potential interventions to address LBW. A combination of literature review and quantitative data analysis were used to inform the objective of this thesis. A variety of physical health, behavioral health, and other long-term issues were found associated with LBW. The consequences of LBW place LBW children at a …

College Students Fail To Identify Nutrition Misinformation On Social Media, Helen Mary Katool

Honors Theses

Social media has become a part of everyday life in our society and has the capability to reach billions, across age groups. Research has shown that there is a direct link between the widespread access to social media and the amount of misinformation that is circulating. In fact, unqualified and uneducated individuals share believable but inaccurate nutrition posts. Therefore, the purpose of this study is to determine if college students can distinguish the difference between nutrition misinformation or factual nutrition information when presented on social media. Male and female college students (>18 years old) from two classes (nutrition and …

The Role Of Ionic Liquids In Gold Nanorod Synthesis, Noah Grovich

Honors Theses

The term cancer is used to define a large set of medical conditions that result from uncontrolled cell proliferation. The severity of cancer ranges depending on several factors, but it is one of the leading causes of death in approximately 60% of the world. Current treatment options are often not efficacious and face many limitations especially regarding limiting the secondary damage to healthy cells. Gold nanorods have shown to be a potential solution for effectively overcoming many of these barriers, but their employment is limited due to toxicity concerns stemming from the use of hexadecyltrimethylammonium bromide (CTAB) in their synthesis. …

Efficacy Of Δ-9-Tetrahydrocannabinol For Hiv-Related Neuropathic Pain, Kaia Horne

Honors Theses

Despite the availability and success of antiretroviral therapeutics, ~30% of patients living with HIV experience neuropathic pain that is often intractable. The mechanisms are not known, but there is evidence to support a role for the HIV virotoxins, Tat and/or gp120, which can damage or degenerate neurons and peripheral nerves. One mechanism by which Tat and gp120 promote nerve damage involves the stimulation of proinflammatory cytokine production from immune cells which can damage or kill bystander cells. Notably, compounds found in Cannabis exert anti-inflammatory effects and many studies report HIV patients to consume more marijuana than seronegative individuals. When people …

Accounting Case Studies, Jack Mcinnis

Honors Theses

Accounting Case Studies is a compilation of independent case studies performed during the Honors Accounting 420 class. The case studies consisted of multiple performed individually, and a case competition with an assigned group. The case studies I performed individually consist of an assessment between the two cities I was interested in beginning my career in, a case study about the presidential debate in 2020, an evaluation of the optimal corporate tax, a mentorship interview, and an analysis of the 2008 housing crisis in the United States. My group for the case study included my fellow classmates; Francena Sekul, Caitlyn Henry, …

Effects Of Instructional Expenditures On Educational Outcomes In Mississippi Public Schools, Richard Grimes

Honors Theses

This thesis examines the relationship between school funding and student success in public schools in Mississippi. Data for 200 public high schools were obtained upon request from the Mississippi Department of Education, including information about school budgets, average composite ACT scores, graduation rates, and other factors. Regression analysis was conducted with the data to determine which factors might influence the success of students, with an initial emphasis on school funding. The findings indicate that allocation of school funding may have a relationship with student success as measured by ACT scores and graduation rates, but that the relationship becomes more difficult …

What Is The Satisfaction Of Youth Participating In A Pilot Reading And Food-Based Stem Education Program In Rural Appalachian Mississippi?, Meagan Smith

Honors Theses

Science, technology, engineering, and mathematics (STEM) education is a vital subsection of primary education which focuses on imparting knowledge to foster STEM literacy and ultimately bolster the workforce of STEM related fields (Holmlund, 2018). Due to both geographic and socioeconomic challenges, STEM education in rural areas suffers from a lack of engaging learning opportunities and contributes to a shortage of STEM professionals originating from rural areas (Munn, 2019)(Murphy, 2020). Rural areas such as Calhoun County, MS, where the pilot program associated with this thesis was conducted, do not have the means to support interactive learning institutions such as aquariums and …

The Neuroprotective Effects Of Estradiol And Genistein In Zebra Finch Cerebellum, Renee E. Breaux

Honors Theses

The estradiol (E2) synthetic pathway converts testosterone to E2 via aromatase (AROM) and plays an important role in neuroplasticity. However, exogenous E2 increases cancer risk and interferes with gonadal function. Phytoestrogens, plant-based estrogens, may provide neuroprotection without negative E2 effects. Genistein (GEN), a soy phytoestrogen, preferentially binds to estrogen receptor beta (ER β), which is expressed at a relatively higher concentration than ER α in the cerebellum (CB). The songbird CB is an ideal model for steroid-mediated plasticity. Songbird brains are highly plastic and CB contains all steroid-synthetic enzymes. Previous studies in zebra finches (ZF) have shown that AROM and …

Evaluating The Barriers Of Entry That Small Commercial Farmers Face And The Implications Of Such Barriers On Rural Communities, Lauren C. Chandler

Honors Theses

The research proposed in this thesis will identify the barriers of entry that

small farmers face when entering the Agricultural Industry. The proposed research will also seek to discover how having these barriers in place affects rural communities. This thesis conducts a literature review of the topic, sets the context for the research to be done, and proposes a research project to further investigate the topic. The proposed research will be done through administering a survey to stakeholders, and then interviewing a small sample of those surveyed to get a comprehensive look at the effects of agribusiness on rural communities. …

Comprehensive Review Of Accounting: A Case-By-Case Study, Cristina Trefry

Honors Theses

This thesis was prepared to investigate a variety of accounting scenarios to further learn and challenge student’s notion of accounting. These accounting scenarios were in the form of 11 case studies done over the course of September 2020 to April 2021. These case studies highlighted a wide variety of accounting concepts, and even challenged students to a case competition highlighted in cases 6 through 10. These case studies not only challenged students to think about accounting concepts in a different light, but also to learn more about the field they are going into through personalized cases. These personalized cases allowed …

Synthesis Of Fluorinated Ketones For Biological Evaluation At The Gaba-B Receptor, Katherine Kreusel

Honors Theses

The proper functioning of the CNS depends on the balance between excitatory and inhibitory neurotransmitters. While excitation is primarily regulated by glutamate, inhibition is regulated by γ-aminobutyric acid (GABA). When GABA binds to a GABA receptor, there is a block in nerve transmission which is important when studying pain and drug addiction. There are two types of GABA receptors that are used as drug targets: GABA-A and GABA-B. While GABA-A receptors are ionotropic and ligand-gated ion channels, GABA-B receptors are G-protein coupled receptors that are used by cells to convert extracellular signals into intracellular responses. Although many therapeutics modulate the …

The Efficacy Of The Covid-19 Vaccine In Mississippi, Ilyse Miriam Levy

Honors Theses

The Efficacy of The COVID-19 Vaccine in Mississippi

(Under the direction of Dr. Xin Dang)

By tracking and analyzing fifty-three weeks of COVID-19 data, this thesis analyzes the efficacy of the COVID-19 vaccine within the State of Mississippi. Over the course of these fifty-three weeks, I have also been able to calculate the confidence intervals for vaccination efficacy and the risk reduction due to vaccination by using data regarding the correlations between deaths and vaccination status, provided to me by the Mississippi Office of Epidemiology. My analysis demonstrates that the COVID-19 vaccine is effective not only in Mississippi but also …

Characterizing The Roles Of Cannabinoid Receptor 1 & 2 In Zebrafish Behavior, Metabolism, And Seizure-Induced Activity, Kayci Kimmons

Honors Theses

Epileptic disorders like Dravet Syndrome require novel studies to determine the most ideal treatment. New research linking the endocannabinoid system (ECS) to epileptic disorders is arising, but there is still much to be discovered about the function and regulatory impact of the endocannabinoid system and its receptors in epilepsies like Dravet. In this study, knockout models of larval and adult zebrafish (Danio rerio) were used to investigate the roles of cannabinoid receptors 1 & 2 in behavior, brain mitochondrial metabolism, and seizure-induced activity following exposure to THC and CBD. Larval zebrafish which lacked cannabinoid receptor 1 exhibited increased …

Species Diversity And Growth Rates Of Overstory Vegetation Over 25 Years In Response To Physical And Chemical Properties In Long-Term Monitoring Plots At The University Of Mississippi Field Station, Mitchell Tharp

Honors Theses

Overstory vegetation for twenty-two long-term monitoring plots (LTMPs) was sampled from 1996 to 2021 to study the changes in vegetation due to natural and human disturbance. From the fall of 2020 through the fall of 2021, the overstory of the 22 LTMPs was resampled and soil samples were collected from each plot. The circumference at breast height (CBH) and species diversity were recorded and compared to previous years’ data. The objectives of this study were to: (1) document changes in the overstory species of the LTMPs, (2) measure growth rates of surviving trees, (3) survey how elevation and slope impact …

Optimization Of A Fluidized Bed Reactor For The Production Of Styrene From Ethylbenzene, Gregory Espenan

Honors Theses

In order to optimize Unit 500, a styrene production plant, the Net Present Value (NPV) was used as the objective function to ensure every optimization strategy had a positive economic effect. To optimize a chemical plant, it is important to note efficiency, economics, product specifications, and production requirements. The goal of this project was to make changes to the base case of Unit 500 to minimize the cost to produce styrene for an upstream unit. PRO/II was used to simulate various points in different unit operations throughout the process. The NPV was measured after each unit operation was simulated to …

Confronting Stigma: Ethical Leadership, Influence, And The Dignity Of People Struggling With Addiction, Jacob Fennell

Honors Theses

People struggling with addiction in the United States of America deserve better treatment. The current stigma of people struggling with addiction as moral failures perpetuates a policy of drugs that sees them as criminal. This policy should be repealed and a better culture of care should be created. People struggling with addiction deserve a standard of treatment based on the core tenet of human dignity. In engaging with the history and cultural beliefs that are the foundation of this mistreatment, this same tenet of dignity must be upheld. This specifically comes into my project when exploring methods of changing these …

American Goldfinches (Spinus Tristis): Changes In Behavior During Mycoplasma Gallisepticum Infection, Hetal Shingrani

Honors Theses

Animal sickness behavior is an important component of disease ecology and is essential to understanding wildlife diseases and how and where animals allocate resources for survival. This study examines sickness behaviors, the extent of conjunctivitis, and the presence of an antibody response in relation to a Mycoplasma gallisepticum (MG) respiratory infection in American goldfinches. We conducted an experimental infection of American goldfinches and recorded behavior videos, and collected blood samples, throat swabs, eye swelling, and mass data at multiple time points throughout the experiment. An ELISA-serum assay was run after the conclusion of the study to identify the presence of …

The Design Of A Pcr-Based Assay To Detect And Isolate The Serine Palmitolytransferase Gene From Environmental Bacteria, Lana Taylor

Honors Theses

Sphingolipids are a natural class of lipids that function as structural elements of cell membranes and signaling molecules for important cellular activities such as cell growth, differentiation, apoptosis, recognition, and adhesion. These lipids can be found universally in eukaryotic cells as well as some species of bacteria, such as those found in the human gut microbiome and in the environment in soils. Though sphingolipid production is rare in bacteria, both eukaryotic and prokaryotic sphingolipid biosynthesis begin with the condensation of serine and palmitoyl CoA into 3-ketodihydrosphingosine catalyzed by the enzyme serine palmitoyltransferase (SPT). In recent years, several studies have shown …

Match Made In Pharmacy - Journey To Commencement, Whitney Tarp

Journey to Commencement

Nason and Shelby Wise found the perfect matches in each other and the profession.

America’S History Of Health Disparities: How Does This Affect The Future Of Healthcare In Mississippi?, Zuri O. Dixon Omere, Jazmin King

Honors Theses

America’s healthcare system runs rampant with healthcare inequalities that have an alarming effect on minorities and people of color. In order for people of color and marginalized groups to receive proper care and treatment, more attention needs to be brought to these inequalities. For example, Covid-19 reflected the health inequalities that are present in this country; minorities were more likely to become hospitalized due to Covid-19 than other non-minorities. In addition, minorities in women’s health, specifically black women, have been affected in various ways that are related to the inequalities in medicine like dying during childbirth and improper care. This …

Oxidized, Ashley Smith

Graduate Theses in Studio Art

No abstract provided.

Design Of An Implanted Vascular Access Device With A Mechanical Septum, Mallory Ann Moffett, Katherine Rose O'Quinn

Honors Theses

As populations continue to age, their need for medical care continues to rise. This is seen by the large need for implanted vascular devices (IVADs). IVADs are essential for individuals with poor venous access and patients requiring long-term venous delivered drugs. This document will explore the existing IVADs, where they fall short, and where our device, the IrisPort system, works to solve the unmet needs of patients. The IrisPort system is a needle-less port system that allows for repeated venous access without the use of a non-coring needle. Prior art searches have shown that the IrisPort is a novel solution …

Airborne And Dermal Collection Methods Of Gunshot Residue For Toxicity Studies, Samuel Cole Smith, Oscar Beau Black, Courtney Roper

Faculty and Student Publications

Gunshot residue (GSR) has potential negative health effects on humans as a result of inhalation and dermal exposure to the chemical and physical characteristics of GSR such as Pb, Sb, Ba, nitrocellulose, nitroglycerine, and particulate size fraction. Filter (size selective) and double-sided tape (non-size selective) samples collected airborne GSR during single and triple firing of a 0.22 caliber revolver. Dermal exposures were considered using hand swabs and de-leading wipes, designed to remove the heavy metals. The samples underwent analysis to investigate physical (morphology, size distribution, zeta potential), chemical (black carbon and element concentrations), and potential to induce oxidative stress (oxidative …

Isolation Of Echimidine And Its C-7 Isomers From Echium Plantagineum L. And Their Hepatotoxic Effect On Rat Hepatocytes, Michał Gleńsk, Marta K. Dudek, Peter Kinkade, Evelyn C.S. Santos

Faculty and Student Publications

Echimidine is the main pyrrolizidine alkaloid of Echium plantagineum L., a plant domesti-cated in many countries. Because of echimidine’s toxicity, this alkaloid has become a target of the European Food Safety Authority regulations, especially in regard to honey contamination. In this study, we determined by NMR spectroscopy that the main HPLC peak purified from zinc reduced plant extract with an MS [M + H]+ signal at m/z 398 corresponding to echimidine (1), and in fact also represents an isomeric echihumiline (2). A third isomer present in the smallest amount and barely re-solved by HPLC from co-eluting (1) and (2) was …

Development Of Α-Tocopherol Succinate-Based Nanostructured Lipid Carriers For Delivery Of Paclitaxel, Sushrut Marathe, Gauri Shadambikar, Tabish Mehraj, Suresh P. Sulochana

Faculty and Student Publications

The management of retinoblastoma (RB) involves the use of invasive treatment regimens. Paclitaxel (PTX), an effective antineoplastic compound used in the treatment of a wide range of malignant tumors, poses treatment challenges due to systemic toxicity, rapid elimination, and development of resistance. The goal of this work was to develop PTX-loaded, α-tocopherol succinate (αTS)-based, nanostructured lipid carrier (NLCs; αTS-PTX-NLC) and PEGylated αTS-PTX-NLC (αTS-PTX-PEG-NLC) to improve ocular bioavailability. The hot homogenization method was used to prepare the NLCs, and repeated measures ANOVA analysis was used for formulation optimization. αTS-PTX-NLC and αTS-PTX-PEG-NLC had a mean particle size, polydispersity index and zeta potential …

Essential Oil Yield, Composition, And Bioactivity Of Sagebrush Species In The Bighorn Mountains, Valtcho D. Zheljazkov, Charles L. Cantrell, Ekaterina A. Jeliazkova, Tess Astatkie

Faculty and Student Publications

Sagebrush (Artemisia spp.) are dominant wild plants in large areas of the U.S., Canada and Mexico, and they include several species and subspecies. The aim was to determine if there are significant differences in essential oil (EO) yield, composition, and biological activity of sagebrush within the Bighorn Mountains, U.S. The EO yield in fresh herbage varied from 0.15 to 1.69% for all species, including 0.25–1.69% in A. tridentata var. vaseyana, 0.64–1.44% in A. tridentata var. tridentata, 1% in A. tridentata var. wyomingensis, 0.8–1.2% in A. longifolia, 0.8–1% in A. cana, and 0.16% in A. ludoviciana. There was significant variability in …

Fractionation Of Sulfated Galactan From The Red Alga Botryocladia Occidentalis Separates Its Anticoagulant And Anti-Sars-Cov-2 Properties, Seon Beom Kim, Mary Zoepfl, Priyanka Samanta, Fuming Zhang

Faculty and Student Publications

Sulfation pattern and molecular weight (MW) play a key role in the biological actions of sulfated glycans. Besides anticoagulant effects, certain sulfated glycans can also exhibit anti-SARS-CoV-2 properties. To develop a more selective antiviral carbohydrate, an efficient strategy to separate these two actions is required. In this work, low MW fractions derived from the red alga Botryocladia occidentalis sulfated galactan (BoSG) were generated, structurally characterized, and tested for activity against SARS-CoV-2 and blood coagulation. The lowest MW fraction was found to be primarily composed of octasaccharides of monosulfated monosaccharides. Unlike heparin or native BoSG, we found that hydrolyzed BoSG products …

A Simple, Cost-Effective, And Green Hptlc Method For The Estimation Of Ascorbic Acid In Solvent And Ultrasound-Assisted Extracts Of Phyllanthus Emblica, Capsicum Annuum, And Psidium Guajava, Ahmed I. Foudah, Prawez Alam, Faiyaz Shakeel, Aftab Alam

Faculty and Student Publications

Greener analytical methodologies for the estimation of ascorbic acid (AA) are poorly reported in the literature. Furthermore, the green indexes of the literature’s analytical assays of AA estimation have not been assessed. As a consequence, the aim of this research is to invent and validate a simple, cost-effective, and green reverse-phase “high-performance thin-layer chromatography (HPTLC)” method for the estimating AA in the solvent extracts (SE) and ultrasound-assisted extracts (UAE) of Phyllanthus emblica, Psidium guajava, and Capsicum annuum. The greener mobile phase for AA estimation was a binary mixture of water and ethanol (70:30, v/v). At a wavelength of 265 nm, …

Rap1a Activity Elevated The Impact Of Endogenous Ages In Diabetic Collagen To Stimulate Increased Myofibroblast Transition And Oxidative Stress, Stephanie D. Burr, Christopher C. Dorroh, James A. Stewart

Faculty and Student Publications

Diabetics have an increased risk for heart failure due to cardiac fibroblast functional changes occurring as a result of AGE/RAGE signaling. Advanced glycation end products (AGEs) levels are higher in diabetics and stimulate elevated RAGE (receptor for AGE) signaling. AGE/RAGE signaling can alter the expression of proteins linked to extracellular matrix (ECM) remodeling and oxidative stressors. Our lab has identified a small GTPase, Rap1a, that may overlap the AGE/RAGE signaling pathway. We sought to determine the role Rap1a plays in mediating AGE/RAGE changes and to assess the impact of isolated collagen on further altering these changes. Primary cardiac fibroblasts from …