Digital Commons Network^™

Selective Inhibition Of Plasmodium Falciparum Atpase 6 By Artemisinins And Identification Of New Classes Of Inhibitors After Expression In Yeast, Catherine M. Moore, Jigang Wang, Qingsong Lin, Pedro Ferreira

Faculty and Student Publications

Treatment failures with artemisinin combination therapies (ACTs) threaten global efforts to eradicate malaria. They highlight the importance of identifying drug targets and new inhibitors and of studying how existing antimalarial classes work. Here, we report the successful development of a heterologous expression-based compoundscreening tool. The validated drug target Plasmodium falciparum ATPase 6 (PfATP6) and a mammalian orthologue (sarco/endoplasmic reticulum calcium ATPase 1a [SERCA1a]) were functionally expressed in Saccharomyces cerevisiae, providing a robust, sensitive, and specific screening tool. Whole-cell and in vitro assays consistently demonstrated inhibition and labeling of PfATP6 by artemisinins. Mutations in PfATP6 resulted in fitness costs that were …

What Happens After Debriefing? The Effectiveness And Benefits Of Postexperimental Debriefing, Rachel Leigh Greenspan, Elizabeth F. Loftus

Faculty and Student Publications

After participating in an experiment, people are routinely debriefed. How effective is debriefing when the experiments involve deception, as occurs in studies of misinformation and memory? We conducted two studies addressing this question. In Study 1, participants (N = 373) watched a video, were exposed to misinformation or not, and completed a memory test. Participants were either debriefed or not and then were interviewed approximately one week later. Results revealed that, after debriefing, some participants continued to endorse misinformation. Notably, however, debriefing had positive effects; participants exposed to misinformation reported learning significantly more from their study participation than control participants. …

Pharmacy Matters - May 2022, University Of Mississippi. School Of Pharmacy

Pharmacy Matters Newsletters

Featured stories: "Pharmacy Professor Brings Interprofessional Experience to Students," "UM Researchers Working for Safe Drinking Water in Mississippi," "Alumna Upholds Pharmacy Legacy Through Service"

Sophomore Speech-Language Pathology Major Wins National Scholarship, Cameron Smith

University of Mississippi News

Amy-Kate Winter selected by National Student Speech Language Hearing Association

Accounting Case Studies, Megan Jansen

Honors Theses

This thesis is a combination of 11 accounting case studies. They are titled: A Tale of Two Cities, Exploring the FASB and GAAP, Presidential Debate, Tax Cuts and Job Act and Taxodus, Professional Interview, Case Competition Disney Overview, Case Competition Disney Audit Analyst, Case Competition Disney Tax Advisor, Case Competition Disney Advisory Consultant, Case Competition Disney’s Equity Position, and The Financial Crisis of 2008.These cases cover a variety of topics in the accounting and professional world. Five of the cases contain research that pertained to a case competition in which I was placed on a team and tasked with creating …

Analysis Of Accounting: A Series Of Case Studies Examining Relevant Topics And Concepts, Jermaine Barnes Jr

Honors Theses

This thesis is a compilation of various case studies addressing relevant issues and concepts within the field of accounting. It is composed of twelve cases designed to address and analyze numerous topics that are currently relevant to the field of accounting and my future career within this field. The information presented herein addresses a wide range of necessary skills and knowledge applicable to this field, and this information was gathered through analysis and documentation of a multitude of topics, such as the Financial Crisis of 2008, the first presidential debate of the 2020 election, the various demographical trends of cities …

Communicating Through A Crisis: An Analysis Of The University Of Mississippi's Initial Covid-19 Crisis Communications, Sydney Waitley

Honors Theses

This thesis, in effort to examine modern-day crisis communications, focuses on the analysis of University of Mississippi’s initial crisis communications during the COVID-19 pandemic during March 2020. The purpose of this research was to evaluate the university’s communication efforts during this crisis in order to determine the effectiveness of the University of Mississippi’s initial COVID-19 crisis communications. First, the researcher analyzed historical case studies on three notable crisis communications (the Johnson & Johnson Tylenol Crisis of 1982, the United Airlines Crisis of 2017, and the Crock-Pot Crisis of 2018). From these case studies, qualities of good crisis communications were determined …

The American Prosecutor And The Carceral State: An Analysis To Address Prosecutorial Power And Discretion In An Effort To Reduce Overincarceration In The United States, Olivia Jordan

Honors Theses

There is perhaps no other actor within our legal system that shares more power and control over the carceral state than the American prosecutor. This thesis examines the powers of the prosecutor at every stage of criminal procedure, how these powers contribute to the carceral state, and how prioritizing prosecutorial policy reform can effectively reduce persistent mass incarceration in the United States. This thesis uses three criteria- effectiveness at reducing overincarceration, feasibility of implementation, and ethical impact- to critically evaluate several proposals for addressing prosecutorial power and discretion. Ultimately, the thesis recommends a combination of three proposals for a more …

Accounting Case Studies, Avery Andress

Honors Theses

This thesis is a collection of accounting case studies. There are twelve cases that comprise this thesis including: A Tale of Two Cities, Asset Concepts, Presidential Debate, Excel Course, Taxodus - Playing The Global Tax Avoidance Game, Business Interview - Tony Huffman, Case Competition - Overview, Case Competition - Audit, Case Competition - Tax, Case Competition - Advisory, Case Competition - Earnings, Stock Price, and Analysis, and Financial Crisis of 2008. There are a variety of topics involved in these cases. I completed a case that involved watching a Presidential Debate and learned more about each candidate’s policies. Also, …

Amlo And Huachicoleo: The Effects And Implications Of The Fuel Theft Crackdown In Mexico, Samuel Starr

Honors Theses

On December 20th, 2018—less than three weeks into new president Andrés Manuel López Obrador’s term—the Mexican federal government initiated a crackdown on fuel theft, or huachicoleo. The crackdown was intensive and nationwide. Its implementation was costly: gas stations throughout the country shut down as fuel pipelines were closed, the newly established National Guard was deployed to protect fuel infrastructure, and cartels threatened acts of terror against the government. The crackdown ended in April of 2019, with the López Obrador administration calling it a success. The overarching goal of this study is to test that assertion empirically by investigating the crackdown’s …

Financial Analysis Of Accountancy In America Today Through Collective Case Studies, Caitlyn Henry

Honors Theses

The following thesis contains a collection of ten accounting case studies that were written and directed under the advisement of Dr. Victoria Dickinson during the enrollment of Honors Accountancy 420. Dr. Dickinson presented us with unique prompts for each case study and guided our research as we dove into the professional world of accounting standards in America today. Five of my cases specifically correlate to The Coca-Cola Company, which my case competition team selected to research as we devised tax, audit, and advisory plans to better the company. We presented our findings to a panel of accounting professionals from numerous …

Peacock Remembered With Recovery Support Fund, Tina Hahn

University of Mississippi News

No abstract provided.

Alumni Offer Advice To New Graduates, Emily Howorth

University of Mississippi News

Eight Ole Miss graduates share wisdom and encouragement

Analysis Of Test Anxiety In Human Anatomy And Physiology I Students At The University Of Mississippi, Anne Piazza

Honors Theses

Student anxiety, specifically test anxiety, is common hindrance to student performance in various courses including Human Anatomy and Physiology at the University of Mississippi. Through a sequence of three surveys we collected demographic information, anxiety data related to the course, and test anxiety in general We researched factors that could potentially influence student anxiety such as at what point in the semester the student is evaluated, when students feel the most stressed, outcomes on previous evaluations, and perceived outcomes of the course. We also examined what effect the anxiety has on the student such as lowered performance, lowered test scores, …

The Legality Of The European Union’S Carbon Border Adjustment Mechanism And The Limitations Of World Trade Organization Rules On Effective Climate Action, Delaney Smith

Honors Theses

In July 2021, the European Union proposed the creation of a carbon border adjustment mechanism, a trade mechanism that would levy a carbon price against imported goods. This mechanism, the first of its kind, has the potential to address weaknesses in the EU’s existing domestic cap and trade system and create a financial incentive for other nations to reduce their carbon emissions. However, legal experts have raised concerns that this mechanism may violate the rules of the World Trade Organization. If another member state raises a complaint against the measure, the European Union will be forced to navigate the World …

Ameliorative Effects Of Minor Cannabinoids Over Hiv-1 Tat-Mediated Visceral Pain, Charlie Worth

Honors Theses

As the total number of people living with HIV continues to rise across the world, an effective HIV treatment is still sought after. While modern-day advanced therapies exist for mitigating much of the negative effects of HIV, the virus remains evasive and problematic in the central nervous system. Thus, even with treatment, many people living with HIV continue to suffer from a plethora of symptoms. However, a large proportion of HIV-positive patients claim to feel a reduction in those persevering symptoms after cannabis usage. This anecdotal evidence has sparked interest in the efficacy of cannabis constituents for HIV therapy. This …

Identification Of The Putative Binding Site Of A Novel Benzimidazole (Etazene) And Its Metabolites On Μ-Opioid Receptor: A Systematic Computational Study And Detection Using Human Liver Microsomes, Isuru Nipun Hewamanna

Honors Theses

The abuse of novel psychoactive substances (NPS) has risen dramatically worldwide, especially among recreational users and regular abusers. The absence of pharmacological and toxicological data on new, illicitly used, and abused opioids, results in serious adverse effects, including death. The synthetic benzimidazole opioid, Etazene (70 times higher analgesic activity than morphine), gained popularity as a recreational drug on the illegal/darknet market; however, no experimental information is available at the

molecular level on the binding mechanism and putative binding site of Etazene and its metabolites at the µ-opioid receptor (MOR). In the present study, we investigated the possibilities of MOR activation …

Q&A With Ashley Smith (Mfa Sculpture), Ashley Smith

Q & A Interviews with Art Students

No abstract provided.

Learning Local Languages As A Means Of Preserving Culture: An Analysis Of The Federal Education Laws’ Treatment Of Regional Languages In The Basque Country And Colombia, Olivia Jaramillo

Honors Theses

Regional languages are essential components of vibrantly diverse cultures. Across all regions of the globalizing modern world, regional languages remain one of the clearest markers of the rich heritage and history that each continent, country, state, city, town uniquely possesses. Unlike the more dominant languages of our evolving international landscape, local and regional languages explicitly capture precise cultural experiences of limited populations. These languages carry specific nuance, meaning, grammar, and vocabulary obscured by other forms of communication. This project, researching and analyzing two individual countries’ regional language education under the federal legal systems, holds the importance of safeguarding local languages …

Mississippi’S Brain Gain - Journey To Commencement, Jennifer Parsons

Journey to Commencement

Grateful for the opportunities, Ajah Singleton weathers multiple challenges to excel in Honors College.

Mark Loftin To Deliver Last Lecture Friday, Edwin B. Smith

University of Mississippi News

Retiring School of Applied Sciences associate dean to share reflections in Bryant Hall

Indie Illness: An Evaluation Of The Orphan Drug Act, Nicholas Castellanos

Honors Theses

The purpose of this study is to evaluate the Orphan Drug Act of 1983 by subtracting the cost of incentives for drug development from the estimated value created by each drug in the form of quality-adjusted life-year gains. Data regarding costs of incentives is retrieved from the FDA as well as a report released by the National Organization for Rare Disorders. Data regarding value created by each drug is retrieved from a Freedom of Information Act request to the FDA, the CEA registry, and a report released by the US Department of Health and Human Sciences. Sufficient data was available …

Speech-Language Pathologists' Skills And Knowledge In Dysphagia Management In Long-Term Care Facilities, Madelyn Griffin

Honors Theses

An increasing amount of current research indicates the prevalence of oral and pharyngeal dysphagia in all age groups, with a higher number of cases present in the geriatric population. Dysphagia is common in age-related diseases such as Parkinson’s disease, Alzheimer’s disease, and Dementia. The purpose of this study was to investigate the knowledge and skills of speech- language pathologists (SLPs) working in long-term care, in the area of oral and pharyngeal dysphagia. Participating SLPs responded to a survey asking to self-identify their knowledge/skills in oral and pharyngeal dysphagia. The findings from this study revealed the variety of expertise of SLPs …

The South In Review, Adam Gussow, Peter Lurie, David Wharton

Study the South

The following books are reviewed in this issue:

• I Am a Man: Photographs of the Civil Rights Movement, 1960-1970 / William R. Ferris and Lonnie G. Burch, III. University Press of Mississippi. Reviewed by David Wharton
• William Faulkner and the Faces of Modernity / Jay Watson. University Press of Mississippi. Reviewed by Peter Lurie.
• New York City Blues: Postwar Portraits from Harlem to the Village and Beyond / Edited by Larry Simon and John Broven. Photos by Robert Schaffer. Reviewed by Adam Gussow.
• Road Through Midnight: A Civil Rights Memorial / Jessica Ingram. University of North Carolina Press. Reviewed by …

The Relationship Between Ptsd-Related Symptoms And Skin Disease Symptom Severity In A Dermatological Sample, Kristin Barnett

Honors Theses

Previous research has demonstrated associations between stress and physical health conditions, including skin disease. The stress cycle, including its associated hormonal responses and stress behaviors, contributes to more severe skin disease symptoms. Psychological stress and anxiety-disorder symptoms are known to be associated with skin disease severity; however, research has yet to examine the relationships between stress disorders and skin disease severity. Therefore, stress disorders (e.g., posttraumatic stress disorder [PTSD]) are hypothesized to have a similar relationship with skin disease severity, wherein greater severity of PTSD-related symptoms would be positively associated with skin disease severity. Participants from Amazon’s Mechanical Turk (N …

Occupational Fine Particulate Matter Exposure And Its Associated Effects On The Cardiovascular System: A Systematic Review, Jordan Rickwa

Honors Theses

Fine particulate matter (PM2.5), the solid and liquid portion of air pollution under 2.5 microns in diameter, has been shown to cause numerous negative effects on the body. These inhalable particles are often researched for their effects on the respiratory system in outdoor settings, however systemic health impacts have been observed following inhalation of PM2.5 . Additionally, exposures to PM2.5 can occur in occupational settings but are less frequently studied compared to outdoors. This literature review seeks to identify studies that determined associations between inhaled PM2.5 and the resulting cardiovascular effects in occupational settings. We conducted a search of literature …

Targeting Platelets Using Ionic Liquid Coated Nanoparticles, Karen Mun Wong

Honors Theses

Platelets are key players in our body’s inflammatory processes upon activation, which can create physiological problems. Researchers are actively seeking solutions by targeting platelets with therapeutics. The objective of the research in this thesis was to investigate a new and potentially less invasive drug delivery platform using nanoparticles. The topic of the project was to explore the world of ionic liquids and their abilities, when coated on nanoparticles, to bind to platelets. A library of choline carboxylic acid-based ionic liquids (ILs) was first synthesized via salt metathesis while PLGA-based nanoparticles were simultaneously being synthesized via the nanoprecipitation method. The ionic …

How To Combat The Negative Effects Of Punishment Drift On Children, Madison Alliston

Honors Theses

Approximately 2.7 million children have a parent that is currently incarcerated in the United States. Despite the fact that these children are innocent, they face a myriad of negative consequences due to the separation from their parents. The negative effect of incarceration on children is known as punishment drift. Because the effects of incarceration tend to “drift” onto children, these individuals typically face psychological impacts (e.g., social anxiety and depression), economic impacts (e.g., poverty and food insecurity), and environmental impacts (e.g., foster care) from punishment drift. Despite all of the detrimental effects, there have been very few policy solutions implemented …

Effects Of Parent Intervention Via Tele-Practice On Children With Autism Spectrum Disorder In Rural Mississippi, Erin Bowens

Honors Theses

Background

The present study explored the use of parent intervention via tele-practice for children with Autism Spectrum Disorders (ASD) and how effective that intervention was in increasing the child’s language and communication skills and the parents’ strategy use in the rural state of Mississippi.

Methods

Two dyads of participants were used. Dyad 1 included a mother and her 4-year-old son with high-functioning ASD, and Dyad 2 included a mother and her 4-year-old daughter with severe ASD. Standardized tests were administered to gather data about the children’s diagnoses. The study included four phases across four months, including pre-test, intervention, post-test, and …

Development Of A Non-Invasive Dna Extraction Method From Teeth, Monalisa Heng

Honors Theses

Forensic dentistry has evolved from simple morphological investigations to genetic and molecular analysis. One of the most important techniques is DNA analysis which requires viable samples from an individual or crime site. The orofacial region can be a good source for DNA samples because the tissues can resist environmental, thermal, electrical, and mechanical challenges. Teeth are especially useful as a source of genetic material because the DNA located in the pulp is surrounded by protective mineral tissue. The DNA in the pulp tissue is currently accessed through destructive methods involving crushing, pulverization, and splitting the tooth. Unfortunately, destructive methods destroy …