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Cannabinoid Modulation Of Cisplatin Induced Neuropathy, Hannah Marie Harris Jan 2015

Cannabinoid Modulation Of Cisplatin Induced Neuropathy, Hannah Marie Harris

Electronic Theses and Dissertations

Endocannabinoid modulation of cancer-related pain is well-documented. Sativex, a cannabinoid extract with a 1:1 ratio of tetrahydrocannabinol (thc) and cannabidiol (cbd) has been shown to alleviate neuropathic pain associated with chemotherapy. This research examined whether thc or cbd alone is effective in attenuating or preventing tactile allodynia associated with cisplatin-administration. Mice (c57bl/6) were given eight doses of 2.3 mg/kg cisplatin or saline solution ip every second day to induce tactile allodynia (ringers on alternate days). Tactile responses to hind-paws were quantified in g of force using an electric von frey (evf) prior to (baseline) and after the cisplatin administration protocol. …

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An Evaluation Of Geophysical Methods In The Detection Of Toddler-Sized Burials During The First Six Months Of Burials, Paul Sullivan Martin Jan 2015

An Evaluation Of Geophysical Methods In The Detection Of Toddler-Sized Burials During The First Six Months Of Burials, Paul Sullivan Martin

Electronic Theses and Dissertations

Geophysical survey has become a major tool in the search for clandestine graves associated with missing person cases. However, relatively little research has been done to evaluate the efficacy of different instruments. Ground-penetrating Radar (GPR), magnetometry, resistivity, conductivity, and susceptibility survey data were collected over the first six months of interment at approximately 30-day intervals for two research plots: an open grassy area and a wooded area. Each area contained five pig burials representing toddler-size (less than 50 pounds) remains and two areas of disturbance or false burials to serve as control graves. The resultant imagery was evaluated in terms …

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Non-Invasive Drug Delivery To The Posterior Segment Of The Eye: Development Of Formulation Strategies And Evaluation Of Ocular Distribution And Pharmacological Activity, Goutham Reddy Adelli Jan 2015

Non-Invasive Drug Delivery To The Posterior Segment Of The Eye: Development Of Formulation Strategies And Evaluation Of Ocular Distribution And Pharmacological Activity, Goutham Reddy Adelli

Electronic Theses and Dissertations

Diseases of the posterior segment of the eye such as diabetic retinopathy, age related macular degeneration and glaucoma are the leading causes for blindness throughout the world. Topical eye drops is the most convenient formulation for daily application. The human eye, however, presents major physiological and dynamic barriers for the topically administered drug/molecule from reaching the retina. Similarly, the blood-retinal and blood-aqueous barriers restricts passage of drug from systemic circulation into the eye. Although intravitreal injections are the gold standards for the treatment of posterior segment ocular diseases, they are associated with pain, inflammation, endopthalmitis and infection. So there is …

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Screening Of Natural Products For Their Effect On Kallikrein-Kinin System: Potential Implications In The Treatment Of Hereditary Angioedema, Hassan Abdu Madkhali Jan 2015

Screening Of Natural Products For Their Effect On Kallikrein-Kinin System: Potential Implications In The Treatment Of Hereditary Angioedema, Hassan Abdu Madkhali

Electronic Theses and Dissertations

Plasma prekallikrein (PK) activation exerts both physiological and pathological effects within the cardiovascular system and central nervous system (CNS). Activated PK (kallikrein) controls cytokine release from human mononuclear cells and controls both the intrinsic blood coagulation and the alternative complement cascades. The uncontrolled activation of these cascades results in the development of pathological pain and angioedema. Increased plasma kallikrein levels are associated with hereditary angioedema (HAE) and myocardial infarction, whereby kallikrein amplifies the generation of activated factor XII (FXIIa) and bradykinin (BK) release from high molecular weight kininogen (HMWK). The primary objective of this study was to screen natural products …

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Fetishizing Southern Brutality: An Intersectional Analysis Of Animalistic Dehumanization In Interracial Pornography, Shawna Faye Felkins Jan 2015

Fetishizing Southern Brutality: An Intersectional Analysis Of Animalistic Dehumanization In Interracial Pornography, Shawna Faye Felkins

Electronic Theses and Dissertations

Pornography has been a widely debated issue within the feminist movement since the sex wars of the 1970’s. The conversation has shifted to a sex radical position within the third movement, seeking to be “sex positive” in representations of pornography as a potential site of empowerment. This work, however, seeks to complicate the idea that all depictions of sex are empowering by examining the popular genre of interracial pornography through the lens of the southern tropes that are often enacted within them: the jezebel, southern belle, and black brute. By using these historical tropes with the work of Judith Butler …

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Method Development For Mass Spectrometric Characterization Of Ultra-Small Nanomolecules And Mass Spectrometry Imaging Of Selected Biomolecules, Nuwan K. Kothalawala Jan 2015

Method Development For Mass Spectrometric Characterization Of Ultra-Small Nanomolecules And Mass Spectrometry Imaging Of Selected Biomolecules, Nuwan K. Kothalawala

Electronic Theses and Dissertations

High sensitivity, selectivity and remarkable identification capabilities facilitate the applicability of mass spectrometry (MS) in diverse fields. This dissertation outlines how this cutting edge technology is used to determine the chemical composition of the ultra-small nanomolecules (NMs) to atomic precision and obtain spatial resolution of selected biomolecules using mass spectrometry imaging (MSI). Chapter I includes introduction to electrospray ionization (ESI) and matrix assisted laser desorption ionization (MALDI) MS used in my PhD research. Chapter II explains how high resolution ESI-MS methods were developed to analyze the polar water-soluble NMs. These new methods express how ESI-MS parameters need to be optimized …

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Systems Biology Approach To Understanding The Control Of Glucose Metabolism In Healthy And Apoptotic Neurons, Hoda Gebril Jan 2015

Systems Biology Approach To Understanding The Control Of Glucose Metabolism In Healthy And Apoptotic Neurons, Hoda Gebril

Electronic Theses and Dissertations

Apoptosis plays a crucial role in sculpting the developing central nervous system (CNS) but can, under certain conditions, contribute to neurodegeneration in the mature CNS. Metabolic disturbances have long been associated with apoptosis-inducing agents, however, the mechanism underlying such changes remains controversial. In this study, our hypotheses was that decreased ATP turnover may bring about other metabolic changes in apoptotic neurons. Accordingly, change in metabolic reactions other than ATP turnover may not be important in the study of apoptotic mechanism. In a living cell, metabolic reactions are highly connected and thus are highly sensitive to kinetic change in one or …

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Carbon Dioxide Capture With Amine Functionlized Graphene Oxide, Renee Zeleszki Jan 2015

Carbon Dioxide Capture With Amine Functionlized Graphene Oxide, Renee Zeleszki

Electronic Theses and Dissertations

Abstract: amine functionalized graphene oxide was used as sorbent in order to achieve carbon dioxide capture. In this study, micro size graphite flakes was prepared according to modified hummers method and "hummers' method with additional kmno4." Graphene oxide was then functionalized with ethylenediamine (eda). Different purification methods for graphene oxide were studied as well as different functionalization method times. Graphite oxide and functionalized graphene oxide has been analyzed with fourier transform infrared spectroscopy (ftir) for chemical structure. Thermal gravimetric analysis (tga) was used to test co2 capture capacity. Functionalized graphene oxide that has been purified with 30 washes via centrifuge …

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Empirical Modeling Of Piping Along Mississippi River Levees In Southwestern Illinois, Rebecca F. Shields Jan 2015

Empirical Modeling Of Piping Along Mississippi River Levees In Southwestern Illinois, Rebecca F. Shields

Electronic Theses and Dissertations

No abstract provided.

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Speaking In Wild Tongues: The Borderlands Of Eudora Welty And Alice Walker, Sara Gabler Thomas Jan 2015

Speaking In Wild Tongues: The Borderlands Of Eudora Welty And Alice Walker, Sara Gabler Thomas

Electronic Theses and Dissertations

In Borderlands/La Frontera Gloria Anzaldúa describes her experience undergoing a dental procedure as a battle between her wild tongue and the dentist. Beginning with a discussion of Anzaldúa’s concept of the wild tongue, this project asks how writers across the US South depict unruly tongues and infelicitous speech. Methodologically, this thesis inverts the comreading model in literary studies of reading Third World writers through First World theorists. Instead, beginning with Anzaldúa, I propose to reverse this process and assert a new reading methodology of reading First World writers through Third World theorists. The trope of the wild tongue will mobilize …

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Is This Fire, Gregory Sherl Jan 2015

Is This Fire, Gregory Sherl

Electronic Theses and Dissertations

Is This Fire is a collection of poems dealing with the themes of faith and loss. In one section, "The Third Testament," parts of the Bible have been reimagined. There are poems about Joan of Arc, as well as poems that touch on miscarriages, as well as the Columbine massacre. There are, of course, also love poems.

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Evaluation Of Novel Ligands For Opioid Receptors, Amer Hussien Tarawneh Jan 2015

Evaluation Of Novel Ligands For Opioid Receptors, Amer Hussien Tarawneh

Electronic Theses and Dissertations

No abstract provided.

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Design, Synthesis And Cannabinoid Receptor Activity Of Benzofuran Ligands, Eric William Bow Jan 2015

Design, Synthesis And Cannabinoid Receptor Activity Of Benzofuran Ligands, Eric William Bow

Electronic Theses and Dissertations

The endocannabinoid system is a complex homeostatic signaling system controlled through the actions of two g-protein coupled receptors, cannabinoid receptor 1 (cb1) and cannabinoid receptor 2 (cb2). Significant neuronal expression and distribution of cb1 throughout the brain establishes its function as a major synaptic signaling receptor, and in regards to the actions of cannabis sativa, it is the primary mediator of the psychotropic effects of marijuana. Conversely, cb2 expression is confined to microglial cells in the brain and predominantly peripheral immune cells. The expression of cb2 provides a pharmacological basis for the well-documented immunomodulatory effects of cannabis, providing a potential …

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Biomolecular Folding Rates As Understood From Single-Reaction-Coordinate Langevin Dynamics And Kramers’ Theory, Md Adnan Kabir Jan 2015

Biomolecular Folding Rates As Understood From Single-Reaction-Coordinate Langevin Dynamics And Kramers’ Theory, Md Adnan Kabir

Electronic Theses and Dissertations

Langevin dynamics was used to model the folding and unfolding of simple, hairpin-like biomolecules whose ends are attached to laser-trapped beads, as occurs in optical tweezers experiments. The Langevin process was evolved numerically, using parameters motivated by real experimental systems. Folding trajectories were generated and analyzed to extract the folding rate as a function of the force applied to the beads. The observed rate was compared to the analytical predictions of Kramers' theory. Strong discrepancies were noted. The failure of the Kramers' theory was attributed to the slow dynamical response of the beads, which it does not account for. The …

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The Dead Rise The Dead And Walk Among The Living: An Examination Of The Haunting South, Queerness, And Grotesqueries In Truman Capote's "Other Voices, Other Rooms" And "Local Color", Jordan Alexis Savage Jan 2015

The Dead Rise The Dead And Walk Among The Living: An Examination Of The Haunting South, Queerness, And Grotesqueries In Truman Capote's "Other Voices, Other Rooms" And "Local Color", Jordan Alexis Savage

Electronic Theses and Dissertations

This project is conceptualized through a multitude of intersecting and overlapping theories that work together to allow an examination of circulations and intersections of queerness, grotesqueries, and the haunting South. Throughout this reading of Truman Capote’s Other Voices, Other Rooms and Local Color I want to think through the ways in which images and moments in the text can be queer and grotesque while also lending themselves to the images and eruptions that make up the haunting South. My reading of grotesqueries and the haunting South purposefully moves away from the Southern Gothic, rooting itself instead in a space that …

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Novel Delivery Systems For Iron Replenishment, Naresh Modepalli Jan 2015

Novel Delivery Systems For Iron Replenishment, Naresh Modepalli

Electronic Theses and Dissertations

Iron is an integral part of hemoglobin and essential for the production of red blood cells. Iron deficiency and the resulting anemia are major nutritional deficiency disorders. The majority of patient populations suffering from iron deficiency anemia (IDA) are women of child bearing age and children of all ages. Iron deficiency is a complication of various other chronic conditions. Oral iron salts or colloidal parenteral iron formulations are treatment options for iron replenishment since several decades, but they are associated with severe side effects along with other patient noncompliance issues. Transdermal delivery of iron could be a potential alternative to …

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Mississippi Asl Project, James Corey Blount Jan 2015

Mississippi Asl Project, James Corey Blount

Electronic Theses and Dissertations

American Sign Language (ASL) is a manual language used by many deaf people in the United States and Canada. For much of its existence, ASL was believed to be a system of rudimentary gestures and signs based on the English language. However, studies that analyzed the linguistic properties of this signed ‘mode’ (Stokoe, 1960) legitimized that it was a language independent of spoken language, with its own system of principles and elements to construct meaningful utterances. Like any language, ASL is influenced by the social demographics of its users. Social demographics such as ethnicity, geographic location, age, gender, and socioeconomic …

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Windows Into Changing Worldviews: A Critical Cartographic Analysis Of Four Influential World Maps From The 13th To The 21st Century, Elizabeth E. Wicks Jan 2015

Windows Into Changing Worldviews: A Critical Cartographic Analysis Of Four Influential World Maps From The 13th To The 21st Century, Elizabeth E. Wicks

Honors Theses

It is an inherent part of human nature to seek knowledge of the world around us. As knowledge of the world grew, so did the need for its visual representation — thus came the introduction of the map into society. The map is a technology that allows us to see an expansive view of the world around us and to understand our own place in the world. In the past, displaying a full view of the world was more of a challenge — many regions remained unexplored or undiscovered. The mapmaker was given the task of representing both known and …

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Spatial Variation Of Bacterial Communities On The Leaves Of Southern Magnolia Trees, Heather L. Valdin Jan 2015

Spatial Variation Of Bacterial Communities On The Leaves Of Southern Magnolia Trees, Heather L. Valdin

Honors Theses

Bacteria are found in almost all environments on earth, including on the surface of other living things. Bacteria that exist on the leaves of plants (the phyllosphere) are of interest because of the potentially harsh nature of the environment they inhabit, and of applied interest. Although there has been a substantial amount of research in phyllosphere microbiology, few studies have examined the effect of spatial variation on phyllosphere community composition. This project investigated the effect of spatial variation on the bacterial communities living on the surface of Magnolia grandiflora leaves. Following DNA extraction, next generation sequencing of 16S rRNA gene …

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A Visualization Tool For Survey Responses And A Unifying Interface Redesign, Iva Cramer Jan 2015

A Visualization Tool For Survey Responses And A Unifying Interface Redesign, Iva Cramer

Honors Theses

As an intern for financial software company FNC, Inc. during the summer of 2014, my fellow interns and I began an innovation project for creating and analyzing surveys for better client feedback methods. I have continued this project even after the internship, and this thesis covers that continuation: the visualization of survey responses and the redesign of the page on which they are contained. The project detailed here was to revamp the survey statistics page with a coherent layout that matches the rest of the site in addition to overhauling the actual graphs and charts for aesthetic and accuracy.

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Ramped Soapbox, Alyssa Marie Radtke Jan 2015

Ramped Soapbox, Alyssa Marie Radtke

Honors Theses

This is a collection of mostly autobiographical disability poetry.

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The Effect Of A Neurotoxic Dose Of Methamphetamine On Attention And Response Learning In The Rat, Anja Kremer Jan 2015

The Effect Of A Neurotoxic Dose Of Methamphetamine On Attention And Response Learning In The Rat, Anja Kremer

Honors Theses

High doses of methamphetamine (neurotoxic doses) have been shown to have an effect on both attention and response learning. In previous literature, meth rats were found to have higher reaction times, and therefore, it has been concluded that meth may cause a deficit in response learning. Our study, using modal initiation time as a measure of response learning, found no effects of methamphetamine or training condition on mode. Studies have also shown positively skewed reaction time distributions, which have been defined as attentional lapses. Our experiment used DevMode to measure these lapses. Although meth did not, training condition did have …

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Secondary Metabolites Isolated From Perovskia Atriplicifolia And Their In Vitro Binding Affinity For Human Opioid And Cannabinoid Receptors, Ashli Fitzpatrick Jan 2015

Secondary Metabolites Isolated From Perovskia Atriplicifolia And Their In Vitro Binding Affinity For Human Opioid And Cannabinoid Receptors, Ashli Fitzpatrick

Honors Theses

Plants and their natural products have been utilized for thousands of years in the treatment of many human diseases. Because of their structural diversity, natural products are ideal lead compounds for drug development. In this thesis, the natural products of the plant Perovskia atriplicifolia were investigated, specifically their in vitro binding affinity to receptors in opioid and cannabinoid classes. Extracts that demonstrated good selective opioid and cannabinoid receptor binding were subjected to bioassay-guided fractionation. Four active compounds were identified from the crude extract in Perovskia atriplicifolia: 1) 5-hydroxy-3',4',6,7-tetramethoxy flavone, 2) 5,7-dihydroxy-3',4',6,-trimethoxy flavone, 3) 5-hydroxy-4',6,7-trimethoxy flavone, and 4) 5,7-dihydroxy-4',6,-dimethoxy flavone. Each …

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Marketing For Entrepreneurs: How To Promote One's Own Craft, Teresa Hendrix Jan 2015

Marketing For Entrepreneurs: How To Promote One's Own Craft, Teresa Hendrix

Honors Theses

This thesis seeks to serve as an alternative, cost efficient resource to those creative entrepreneurial ventures with a product (or service) that needs both people to consume it and a profit eventually sufficient to support its creators. By excluding excess details unrelated to promotion, and supplementing with specific, anecdotal advice directly from interviews with successful small business owners, this thesis aims to provide a plethora of marketing techniques that an entrepreneur can test before facing the daunting cost of an agency. Based on an extensive bibliography of primary and secondary sources*, this thesis explores three common components that manifest themselves …

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Exploration Of Cannabinoid And Opioid Agents From Plants Used In Traditional Medicine, John Fitzpatrick Jan 2015

Exploration Of Cannabinoid And Opioid Agents From Plants Used In Traditional Medicine, John Fitzpatrick

Honors Theses

Ten plants, with known medicinal uses, were gathered to study for their possible production of secondary metabolites that act as opioid and cannabinoid agents. All plants were subjected to in vitro bioassays testing for their affinity for the opioid and cannabinoid receptors. Banisteriopsis caapi extracts displayed the greatest affinity for both opioid and cannabinoid receptors. B. caapi extracts underwent column fractionation yielding fractions that were subjected to further in vitro studies. We discovered that the ethanolic extract of this plant (foliage) binds to all three opioid receptors (µ, κ and δ) and cannabinoid receptors (CB1 and CB2) with values ranging …

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Societal Dysfunction: The Floundering Policies Of Rehabilitation And Incarceration For Non-Violent Alcohol And Drug Offenders In The United States Of America, Josh Horton Jan 2015

Societal Dysfunction: The Floundering Policies Of Rehabilitation And Incarceration For Non-Violent Alcohol And Drug Offenders In The United States Of America, Josh Horton

Honors Theses

No abstract provided.

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X-Dimer Mutations And Their Effects On The Folding Stability And Assembly Of Ecad12 At The K14-D138 Interface, Martha Kaitlyn Coghlan Jan 2015

X-Dimer Mutations And Their Effects On The Folding Stability And Assembly Of Ecad12 At The K14-D138 Interface, Martha Kaitlyn Coghlan

Honors Theses

Classical cadherins were first identified by their function in mediating calcium-dependent cellular adhesion and constitute a large family of cellular adhesion receptor proteins whose differential binding is central to the development and maintenance of tissue architecture. The interface underlying the binding interaction reveals that all classical cadherins share a common adhesive interface in which the portion of the β-A strand closest to the N-terminus is swapped between EC1 domains of the adhesive partner protomers. A second dimeric configuration, known as the 'X-dimer', is the face-to-face association of two protomers in which their orientation is dictated by three symmetrical noncovalent interactions …

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In Vino Veritas: A Comparison Of Organic Winemaking And Attitudes Towards Organic Wine In Four Global Regions, Mary Sloan Merkel Jan 2015

In Vino Veritas: A Comparison Of Organic Winemaking And Attitudes Towards Organic Wine In Four Global Regions, Mary Sloan Merkel

Honors Theses

Organic winemaking is a very high value adding activity for the economy, but the industry has seen different levels of growth throughout the world. It is unclear whether organic winemaking is a viable long-term activity in prominent winemaking regions. This thesis looks at the regulations dealing with organic winemaking and attitudes towards organic wine in four major wine producing areas in the world: the United States, Italy, Argentina, and New Zealand. This thesis uses an extensive literature review of existing studies and papers dealing with organic wine, as well as government regulations and private standards to determine the current practices …

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Honestly, Woman, You Call Yourself Our Mother?: Mothers And Witches In Harry Potter, Mary-Eileen Rankin Rankin Jan 2015

Honestly, Woman, You Call Yourself Our Mother?: Mothers And Witches In Harry Potter, Mary-Eileen Rankin Rankin

Honors Theses

This thesis aims to analyze the importance of maternal nurture and the witches as mothers trope in the Harry Potter series. This nurture is traditional as well as perverse and appears in characters besides the adult women. Rowling creates characters who appeal to paradigms of the Early Modern bad mother witch who harmed children among other accusations associated with female sexuality and motherhood. Additionally, Rowling challenges the negative stereotype of associating witches and bad mothering by presenting witches as good mothers. The power of maternal nurture in the series is best seen through the good mothers. This theme plays such …

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Understanding The Implications Of Climate Change For Birds Of The Family Phasianidae: Incorporating Fleshy Structures Into Models Of Heat Dissipation Capacity, Megan L. Smith Jan 2015

Understanding The Implications Of Climate Change For Birds Of The Family Phasianidae: Incorporating Fleshy Structures Into Models Of Heat Dissipation Capacity, Megan L. Smith

Honors Theses

Though widespread acceptance of global warming has generated a plethora of studies evaluating the potential responses of species to increased temperatures, until recently, species and genus-specific studies were not common and for many taxa such studies have yet to be completed. One particularly understudied group in this regard is the avian order Galliformes. In this study, I focus on the tribe Phasianidae. Furthermore, most studies evaluating the potential range changes of species in response to a changing climate fail to account for the ability of organisms to adapt to the changing climatic conditions, either via plastic adaptations or genetic adaptations. …

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