Digital Commons Network^™

Underground Blast Fragmentation Modeling For Use In The Mine-To-Mill Strategy, Lauren Shields

Theses and Dissertations--Mining Engineering

More than 40 years ago, the mine-to-mill concept was introduced in the mining industry by establishing a relationship or link between processing and mining activities. To date, many successful case studies have documented the evident benefits of the mine-to-mill approach. In most cases, the basis of the mine-to-mill approach is to tailor the details of a blast design and its proper execution in order to satisfy specific mineral processing requirements downstream. Most of the available literature and case studies deal with surface mine operations. Due to the relative simplicity of surface mining, the relationship between the powder factor, defined as …

Strategic Nutritional Interventions With Probiotics And Their Relationship To Performance, Feeding Behavior, And Reticulorumen Environment In Cows And Calves Under Subacute Ruminal Acidosis Risk, Gustavo Mazon Correa Alves

Theses and Dissertations--Animal and Food Sciences

Subacute ruminal acidosis (SARA) is a digestive disorder in ruminants characterized by extended periods of low reticulorumen pH. This digestive disorder is commonly observed in ruminants fed diets with elevated proportions of non-fibrous carbohydrates. This disorder has been vastly studied in adult dairy cattle and has been associated with losses in milk production, changes in feeding behavior, damage to the gastrointestinal tract, and premature culling. Although vastly studied in adult cattle, there is limited research on the effects of SARA in calves. SARA might be prevented by modifying the reticulorumen environment with probiotic supplements containing lactateutilizing bacteria such as Megasphaera …

Identifying Public Perceptions Towards Precision Dairy Technology Use, Brad Kelly

Theses and Dissertations--Animal and Food Sciences

To remain sustainable, the dairy industry must demonstrate commitment to addressing concerns from the public, such as sustainability and animal welfare. Precision dairy technologies (PDT) are a potential solution to ameliorate this issue, but public perceptions towards PDT are currently underinvestigated. This thesis aims to describe public perceptions towards PDT. Specifically, the objectives are to 1) describe baseline perceptions of the U.S. public towards PDT, 2) determine the effects of framing information about human-animal bond, data transparency, and animal welfare on PDT perceptions, and 3) evaluate how demographic characteristics mediate these perceptions. An online survey was used to measure baseline …

Navigating Success In Higher Education: Generative Ai, Financial Well-Being, And Parental Support, Tanya Gardner

Theses and Dissertations--Public Policy and Administration

Postsecondary education is viewed as a sure path to economic mobility. This dissertation contains three essays which examine correlates of postsecondary value. Postsecondary students face a variety of stressors throughout their college career which may impact their ability to be successful. They must complete their coursework and pass their classes while balancing work, social, and familial obligations. Tools such as generative AI may help students achieve their goals even in the face of personal challenges such as low financial stability or the inability to afford the high costs of college. Together these essays add to the body of literature which …

Essays On The Dynamics Of Subnational Public Finance In Indonesia, Much Rosidi

Theses and Dissertations--Public Policy and Administration

This dissertation comprises three essays that collectively explore the intricacies of subnational public finance in Indonesia: vehicle tax amnesty, property tax competition, and corruption. The research aims to understand the dynamics shaping fiscal policies at the subnational level.

In the first essay, I examine vehicle tax amnesty programs in Indonesia that have been very popular in dealing with high delinquency rates. From 2008 to 2020, provincial amnesties occurred every 2.5 years on average. Using the variation in the timing of the province’s amnesty adoptions, I estimate the effect of vehicle tax amnesty on vehicle tax revenue using difference-in-differences. The short-run …

Relationships Between Local Revenue And Expenditure Policies And Urban Housing Markets, Lucas Taulbee

Theses and Dissertations--Public Policy and Administration

This dissertation consists of three essays on urban/local public finance, specifically residential property tax assessment and the provision of local public services. A general theme of the essays is the interplay between local financial policies and housing markets. Both revenue (tax) and expenditure policies can have significant effects on housing prices which can, in turn, have feedback effects on current and future revenues and expenditures. In the first chapter, Assessment Regressivity and Capitalization of Property Taxes, I consider assessment regressivity, the phenomenon in which higher-priced homes tend to be underassessed while lower priced homes tend to be overassessed. This may …

Essays On Public And Nonprofit Financial Dynamics, Yunjun Kim

Theses and Dissertations--Public Policy and Administration

This dissertation consists of three essays that explore different dimensions of financial dynamics in the public and nonprofit sectors. Each chapter examines how the fiscal behavior of neighboring jurisdictions, policy interventions, and financial practices influence fiscal decision-making and financial performance within these entities.

In the first essay, I investigate yardstick competition in local government spending in South Korea by leveraging the exogenous variation introduced by by-elections. This approach allows me to estimate the influence of neighboring jurisdictions on local expenditures. Contrary to previous empirical studies from other countries, my findings reveal no significant interdependence in spending among South Korean municipalities, …

How Black Undergraduate Students Experience Whiteness In Postsecondary Education, Karen Margaret Guettler-James

Theses and Dissertations--Educational, School, and Counseling Psychology

Critical whiteness scholars have described whiteness as a system of oppression that privileges White identities above others and perpetuates White supremacy. On the college campus, institutional, social, and historical norms reinforce the educational status quo and work together to maintain a system of whiteness that marginalizes Black students. This study investigated perceptions of whiteness held by student participants who self-identify as Black undergraduate students. Through focus group interviews, participants were asked to share their lived experiences with whiteness on the college campus. With the words of the participants, I reveal how campus standards that align with White Eurocentric norms devalue …

The Value Of Descriptive, Multi-Level Rubrics, Thomas R. Guskey, Mctighe Jay, Susan M. Brookhart

Educational, School, and Counseling Psychology Faculty Publications

Single-point rubrics have become popular in schools, but they may be leading teachers astray.

Look Beyond The Satisfaction Survey: A Framework To Evaluate Results Of Professional Learning., Thomas R. Guskey

Educational, School, and Counseling Psychology Faculty Publications

Professional Learning evaluations consider five crucial levels of data to determine effects on teachers' instructional practices and student learning outcomes.

Exploring The Therapeutic Relationship In Mental Health Therapy With Queer And Disabled Adults, Rachel Womack

Theses and Dissertations--Social Work

Queerness and disability have been shown to be intimately connected, with members of the LGBTQIA+ community significantly more likely to identify as disabled compared to the general population. Though there are roughly 3-5 million queer and disabled individuals living in the United States, this remains a multiply marginalized and understudied population. Owing partially to stigma, minority stress, and discrimination, these individuals face an increased risk of a variety of mental health problems including depression, anxiety, self-harm, PTSD, and suicidality. Additionally, several barriers to mental health treatment exist, including inaccessible services, lack of provider knowledge, and outright discrimination from providers. Though …

Fowl Play And Lame Ducks: How A Three-Headed Circuit Split Confuses Century-Old Migratory Bird Protections, Omer Arain

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Predicting Motorcycle Crash Injury Severity In Utah: Utilizing Machine Learning Methods, Isaac Baah, Milan Zlatkovic, Mohamed M. Ahmed

Kentucky Transportation Center Presentations

No abstract provided.

Accurate Knowledge Of Roadway Horizontal And Vertical Alignment Is Essential, Bekir Bartin, Mojibulrahman Jami, Kaan Ozbay

Kentucky Transportation Center Presentations

No abstract provided.

Three Essays On Environmental Risk And Policy, Samuel Owens

Theses and Dissertations--Public Policy and Administration

This dissertation comprises three essays that investigate different facets of environmental hazards and their implications for policy and governance. While each essay examines a different topic area, they are all linked by examining how entities respond to incentives at the intersection of environmental risk and public policy. Each chapter informs a distinct literature within environmental policy and utilizes different methodologies to examine largely unexplored research questions.

In the first essay, I examine how individuals respond to the low-visibility, long-term environmental risk presented by radon. I employ radon zone data from the Kentucky Geological Survey and home information from Zillow to …

Policy Brief, Zachary Owen

Libraries Award for Undergraduate Scholarship

The US grapples with a housing crisis, exacerbated in part by a shortage of conventional mortgage loans. Data from 2020 reveals a severe racial disparity, with 27.1% of Black mortgage applicants denied compared to only 13.6% of White mortgage applicants. These denial trends are highly correlated with homeownership rates. Current trends in homeownership by race mirror or exceed those present during the discriminatory practices of the 1960s. Lenders often cite low credit scores and high debt-to-income ratios as grounds for denial. Therefore, proposed solutions include mandating the inclusion of rental payment history in credit scores, offering free homebuying education, and …

Astrocyte Ca2+ In The Dorsal Striatum Suppresses Neuronal Activity To Oppose Cue-Induced Reinstatement Of Cocaine Seeking, Navid S. Tavakoli, Samantha G. Malone, Tanner L. Anderson, Ryson E. Neeley, Artin Asadipooya, Michael T. Bardo, Pavel I. Ortinski

Psychology Faculty Publications

Recent literature supports a prominent role for astrocytes in regulation of drug-seeking behaviors. The dorsal striatum, specifically, is known to play a role in reward processing with neuronal activity that can be influenced by astrocyte Ca2+. However, the manner in which Ca2+ in dorsal striatum astrocytes impacts neuronal signaling after exposure to self-administered cocaine remains unclear. We addressed this question following over-expression of the Ca2+ extrusion pump, hPMCA2w/b, in dorsal striatum astrocytes and the Ca2+ indicator, GCaMP6f, in dorsal striatum neurons of rats that were trained to self-administer cocaine. Following extinction of cocaine-seeking behavior, the rats over-expressing hMPCA2w/b showed a …

Elucidating The Role Of Fatty Acid Synthase In Apc-Driven Colorectal Cancer, Courtney O. Kelson

Theses and Dissertations--Toxicology and Cancer Biology

Globally, colorectal cancer (CRC) is the second leading cause of cancer related deaths. Currently, there is a growing incidence rate for individuals aged 20-49 years. Genetic and environmental factors contribute to the risk of this cancer. Early detection of CRC allows for the most effective treatment option in which surgical resection of the primary tumor occurs along with adjuvant chemotherapy. This therapeutic approach contributes to 5-year survival rate of 91%. However, surgical procedures and chemotherapy struggles against metastatic and relapsed CRC resulting in 5-year survival rate of 14%. Inefficacious treatments for relapsed and metastatic diseases emphasizes the need for more …

Southeastern Law Librarian Winter 2024, Seaall

Newsletters

No abstract provided.

Co-Authorship Maps To Support Leadership Selection, Robert Hc Chen

Research Analytics Summit 2024

VOSViewer co-authorship mapping is a powerful tool typically used for analyzing research collaboration. Users provide publication data and VOSViewer produces a map where authors are plotted on a 2-dimensional map based on how often they are in the author lists of the same publication.

In this presentation, I propose a series of tweaks to the input data that can leverage co-authorship maps to support leadership selection based on how often candidates co-author papers with their institutional peers and some of the attributes of these papers. I will suggest how best to interpret the resulting maps and address the major assumptions …

Project Final Report Watershed Center Of Excellence, Kentucky Water Resources Research Institute

KWRRI Research Reports

With the goal of providing a structured foundational background for watershed management to Kentucky’s watershed coordinators and other water quality professionals, the Kentucky Water Resources Research Institute developed the Kentucky Watershed Academy, a six-module series of core training content. The modules address the following subject areas:

• Module 1: The Clean Water Act & Related Water Quality Laws

• Module 2: Water Quality Basics

• Module 3: Dealing with Data

• Module 4: Land Use Impacts & Related Best Management Practices

• Module 5: Likely Partners

• Module 6: Effective Communications

As a result of this project, a total of …

Maximizing Mining Operations: Unlocking The Crucial Role Of Intelligent Fleet Management Systems In Surface Mining’S Value Chain, Arman Hazrathosseini, Ali Moradi Afrapoli

Earth and Environmental Sciences Faculty Publications

On the one side, the operational expenses of mining enterprises are showing an upward trend; and on the other side, conventional mining fleet management systems (FMSs) are falling short in addressing the high-dimensionality, stochasticity, and autonomy needed in increasingly complex operations. These major drivers for change have convinced researchers to search for alternatives including artificial-intelligence-enabled algorithms recommended by Mining 4.0. The present study endeavors to scrutinize this transition from a business management point of view. In other words, a literature review is carried out to gain insight into the evolutionary trajectory of mining FMSs and the need for intelligent algorithms. …

Elucidation Of Mismatch Repair Regulation By Abl1: Advantages/Disadvantages Of Tyrosine Kinase Inhibitor Treatment, Hannah Daniels

Theses and Dissertations--Toxicology and Cancer Biology

DNA mismatch repair (MMR) is a critical repair process necessary for not only repairing mispairs incorporated into the DNA during replication, but also for inducing apoptosis in response to certain types of DNA damage. MMR is required for maintaining genomic integrity and due to the importance of this pathway, any impairment of its function can lead to increased mutation frequency, which is well known to be a driving force of cancer development, progression, and resistance. Despite extensive studies involving the proteins involved in the MMR pathway, the regulation of those proteins remains relatively unknown. Regulation of MLH1, a protein necessary …

Acquired Treatment Resistance In Prostate Cancer Via The Production Of Radiation Derived Extracellular Vesicles Containing Mitochondrial Proteins, Caitlin Miller

Theses and Dissertations--Toxicology and Cancer Biology

Radiation treatment (RT) is one of the most commonly administered treatments for prostate cancer (PCa) patients, yet the recurrence of tumors after RT remains one of the significant challenges in the eradication of PCa. In addition to induction of DNA damage, ROS production, and cell death, we found that RT promotes Extracellular vesicle (EV) production in PCa cells, at least in part, through H₂O₂ production (Miller CE et al., Antioxidants 2022, PMID 36358489). Since we observed EV production upon RT, EVs and their contents could play a role(s) in cancer survival after RT. By using flow cytometry …

Understanding The Mechanism Of Ferroptosis Susceptibility Variation In Colorectal Cancer, Aziza Alshahrani

Theses and Dissertations--Toxicology and Cancer Biology

Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Despite the use of chemotherapeutic agents, CRCs remains to be difficult to cure at least partially due to their intrinsic and/or acquired resistance to cell death inducers. Ferroptosis is a form of regulated cell death that caused by the accumulation of lipid peroxides. Studies have shown that dysregulation of ferroptotic pathways is associated with the development of resistance to various cancer treatment. Glutathione peroxidase 4 (GPX4) is a known target for inducing ferroptosis due to its critical role in detoxifying lipid hydroperoxides, and ferroptosis suppressor protein (FSP1) also …

Porcupine’S Role In The Enhancement Of Enzalutamide Efficacy In Drug Resistant Prostate Cancer, Katelyn Jones

Theses and Dissertations--Toxicology and Cancer Biology

Androgen receptor (AR) signaling continues to participate as a vital component of castration-resistant prostate cancer (CRPC). Subsequently, this has led to the development of Androgen Signaling Inhibitors (ASI), specifically Enzalutamide (ENZ), which is a direct inhibitor of AR, to clinically manage CRPC. Inevitably, ENZ treatment only provides improvement for approximately two months before advancing to an incurable form, ENZ-resistant CRPC. With PCa ranking as the second leading cause of cancer-related deaths in USA males, there is an urgency and necessity for the discovery and development of novel therapeutic approaches for CRPC. Wnt signaling has been extensively documented in its involvement …

Therapeutic Approaches And Novel Mechansims In Cancer Progression, Kendall Simpson

Theses and Dissertations--Toxicology and Cancer Biology

Prostate cancer (PCa) remains the most diagnosed cancer among men in the United States. There are various therapeutic routes that are implored to combat this fatal disease, and our work aims to increase the options made available to PCa patients. A combination treatment of Enzalutamide (Enz), an FDA approved drug for castration-resistant PCa patients, and Metformin, an FDA approved drug for type 2 diabetes, was utilized to enhance the efficacy of Enz in Enz-resistant PCa, both in vitro and in vivo. Thymic Lymphoma is one of the most common malignancies that can occur in various tissues and organs. Genomic stability …

Delineating Contributions Of Genotype And Lineage To Lung Cancer Therapy Response, Kassandra Jo Naughton

Theses and Dissertations--Toxicology and Cancer Biology

Non-small cell lung cancer (NSCLC) heterogeneity is a major challenge for determining effective treatment strategies. Adenocarcinomas (ADCs) and squamous cell carcinomas (SCCs) are histologically and epigenetically distinct subtypes of NSCLC. Patients with ADC tumors harboring mutations in both KRAS and LKB1 (aka STK11) have lower survival rates than those with KRAS-only tumors. KRAS/LKB1 tumors are not only aggressive, but also respond poorly to immunotherapy. However, these data are limited to ADCs, and it is unclear if SCCs with this genotype are also resistant to immunotherapy. We developed a mouse model of Kras^mut/Lkb1^mut capable of producing …

Rps6kb1 Is A Critical Target For Overcoming Tumor Lineage Plasticity And Therapy Resistance, Saptadwipa Ganguly

Theses and Dissertations--Toxicology and Cancer Biology

Most tumors initially respond to treatment, yet refractory clones subsequently develop owing to resistance mechanisms which can be classified as intrinsic or extrinsic resistance. The intrinsic resistance is usually present prior to any treatment whereas the extrinsic resistance develops as a result of exposure to some kind of therapy. In order to target these “therapy resistant” tumor cells an unbiased screen of an FDA-approved drug library against cancer cells was performed. This was followed by synthesis of chemical analogs of the most effective drug.

The studies led to the identification of a derivative of the antihistamine drug ebastine, designated Super-ebastine …

Generating Climate Resilience Or Intensifying Vulnerabilities? A Feminist Poltitical Ecology Analysis Of Climate Resilient Agriculutre Projects In Sri Lanka’S Dry Zone, Nethmi Sachithma Perera Bathige

Theses and Dissertations--Geography

Conserving water for irrigation of crops has become a concern in the dry zone of Sri Lanka due to changes in climate patterns. In response, the United Nations Development Program (UNDP) has developed climate-resilient water management projects designed to build climate-resilience and water management practices among farmers. One such program called ‘Wew Gam Pubuduwa’ disseminates climate smart home gardening techniques, where women farmers receive sprinkler and drip irrigation systems, seeds and fertilizers, as well as training on water management methods. This study draws on a feminist political ecology framework to analyze the experiences of women home gardeners who …