Digital Commons Network^™

Multi-Jurisdictional Hazard Mitigation Plan For Landslides For The Big Sandy Area Development District, Kentucky, Matt M. Crawford, Hudson J. Koch, Jason M. Dortch

Contract Reports--KGS

Landslides are a complex geologic hazard that occurs worldwide, impacting lives, infrastructure, and property. The Big Sandy Area Development District, Kentucky incurs high landslide activity impacting several municipalities. This hazard mitigation planning project includes landslide susceptibility and risk assessments for the Big Sandy Area Development District. We based the landslide susceptibility model on statistics of hillslope morphological features such as slope, curvature, roughness, aspect, and elevation. Using a dual machine learning approach, we modeled the probability of landslide occurrence, defined as an area that is occupied, or might be occupied in the future, by a landslide. We also developed the …

Aggravated Ulcerative Colitis Via Circnlgn-Mediated Suppression Of Nuclear Actin Polymerization., William W Du, Chi Zhou, Hui Yang, Shuoyang Wen, Yu Chen, Eric X Chen, Xiuwei H. Yang, Feiya Li, Kevin Y Du, Hui Yuan, Ting Ye, Javeria Qadir, Burton B Yang

Pharmacology and Nutritional Sciences Faculty Publications

Colitis is a chronic bowel disease characterized by damage to the lining of the large intestine, with its precise underlying causes remaining incompletely understood. In this study, we provide evidence that circular RNA circNlgn plays a pivotal role in promoting the development of colitis. Colitis patients produce significant higher levels of circNlgn. Transgenic mice expressing circNlgn exhibit heightened susceptibility to colitis development and progression, primarily attributed to the presence of the protein isoform Nlgn173 encoded by circNlgn. Nlgn173 undergoes translocation into cell nuclei, where it interacts with actin, impeding the binding of actin-related protein 2 and 3 (Arp2/3) complex to …

Artificial Intelligence And The Practice Of Law Part 2: Working With Your New Ai Staff Attorney, Michael D. Murray

Law Faculty Popular Media

No abstract provided.

Digital Footprints: Freedom On The Move At The University Of Kentucky, Vanessa Holden, Reinette F. Jones, Jennifer A. Bartlett, Kopana Terry

Library Presentations

During the late 18th through the mid-19th centuries, the Commonwealth of Kentucky saw significant movement of self-emancipated people seeking freedom from bondage. Often referred to as “runaways” or “fugitive slaves,” in historical texts, self-emancipated people defined freedom in many ways. These migrations were widely documented in newspaper advertisements known as fugitive slave advertisements and runaway ads in local newspapers published throughout the state. Access to these materials (often buried in databases or on microform) has been problematic at best. Enter the Self Emancipated and Enslaved People in Kentucky (SEEK) Project, a partnership between faculty in the University of Kentucky Libraries …

A Breast Cancer Stem Active Cobalt(Iii)-Cyclam Complex Containing Flufenamic Acid With Immunogenic Potential, Jiaxin Fang, Owamagbe N. Orobator, Chibuzor Ngozi Olelewe, Ginevra Passeri, Kuldip Singh, Samuel G. Awuah, Kogularamanan Suntharalingam

Chemistry Faculty Publications

The cytotoxic and immunogenic-activating properties of a cobalt(III)-cyclam complex bearing the non-steroidal anti-inflammatory drug, flufenamic acid is reported within the context of anti-cancer stem cell (CSC) drug discovery. The cobalt(III)-cyclam complex 1 displays sub-micromolar potency towards breast CSCs grown in monolayers, 24-fold and 31-fold greater than salinomycin (an established anti-breast CSC agent) and cisplatin (an anticancer metallopharmaceutical), respectively. Strikingly, the cobalt(III)-cyclam complex 1 is 69-fold and 50-fold more potent than salinomycin and cisplatin towards three-dimensionally cultured breast CSC mammospheres. Mechanistic studies reveal that 1 induces DNA damage, inhibits cyclooxygenase-2 expression, and prompts caspase-dependent apoptosis. Breast CSCs treated with 1 exhibit …

Design And Optimization Of High-Efficiency Coreless Pcb Stator Axial Flux Pm Machines With Minimal Eddy And Circulating Current Losses, Yaser Chulaee, Greg Heins, Ben Robinson, Ali Mohammadi, Mark Thiele, Dean Patterson, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper proposes a systematic multi-step design procedure for highly efficient printed circuit board (PCB) stator coreless axial flux permanent magnet (AFPM) machines with minimal eddy and circulating current losses. The process begins with initial sizing, providing specific coefficients based on experience with multiple design projects. It continues with the optimization of the machine envelope design using an evolutionary algorithm and computationally efficient 3D finite element analysis (FEA) models. The subsequent step focuses on the detailed design of a PCB stator, aiming to minimize eddy and circulating current losses. Several open circuit loss mitigation techniques are proposed based on analytical …

An Exploration Of Affective Influences Of Mediation And Instructional Delivery Styles In The U.S. Adult Media Literacy Learning Context, Joe Huber

Theses and Dissertations--Communication

This dissertation explores how varied delivery strategies may influence college student affective learning in a mediated setting. I employed a hybrid-grounded approach to the exploration of student-participant interviews wherein student-participants engaged with one of two online media literacy learning modules. The results of this study illustrate that students at varying points of their epistemological development (Perry, 1968) may face different affective hurdles depending on how media literacy curriculum is presented. We may anticipate that: (1) students who are less epistemologically developed (those featuring dualistic attitudes) may struggle to receive content, especially in the case where a teacher-centric delivery-style is employed; …

"Spreading Inoculation": The Effects Of Direct And Indirect Inoculation And Postinoculation Talk (Pit) On Graduate Students' Sense Of Belonging And Social Network Development During Socialization, Amanda Ruth Slone

Theses and Dissertations--Communication

During their first semester in graduate school, graduate students, many of whom are also employees of the university (BLS, 2019), encounter multiple challenges to successful socialization (Council of Graduate Schools, 2010; Weidman et al., 2001) —several of which are related to their sense of belonging (O’Meara et al., 2017; Pascale, 2018) — and if left unaddressed, these challenges can contribute to high attrition rates (Cassuto, 2013; Gardner & Barker, 2020), with one in four graduate students typically failing to graduate within ten years, even under favorable circumstances (Baum & Steele, 2017). Since the best time to influence an individual’s sense …

The Effects Of Controlling Language And Source Social Group Membership On Resistance To Persuasion, Zane A. Dayton

Theses and Dissertations--Communication

Persuasive attempts often fail. One theory that attempts to explain when and why people resist persuasion is psychological reactance theory (PRT; J. W. Brehm, 1966; S. S. Brehm & J. W. Brehm, 1981). According to the theory, people have an inherent desire to maintain their autonomy, or freedom. When they perceive that a persuasive message threatens their freedom, they experience psychological reactance, an aversive motivational state, which motivates them to restore their freedom by resisting the persuasive message. Whereas past studies have demonstrated that various message features (e.g., controlling language) and source characteristics (e.g., social group membership) can, individually, influence …

Examining The Effects Of Restorative Narratives On Prosocial Behavioral Intentions: A Sem Analysis, Mehroz Sajjad

Theses and Dissertations--Communication

Society grapples with an array of intricate and intertwined social challenges, often characterized as wicked problems due to their multifaceted, persistent nature. The refugee crisis and food insecurity stand as poignant examples of these complex issues, with millions affected worldwide. In response to these challenges, there is a pressing need for individuals to engage in prosocial behaviors, aiming to alleviate the impacts of these crises.Against this backdrop, this dissertation delved into the realm of narrative persuasion to examine the effectiveness of restorative narratives and framing strategies as potential drivers of greater behavioral intentions. To address the hypotheses and research question, …

Breaking The Silence: A Mixed Methods Study On Opioid Education, Overdose Risks, And Treatment Education Among College Students, Anita Silwal

Theses and Dissertations--Communication

The opioid crisis is a national public health emergency in the United States. Opioid education, naloxone training, and medication for opioid use disorder treatment (MOUD) are evidence-based practices to mitigate opioid overdose. The opioid crisis is affecting people of all ages, including college students. Research indicates the gap in research among college students on how they perceive this public health emergency and how it is affecting them; thus, this dissertation aims to address the gap by examining college students' knowledge, attitude, and behavioral intentions toward opioid education, naloxone training, and referral to MOUD to those struggling with opioid addiction. The …

Characterizing The Relationship Between The Presence Of Depression Risk, Post-Traumatic Stress Disorder, And Benzodiazepine Use To Get High, Julia Kollitz

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Aim: To determine if there is a relationship between depression risk, post-traumatic stress disorder (PTSD), and engaging in benzodiazepine misuse.

Methods: A secondary cross-sectional analysis was conducted on data from a sample of people who use drugs (n=743). Depression risk was assessed via the Center for Epidemiological Studies-Depression scale. Meeting DSM-IV criteria for PTSD was identified using the Mini International Neuropsychiatric Interview (MINI). We used simple and multivariable logistic regression models to estimate the association between mental health factors of interest and benzodiazepine misuse, defined as self-reported benzodiazepine use “to get high” in the past six months.

Results: Of the …

A Case Study In Program Evaluation: A Prospective Program Evaluation Of Timely Reporting And Action Of An Infectious Disease Outbreak, Destiny Cozart

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Methicillin-resistant Staphylococcus aureus also known as MRSA is an infection of a staph bacteria. High school athletes are at risk of contracting MRSA through skin to skin contact and/or MRSA contaminated equipment. This case study uses the CDC's six-step framework for program evaluation to measure the effectiveness of the online training modules designed to increase the knowledge of staff and stakeholders about MRSA and infectious disease outbreaks. The findings from this evaluation will advise the potential change(s) implemented in training modules, ultimately to enhance competency for decision makers and prevent MRSA and infectious disease outbreak amongst high school athletic programs.

Prevalence Of Hpv16 E6 Antibodies And Oral Hpv Among Men Living In Kentucky, Christopher O. Otieno

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

ABSTRACT

Objective: The incidence of human papillomavirus-driven oropharyngeal cancer (HPV-OPC) is surging in the United States, particularly in the southeast and Appalachia. The reason for this increase is unknown. We evaluated the prevalence of two markers of increased risk, HPV16 E6 antibodies and oral HPV infection, among men in Appalachian and non-Appalachian Kentucky.

Methods: This study was nested within an ongoing HPV-OPC screening study of healthy men aged 45+ residing in urban (non-Appalachian) and rural (Appalachian) Kentucky and included the first 1,581 participants with either HPV serologic and/or oral HPV testing. Blood and oral rinse samples were collected at enrollment. …

Dental Outreach In Academic Dental Settings, Tisha Clayborn

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Creating an effective outreach program in a dental academic setting involves a strategic approach combining educational objectives and community service. This Dental Outreach Program Guide aligns with organizational objectives, contributes to community well-being, and serves as a model for future outreach initiatives in academic dental settings. This program utilizes the PRECEDE-PROCEED planning model to design and evaluate an oral health strategy. This program aims to outline a strategic plan incorporating evidence-based decision-making, data-driven metrics, and a comprehensive roadmap for successful implementation.

Fall 2023 Covid-19, Influenza, And Respiratory Syncytial Virus Vaccine Uptake In Kentucky, Abigail Dial

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Fall 2023 COVID-19, Influenza, and Respiratory Syncytial Virus Vaccine Uptake in Kentucky

Background: In the fall of 2023, vaccine recommendations included updated COVID-19 and influenza vaccines, as well as a new vaccine and immunization for respiratory syncytial virus (RSV). Vaccine co-administration, the administration of more than one vaccine in one vaccination session, is safe and effective for COVID-19, influenza, and RSV vaccines and can improve vaccine uptake for all recommended vaccines (Bonanni, et al., 2023; CDC, 2023). The COVID-19 pandemic altered the landscape for locations where people receive vaccinations, and it may be beneficial to public health to have …

Decoding The Tapestry Of Road Safety: A Comprehensive Exploration Of Safety Restraints, Seat Positions, And Collision Type Interactions Using Traditional And Random Parameter Modeling, Muthumari Anbumani, Srinivas S. Pulugurtha

Kentucky Transportation Center Presentations

No abstract provided.

Pipeline For Fast Digital Twin Development And Integration In Driving Simulation, Zhanqian Wu, Luying Zhang, Jaime Hernandez, Chase Leibowitz, Helen Loeb, Xiaoxia Dong, Erick Guerra, Rahul Mangharam

Kentucky Transportation Center Presentations

The use of digital mapping with precise GPS coordinates has allowed intelligent navigation, which is now ubiquitous in vehicles. The flat 2D imagery provided by Google maps was recently enhanced by the introduction of dynamic 3D representations of the Earth. Unity3D and Unreal Games Engines now offer Application Programming Interfaces that can be leveraged for geospatial applications. This technology, which offers visually compelling results for flight simulation and drone applications, opens new opportunities for driving simulation.This paper presents an innovative approach for developing a drivable Digital Twin of Philadelphia’s Roosevelt Boulevard to enhance urban planning and traffic management using advanced …

Leveraging Technology For Safer Roads For Vulnerable Road Users In South Africa, Ntombifuthi Ngobeni, Busisiwe Marole, Koketso Bosilong, Hlulani Nkuna

Kentucky Transportation Center Presentations

This research aims to enhance road safety, particularly for Vulnerable Road Users (VRUs) such as pedestrians and cyclists, through the use of both cutting-edge technologies and consideration of conventional engineering methods and solutions. The study focuses on innovative solutions related to the road environment and their impact on VRU safety, piloted at selected sites in South Africa. The research investigates the use of technologies such as video cameras, video analysis software, artificial intelligence and machine learning to conduct route risk assessments. These assessments inform the selection and implementation of effective safety measures tailored to enhance VRU safety. By understanding the …

Considerations And Applications Of Environmental Dna In Biodiversity Studies, Sarah Tomke

Theses and Dissertations--Forestry and Natural Resources

Environmental DNA (eDNA) sampling—the detection of species through genetic material shed into the environment—has become an efficient and reliable method for biodiversity assessments. The method has grown in popularity due to its non-invasive and non-destructive nature, and has revolutionized monitoring efforts for rare, elusive, and cryptic species for which traditional sampling approaches are often costly and ineffective. Hundreds of studies have utilized this technique to study species occupancy, delineate distributions, and assess relative community composition. Although eDNA sampling is an effective strategy for many conservation and ecological studies, recently, light has been shed on some of its potential drawbacks and …

Africa’S Overlooked Top Predator: Towards A Better Understanding Of Martial Eagle Feeding Ecology In The Maasai Mara, Kenya, Richard Stratton Hatfield, Allison G. Davis, Ralph Buij, John J. Cox, Shiv Kapila, Lemein Parmuntoro, Simon Thomsett, Munir Z. Virani, Peter Njoroge, Frank Van Langevelde

Forestry and Natural Resources Faculty Publications

Raptors exert top-down influences on ecosystems via their effects on prey population dynamics and community composition. Most raptors are sympatric with other predators, thus complicating our understanding of their relative influence in these systems. Estimates of kill rates and prey biomass recycling have been used as predation metrics that allow quantitative comparison among species and assessment of the relative role of single species within complex food webs. Few studies have produced findings of kill rates or prey biomass recycling for raptors. We used a supervised machine learning algorithm to behaviourally classify high resolution accelerometer informed GPS locations of tagged adult …

Investigating The Use Of Serious Games For Cancer Control Among Children And Adolescents: Scoping Review, Sunghak Kim, Ebling Library, Olufunmilola Abraham

Pharmacy Practice and Science Faculty Publications

Background: Effective health care services that meet the diverse needs of children and adolescents with cancer are required to alleviate their physical, psychological, and social challenges and improve their quality of life. Previous studies showed that serious games help promote people’s health. However, the potential for serious games to be used for successful cancer control for children and adolescents has received less attention.

Objective: This scoping review aimed to map the use of serious games in cancer prevention and cancer care for children and adolescents, and provide future directions for serious games’ development and implementation within the context of cancer …

Biodegradable Nanoparticles Targeting Circulating Immune Cells Reduce Central And Peripheral Sensitization To Alleviate Neuropathic Pain Following Spinal Cord Injury., Michael N. Saunders, Kate V. Griffin, Irina Kalashnikova, Daniel Kolpek, Dominique R. Smith, Eiji Saito, Brian J. Cummings, Aileen J. Anderson, Lonnie D. Shea, Jonghyuck Park

Pharmaceutical Sciences Faculty Publications

Neuropathic pain is a critical source of comorbidity following spinal cord injury (SCI) that can be exacerbated by immune-mediated pathologies in the central and peripheral nervous systems. In this article, we investigate whether drug-free, biodegradable, poly(lactide- co -glycolide) (PLG) nanoparticle treatment mitigates the development of post-SCI neuropathic pain in female mice. Our results show that acute treatment with PLG nanoparticles following thoracic SCI significantly reduces tactile and cold hypersensitivity scores in a durable fashion. Nanoparticles primarily reduce peripheral immune-mediated mechanisms of neuropathic pain, including neuropathic pain-associated gene transcript frequency, transient receptor potential ankyrin 1 nociceptor expression, and MCP-1 (CCL2) chemokine …

13 C-Stable Isotope Resolved Metabolomics Uncovers Dynamic Biochemical Landscape Of Gut Microbiome-Host Organ Communications In Mice, Xia Xiao, Yixuan Zhou, Xinwei Li, Jing Jin, Jerika Durham, Zifan Ye, Yipeng Wang, Bernhard Hennig, Pan Deng

Animal and Food Sciences Faculty Publications

ackground Gut microbiome metabolites are important modulators of host health and disease. However, the overall metabolic potential of the gut microbiome and interactions with the host organs have been underexplored. Results Using stable isotope resolved metabolomics (SIRM) in mice orally gavaged with 13 C-inulin (a tracer), we first observed dynamic enrichment of 13 C-metabolites in cecum contents in the amino acids and short-chain fatty acid metabolism pathways. 13 C labeled metabolites were subsequently profiled comparatively in plasma, liver, brain, and skeletal muscle collected at 6, 12, and 24 h after the tracer administration. Organ-specific and time-dependent 13 C metabolite enrichments …

A Cooperative Study Assessing The Effects Of A Second Iron Injection Administered Before Weaning On Growth Performance, Hematological Status, And Tissue Mineral Concentrations Of Nursery Pigs*, Tyler Chevalier, O. Adeola, S. D. Carter, C. R. Dove, M. J. Estienne, C. L. Levesque, C. V. Maxwell, T. Tsai, Merlin D. Lindemann

Animal and Food Sciences Faculty Publications

Objective: A study involving 7 experiment stations evaluated the effects of a second iron injection administered before weaning on growth and hematological measures of pigs.

Materials and Methods: Pigs (n = 514) were given an iron injection (100–200 mg) on the first day of life. Piglets were then allotted to pairs of similar-weight, samesex siblings 3 to 5 d before weaning (on d 18–24) with one piglet from each pair receiving a second iron injection. All pigs received common station-specific postweaning diets. Data were subjected to ANOVA with the model containing the terms treatment, station, pair within station, and treatment …

Industrial Hemp Production And Potential Risks In Kentucky, Hoyeon Jeong

Theses and Dissertations--Agricultural Economics

Since the Agricultural Improvement Act of 2014 and 2018 legalized Industrial Hemp (Cannabis Sativa. L), interest in grain, fiber, and floral hemp production has seen growing pains. As an emerging crop, there is a research gap in the impact of weather and agronomic conditions on hemp production including THC (Delta 9 Tetrahydrocannabinol) and pollen drift as risks in hemp cultivation. The first essay aims to measure the impact of weather and agronomic factors on hemp grain, fiber, and floral yields in Kentucky using a yield-weather model with information on field locations. The results show that heat conditions during the growing …

Generating Functions For The Cd-Indices Of Simplices And Cubes, Richard Ehrenborg

Mathematics Faculty Publications

Inspired by the grammatical calculus of William Chen, we derive an expression for the exponential generating function for the cd-indices of the n-dimensional simplices and the n-dimensional cubes. This expression for simplices differs from a similar expression obtained by Stanley.

Catalan–Spitzer Permutations, Richard Ehrenborg, Gábor Hetyei, Margaret Readdy

Mathematics Faculty Publications

We study two classes of permutations intimately related to the visual proof of Spitzer’s lemma and Huq’s generalization of the Chung–Feller theorem. Both classes of permutations are counted by the Fuss– Catalan numbers. The study of one class leads to a generalization of results of Flajolet from continued fractions to continuants. The study of the other class leads to the discovery of a restricted variant of the Foata–Strehl group action.

Equivariant Resolutions Over Veronese Rings, Ayah Almousa, Michael Perlman, Alexandra Pevzner, Victor Reiner, Keller Vandebogert

Mathematics Faculty Publications

Working in a polynomial ring (Formula presented.), where (Formula presented.) is an arbitrary commutative ring with 1, we consider the (Formula presented.) th Veronese subalgebras (Formula presented.), as well as natural (Formula presented.) -submodules (Formula presented.) inside (Formula presented.). We develop and use characteristic-free theory of Schur functors associated to ribbon skew diagrams as a tool to construct simple (Formula presented.) -equivariant minimal free (Formula presented.) -resolutions for the quotient ring (Formula presented.) and for these modules (Formula presented.). These also lead to elegant descriptions of (Formula presented.) for all (Formula presented.) and (Formula presented.) for any pair of these …

Safety Evaluation Of 2+1 Roadway Design, Kenneth R. Agent, Jeff Jasper

Kentucky Transportation Center Research Report

An assessment and analysis of the safety of 2+1 roads introduced in 2013 and later.