Digital Commons Network^™

The Rhetoric Of Responsibilization: A Rhetorical Analysis Of Pre-Exposure Prophylaxis Campaigns For Hiv Prevention, Catherine M. Pabalate

Kentucky Undergraduate Journal for the Health Humanities

Responsibilization refers to the process by which patients are made accountable for their health and wellbeing, which is determined by their habits and behaviors. Though responsibilization affords greater agency to patients, it can also result in anxiety and guilt when the patient appears "deviant" or "noncompliant." Because sexual behavior is attributed to the causality of HIV/AIDS, patients’ sexual patterns and choices are included within their medical decision-making. This rhetorical analysis focuses on pharmaceutical campaigns and commercials for pre-exposure prophylaxis (PrEP), which were released between 2012 and 2024 and are targeted towards patients at-risk for HIV/AIDS. Findings suggest that specific rhetorical …

You Are Here: Defining Our Hidden Born-Digital Backlog, Andrew Mcdonnell

Library Presentations

The digital archivist position was created at the University of Kentucky two years ago to help create and refine workflows and process born-digital collections in our manuscripts and university archives collections. While much of the initial work of these last two years was on newly acquired collections and materials, in the decades prior, a variety of born-digital materials on physical media had been gathered in hybrid collections and stored and described in myriad ways. This presentation will demonstrate my processes for discovering and assessing unmigrated born-digital materials on physical media hidden throughout our collection. The process is built on documentation …

Association Of Fentanyl Test Strip Results And Change In Drug Use Behaviors, Kitty H Gelberg, Nabila El-Bassel, Denise C Babineau, Rachel A Vickers-Smith, Laura C Fanucchi, Janet E Childerhose, Megan E Hall, Megan E Dzurec, Jennifer Villani, Mary R Russo, Patricia Lebaron, Katherine R Marks, Kathyrn E Lancaster, Louisa Gilbert, James L David, Barry S Eggleston, Carter A Roeber, Emmanuel A Oga, Redonna K Chandler, Sharon L Walsh

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: The Stay Safe Study, conducted between May and December 2023 in the United States, investigated the association between fentanyl test strip (FTS) use and risk reduction behaviors. This paper examines the association between self-reported FTS results and change in drug use behaviors.

METHODS: We solicited self-reported drug and FTS use among people who use drugs (PWUD), with a baseline and four weekly surveys over a 28-day observation period in three states (Kentucky, New York and Ohio). For each day participants reported drug use, they were asked types of drugs used, use of FTS, FTS results, and 12 drug use …

Green Synthesis Of Ultrathin Ws2 Nanosheets For Efficient Hydrogen Evolution Reaction, Nadeesha L. Kothalawala, Nipun Chandrasiri, Manisha De Alwis Goonatilleke, Keerthan R. Rao, Sujan Shrestha, Udari S. Kodithuwakku, Irene Y. Kim, Chad Risko, Ambrose Seo, Beth S. Guiton, Fuqian Yang, Doo Young Kim

Chemistry Faculty Publications

Transition metal dichalcogenide (TMD) nanostructures have emerged as promising electrocatalysts for the hydrogen evolution reaction (HER) as there is an increasing demand for cost-effective and sustainable hydrogen production. Despite significant progress, there is still a critical need for developing facile and green methods for synthesizing ultrathin TMD nanostructures. In this study, we introduce a green, top-down synthesis method to produce highly exfoliated WS₂ nanosheets. The process combines the ultrasonication of bulk WS₂ in a binary water-ethanol solvent with a solvothermal treatment. The resulting ultrathin WS₂ nanosheets exhibit clean surfaces free of surface ligands and impurities, high crystallinity …

How To Gender Include, Stephen Krueger

Library Faculty and Staff Publications

Gender inclusion is not an optional part of library work—at least, it isn’t if we want all those “Libraries Are For Everyone” signs to be true. And yet, the reality is that many libraries fail the most basic aspects of gender inclusion for patrons, employees, or both. Even in libraries where Trans 101 trainings do occur and are well received, or where the baseline of knowledge among employees is relatively high, the question remains: What now?

This article intends to answer that question. Very broadly speaking, gender inclusion work in libraries means sustained action to ensure that some patrons and …

From Disruption To Recovery: Charter School Performance During And After The Covid-19 Pandemic, Adam Kho, Shelby Smith, Ron Zimmer

Public Policy and Administration Faculty Publications

In recent decades, an increasing number of students have pursued alternative educational options, including charter schools, as school choice has continued to expand. This trend was accelerated by the COVID-19 pandemic. While it is well established that students experienced widespread learning loss during the pandemic, it remains unclear whether the extent of that loss or the pace of recovery has differed between charter and traditional public schools (TPS). In the current study, we examine the effects of Tennessee charter schools on student achievement during and after the pandemic. Using student-level data from 2017-18 to 2022-23, we estimate the charter school …

A Single-Blind, Randomized, Controlled Contingency Management Trial On Physiological Indices And Biomarkers Of Cardiovascular Health In People With Cocaine Use Disorder, William W. Stoops, Thomas P. Shellenberg, Sean D. Regnier, David H. Cox, Reuben Adatorwovor, Lon R. Hays, Danielle M. Anderson, Joshua A. Lile, Joy M. Schmitz, Jennifer R. Havens, Travis R. Sexton, Mary B. Fisher

Epidemiology and Environmental Health Faculty Publications

Introduction: Limited prospective research has evaluated the health benefits associated with changing levels of drug use, aside from complete abstinence. This study determined whether lower levels of cocaine use impacted physiological indices (e.g., mean arterial pressure) and biomarkers (e.g., stromal cell derived factor-1a [SDF-1a], soluble intercellular adhesion molecule-1 [ICAM-1], neutrophil activating peptide-2 [CXCL7]) of cardiovascular health. Methods: Treatment seeking participants enrolled in a 12-week single-blind, randomized, controlled cocaine contingency management trial. Participants were randomly assigned to High Value Reinforcers for cocaine abstinence (n = 41), Low Value Reinforcers for cocaine abstinence (n = 33) or a non-contingent Control group (n …

Variation In The Potentially Inappropriate Use Of Antipsychotic And Benzodiazepine Medications Among Individuals Receiving Residential Medication Management Reviews, Mouna J. Sawan, Alexander J. Clough, Jodie Hillen, Andrew R. Zullo, Daniela C. Moga, Natalie Soulsby, Danijela Gnjidic

Epidemiology and Environmental Health Faculty Publications

Objectives To describe the variation in the use of potentially inappropriate antipsychotic and benzodiazepine medications in residents who have received a medication review and to evaluate the extent to which this variation is associated with aged care home (ACH) and resident characteristics. Methods This cross-sectional, retrospective study used pharmacist-extracted data from 15,442 residents across 342 Australian ACHs who had a medication review during 2019. The proportion of residents receiving ≥1 potentially inappropriate antipsychotic and benzodiazepine medication according to Beers criteria were classified into quintiles by facility usage (Q1-Q5). Quintile characteristics were compared using descriptive analysis of facility and resident data. …

Comparison Of The Association Between Covid-19 And New Onset Diabetes In A Regional And National Dataset, Mary E. Lacy, Aaron P. Smith, Lindsey R. Hammerslag, Kory R. Heier, James Aaron, Alicia Fields, John L. Fowlkes, Simon J. Fisher, Jeffery Talbert, Philip A. Kern

Epidemiology and Environmental Health Faculty Publications

Aims: This study examined new onset diabetes following COVID-19 infection in large datasets. Methods: A retrospective cohort study design was used in three distinct databases: data from a large academic medical center (University of Kentucky Healthcare, UKHC), claims data from privately insured patients in the Merative MarketScan (MarketScan) database, and a subset of the MarketScan database with lab tests. Control groups included patients from the prepandemic timeframe (prepandemic cohort), as well as COVID-era patients without documented COVID infection (COVID − cohort). Results: Incident diabetes in COVID infected patients was higher in all datasets. In the UKHC and MarketScan datasets, the …

Detecting Spatial Clusters Of Crimean Congo Hemorrhagic Fever In Iraq In 2023, Hanan Abdulghafoor Khaleel, Riyadh Abdulameer Alhilfi, Sabrina Brown

Epidemiology and Environmental Health Faculty Publications

Background: Since the start of the first large outbreak of Crimean Congo Hemorrhagic Fever (CCHF) in Iraq in 2022, there has been no assessment of clustering of cases by district. The aim of this study is to identify clusters of high and low incidences of human CCHF to guide preventive and control measures, and distribute limited resources. Methods: This is a cross-sectional study of reported and confirmed CCHF cases in Iraq from January 1, 2023 to December 11, 2023. We used a retrospective purely spatial Poisson scan statistic model to identify clusters of high and low incidences of CCHF at …

Wetland Treatment Systems For Municipal Wastewater At A Bourbon Distillery And Potential Value Of Incorporating Stillage For Water Treatment Enhancement, Katherine Ristola, Tiffany Messer, Czarena Crofcheck, Tyler Barzee, Wayne Sanderson

Epidemiology and Environmental Health Faculty Publications

The use of constructed treatment wetlands as a secondary treatment method for wastewater effluent from package treatment plants and distillery stillage has the potential to be an innovative, sustainable method for improving water quality. However, the use of constructed wetlands to treat bourbon whole stillage and a distillery bottling facility’s wastewater treatment plant effluent has been limited. Therefore, the objectives of this study were to (1) quantify constructed wetland water quality improvement as a secondary treatment method for a distillery’s municipal wastewater, (2) optimize treatment design to meet wastewater effluent discharge limits, and (3) quantify the potential to enhance constructed …

Thriving In The Tropics, Hansika K. Herath, D. Nicholas Mcletchie

Biology Faculty Publications

Increasing frequency and intensity of global warming pose a profound threat to plant species persistence. Most investigations on plants' resilience to heat events focus on few genotypes of model species. Novel insights into resilience mechanisms will be gained by focusing on natural variation in thermotolerance and its relationship to local-abiotic factors. Additionally, studying species that survived 'ancient periods' of high temperatures provides insight into resilience mechanisms. Within a species, we assessed spatial thermotolerance variation, its association with temperature and light, while testing for thermotolerance sex differences and its relationship with population sex ratios. We used Marchantia inflexa, a species with …

Development Of A Health And Wellness Assessment For Kytc Personnel, Gabriel Dadi, Farshid Taherpour, Caitlin Pope

Kentucky Transportation Center Research Report

Highway construction workers operate in high-stress, hazardous settings where they have to perform physically taxing labor in environments where exposure to variable weather conditions, heavy equipment, high volumes of vehicle traffic, and other conditions that induce stress and anxiety are the norm. Up to 70% of workers in this industry have reported experiencing mental health issues, including secondary traumatic stress, post-traumatic stress disorder, depression, anxiety, and substance abuse disorders. Few state departments of transportation, however, offer adequate resources staff can draw on to effectively manage their psychological well-being. To help Kentucky Transportation Cabinet (KYTC) roadway maintenance and construction workers develop …

Using Photovoice To Define “Community” In Substance Use Disorder Research Engaging Service Users, Providers, And Policymakers, Mcgladrey Margaret L, Marisa Booty, Ramona Olvera, Peter Balvanz, Hilary L. Surratt, Shannon Matthews, Susannah Stitzer, Owusua Yamoah, Sylvia Ellison, Kevin Campbell, Amy Farmer, Bethany Gealy, Mike Greenwell, Felicia Harris, Amy Kuntz, Sara Szelagowski, Alexandrea Shouse, Carrie B. Oser

Sociology Faculty Publications

(197 words)The ideals of community-engaged health research are challenging to realize ethically and methodologically, particularly when focused on substance use disorder (SUD), in which the power differentials inherent to stigma marginalize people with lived experience (LE) as full community participants. This study provides a typology and exploratory data generated through Photovoice to understand relationships among community members with different roles related to LE of SUD (i.e., SUD service providers, service users, and the public) in the context of a large-scale community-engaged opioid overdose reduction intervention. A team of 14 participants and researchers used an adapted thematic analysis method to interpret …

Aggregator Zone Selection For Ev Smart Controls Based-On Ml Clustering Of Grid Strength, Distance, And Charging Homogeneity, Rosemary E. Alden, Sam H. Lowe Ii, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Smart electric vehicle (EV) charging control methods from a central utility hub often require communication infrastructure over a large service area of electric power distribution systems with a large number of nodes. Industry standards such as Open Charge Point Protocol (OCPP) 2.1 have evolved to include topologies for local controllers to the individual chargers, i.e. EV aggregator zones. A machine learning (ML) application of k-means clustering is proposed to establish zones for coordination of EV charging based on grid strength and EV owner decision-making to charge per day. Very large-scale distribution networks including the IEEE 123 and 8500 benchmark feeders …

Cluster-Based Volt/Var Optimization On A Utility Distribution Feeder With Forecasted Ev Penetration, Steven B. Poore, Grant M. Fischer, Rosemary E. Alden, Evan S. Jones, Aron Patrick, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

With significant increase in EV adoption expected in the near future and the associated impacts on power systems, the effect of volt/var optimization (VVO) as the next step to conservation voltage reduction (CVR), requires reevaluation. Implementation of a cluster-based VVO control strategy employs a novel approach with machine learning (ML) load forecasting to reduce device adjustments through k-means clustering of contiguous time steps with similar active power load in which a single adjustment would be sufficient. The cluster-based VVO method is tested on a complex real world utility distribution feeder with 2,018 nodes, 8.65MW peak load, 9 capacitor banks (CBs), …

Hybrid Fea And Meta-Modeling For De Optimization Of A Pm Stator-Excited Motor With A Reluctance Rotor, Oluwaseun A. Badewa, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper presents an innovative method for designing high-performance electric motors by integrating machine learning (ML) based meta-modeling with a differential evolution (DE) optimization algorithm. The approach utilizes finite element analysis (FEA) data to train the ML meta-model, allowing for efficient optimization of high-power-density machines, such as the reluctance rotor and permanent magnet (PM) stator combined excitation motor, which is characterized by nonlinearities. The meta-modeling process employs an Artificial Neural Network (ANN) with 3 hidden layers and uses the motor’s geometrical variables as inputs. The accuracy of the meta-model in capturing the nonlinear relationships between design parameters, core losses, and …

Three And Two Phase Rotating Field Inductive Couplers For Wireless Power Transfer With One Phase Per Layer Windings, Donovin D. Lewis, Lucas Gastineau, Omer Onar, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Multiphase inductive wireless charging coils have been proposed recently to improve coupler surface power density, reduce component stress and size, and provide near-constant power delivery to charge mobile electric systems. Several aspects for the fundamental characterization of multiphase coils are explored up to six phases including approximate mutual inductance with size and turn variation, induced voltage, and output power estimation. The relative component stress and size of passive components for resonant operation are compared between the multiphase variants. A combination of an experimentally validated 3D electromagnetic finite element analysis (FEA) and power electronic co-simulations are used to validate the estimated …

Cryogenic Thermal System For Coreless Axial Flux Pm Machine With Litz Wire Winding For Electric Aircraft Propulsion, Matin Vatani, Chaianan Sailabada, Philippe Masson, Juan C. Ordonez, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Electric machines for aviation demand ultra-efficient, compact designs with high specific power density, which can be achieved through advancements in both electromagnetic design and thermal management. This paper proposes and investigates an integrated thermal management approach for a coreless stator axial flux permanent magnet (AFPM) machine featuring a double-sided Halbach array PM rotor, two stators, and an aluminum nitride (AlN) cold plate positioned between the stators for direct cooling. The cold plate incorporates internal serpentine channels for liquid hydrogen circulation. The electromagnetic performance and efficiency of the machine at cryogenic temperatures are assessed using temperature-dependent data from the literature, indicating …

Mitigation Of Pm Eddy Current Losses Using Offset Windings In Coreless Afpm Machines, Matin Vatani, Diego A. Lopez Guerrero, John F. Eastham, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Permanent magnet eddy current losses can become substantial in coreless stator axial flux permanent magnet (AFPM) machines operating at high speeds and under high electric loading, potentially leading to elevated temperatures and an increased risk of demagnetization. This paper investigates the origins of these losses through a detailed harmonic analysis of the winding factor and introduces a mitigation strategy. The proposed method utilizes two-layer offset windings, effectively minimizing undesirable armature flux harmonics through harmonic interaction between the offset layers. Two cases are studied: one in which each stator layer is connected to a separate inverter and another in which both …

Characterizing Risk And Protective Factors For Alzheimer's Disease And Related Dementias In American Samoa, Danielle Eakins, Jessica Williams-Nguyen, Nancy Schoenberg, Va'atausili Tofaeono

Anthropology Faculty Publications

No abstract provided.

Research Into Job Classifications For Kentucky Department Of Vehicle Regulation Employees, Mallory Brown, Andrew Martin, Jeeyen Koo, Jennifer Walton

Kentucky Transportation Center Research Report

The Kentucky Department of Vehicle Regulation (DVR) faces persistent challenges with employee recruitment, retention, and workforce alignment due to outdated job classifications and compensation structures. This study investigates if DVR’s reliance on the general Administrative Specialist job series is warranted given the duties performed by its staff. Through a job task analysis, financial modeling, and personnel data review, researchers assessed the feasibility of introducing a new DVR-specific job series based on the Vehicle Regulation Specialist (VRS) position currently being used by the Division of Motor Carriers. The proposed VRS series includes two levels — VRS I (Grade 13) and VRS …

Exploring The Impact Of Mitoquinone Supplementation On Glycan Profiles In A Repeated Mild Traumatic Brain Injury Mouse Model, Mona Goli, Akeem Sanni, Sakshi Gautam, Khalil Mallah, W. Brad Hubbard, Mohammad Reslan, Muhammad Ali Haidar, Karim Halabi, Joseph Walker, Stefania Mondello, Firas Kobeissy, Yehia Mechref

Physiology Faculty Publications

Traumatic brain injury (TBI) represents a significant cause of injury-related deaths and disabilities. Repeated exposure to mechanical impact can lead to metabolic and ionic imbalance, which can cause oxidative stress and worsen the cellular dysfunction initiated by the initial mild TBI (mTBI). Currently, no FDA-approved drug targets repeated mTBI (rmTBI) and its potential sequelae. Mitoquinone (MitoQ) is a mitochondrion-targeted drug that has proven beneficial in different brain-related diseases. We have previously demonstrated the neurotherapeutic effects of MitoQ at a 30-day chronic time point in a similar rmTBI mouse model, where we observed decreased neuroinflammation, enhanced behavioral outcomes, and diminished oxidation. …

From Gains To Liver Pain, Benjamin I. Burke, John J. Mccarthy, Ahmed Ismaeel

Physiology Faculty Publications

A recent study from Liu et al. described the role of skeletal muscle-derived extracellular vesicles in promoting liver fibrosis as an outcome of chronic overtraining in mice. Here, we highlight this work and discuss its implications within the fields of exercise physiology and inter-organ communication.

Current Intraoperative Mechanical Circulatory Support Strategies For Bilateral Lung Transplantation Surgery, Omar Toubat, Asad A. Usman, Paulo Gregorio, Max Shin, Audrey Spelde, Jacob Gutsche, Edward Cantu, Mauer Biscotti, Christian A. Bermudez

Surgery Faculty Publications

Objective: To discuss technical strategies and considerations to facilitate intraoperative extracorporeal membrane oxygenation (ECMO) management during lung transplantation. Methods: We review our institutional approach to the management of intraoperative ECMO during bilateral lung transplantation. Our proposed algorithm summarizes technical considerations based on the mechanical circulatory support (MCS) platform encountered in the operating room. Results: For patients without preoperative ECMO, an assessment of indications and available configurations in anticipation of the need for intraoperative ECMO is required. Our initial MCS approach for isolated respiratory failure is venovenous (VV) ECMO. If patients have pulmonary hypertension or right ventricular dysfunction with acceptable vascular …

Neurotensin Inhibits Ampk Activity And Concurrently Enhances Fabp1 Expression In Small Intestinal Epithelial Cells Associated With Obesity And Aging, Jing Li, Jun Song, Baoxiang Yan, Haoming Wu, Moumita Banerjee, Leif Magnuson, Yajuan Liu, Shulin Zhang, Jinpeng Liu, Chi Wang, Tianyan Gao, Jianhang Jia, Heidi L. Weiss, B. Mark Evers

Surgery Faculty Publications

We previously demonstrated that neurotensin, a 13-amino-acid gut hormone peptide, enhances small intestinal epithelial cell fatty acid uptake through inhibition of AMPK. Here, utilizing Drosophila and mouse models in vivo, as well as mouse and human small intestinal epithelial organoids or monolayers ex vivo, we determine the targets of neurotensin and AMPK associated with obesity and aging. High-fat diet and aging decreased AMPK and insulin signaling, which was prevented by neurotensin deficiency. High-fat diet feeding increased FABP1 protein expression in wild-type mice; this effect was attenuated in neurotensin-deficient mice. AICAR and metformin increased AMPK phosphorylation in young but not in …

Male Layer-Type Birds (Lohmann Brown Classic Hybrid) As A Meat Source For Chicken Pâtés, Nikolay Kolev, Desislav Balev, Stefan Dragoev, Teodora Popova, Evgeni Petkov, Krasimir Dimov, Surendranath Suman, Ana Paula Salim, Desislava Vlahova-Vangelova

Animal and Food Sciences Faculty Publications

The valorisation of underutilized male layer-type chickens offers a sustainable and ethically aligned opportunity for the poultry industry. This study evaluated the feasibility of male layer-type chicken meat in the production of chicken pâtés and compared the effects of different meat sources—commercial broiler (CP), and 5 (5wP) and 9-week-old (9wP) male layer-type chickens—on product quality during refrigerated storage using the general linear model with the Tukey–Kramer post-hoc test. Pâtés made from 5wP meat exhibited the most favourable technological properties, including the lowest (p < 0.05) total expressible fluid (TEF), highest (p < 0.05) water retention (TEF_Water), and lowest (p < 0.05) fat content (TEF_Fat) than CP and 9wP indicating superior emulsion stability. The 5wP …

Inferring The Timing Of Antiretroviral Therapy By Zero-Inflated Random Change Point Models Using Longitudinal Data Subject To Left-Censoring, Hongbin Zhang, Mckaylee Robertson, Sarah L. Braunstein, David B. Hanna, Uriel R. Felsen, Levi Waldron, Denis Nash

Biostatistics Faculty Publications

We propose a new random change point model that utilizes routinely recorded individual-level HIV viral load data to estimate the timing of antiretroviral therapy (ART) initiation in people living with HIV. The change point distribution is assumed to follow a zero-inflated exponential distribution for the longitudinal data, which is also subject to left-censoring, and the underlying data-generating mechanism is a nonlinear mixed-effects model. We extend the Stochastic EM (StEM) algorithm by combining a Gibbs sampler with a Metropolis–Hastings sampling. We apply the method to real HIV data to infer the timing of ART initiation since diagnosis. Additionally, we conduct simulation …

The Positive Association Of Physical Activity On Sadness And Suicide Behaviors For Youth Who Have Been Bullied, Katelon Kerns, Kahir Jawad, Yana Feygin, V. Faye Jones, W. David Lohr, Jennifer Le, Kiana Fields, Jennifer Porter, Sarah Ouellette, Theresa Kluthe, Deborah Winders Davis

Biostatistics Faculty Publications

Background: Youth mental health is a public health crisis. Bullying has been associated with adverse mental health outcomes including depression and suicidal ideation. We aimed to update information regarding the associations between bullying and sadness and three suicide-related outcomes, along with the potential moderating effect of physical activity (PA). Methods: Using the 2017–2021 Youth Risk Behavior Surveillance System (YRBSS) with students in grades 9–12 we used descriptive statistics, chi-square tests, and multivariable logistic regressions to examine the association between students who have been bullied and who reported feeling sad or hopeless, as well as considered, planned, and/or attempted suicide, within …

Late-Nc Stage 3, Ryan K. Shahidehpour, Yuriko Katsumata, Dennis W. Dickson, Nikhil B. Ghayal, Khine Zin Aung, Xian Wu, Panhavuth Phe, Gregory A. Jicha, Allison M. Neltner, Jessalin R.C. Archer, Maria M. Corrada, Claudia H. Kawas, S. Ahmad Sajjadi, Davis C. Woodworth, Syed A. Bukhari, Thomas J. Montine, David W. Fardo, Peter T. Nelson

Biostatistics Faculty Publications

A diagnostic rubric is required to distinguish between limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). In LATE-NC Stage 3, TDP-43 proteinopathy is present in the middle frontal gyrus (MFG), thus posing a potential diagnostic challenge in differentiating these severe LATE-NC cases from FTLD-TDP. LATE-NC Stage 3 cases and other TDP-43 proteinopathies were analyzed from the University of Kentucky (total n = 514 with TDP-43 pathology assessed), The 90+ Study at the University of California Irvine (n = 458), and the Mayo Clinic (n = 5067) brain banks. Digital pathology was used to …