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Soybean Meal Mitigates Vasoconstriction And Serotonin Suppression During Fescue Toxicosis In Beef Cattle, Luiz C.O. Sousa, Brittany E. Davis, David L. Harmon, Ronald J. Trotta

Animal and Food Sciences Faculty Publications

Legume supplementation has been shown to mitigate fescue toxicosis in beef cattle. However, no studies have directly compared the use of soybean-based feeds to alleviate symptoms of fescue toxicosis under controlled environmental heat and equalized feed intake. The objectives were to evaluate the effects of soybean hulls, whole soybeans, or soybean meal (SBM) supplementation on the mitigation of vasoconstriction, heat stress, and inflammatory responses in beef cattle during fescue toxicosis. Ten ruminally-cannulated Angus × Holstein steers were used in a 5 × 10 Latin rectangle design. Five treatments were evaluated: 1) non-toxic endophyte-infected tall fescue seed (NTE), 2) toxic endophyte-infected …

Stressful Life Events And Ocd Treatment: A Thematic Analysis Of Patient Perspectives, Emily E. Fenlon

Theses and Dissertations--Psychology

Trauma exposure, including interpersonal violence (IPV), is associated with increased risk and severity of obsessive-compulsive disorder (OCD). Exposure and response prevention (ERP) is the treatment of choice for OCD, yet research suggests a history of trauma and comorbid PTSD may adversely impact treatment outcomes. No studies have yet evaluated patient perspectives on the relationship between trauma, IPV and related sequelae and OCD treatment. The present study applies reflexive thematic analysis to interviews from individuals with a history of IPV who received exposure-based therapy for OCD. Interviews explored the influence of posttraumatic distress, impairment, and psychopathology on the treatment of OCD, …

Menstrual Cycle Phase Effects On Alcohol-Impaired Driving Performance And Risk Awareness, Annie K. Griffith

Theses and Dissertations--Psychology

Growing evidence indicates that risky behavior among women is elevated during the late follicular phase of the menstrual cycle, likely due to increased estradiol levels. Furthermore, alcohol-induced impairment of women’s inhibitory control is significantly greater during the late versus early follicular phase. Consequently, cycle phase may influence outcomes of poor inhibitory control while intoxicated, such as alcohol-impaired driving. Alcohol-impaired driving risk manifests in two ways: risk-taking while driving, and risk awareness regarding the decision to drive. This dissertation tested the hypothesis that alcohol-induced increases in driver risk-taking and decreases in risk awareness would be exacerbated during the late versus early …

Daily Rhythms In Psychosocial Stress, Sleep, And Mood: A Multimethod Approach To Transdiagnostic Psychopathology Risk And Intervention, Gabriel Gilmore

Theses and Dissertations--Psychology

Rhythms are central to nearly every core physiological and psychological process and have profound influences on overall health and well-being, particularly in the context of mood disorders. This dissertation emphasizes a rhythm-centered framework for understanding transdiagnostic psychopathology, proposing that the temporal organization of psychosocial stress, sleep, and mood provides crucial information for the development and treatment of mood disorder symptomology. Current literature relies primarily on mean symptom levels, overlooking day-to-day patterns in psychosocial experiences. To address this key methodological gap, three studies are examined. Study 1 develops and validates the Psychosocial Stress Regularity Measure (PSRM), a brief single-item measure of …

Relative Utility Governs Working Memory For Drug-Associated Stimuli In A Novel Translational Paradigm, Maxwell E. Boileau

Theses and Dissertations--Psychology

Substance use disorder (SUD) remains a prevalent health concern, partially characterized by continued drug use despite aversive consequences. Contrary to accounts emphasizing cognitive deficits, drug versus non-drug choice data reflect sensitivity to reinforcement dimensions, with preference shifting systematically as a function of magnitude and probability. The present study tested whether another cognitive system, working memory, is similarly affected by relative utility. Preclinical studies have demonstrated sensitivity of working memory to reinforcement dimensions, but these are often attributed to the differential outcomes effect. Generalized matching models were fit to allomorphic choice data, allowing estimation of exchange rate parameters. A concurrent solid- …

Working Memory In The Pigeon: An Alternative Paradigm, Daniel Peng

Theses and Dissertations--Psychology

One of the most widely used measures of working memory in non-human animals is the delayed matching to sample (DMTS) design. While this design can assess for duration of working memory, alternative accounts can be made to explain decrements in retention. In addition, DMTS does not assess capacity of working memory in terms of number of items able to be held. The works in this dissertation aims to design a paradigm to measure capacity of number of items held in memory for non-human animals by asking animals to make a specific response after presentation of a random spatial sequence. While …

The Relationship Between Estradiol And Progesterone Concentration Levels, Alcohol Consumption, And Inhibitory Control, Layne Elizabeth Robinson B.S.

Theses and Dissertations--Psychology

Alcohol use is increasing among women, with estimates for binge drinking having risen to levels similar to those seen in men. Despite this trend, sex differences regarding mechanisms of alcohol consumption have seldom been investigated. Our group and others have found evidence to suggest that ovarian sex hormones are associated with alcohol consumption and mechanisms that might be related to alcohol consumption, such as executive function deficits. The current study sought to extend this prior research in a larger sample with higher drinking rates and more rigorous methods, and to explore inhibitory control associations with drinking. Across the two samples …

Does Confronting Depend On The Target?: The Influence Of Target Gender On Intentions To Confront Sexism, Paige A. Taylor

Theses and Dissertations--Psychology

The Intergroup Sensitivity Effect (ISE) suggests criticism from outgroup members is evaluated more negatively than the same criticism coming from ingroup members. The current study used the ISE to evaluate sexism. Women (N = 400) read one of 8 blogposts where a man or woman author made hostile or benevolent comments about men or women. After reading the blogpost, participants evaluated the speaker and the post then reported intentions to confront and reporting the speaker for their prejudiced remarks. Results did not find support for the ISE. Instead, speaker evaluations were more positive when speakers were hostile targeting men. Hostile …

Next-Day Effects Of Binge Drinking On Inhibitory Control In Laboratory And Naturalistic Settings, Justin Verlinden

Theses and Dissertations--Psychology

Binge drinking occurs at an alarmingly high rate, despite its negative consequences on behavior, health, and cognition. One acute cognitive consequence of binge drinking is the impairment of inhibitory control, or the ability to stop oneself from engaging in maladaptive or inappropriate behaviors. Specifically, during a binge episode, individuals display impaired inhibitory control while completing Go/NoGo or Stop Signal Tasks (SST). This impairment has been shown to be maintained for up to five hours post-drinking, even as breath alcohol concentration (BrAC) approaches zero. Evidence also suggests that binge drinking results in next-day deficits in attention, memory, and psychomotor speed. However, …

Patient Perspectives Of Psychotherapy Duration And Treatment Outcomes, Doug Terrill

Theses and Dissertations--Psychology

The duration of psychotherapeutic treatment is a longstanding and clinically consequential question in psychotherapy research. Premature dropout from therapy is common, indicating some patients do not receive adequate benefit. On the other hand, some patients remain in treatment beyond the point at which they receive significant benefit, which may delay care for those on patient waitlists. Researchers have proposed two contemporary models of the relation between treatment duration and symptom improvement; 1) the dose-effect (DE) model, which posits that patients improve at similar rates following a negatively accelerated symptom curve, suggesting treatment should end when sessions no longer provide significant …

Effects Of Transcranial Direct Current Stimulation On Urge During Cue-Exposure To Body-Focused Repetitive Behaviors, Hannah Rebecca Wild

Theses and Dissertations--Psychology

Body-focused repetitive behaviors (BFRBs) are unnecessary, repetitive grooming behaviors linked to abnormalities in sensory and reward processing, as well as top-down inhibition. The left dorsolateral prefrontal cortex (dlPFC) is implicated in these processes and plays a key role in cravings among individuals facing addiction. Transcranial direct current stimulation (tDCS) targeting the left dlPFC shows promise in reducing craving for addictive substances. Despite phenomenological similarities between BFRBs and addictive disorders, no controlled studies have examined tDCS’s effect on BFRBs. This study used a randomized, double-blind design to examine whether a single session of anodal multifocal tDCS targeting the left dlPFC reduced …

Comparing Domain- And Facet-Based Models Of Personality Disorder: Incremental Predictive Validity And Model Fit, Alexandra Hines

Theses and Dissertations--Psychology

Personality disorders (PDs) have historically been conferred using a categorical diagnostic framework (i.e., present versus absent). However, recent research supports a transition toward dimensional models of PDs wherein personality traits are measured along a continuum. Some dimensional models contain personality domains only, whereas other models contain both personality domains and facets of each of those domains. The leading models of each type are the PD model in the eleventh edition of the International Classification of Diseases (ICD-11) and the Alternative Model of Personality Disorders (AMPD) in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), respectively. …

A Mixed Method Investigation On The Effects Of Information And Motivation On Self-Regulation Skills And Fruit And Vegetable Consumption, Kristen Buford

Theses and Dissertations--Psychology

Introduction: The purpose of this research study is to understand the interplay between health information and health motivation on eating behaviors in African American emerging adults. Greater knowledge of nutrition is linked to healthier eating outcomes, but the motivations that individuals possess about their ability to improve their health also play a pivotal role. However, the joint effect of such constructs (i.e., information and motivation) on eating behaviors is unknown. Emerging adults are still developing their capacities to exercise their health autonomy, and this developmental period represents an opportunity to intervene before the onset of age-related chronic diseases in middle …

Examining Marginalized Sexual Identity Development Through Perry’S Scheme Of Cognitive Development, Miranda Bejda

University of Kentucky Doctoral Dissertations

Existing models of LGBTQ+ sexual identity development are critiqued for their linearity and lack of inclusion for diverse experiences and sexual identities. There is a call for a more robust understanding of the cognitive aspect of sexual identity development. The purpose of this dissertation is to further the understanding of how people think about their sexual identity through the developmental process using Perry’s scheme of cognitive development as a framework. Through semi-structured interviews, I analyze the LGBTQ+ sexual identity development process (Stage 1), how Perry’s scheme applies to LGBTQ+ sexual identity development (Stage 2), and propose a Perry-informed model of …

Coexistence Between Ci And Feminization Inducing Symbionts: A Theoretical Perspective, Dylan Thorp

University of Kentucky Master's Theses

Endosymbiotic bacteria that manipulate the reproduction of their host are abundant in arthropods. Theoretical efforts to model these bacteria have seldom included symbionts that feminize their hosts, and those that do have assumed an environmental sex determination system. Here, I expand upon other theoretical works to model the dynamics of a host population with an XX/X0 sex determination system that contains separate CI and feminization inducing symbionts. I found that coexistence cannot occur without double infection, consistent with previous models. However, I also found that without double infection, the presence of the feminizing symbiont can facilitate the spread of the …

Development Of An Atmospheric Particle Imaging System (Apis), James W. Hebert

University of Kentucky Master's Theses

The study of atmospheric particulates plays a crucial role in both climate change studies and the improvement of hypersonic travel. The current issue at hand is a lack of knowledge of stratospheric particulate content and the high cost that is associated with conducting research at these altitudes. This project focuses on the development of an Atmospheric Particle Imaging System (APIS) to be a low-weight, low-cost optical payload. The goal is to make a device that can be mounted onto an uncrewed aerial system that has the capability of imaging particulates moving at steady flow velocities, and thereby characterize the individual …

Regulating Galaxy Growth: Ionized Gas Conditions, Star Formation Histories, And Environmental Effects, Shweta Jain

University of Kentucky Doctoral Dissertations

Understanding galaxy formation and evolution requires tracing how baryons cycle between stars, gas, and the interstellar medium (ISM) across cosmic time. The efficiency of star formation, the buildup of metals, and the regulation of gas inflows and outflows are governed by evolving physical conditions within galaxies and their environments. My thesis investigates how the ionized ISM, star formation histories, and environmental processes have shaped galaxy evolution over the past ∼ 12 Gyr. The primary focus of this work is the evolution of the physical conditions of ionized gas in galaxies, including gas-phase metallicity and ionization state. Using new and archival …

Numerical Modeling Of Multi-Scale Jet Feedback In Seyfert Galaxies, Julianne Goddard

Theses and Dissertations--Physics and Astronomy

We present a suite of high-resolution cosmological zoom-in simulations investigating the impact of mechanical and thermal feedback from low-luminosity jets launched from supermassive black holes (SMBHs) on Seyfert galaxy evolution from early cosmic times to the present (z ≤ 10). Our models follow the formation of central galaxies within identical dark matter halos of logMhalo/M⊙ ∼ 11.8 at z = 0, seeded with ∼ 10^6M⊙ SMBHs at z ∼ 9.1 and z ∼ 3.7. Feedback from active galactic nuclei (AGN) is implemented in the form of bipolar jets launched along the SMBH spin axis, with jet powers spanning Ljet ∼ …

Correlates Of Recovery Capital Among Women In Jails: Leveraging A Dimensional Recovery Framework, Amanda Fallin-Bennett, Martha Tillson, Jaxin Annett, Hartley Feld, Michele Staton

Nursing Faculty Publications

Background: Recovery capital encompasses internal and external factors that support recovery from substance use disorder, such as employment, social support, and physical and mental health. There is a need for more research on recovery capital among women who are incarcerated, who often face complex barriers to recovery, such as poverty, unemployment, and histories of trauma.

Methods: Women (N ¼ 900) were recruited from Kentucky jails as part of the broader NIDA-funded Kentucky Justice Community Opioid Innovation Network (JCOIN) cooperative project. Measures from baseline interviews (during incarceration) were selected in alignment with the Substance Abuse Mental Health Service Administration (SAMHSA)’s four …

“Being Treated As The Expert:” A Blueprint For A Community Advisory Board Approach To Elevate The Voice Of People With Living Experience With Substance Use In Academic Research, Trevor Moffitt, Survivors Union Of The Bluegrass, Bryson Henson, April M. Young, Sharon L. Walsh, Rachel Vickers-Smith, Junior Cruz, Jeremy Byard, Brook West, Amanda Fallin-Bennett

Nursing Faculty Publications

Introduction: Researchers have traditionally engaged Community Advisory Boards (CABs) to meaningfully involve community members in the research process. However, CABs are often formed only after a grant is funded, leading to criticisms of functioning merely as “ethical approvers.” For substance use researchers, the inclusion of people with living experience (PWLE; current experience with drug use) across all stages of research is especially important as they have historically been the experts in the needs of their community.   Methods: In response to this need for community engagement in research, the University of Kentucky, in partnership with a local recovery community center (RCC; …

Coalition Building And Citizen Science For Radon Risk Reduction, Stacy Stanifer, Kathy Rademacher, Whitney Sedio, Naomi Cheek, David Gross, Caitlyn Curtis, Amanda Thaxton-Wiggins, Mary Kay Rayens, Ellen J. Hahn

Nursing Faculty Publications

We evaluated the implementation of local coalitions led in partnership with citizen scientists, community-based organizations, and public libraries in four rural communities to lower exposure to radon in the home. The objectives were to (1) describe the Reach-Effectiveness-Adoption-Implementation-Maintenance (RE-AIM) of four radon coalitions, and (2) compare RE-AIM factors among citizen scientists who participated in the coalitions and those who did not. A larger community-engaged research project embedded coalition building using a citizen science approach. Three of the four coalitions focused on health and wellness more broadly (18–34 members); one focused solely on radon (10 members). Coalition membership and activities varied …

Evaluation Of A Tobacco Treatment Specialist Training Program Targeted To Behavioral Health Professionals, Chizimuzo T. C. Okoli, Sarret Seng, Bassema Abu Farsakh, Emily Koyagi, Heather Beck, Audrey Darville

Nursing Faculty Publications

Tobacco use remains disproportionately high among adults living with mental illnesses (MIs), contributing to excess morbidity and mortality, particularly in high-burden states such as Kentucky. Behavioral healthcare providers are well-positioned to address this disparity but often lack formal training in evidence-based tobacco treatment. Tobacco Treatment Specialist (TTS) training provides healthcare providers with skills to deliver evidence-based tobacco treatment; however, traditional TTS training models often rely on synchronous, in-person or live virtual formats, which may limit accessibility for some healthcare workforces. Asynchronous, web-based delivery models may reduce these barriers. This study evaluates a targeted, asynchronous TTS training program designed for providers …

Financial Status, Fatalism, And Self-Care Of Cardiovascular Disease Risk Factors Among Rural Adults Living In Socioeconomically Distressed Areas, Ashmita Thapa, Geunyeong Cha, Dustin Hodges, Jia-Rong Wu, Misook L. Chung, Martha J. Biddle, Jennifer L. Smith, Debra K. Moser

Nursing Faculty Publications

Purpose: Adults with fewer financial resources often have poor self-care. Rural dwellers commonly have fewer financial resources than urban dwellers and are often stereotyped as fatalistic about health. We examined whether fatalism mediates the association of financial status with cardiovascular disease (CVD) self-care in rural adults in economically distressed areas. We hypothesized that those with fewer financial resources would have poorer self-care, and fatalism would mediate this relationship.

Methods: We enrolled 1,122 adults (53 ± 15 years) at risk for CVD. Financial status was reflected by individuals’ perceptions of how well they made “ends meet” with their financial resources, fatalism …

Prevalence And Incidence Of Heart Failure Phenotypes Among Transgender And Gender-Diverse Adults In The United States, Ian K. Everitt, Emily K. Quinn, Meredith S. Duncan, Chris Grasso, Sari L. Reisner, Guneet K. Jasuja, Tonia Poteat, Ayelet Shapira-Daniels, Howard Cabral, Vin Tangpricha, Michael K. Paasche-Orlow, Emelia J. Benjamin, Monica Mukherjee, Carl G. Streed

Biostatistics Faculty Publications

BACKGROUND: Prevalent and incident heart failure (HF) and its comorbidities have not been characterized in transgender and gender-diverse (TGD) populations. This study determines the prevalence and incidence of HF phenotypes by gender identity. METHODS: A retrospective cohort analysis was performed using deidentified administrative claims from the Optum Labs Data Warehouse (2006-2022). TGD adults and a sample of demographically similar cisgender comparators were identified using a validated algorithm, and gender identity was categorized as cisgender man, cisgender woman, transmasculine, transfeminine, or unclassified TGD. Prevalent and incident HF, including systolic, diastolic, and unclassified phenotypes, were assessed using diagnosis codes. Multivariable logistic and …

Unexpected Longevity In Myasthenia Gravis, Bhupendra O. Khatri, Scott Schutten, Sergey Tarima

Biostatistics Faculty Publications

Background: This study compares age at death in patients with myasthenia gravis (MG) and multiple sclerosis (MS) with the general U.S. population and examines age at death patterns during a period preceding modern high-efficacy therapies. Objective: To compare age at death among individuals with MG and MS with the general population and assess differences in age at death between MG and MS. Design: Retrospective population-based study using death certificate data from four U.S. states (Florida, Wisconsin, Texas, and New York) for 2000, 2005, 2010, and 2015. Methods: Individuals with MG or MS listed on death certificates were identified. Age at …

Catwalk Xt Enables Sensitive Detection Of Locomotor Deficits After C2 Hemisection And Integrates Readily Into Ongoing Experimental Workflows In Adult Female Rats, Aaron L. Silverstein, Christopher M. Calulot, Christopher J. Mclouth, John C. Gensel, Warren J. Alilain

Biostatistics Faculty Publications

Over half of all spinal cord injuries (SCIs) in the United States occur at the cervical level and often cause both life-threatening breathing dysfunction and profound locomotor deficits. Although the C2 hemisection (C2Hx) model is vital for study of breathing dysfunction after experimental SCI, post-C2Hx locomotor deficits have only been assessed by metrics such as the Martínez Scale and ladder tests, which require time-intensive scoring by human observers. However, the CatWalk XT Gait Analysis system (Noldus Information Technology) delivers automated, quantitative assessment of interlimb coordination, gait cycle, and paw function, providing robust locomotor data in a time-efficient and practical manner. …

Integration Of Community-Engaged Research Technology And Methods To Guide Tobacco Regulatory Science In Rural Communities, Melissa H. Abadi, Stephen R. Shamblen, Mary Kay Rayens, Kirsten T. Thompson, Amy Wildman, Kathy Rademacher, William Wieczorek, Raphael Nishimura, Shyanika W. Rose, Mikhail N. Koffarnus, Seth Himelhoch, Ellen J. Hahn

Biostatistics Faculty Publications

Objective – This study aims to build a rural Appalachian cohort to examine how US Food and Drug Administration (FDA) Center for Tobacco Products (CTP) regulatory policies influence tobacco and nicotine product use across levels of rurality. Methods – The AppalTRUST (Appalachian Tobacco Regulatory Science Team) Cohort integrates four inter-connected Community-engaged Research + Technology (CEnRT) elements to support recruitment and retention: (1) building trust and cultural relevance; (2) addressing barriers to participation in research; (3) focusing on ethics and confidentiality; and (4) fostering ongoing and consistent collaboration between the scientific and field teams. The study uses a dual sampling design …

Raising The Profile Of Collaborative Biostatisticians In Team Science, Margaret R. Stedman, C. Christina Mehta, Emily Slade, Patricia L. Hibberd, Glenn M. Chertow, Robert H. Podolsky, Sowmya R. Rao

Biostatistics Faculty Publications

Recent emphasis on transdisciplinary teams in science offers an opportunity for biostatisticians to assume roles beyond data management and analysis. Biostatisticians contribute to all phases of research, from hypothesis formulation and rigorous study design to data analysis and interpretation. Yet, their contributions are often underrecognized. We argue for better integration of biostatisticians in research training and team structures. Postgraduate physician-scientist training should include mentorship from biostatisticians and education on collaborative skills. Fully integrating biostatisticians as co-investigators improves rigor, reproducibility, and innovation. Institutional support, including protected time and updated promotion criteria, is essential to support sustained collaboration. Structural changes must address …

Reimagining Hospital Medicine For Long-Term Sustainability, Samantha Murray-Bainer, Margaret Shyu, Rachel Peterson, Michael Hendricks, Christine Welles, Gopi Astik, Khoosh Dayton, Kristen Mcquerry, Joy Engblade

Biostatistics Faculty Publications

Background: High rates of burnout and turnover exist in the field of hospital medicine. Factors that make the career less sustainable and impact hospitalists as they age are not well understood. Objective: To identify factors that promote or impede hospitalist career longevity and understand job- and age-related challenges faced by older hospitalists. Design: Mixed-methods study of semi-structured qualitative focus groups within a national hospitalist consortium followed by a brief participant survey. Focus group discussions were recorded, summarized, and analyzed using matrix analyses to identify themes and subthemes. Participants: Thirty-seven attendees of the HOMERuN collaborative session in November 2024 participated in …

Rethinking Team Science Metrics Through Collaborative Guideposts, Kristen J. Mcquerry, Kelsey Karnik, Megan E. Hall, Caitline Phan, Yana Feygin, Emily Slade

Biostatistics Faculty Publications

Introduction – The increasing reliance on interdisciplinary and transdisciplinary teams has reshaped how science is conducted, yet evaluating the success of such teams remains a persistent challenge. Traditional metrics, such as publication counts, impact factors, and citation indices, fail to capture the full scope of team contributions, particularly in contexts where success may be defined by community engagement, mentorship, or long-term collaboration. Methods – In this Perspective, we introduce Collaborative Guideposts, a framework designed to align success metrics with a team’s organizing priorities. We illustrate this approach through two contrasting team models from a biostatistical collaboration center: Team A, a …