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Articles 1501 - 1530 of 52414
Full-Text Articles in Entire DC Network
Philsongs: A Study Of Campfire Music Performed At Scouting America’S Philmont Scout Ranch (2014 To 2021), Ellyn Rager
Philsongs: A Study Of Campfire Music Performed At Scouting America’S Philmont Scout Ranch (2014 To 2021), Ellyn Rager
Theses and Dissertations--Music
This dissertation focuses on Philmont Scout Ranch, a national Scouting America high adventure base in New Mexico and the largest youth camp in the world, arguing that music at Philmont serves as a cultural force that fosters an intensive communal bond among staff and campers by blending participatory and presentational music-making practices, while producing and reinforcing memories of Philmont through interpretive performances that negotiate the place’s historical narratives. Using surveys, interviews, and Thomas Turino’s framework of participatory and presentational music-making to interpret the author’s 100 hours of field recordings, this study examines aspects of Philmont’s musical habits between 2014 and …
From Financial Education To Financial Decisions: Evidence On College Financing, Personal Finance Behavior, And Student Attitudes, Dongwei Shi
University of Kentucky Doctoral Dissertations
I examine how financial education shapes students’ financial knowledge, college financing decisions, and longer-term financial behavior.
The first chapter studies whether taking high school financial education in Kentucky affects students’ college financing decisions using linked administrative records on high school course-taking and postsecondary financial aid. Using school-level financial education course availability as an instrument, the chapter evaluates whether exposure to financial education is associated with differences in student loan borrowing and receipt of need-based aid.
The second chapter examines whether exposure to state high school financial education mandates improves financial literacy and longer-term personal finance behavior among U.S. adults. Using …
Elevating Teacher Agency In School Decision-Making Through Trust-Building: Applying Appreciative Inquiry Within A Mixed Methods Action Research Framework, Alison S. Bellamy
Elevating Teacher Agency In School Decision-Making Through Trust-Building: Applying Appreciative Inquiry Within A Mixed Methods Action Research Framework, Alison S. Bellamy
University of Kentucky Doctoral Dissertations
This mixed methods action research (MMAR) study examined how Appreciative Inquiry–based professional learning influenced relational trust, teacher voice, and teacher agency in elementary school decision-making within New Hanover County Schools. Grounded in Teacher Agency Theory, Distributed Leadership Theory, and Appreciative Inquiry, the study addressed the gap between teachers’ perceptions of trust and their opportunities to influence school-level decisions. The study was conducted across three mid-quintile elementary schools using a concurrent QUAN–QUAL design. Quantitative data was collected through pre- and post-intervention relational trust surveys. Qualitative data included focus groups, participant reflections, field notes, and collaborative dialogue from two professional learning sessions …
Promptable Segmentation For Adaptive And Data-Efficient Medical Image Analysis, Tyler Ward
Promptable Segmentation For Adaptive And Data-Efficient Medical Image Analysis, Tyler Ward
University of Kentucky Doctoral Dissertations
Image segmentation is a fundamental task in computer vision. While segmentation models have traditionally been trained in a fully-supervised manner, recent approaches have leveraged large-scale pre-training and prompting mechanisms to great effect. However, the performance of such approaches often degrades when applied to domain-specific tasks like medical image analysis. A major reason for this lies is that these models are trained on large, labeled datasets of natural images, which have drastically different characteristics compared to medical images, limiting the generalizability of the methods when applied to medical data. This dissertation presents several data-efficient, adaptive, and promptable medical image segmentation models. …
Investigation Of Genx Exposure To Pathways Associated With Colorectal Cancer Risk, Emily J. Ferguson
Investigation Of Genx Exposure To Pathways Associated With Colorectal Cancer Risk, Emily J. Ferguson
Theses and Dissertations--Toxicology and Cancer Biology
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants widely detected in drinking water and food sources, resulting in chronic human exposure. Among these compounds, hexafluoropropylene oxide dimer acid (HFPO-DA), commonly known as GenX, has been introduced as a short-chain replacement for legacy PFAS such as perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). Although GenX is believed to be a safer alternative, emerging research suggests it can still affect human health.
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related death in the United States, highlighting the need to better understand environmental …
Uncovering The Mechanism Of Reep2-Mediated Emt-Driven Membrane Trafficking In Lung Adenocarcinoma, Kevin Fulp
Uncovering The Mechanism Of Reep2-Mediated Emt-Driven Membrane Trafficking In Lung Adenocarcinoma, Kevin Fulp
Theses and Dissertations--Toxicology and Cancer Biology
Membrane trafficking is frequently disrupted during cancer progression, and the underlying mechanisms remain largely unknown. Currently, no effective drugs target dysregulated membrane trafficking for cancer treatment. Recent evidence has demonstrated that epithelial-to-mesenchymal transition (EMT) in lung adenocarcinoma (LUAD) employs a membrane trafficking program to coordinate cancer cell invasion and immunosuppression. To further dissect the pro-tumorigenic membrane trafficking program, we initiated an in vivo CRISPRi screen to assess more than 2,000 membrane trafficking-related genes in a syngeneic mouse LUAD model. We identified REEP2, an endoplasmic reticulum (ER) shaping protein, as a novel regulator of EMT-driven membrane trafficking. High REEP2 expression is …
Reep2-Driven Pro-Metastatic Secretion Promotes Lung Cancer Progression, Oluwafunminiyi E. Obaleye
Reep2-Driven Pro-Metastatic Secretion Promotes Lung Cancer Progression, Oluwafunminiyi E. Obaleye
Theses and Dissertations--Toxicology and Cancer Biology
Membrane trafficking plays a critical role in cellular function and is frequently dysregulated in cancer to promote metastasis. In lung adenocarcinoma (LUAD), the epithelial-to-mesenchymal transition (EMT) activating transcription factor, ZEB1, drives a pro-metastatic membrane trafficking program; however, the underlying molecular mechanisms remain poorly understood. Using a CRISPR interference (CRISPRi) in vivo screen of 2,099 membrane trafficking regulators in a syngeneic mouse model of EMT-driven LUAD, we identified REEP2 — an endoplasmic reticulum (ER) shaping protein — as a critical regulator of tumor progression. REEP2 mRNA expression correlates with poor prognosis, EMT signatures, and an immunosuppressive tumor microenvironment in LUAD patients. …
Supramolecular Self-Assemblies Of Ru( Ii ) Phototherapeutics: Biological Activity Of Micro- And Nano-Particles Acting As Reservoirs, Jérôme Laisney, Sarah M. Kriger, Dmytro Havrylyuk, Jason M. Unrine, David K. Heidary, Edith C. Glazer
Supramolecular Self-Assemblies Of Ru( Ii ) Phototherapeutics: Biological Activity Of Micro- And Nano-Particles Acting As Reservoirs, Jérôme Laisney, Sarah M. Kriger, Dmytro Havrylyuk, Jason M. Unrine, David K. Heidary, Edith C. Glazer
Chemistry Faculty Publications
Ruthenium( II) coordination complexes have many appealing properties as prodrugs, but can suffer from poor aqueous solubility and short circulation times, drastically decreasing efficiency in vivo. Nanoformulations using a variety of carriers, such as inclusion in polymers/lipids or adsorption on inorganic nanoparticles have been applied to overcome this limitation, but unfortunately, these approaches raise additional concerns regarding the fate of the carriers, with potential long-term toxicity and accumulation in vital organs. Here, we present an alternative delivery strategy with formation of pure and polymer-supported supramolecular self-assemblies of Ru(II) complexes acting as ‘‘reservoirs’’. A facile preparation of size-controlled particles was achieved …
Characterization And Antimicrobial Activity Of Lignin-Derived Compounds In Ground Hurd Tissue Of Cannabis Sativa L. (Hemp) Cultivars, Jourdan E. Lakes, Anjam Sadik, Robert C. Pearce, Barbara L. Knutson, Stephen E. Rankin, Bert C. Lynn, Michael D. Flythe
Characterization And Antimicrobial Activity Of Lignin-Derived Compounds In Ground Hurd Tissue Of Cannabis Sativa L. (Hemp) Cultivars, Jourdan E. Lakes, Anjam Sadik, Robert C. Pearce, Barbara L. Knutson, Stephen E. Rankin, Bert C. Lynn, Michael D. Flythe
Chemistry Faculty Publications
Objectives: Characterize lignin-derived compounds from the hurd of 10 fiber/grain Cannabis sativa L. cultivars and investigate the antimicrobial activity of select compounds on the wasteful ruminant bacterium, Acetoanaerobium sticklandii SR. Methods: Hurd was processed using an aqueous ethanol solvent system and analyzed via GC-MS to identify and characterize lignin derivatives. Antimicrobial activity of the hurd and three monomers was assessed using solid (hurd) and liquid medium (monomers) bioassays against SR. Results: 27 compounds were identified, most as monomers but a few were dimers, ethylated derivatives, and organic acids. There were approximately equal G- and S-units with substantially fewer H-units. Several …
Enhanced Photostability Through Rapid Exciton Decay In Desymmetrized Cyclopentannulated Acenes With Strong Face-To-Face Pi Stacking, Chad D. Cruz, Karl J. Thorley, Zachary J. Knepp, Jared Wahlstrand, Gil M. Repa, John C. Stephenson, Sean Parkin, Lisa A. Fredin, John E. Anthony, Emily G. Bittle
Enhanced Photostability Through Rapid Exciton Decay In Desymmetrized Cyclopentannulated Acenes With Strong Face-To-Face Pi Stacking, Chad D. Cruz, Karl J. Thorley, Zachary J. Knepp, Jared Wahlstrand, Gil M. Repa, John C. Stephenson, Sean Parkin, Lisa A. Fredin, John E. Anthony, Emily G. Bittle
Chemistry Faculty Publications
The photophysics of organic semiconductors impacts their efficiency in optoelectronic devices where exciton transitions, including singlet fission, intersystem crossing and the formation of charge transfer states influence the ability to convert between bright and dark states and to dissociate into free charges. Unfortunately, photodegradation and spurious signals often confound the results of optical studies, especially of important triplet states. Here four asymmetric cyclopentannulated acenes are synthesized and studied. This system represents an extreme in photophysics achieved via molecular design to fully quench the photoluminescence and bypass triplet formation allowing for comparative studies with other highly absorbing acenes. Rapid molecular exciton …
Analytical Commentary And Performer's Guide To Carlos R. Martinez's Four Pieces For Trombone, Bailey Jean Hardy-Price
Analytical Commentary And Performer's Guide To Carlos R. Martinez's Four Pieces For Trombone, Bailey Jean Hardy-Price
Theses and Dissertations--Music
Musicians with hearing loss are documented in prominent figures, such as Ludwig van Beethoven. In the age of developing medical technology, hearing aids can turn the course for many musicians. Music can serve as an audio medium for this journey.
Carlos R. Martinez (b. 1978) is an active composer and pianist commissioned to create a piece that explores the journey of hearing loss in a musician. Martinez’s Four Pieces for Trombone and Piano illustrate a musician’s discovery of their hearing loss, its consequences, and joy in implementing the use of a hearing aid. The detailed discussion of the composer and …
Eco-Friendly Solvent-Based Fabrication Of Single-Layer And Polydopamine-Modified Bilayer Pvdf-Hfp Membranes, Eesh M. Kulshrestha
Eco-Friendly Solvent-Based Fabrication Of Single-Layer And Polydopamine-Modified Bilayer Pvdf-Hfp Membranes, Eesh M. Kulshrestha
Theses and Dissertations--Chemical and Materials Engineering
The growing global demand for clean drinking water has intensified the need for advanced water treatment technologies capable of efficiently removing contaminants while maintaining environmental sustainability. Polymeric membrane systems have emerged as an effective approach for water separations due to their high separation efficiency, simplicity, and adaptability to a wide range of water treatment applications. However, traditional membrane fabrication processes often rely on toxic organic solvents, such as N-methyl-2-pyrrolidone (NMP) and diemethylacetamide (DMAc), which pose environmental and health risks. These concerns have led to an increase in regulatory restrictions, primarily through the Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH) …
Investigation Of Succinylated Zwitterionic Polyethylenimine/Dna Complexes: Performance In Serum, Internalization, And Intracellular Fate, Levi Lampe
Theses and Dissertations--Chemical and Materials Engineering
Gene therapy has promised to revolutionize medicine since the earliest clinical trials, but a lack of delivery methods that are both safe and efficient has hampered progress. Gene therapy with viral vectors is effective at delivering nucleic acids to cells, but is associated with dangerous immunogenic responses and cancer-causing insertions into the genome. Viral vectors are also among the most prohibitively costly therapeutics in medicine. Polymeric vectors avoid these dangers and are made from inexpensive, off-the- shelf materials, but have been hindered by poor efficiency compared to viral vectors.
A benchmark polymer for in vitro nucleic acid delivery has been …
Aqueous Synthesis Of Luminescent Semiconductors For Opto-Electronic Applications, Saurabh Singh
Aqueous Synthesis Of Luminescent Semiconductors For Opto-Electronic Applications, Saurabh Singh
Theses and Dissertations--Chemical and Materials Engineering
The advancement of opto-electronic and scintillation technologies relies heavily on developing low-temperature, eco-friendly, and scalable synthesis routes for high performance luminescent halide-based semiconductor materials. However, traditional synthesis methods for halide-based semiconductors, including hot-injection, solvothermal, solid-state reactions, Ligand-Assisted Reprecipitation (LARP), microwave-assisted synthesis, and thin film deposition techniques (spin coating, physical vapor deposition (PVD), chemical vapor deposition (CVD), etc.), often demand toxic organic/inorganic solvents, elevated processing temperatures, and high vacuum/inert environments. Such constraints limit their scalability, raise environmental concerns, and impede their commercial-level device integration. This research overcomes these long-standing challenges by employing water as a powerful crystallization-directing, and environmentally benign medium …
A Performer's Guide To Selected Trumpet Excerpts Of Orchestral Works By Women Composers, Julia Stowell
A Performer's Guide To Selected Trumpet Excerpts Of Orchestral Works By Women Composers, Julia Stowell
University of Kentucky Doctoral Dissertations
Orchestral excerpts are brief passages from symphonic repertoire that are intended to demonstrate a player’s musical and technical abilities. The canon of orchestral trumpet audition excerpts has been relatively unchanged for several generations. This established canon of excerpts rarely features works written by women. As orchestras begin diversifying their programs, the frequently requested orchestral excerpts require new considerations to reflect these changes. In order for excerpts to be reflective of the orchestral canon, they must be updated as the canon changes.
Once an excerpt has been identified and obtained, the next issue is addressing its unique musical and technical challenges. …
Leading On An Uneven Playing Field: How Systems Of Race And Gender Shape African American Women’S Leadership Advancement, Nikki Goins-Hughes
Leading On An Uneven Playing Field: How Systems Of Race And Gender Shape African American Women’S Leadership Advancement, Nikki Goins-Hughes
DSW Capstone Projects
Systemic barriers to leadership for African American women are deeply rooted in historical and structural inequities within the United States. Intersecting identities of race and gender have historically shaped access to leadership advancement opportunities for African American women. Despite efforts to prioritize gender and racial equity in leadership, African American women continue to experience exclusion or are highly scrutinized in decision-making spaces, contributing to their continued marginalization in leadership. Therefore, this capstone draws on a systematic literature review, conceptual framework, and practice application to examine the systemic barriers that limit access to leadership advancement opportunities for African American women and …
Navigating Mental Wellness: A Peer-Led Journey Into Adult Services, Kristin G. Haberek
Navigating Mental Wellness: A Peer-Led Journey Into Adult Services, Kristin G. Haberek
DSW Capstone Projects
Students with severe emotional disturbances (SED) occupy one of the most underserved intersections in American education and mental health care. As they age out of children’s services, they face abrupt service discontinuation, disrupted therapeutic relationships, and adult systems ill-equipped to meet their needs. These vulnerabilities, including heightened risks of crisis, hospitalization, homelessness, and justice involvement, constitute a central practice problem. This capstone addresses these transitions across three scholarly products: a systematic literature review, a theoretical concept paper, and a practical application paper, tracing a unified arc from diagnosing structural failures to proposing an evidence-informed, equity-oriented clinical response. Synthesizing key findings …
Utilizing Coal For Mesophase Pitch-Based Carbon Fiber Production: Precursors, Processes, And Progress, Christina M. Thompson
Utilizing Coal For Mesophase Pitch-Based Carbon Fiber Production: Precursors, Processes, And Progress, Christina M. Thompson
Theses and Dissertations--Chemistry
Graphitic materials possess unique properties due to the unique combination of layered crystalline structure and carbon’s low atomic weight. High performance carbon fiber is one such example, displaying exceptional strength-to-weight ratios, stiffness, and thermal and chemical resistance. These properties render high performance carbon fiber a critical structural reinforcement material in the manufacture of composites across various industries, such as for automotive and aerospace applications. However, balancing fiber performance with precursor and processing costs remains a challenge. As alternative carbonaceous feedstocks are explored, coal has gained interest for utilization in graphitic products as a relatively abundant and low-cost source of aromatic …
Elucidating The Impacts Of Non-Covalent Interactions In Organic Materials Through A Multiscale Computational Approach, Sashen A. Ruhunage
Elucidating The Impacts Of Non-Covalent Interactions In Organic Materials Through A Multiscale Computational Approach, Sashen A. Ruhunage
Theses and Dissertations--Chemistry
Noncovalent interactions (NCIs) in π-conjugated organic materials serve as tunable levers that influence molecular structure and intermolecular interactions in the condensed phase and, in turn, impact the electronic, optical, and mechanical properties of these materials. NCIs include attractive dispersion, electrostatic, and induction interactions, as well as repulsive exchange interactions. However, how to design materials with NCI considerations remains an open question across many fields. Here, we seek to provide an electronic and atomistic perspective on these interactions through multiscale simulations to aid materials design, processing, and performance optimization. In this study, we investigate NCIs and their effects across various systems …
Student Familiarity With The Periodic Table Of The Elements: Results From Cued-Recall And Eye-Tracking Assessments On Memory, Victor A. Okuo
Student Familiarity With The Periodic Table Of The Elements: Results From Cued-Recall And Eye-Tracking Assessments On Memory, Victor A. Okuo
Theses and Dissertations--Chemistry
Learning element symbol–name associations and the spatial organization of elements on the periodic table is a foundational step in learning chemistry, supporting later understanding of chemical formulas, equations, bonding, and stoichiometry. Although students often rely on memorization strategies to learn periodic table content, this task is challenging due to the large number of elements and the apparent ambiguity in matching some element symbols to their names.
This study explores students’ recall of element names when given element symbols as cues and their knowledge of element locations on the periodic table when given element names as cues. The study also examines …
Preoperative Glucagon-Like Peptide-1 Therapy In Bariatric Surgery Patients With Morbid Obesity (Premo): Rationale And Study Design For A Randomized Controlled Trial, Varun Jain, Colleen A. Mcmullen, Joy I. Kimbrough, Anna K. Rockich, Daniel L. Davenport, Gregory S. Hawk, Barbara S. Nikolajczyk, Philip A. Kern, Simon J. Fisher, Joshua P. Steiner, William B. Inabnet Iii, Marlene E. Starr
Preoperative Glucagon-Like Peptide-1 Therapy In Bariatric Surgery Patients With Morbid Obesity (Premo): Rationale And Study Design For A Randomized Controlled Trial, Varun Jain, Colleen A. Mcmullen, Joy I. Kimbrough, Anna K. Rockich, Daniel L. Davenport, Gregory S. Hawk, Barbara S. Nikolajczyk, Philip A. Kern, Simon J. Fisher, Joshua P. Steiner, William B. Inabnet Iii, Marlene E. Starr
Surgery Faculty Publications
Introduction: Bariatric surgery is the most effective treatment modality for individuals with morbid obesity, providing significant and durable weight loss and comorbidity resolution. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide receptor agonists have shown promise as weight loss drugs, in addition to their use in the treatment of metabolic disorders. While multimodal weight management is the standard of care for individuals with morbid obesity, the benefit of antecedent GLP-1 therapy prior to bariatric surgery has not been well-studied. The objective of this study is to conduct a clinical trial testing the hypothesis that preoperative treatment with a dual GLP-1/glucose-dependent insulinotropic …
Amustaline/Glutathione Pathogen-Reduced Red Cell Hemoglobin Utilization In Complex Cardiac Surgery, Ian J. Welsby, Michael E. Sekela, Edward L. Snyder, James D. Gorham, John S. Mcneil, Kathy Liu, Stanley Bentow, Thomas Gniadek, Laurence Corash, Nina Mufti, Richard J. Benjamin
Amustaline/Glutathione Pathogen-Reduced Red Cell Hemoglobin Utilization In Complex Cardiac Surgery, Ian J. Welsby, Michael E. Sekela, Edward L. Snyder, James D. Gorham, John S. Mcneil, Kathy Liu, Stanley Bentow, Thomas Gniadek, Laurence Corash, Nina Mufti, Richard J. Benjamin
Surgery Faculty Publications
Background: The ReCePI randomized, controlled trial compared amustaline/glutathione pathogen-reduced (PR) and conventional red blood cell (RBC) transfusions in cardiac surgery. Study design and methods: We performed a post-hoc analysis of hemoglobin (Hb) utilization and safety outcomes. Hb content of study RBCs was measured at manufacture. Subject Hb levels, estimated blood loss and blood product use were recorded during and for 7 days post-surgery. Acute kidney injury (AKI) incidence was graded over 7 days, and adverse events were assessed for 28 days. Results: PR-RBCs contained 5.2% less Hb (mean [SD] Test 58.1 [6.5] g; Control 61.5 [6.8] g Hb, p <.001) due to manufacturing volume losses. Four hundred fifty-six PR- and 524 conventional RBCs were transfused to 159 Test and 162 Control subjects, respectively. Mean subject baseline and post-surgery Hb levels, and blood loss were not different between groups. Test subjects tended to require fewer total RBCs (3.5 [2.7] Test vs. 4.0 [3.5] Control, p =.08) resulting in 17.6% significantly less mean total Hb transfused (Test 203.2 g; Control 246.8 g Hb, p =.01). The proportions of subjects transfused with, and the number of platelet and cryoprecipitate units transfused were not different. Test subjects received less plasma (2.3 [1.8] units Test vs. 3.5 [3.8] Control, p =.03). Overall incidence of adverse events and AKI were not clinically different. Imbalances in AKI severity (Grade III Test 15/159 [9.4%]; Control 7/162 [4.3%], p =.07) may suggest under-transfusion in the highest-risk Test subjects. Discussion: Test patients required less transfused Hb than control subjects to maintain equivalent daily hemoglobin levels following similar blood loss.
Prolonged Invasive Mechanical Ventilation Is Associated With Decreased Survival After Lung Transplantation Among Recipients With Primary Graft Dysfunction, Meghan Aversa, Shaf Keshavjee, Tereza Martinu, Marcelo Cypel, Andrew T. Sage, Joshua M. Diamond, Jonathan P. Singer, Scott M. Palmer, Krishna Pandya, Edward Cantu, Jason D. Christie, Michaela R. Anderson
Prolonged Invasive Mechanical Ventilation Is Associated With Decreased Survival After Lung Transplantation Among Recipients With Primary Graft Dysfunction, Meghan Aversa, Shaf Keshavjee, Tereza Martinu, Marcelo Cypel, Andrew T. Sage, Joshua M. Diamond, Jonathan P. Singer, Scott M. Palmer, Krishna Pandya, Edward Cantu, Jason D. Christie, Michaela R. Anderson
Surgery Faculty Publications
Introduction: Prolonged invasive mechanical ventilation (IMV) after lung transplantation is an appealing early prognostic outcome as it can be reproducibly assessed both prospectively and retrospectively. Whether use of IMV at 72 h after lung transplantation is associated with post-transplant graft survival is unknown. Methods: We performed a retrospective cohort study of 1511 participants in the multi-center Lung Transplant Outcomes Group cohort (2011–2018). Using Cox proportional hazards models and restricted mean survival time, we investigated whether IMV at 72 h was associated with post-transplant graft survival. We secondarily evaluated whether IMV at 72 h was concordant with severe primary graft dysfunction …
Mouse Models For Post-Sepsis Syndrome, John Matthew K. Ang, Stephanie F. Mori, Erick Lewis, Maria E.C. Bruno, Arnold Stromberg, Hiroshi Saito
Mouse Models For Post-Sepsis Syndrome, John Matthew K. Ang, Stephanie F. Mori, Erick Lewis, Maria E.C. Bruno, Arnold Stromberg, Hiroshi Saito
Surgery Faculty Publications
Background – Sepsis survivors commonly suffer from chronic Post-Sepsis Syndrome (PSS). To understand the mechanisms of PSS, it is critical to utilize appropriate animal models. While cecal ligation and puncture (CLP) is a widely used model of sepsis, a concern exists regarding its suitability for studying long-term outcomes. Alternatively, we previously optimized a highly reproducible murine cecal slurry (CS)-injection model of sepsis. The objective of this study was to compare the suitability of CS and CLP models for investigating PSS. Methods – Male 4-month-old C57BL/6 mice were divided into 7 groups: (1) Naïve control; (2) Sham: laparotomy control; (3) CL: …
Scrolling, Searching, And Self-Diagnosing: Examining How Social Media Influences Self- Diagnosis And Shapes Mental Health Literacy, Conceptualization, And Identity Development, Sara Elaine Hamilton
Scrolling, Searching, And Self-Diagnosing: Examining How Social Media Influences Self- Diagnosis And Shapes Mental Health Literacy, Conceptualization, And Identity Development, Sara Elaine Hamilton
DSW Capstone Projects
This capstone examines the influence of social media on the growing issue of self-diagnosis of mental health disorders through three scholarly works: a systematic literature review (SLR), a conceptual paper, and practice application paper. Accessibility, anonymity, and social isolation are identified as contributing factors of self-diagnosis, as individuals increasingly prioritize convenience over traditional help-seeking methods. Research suggests that self-diagnosis is influenced by misinformation and reinforced by validation and a sense of belonging, leading individuals to internalize mental health disorders as part of their identity. Findings further indicate that social media plays a significant role in the dissemination of misinformation about …
The Impact Of Medicaid Policy Limitations On Access To Eating Disorder Treatment: Uncovering The Consequences Of A System Built To Fail, Meghan Frost
DSW Capstone Projects
Individuals who rely on Medicaid face major barriers when trying to access eating disorder (ED) treatment, reflecting broader patterns of structural disadvantage in publicly funded health care. Research shows delayed diagnosis, limited access to ED specialists, and frequent denials for recommended services. These gaps occur because Medicaid policies do not match the needs of evidence based ED care, resulting in delayed or incomplete care for many individuals with eating disorders.
This issue is highly relevant to social work practice because the policies shaping these barriers are complex and difficult for clients and ED providers to navigate. Social workers across clinics, …
Investigating Intersectionality: How Multiple Marginalized Identities And Social Perceptions Of Victims Influences The Efficacy Of Panic-Defense Narratives In Bathooms, Demitri James Aguilar
Investigating Intersectionality: How Multiple Marginalized Identities And Social Perceptions Of Victims Influences The Efficacy Of Panic-Defense Narratives In Bathooms, Demitri James Aguilar
Theses and Dissertations--Psychology
Despite transgender Women of Color being the main victims of violent victimization and panic-narrative cases, very little research has investigated how race/ethnicity might impact perceptions of violence or the influence of panic-narratives. Thus, the current experiment (N = 1275) examined the social and legal ramifications of using panic-narratives against transgender and cisgender women of color (Black vs. Latino vs. White) in bathroom victimization contexts. The predictions were partially supported. Regardless of racial identity, the justification of transgender (versus cisgender) victimization via panic-narratives produced more anti-victim (e.g., increased victim guilty verdicts, sentencing, victim culpability, perceived deception, and threat) and prodefendant outcomes …
Brief Exposure Therapy With Exercise For Ptsd: A Pilot Study Using Single Case Experimental Design, Troy J.J. Hubert
Brief Exposure Therapy With Exercise For Ptsd: A Pilot Study Using Single Case Experimental Design, Troy J.J. Hubert
Theses and Dissertations--Psychology
Posttraumatic stress disorder (PTSD) is a common and often disabling psychiatric disorder associated with an increased risk of multiple mental and physical health conditions. Exposure therapy is a gold standard treatment for PTSD, but attrition rates and treatment response are notable limitations. Animal and human research collectively indicate that aerobic exercise can enhance preclinical and experimental models of exposure by improving consolidation of fear-extinction memories. To date, only one clinical trial has attempted to translate exercise augmented exposure therapy for PTSD. The current study is an open-label pilot clinical trial aiming at gauging the effectiveness of a brief eight-session PTSD …
The Power Of A Picture: Building Visual Depictions Of The Eppm Bolstering Sunscreen Application Motivation, Ansley M. George
The Power Of A Picture: Building Visual Depictions Of The Eppm Bolstering Sunscreen Application Motivation, Ansley M. George
University of Kentucky Doctoral Dissertations
This study investigates visual depictions of efficacy skin cancer health risk messages. Using Witte's Extended Parallel Processing Model (EPPM) and existing literature on fear appeals and visual persuasion as a theoretical framework, the study aims to explore how self and response efficacy imagery impacts individuals' perceptions of health risk messages in the context of skin cancer prevention when emphasizing specific principles of design. Formative research was employed via qualitative photo sorts and participants were exposed to an assortment of images depicting efficacy in the context of skin cancer prevention where they discussed why they felt they were or were not …
Effect Of Substrate Dispersion Method And Particle Size On In Vitro Digestibility, Gas Production Kinetics And Composition, And Fermentation Characteristics In Different Feed Types, Luiz C. O. Sousa, Ellem M. A. Matos, Ronald J. Trotta, Edenio Detmann, David L. Harmon
Effect Of Substrate Dispersion Method And Particle Size On In Vitro Digestibility, Gas Production Kinetics And Composition, And Fermentation Characteristics In Different Feed Types, Luiz C. O. Sousa, Ellem M. A. Matos, Ronald J. Trotta, Edenio Detmann, David L. Harmon
Animal and Food Sciences Faculty Publications
Our objective was to evaluate the influence of substrate dispersion method and particle size on in vitro digestibility, gas production kinetics and composition, and fermentation characteristics of different feed types. Alfalfa hay, tall fescue hay, ground corn, soybean meal, and a total mixed ration (TMR) were used as substrates. Treatments were designed according to a 2 × 2 × 5 factorial arrangement: two substrate dispersion methods (loose substrate and in filter bags), two particle sizes (1 mm and 2 mm), and five feeds. Filter bags decreased (P ≤ 0.001) digestibility and gas production compared with loose samples. Filter bags decreased …