Digital Commons Network^™

Hybrid Fabrication Of An Electrochemical Electrode Via Inkjet Printing On 3d-Printed Substrates, Md Tawabur Rahman, Jessica Bone, Thomas J. Roussel, Judith L. Jenkins, Aron J. Huckaba

Chemistry Faculty Publications

Combinations of additive manufacturing methods such as inkjet printing and various 3D printing techniques have led to advances in customizable electronic devices by reducing the need for the complex assembly of individually fabricated components. Such combinations are particularly attractive for the fabrication of electrochemical sensing platforms, where the sizes and spatial configurations of electrodes enable (or limit) the sensitivity of the sensors. However, to realize the potential of the combined fabrication methods, the parameters of each printing technique must be mutually compatible. For instance, electrochemical sensing assemblies consisting of inkjet-printed metals on 3D-printed plastics require post-processing steps that convert nanoparticular …

Student Perspectives On Grading In Higher Education Stem Courses, Christopher Sean Burns, Daniela D.S. Digiacomo, Jennifer Pusateri, Katherine Ritchie, Christine Wusylko

Information Science Faculty Publications

Purpose

Despite a growing awareness of instructional practices that support student learning and well-being, higher education classrooms tend to still be dominated by the use of rigid approaches to assessment and course design. This study aims to understand the experiences of students in courses that implement a universal design for learning (UDL) pedagogical approach and an ungrading assessment approach. Design/methodology/approach

Leveraging a qualitative methodological approach, authors interviewed 13 graduate students in two library and information science technology courses and 11 undergraduate students in a computer science course in discrete mathematics about their experiences with ungrading within the context of UDL-designed …

The Impact Of Seyfert Jets On Galaxy Evolution Across Major Scaling Relations, Julianne Goddard, Isaac Shlosman, Emilio Romano-Diaz

Physics and Astronomy Faculty Publications

We analyze a suite of high-resolution cosmological zoom-in simulations of jetted Seyfert galaxies over z < ∼10 projected on the major scaling relations, comparing trajectories of “normal” versus jet-hosting galaxies. Models include thermal and mechanical jet feedback launched from supermassive black holes (SMBHs) seeded at z ∼ 9.1 and z ∼ 3.7 with M_• ∼ 10⁶ M_⊙ in galaxies within dark matter halos of (Formula presented) logMhalo/M⊙∼11.8 at z = 0. A single parameter, the SMBH accretion efficiency, has been varied, resulting in L_jet ∼ 10⁴⁰⁻⁴² erg s⁻¹, and SMBH accretion rates range between ∼0.2 and 10⁻⁴ of the Eddington rate. We find that jet feedback (1) suppresses central star formation rates (SFRs), redistributes gas to larger radii, (2) generates long-lived expanding shocks that couple to the interstellar medium and circumgalactic …

First Covid-19 Vaccination Rates Among Pregnant Tennessee Women By Month Of Conception And Urbanization Level: March 2021 – November 2021, Claudia Valenzuela, Anne K. Driscoll, Elizabeth Harvey, Heather Wingate

Journal of Appalachian Health

Introduction: Throughout the pandemic, COVID-19 vaccination coverage was lower for the general population living in rural counties than in urban counties. In Tennessee (TN), COVID-19 vaccinations became available to pregnant women in March 2021. Little is known about rates of COVID-19 vaccination in pregnancy during the pandemic, or whether these rates changed or differed by urbanization level.

Purpose: The purpose of this study is to describe COVID-19 vaccination rates among pregnant women in TN by month of conception and urbanization level.

Methods: COVID-19 vaccination data from the TN Immunization Information System and the TN Surveillance for Emerging Threats to Mothers …

Rural Community Perspectives On Hurricane Helene In Western North Carolina, Jennifer A. Horney, Lilly Moreau, Search Wnc

Journal of Appalachian Health

Introduction: After making landfall on the Florida Gulf Coast in September 2024, Hurricane Helene impacted Western North Carolina (WNC) with historic flooding, landslides, and hurricane-force winds. More than 100 deaths in the region were attributed to the storm’s direct impacts.

Purpose: The purpose of this study was to assess community perspectives of long-term recovery in Mitchell and Yancey Counties, two rural WNC counties severely impacted by Hurricane Helene.

Methods: A 14-question interview guide was developed based on prior disaster research and the community engagement work of Sustaining Essential and Rural Community Healthcare (SEARCH). Questions covered post-Helene experiences related to access …

Exploring Systemic Challenges In The Western North Carolina Dental Safety Net: A Qualitative Analysis, Blaire Mirmow, Bill Milner, Nadia Laniado

Journal of Appalachian Health

Introduction: Despite statewide growth, rural communities in Western North Carolina (WNC) face persistent barriers to oral health care driven by chronic dental workforce shortages and systemic geographic disparities. Within this Appalachian region, the dental safety net serves as a vital yet strained support system, struggling with limited financial resources and a lack of provider participation that leaves many underserved populations without essential oral health services.

Purpose: This study aims to explore the experiences of individuals working within the WNC dental safety net to identify barriers and strategies required to strengthen the delivery of oral health care in high-need rural settings. …

Infective Endocarditis Hospitalizations In Kentucky, 2008-2018: Spatial And Temporal Trends, Meera Marji, Steve Browning, W. Jay Christian, Richard Charnigo, Steve W. Leung, Anna Kucharska-Newton

Journal of Appalachian Health

Introduction: Infective endocarditis (IE) hospitalization rates have increased significantly in the last decade, primarily due to the opioid epidemic. In 2016, Kentucky (KY) ranked among the top ten states for opioid-related overdose deaths, but limited data exist on IE trends in KY.

Purpose: This study seeks to examine county-level spatial and temporal trends in IE hospitalization rates in KY.

Methods: Hospital inpatient discharge data from 2008–2018 for KY residents aged 18 and older were analyzed. IE admissions and drug use status were identified using ICD-9 & 10 diagnosis codes. U.S. Census data calculated yearly IE hospitalization rates per 100,000 residents. …

Starting With Story, Not Symptom: Narrative Collapse And Cultural Repair In Appalachia, Wayne Coombs Ph.D.

Journal of Appalachian Health

Appalachia’s opioid crisis reflects uneven burdens, especially in distressed coalfield counties, and it cannot be solved by symptom tracking alone. This commentary argues for a narrative shift, starting with story and cultural repair alongside clinical care. Narrative collapse is defined here as the loss of shared, dependable public meaning across groups, not the absence of storytelling in families, churches, and recovery circles. Trauma science suggests that chronic threat reshapes nervous systems across generations, making safety a prerequisite for renewed trust. Drawing on narrative identity research, the piece proposes peer story work as infrastructure that can reduce shame, support treatment engagement, …

Gender And Power Dynamics In Three Types Of Injection Partnerships Among Young Women In Rural Appalachia, Cheyenne R. Wagi, Jaelyn Murphy, Madison N. Enderle, Hannah Piscalko, Kathleen L. Egan, Christina S. Meade, Bridget Freisthler, April M. Young, Angela Estadt, Kathryn E. Lancaster

Epidemiology and Environmental Health Faculty Publications

Background: Young women who inject drugs (YWID) face heightened risks for HIV, hepatitis C, and overdose that are shaped by the relational contexts in which they inject. Injection partnerships, defined as dyadic relationships between people who inject together, remain understudied beyond male–female intimate pairs. Methods: We conducted 26 semi-structured interviews with YWID (ages 18–35) in rural Appalachian Ohio to explore dynamics within three partnerships types: dual partnerships with male intimate partners, family partnerships, and friend partnerships, with attention to female peer partnerships as a distinct subset. Guided by the Theory of Gender and Power and Bourdieu’s concept of cultural capital, …

Constraining The Subgalactic Relationship Between Star Formation And The Hot Interstellar Medium In Ngc 4254, Erik B. Monson, Bret D. Lehmer, Amirnezam Amiri, Karina Barboza, Ashley T. Barnes, Antara R. Basu-Zych, Daniel A. Dale, Sanskriti Das, Simthembile Dlamini, Simon Glover, Kathryn Kreckel, Laura A. Lopez, Sebastian Lopez, Smita Mathur, Hsi An Pan, Jennifer A. Rodriguez, Karin Sandstrom, Sumit K. Sarbadhicary, Jiayi Sun, Thomas G. Williams

Physics and Astronomy Faculty Publications

We investigate the relationship between star formation and X-ray emission from the hot interstellar medium (ISM) on ∼kiloparsec scales in NGC 4254 (M99) by combining spatially resolved star formation histories (SFHs) and Bayesian X-ray spectral fitting. We measure subgalactic star formation rates (SFR) by modeling spectrophotometric UV-IR data with flexible SFHs, and we produce point-source-subtracted maps of the diffuse X-ray emission using Chandra data. We extract and fit the spectra of five regions selected by their SFR density Σ_SFR, deriving hot gas luminosities and plasma temperatures. We examine the subgalactic kT–Σ_SFR and L_X^gas − Σ …

Patients' Attitudes Towards Deprescribing And Associations With Patient-Related Factors Across Two Hospital Settings, Louise Westberg Strejby Christensen, Iman El Gamah, Amina Osman Ismail Barre, Daniela Claudia Moga, Anissa Aharaz, Olivia Bornæs, Rikke Lundsgaard Nielsen, Aino Leegaard Andersen, Esben Iversen, Kim Peder Dalhoff, Ove Andersen, Helle Gybel Juul-Larsen, Morten Baltzer Houlind

Epidemiology and Environmental Health Faculty Publications

Medication deprescribing is a targeted strategy to reduce inappropriate polypharmacy. Patients in primary care settings have reported high willingness to discontinue medications, but this phenomenon is less well studied in hospital settings. In this explorative post hoc analysis of two previously described clinical trials, we assessed patients' attitudes towards deprescribing in two hospital-based cohorts: acutely admitted older medical patients (≥ 65 years) in the emergency department at Copenhagen University Hospital Hvidovre (October 2018–April 2021) and multimorbid patients (≥ 18 years) referred to an outpatient clinic at Copenhagen University Hospital Amager (March 2019–December 2019). Among 104 and 72 patients in each …

Avoiding Misleading Estimates Of Among-Individual Variance Caused By Non-Random Sampling Of Individuals In A Changeable Environment, Denis Réale, Hassen Allegue, Yimen G. Araya-Ajoy, Ned A. Dochtermann, Shinichi Nakagawa, Joel L. Pick, Holger Schielzeth, David F. Westneat, Niels J. Dingemanse

Biology Faculty Publications

Animal ecologists frequently quantify variance in hierarchically structured traits in wild populations. Importantly, phenotypic plasticity within the period of measurement can modify the trait of interest in response to various unmeasured, temporally or spatially changeable, environmental conditions. Non-random sampling among units of the random effect (e.g. individuals) regarding the environment at issue may lead to estimates of the variance among ((Formula presented.)) or within ((Formula presented.)) such units that conflate several types of processes. This mixing of underlying biology can affect interpretations of the random effect variance. Here, we explore the conditions leading to this situation and assess potential solutions …

Joint Map Of Warren County, Kentucky, Steven L. Martin, Emily R. Morris

Map and Chart--KGS

This fracture map is a compilation of joint locations and faults mapped in Warren County, Kentucky, and provides orientations of fractures (joints and faults) for hydrological, geotechnical, slope stability, and rockfall mitigation analysis. The joint data include orientations collected from 2023 to 2024, and those collected during the U.S. Geological Survey (USGS) geologic mapping of the Woodburn 7.5 -minute quadrangle (Shawe, 1963c). New joint orientations were measured to fill gaps in the published geologic map data. Joints are fractures with no appreciable movement parallel to the fracture plane and only slight movement normal to the fracture plane, whereas faults exhibit …

Simulation And Optimization Of The Active Magnetic Shield Of The N2edm Experiment, N. J. Ayres, G. Ban, G. Bison, K. Bodek, V. Bondar, T. Bouillaud, G. L. Caratsch, E. Chanel, W. Chen, C. Crawford, V. Czamler, C. B. Doorenbos, S. Emmeneger, S. K. Ermakov, M. Ferry, M. Fertl, A. Fratangelo, D. Galbinski, W. C. Griffith, Z. D. Grujic, K. Kirch, V. Kletzl, J. Krempel, B. Lauss, T. Lefort, A. Lejuez, K. Michielsen, J. Micko, P. Mullan, O. Naviliat-Cuncic, F. M. Piegsa

Physics and Astronomy Faculty Publications

The n2EDM experiment at the Paul Scherrer Institute aims to conduct a high-sensitivity search for the electric dipole moment of the neutron. Magnetic stability and control are achieved through a combination of passive shielding, provided by a magnetically shielded room (MSR), and a surrounding active field compensation system by an Active Magnetic Shield (AMS). The AMS is a feedback-controlled system of eight coils spanned on an irregular grid, designed to provide magnetic stability to the enclosed volume by actively suppressing external magnetic disturbances. It can compensate static and variable magnetic fields up to ± 50 μT (homogeneous components) and ± …

Muscle Atrophy After Acl Reconstruction Involves Molecular Mechanisms Beyond Unloading, Alexander R. Keeble, Gonzalez Velez Sara, Nicholas T. Thomas, Allison M. Owen, Austin V. Stone, Darren L. Johnson, Julián Candia, Luigi Ferrucci, Marco Narici, Esther E. Dupont-Versteegden, Brian Noehren, Martino V. Franchi, Christopher S. Fry

Physiology Faculty Publications

Anterior cruciate ligament reconstruction (ACLR) leads to profound muscle atrophy and weakness that remain resistant to rehabilitation. Although early recovery typically involves a brief period of limb unloading, the degree to which disuse alone accounts for muscle pathology after ACLR remains unclear. Here, we leveraged publicly available RNA-seq datasets of muscle biopsies from vastus lateralis obtained 7 days after ACLR or 10 days after unilateral lower limb suspension (ULLS), each with matched control limbs, to directly compare disuse-driven and ACLR-specific early transcriptional responses. Despite similar periods of reduced loading, substantial transcriptomic divergence was identified using both intersection and interaction bioinformatic …

The Association Between Apoe Ε4 Carrierships And The Detection Of Amyloid Positivity Using An Alzheimer's Disease Proteomic Blood Test In Asymptomatic Down Syndrome, Lubnaa Badriyyah Abdullah, Fan Zhang, Melissa Petersen, James Hall, Benjamin L. Handen, Mark Mapstone, Brad Christian, Elizabeth Head, Sigan Harley, Howard Andrews, Joseph H. Lee, Dana Tudorascu, Christy Hom, Shahid Zaman, Adam M. Brickman, Diana Rosas, Annie Cohen, Jordan P. Harp, Frederick Schmitt, Lauren Ptomey, Jeffrey M. Burns, Ira T. Lott, Florence Lai, Charles Laymon, Carlos Cruchaga, Sid O'Bryant, Beau M. Ances

Neurology Faculty Publications

INTRODUCTION: This study evaluates plasma-based proteomic profiles for predicting amyloid positivity in adults with Down syndrome (DS) and examines the impact of apolipoprotein E ε4 (APOE ε4) on test performance. METHODS: Cross-sectional data from 290 adults with DS were analyzed using single molecule array (SIMOA) technology to measure plasma amyloid beta (Aβ)42, Aβ40, neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), tau phosphorylated at threonine 181, and total tau. Amyloid burden was quantified using Pittsburgh Compound B and (18)F-florbetapir Aβ positron emission tomography. Support vector machine analyses were conducted with biomarkers as predictors and age, sex, and APOE ε4 …

Systemic Consequences Of Chronic Ethanol Intake, Muni Swamy Ganjayi, Thomas A. Krauss, Gage E. Demster, Sehyung Park, Garrett B. Anspach, Sarah R. Anthony, Shaohua Wang, Michael Tranter, Robert N. Helsley, Cory W. Baumann

Markey Cancer Center Faculty Publications

Chronic ethanol (EtOH) consumption is a major contributor to multi-organ dysfunction, yet its systemic effects remain incompletely understood. To address this, we utilized a physiologically relevant long-term mouse model, administering 20% EtOH in drinking water for 60 weeks, to investigate the integrated consequences of chronic exposure. EtOH-consuming mice (0.4–0.5 mL/day) exhibited > 30% reductions in chow and fluid intake, resulting in a 12% decrease in total caloric intake compared to controls (p < 0.001). Body mass remained similar until Week 52, after which EtOH-treated mice had lower body mass due to reductions in both lean and fat mass (p ≤ 0.004). Functional assessments revealed impaired treadmill endurance (−17%) and grip strength (−11%) (p ≤ 0.037), while motor coordination remained unaffected (p = 0.203). Chronic EtOH exposure significantly altered gut microbiota composition, reducing Lactobacillus and enriching Faecalibaculum, Clostridium, and Bifidobacterium at the genus level. These changes were accompanied by marked depletion of short-chain fatty acids (p ≤ 0.05). Indirect markers of gut permeability (serum LPS & zonulin) and liver injury (serum ALT & AST, hepatic amyloid content) were elevated, alongside increased total cholesterol and > 62% upregulation of hepatic TNFα, IL-6 & serum amyloid A (p ≤ 0.046). EtOH also induced dyslipidemia and glucose intolerance (p ≤ 0.041), although transcriptomic changes in white adipose …

National Trends And In-Hospital Outcomes Of Valve-In-Valve Transcatheter Aortic Valve Replacement With Cerebral Embolic Protection, Ammar A. Hasnie, Avneet Hans, Emad A. Chishti, Joseph Leith, Hannah Murphy, Alyssa H. Harris, Kory Heier, Kristen Mcquerry, Steve W. Leung, Islam Y. Elgendy

Radiology Faculty Publications

No abstract provided.

Treating Maternal Mental Health Problems With An App-Based Program, Leslie E. Roos, Anna L. Mackinnon, E. Bailin Xie, Kaeley M. Simpson, Charlie Rioux, Kristin A. Reynolds, Ryan J. Giuliano, Jennifer Harrington, Jennifer L.P. Protudjer, Shannon Sauer-Zavala, Gerald F. Giesbrecht, Catherine Lebel, Dana Watts, Madeline Belows, Lara Penner-Goeke, Makayla Freeman, Lianne Tomfohr-Madsen

Psychology Faculty Publications

OBJECTIVES: Exposure to maternal mental illness in the first 3 years of life is associated with poor child outcomes. Many mothers experience mental health problems and few have access to evidence-based treatments. Mobile health treatments show promise for mood and anxiety disorders but rarely include parenting strategies. This study evaluated the efficacy of Building Emotional Awareness and Mental Health (BEAM), a 10-week app-based therapist-guided program, which responds to maternal mental health and parenting needs. METHOD: A two-arm, Phase III randomized controlled trial was conducted to evaluate the BEAM intervention compared to unrestricted services-as-usual. Participants completed self-report measures at eligibility, prior …

Oral Health In People With Schizophrenia, Leire Urien, Ainara Arnaiz, Xabier Marichalar-Mendia, Unax Lertxundi, Jose De Leon, Agate Txurruka, Nerea Jauregizar, Teresa Morera-Herreras

Psychiatry Faculty Publications

Aim This study aimed to assess the oral health status of individuals with schizophrenia and explore its association with behavioural and pharmacological factors, with particular focus on long-term antipsychotic treatment and cumulative anticholinergic burden. Methods A total of 153 adults with schizophrenia (18–65 years) from the Mental Health Network of Bizkaia (Spain), all under antipsychotic treatment for ≥12 months, were evaluated and compared with 153 controls from the general population. Data on socio-demographic variables, tobacco use and oral hygiene habits were collected. Oral health was assessed using the Decayed, Missing and Filled Teeth (DMFT) index and the Community Periodontal Index …

Generative Models And Synthetic Data In Clinical Prediction Models, Anthony A. Mangino, Taha Ahmed, Vincent L. Sorrell

Radiology Faculty Publications

Introduction: Reproducibility, consistency, and transparency are essential to responsible and ethical scientific inquiry, though practices supporting these qualities are often neglected. However, in many cases data are confidential or otherwise unable to be shared publicly. This tutorial describes a method utilizing generative adversarial networks (GANs) to create synthetic data that are sufficiently similar to the original dataset in such cases where the source data cannot be shared or where the source data are too sparse as to internally validate results. Methods: Utilizing an exemplar study that aimed to create a clinical prediction model employing a novel echocardiographic measurement to differentiate …

The Supreme Court's Goldilocks: Why The Major Questions Doctrine Is The Ideal Compromise Between Two Unattractive Extremes, Bradley P. Simpson

Kentucky Law Journal

No abstract provided.

Exposing Car Dealerships' Final Hidden Sales Con: A Call For The Disclosure Of Interest Rate Markups When "Helping" Buyers With Indirect Financing, John C. Simms

Kentucky Law Journal

No abstract provided.

Congress's Mistaken Ip Power And Our Hybrid Constitutionalism, Barry P. Mcdonald

Kentucky Law Journal

No abstract provided.

The Brave New World Of Judicial Elections, Charles Gardner Geyh

Kentucky Law Journal

No abstract provided.

A Tale Of Two Landlords, Christopher J. Ryan Jr.

Kentucky Law Journal

No abstract provided.

Table Of Contents For Volume 114, Issue 1, Kentucky Law Journal

Kentucky Law Journal

No abstract provided.

The Case For Lgbtq+ Adoption Rights In The Post-Roe Era, Tate Craft

Kentucky Law Journal

No abstract provided.

Domestic Guestworkers: A Call To End The H-2b Program And Empower American Workers, Preston Huennekens

Kentucky Law Journal

No abstract provided.

Impeachment Can Be Based On Non-Criminal Misconduct: Corpus-Linguistic And Historical Evidence, Clark D. Cunningham, Ute Römer-Barron

Kentucky Law Journal

No abstract provided.