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Development Of Poly(Acrylamide)-Based Hydrogel Composites With Powdered Activated Carbon For Controlled Sorption Of Pfoa And Pfos In Aqueous Systems, Maria Victoria X. Klaus, Angela M. Gutierrez, J. Zach Hilt Nov 2023

Development Of Poly(Acrylamide)-Based Hydrogel Composites With Powdered Activated Carbon For Controlled Sorption Of Pfoa And Pfos In Aqueous Systems, Maria Victoria X. Klaus, Angela M. Gutierrez, J. Zach Hilt

UK CARES Faculty Publications

Per- and polyfluoroalkyl substances (PFAS) are anthropogenic compounds developed for various applications; some are connected to adverse health impacts including immunosuppression and higher susceptibility to some cancers. Current PFAS remediation treatments from aqueous sources include granular activated carbon (GAC) adsorption, membrane separation, and anion- exchange resin (AER) removal. Each has specific disadvantages, hence the need for a new and efficient technology. Herein, acrylamide-based hydrogel composites were synthesized with powdered activated carbon (PAC) and characterized to determine their affinity for PFAS. Physicochemical characterization included Fourier-Transform infrared spectroscopy (FTIR) to identify chemical composition, thermogravimetric analysis (TGA) to confirm PAC loading percentage, and …


Α-Synuclein Is The Major Platelet Isoform But Is Dispensable For Activation, Secretion, And Thrombosis, Alexis N. Smith, Smita Joshi, Harry Chanzu, Hammodah Rawhi Hammodah Alfar, Kanakanagavalli Shravani Prakhya, Sidney W. Whiteheart Nov 2023

Α-Synuclein Is The Major Platelet Isoform But Is Dispensable For Activation, Secretion, And Thrombosis, Alexis N. Smith, Smita Joshi, Harry Chanzu, Hammodah Rawhi Hammodah Alfar, Kanakanagavalli Shravani Prakhya, Sidney W. Whiteheart

Saha Cardiovascular Research Center Faculty Publications

Platelets play many roles in the vasculature ensuring proper hemostasis and maintaining integrity. These roles are facilitated, in part, by cargo molecules released from platelet granules via Soluble NSF Attachment Protein Receptor (SNARE) mediated membrane fusion, which is controlled by several protein-protein interactions. Chaperones have been characterized for t-SNAREs (i.e. Munc18b for Syntaxin-11), but none have been clearly identified for v-SNAREs. α- Synuclein has been proposed as a v-SNARE chaperone which may affect SNARE-complex assembly, fusion pore opening, and thus secretion. Despite its abundance and that it is the only isoform present, α-synuclein’s role in platelet secretion is uncharacterized. In …


Phosphorylation Of Ahr By Plk1 Promotes Metastasis Of Luad Via Dio2-Th Signaling, Chaohao Li, Derek B. Allison, Daheng He, Fengyi Mao, Xinyi Wang, Piotr G. Rychahou, Ibrahim A. Imam, Yifan Kong, Qiongsi Zhang, Yanquan Zhang, Jinghui Liu, Ruixin Wang, Xiongjian Rao, Sai Wu, B. Mark Evers, Qing Shao, Chi Wang, Zhiguo Li, Xiaoqi Liu Nov 2023

Phosphorylation Of Ahr By Plk1 Promotes Metastasis Of Luad Via Dio2-Th Signaling, Chaohao Li, Derek B. Allison, Daheng He, Fengyi Mao, Xinyi Wang, Piotr G. Rychahou, Ibrahim A. Imam, Yifan Kong, Qiongsi Zhang, Yanquan Zhang, Jinghui Liu, Ruixin Wang, Xiongjian Rao, Sai Wu, B. Mark Evers, Qing Shao, Chi Wang, Zhiguo Li, Xiaoqi Liu

Markey Cancer Center Faculty Publications

Metastasis of lung adenocarcinoma (LUAD) is a major cause of death in patients. Aryl hydrocarbon receptor (AHR), an important transcription factor, is involved in the initiation and progression of lung cancer. Polo-like kinase 1 (PLK1), a serine/threonine kinase, acts as an oncogene promoting the malignancy of multiple cancer types. However, the interaction between these two factors and their significance in lung cancer remain to be determined. In this study, we demonstrate that PLK1 phosphorylates AHR at S489 in LUAD, leading to epithelial-mesenchymal transition (EMT) and metastatic events. RNA-seq analyses reveal that type 2 deiodinase (DIO2) is responsible for EMT and …


Kytc Department Of Aviation Aircraft Maintenance Technician (Amt) Program Optimization, Bethany Paris, P. Gayle Marks, Bryan Gibson Nov 2023

Kytc Department Of Aviation Aircraft Maintenance Technician (Amt) Program Optimization, Bethany Paris, P. Gayle Marks, Bryan Gibson

Kentucky Transportation Center Research Report

The aviation industry is a linchpin of Kentucky’s economy. Major firms such as UPS, Amazon, and DHL have major hubs at Louisville Muhammad Ali International Airport (SDF) and Cincinnati/Northern Kentucky International Airport (CVG). As of December 2022, 4,570 aircraft mechanics and service technicians (AMTs) were employed in the state. Demand in this sector is poised to grow. As such, it is critical to understand what resources Kentucky has available to train the next generation of professionals and the number of people the aviation industry is likely to employ statewide over the next decade. Kentucky and the surrounding states are home …


Tricritical Point As A Crossover Between Type-Is And Type-Iis Bifurcations, Prabakaran Rajamanickam, Joel Daou Oct 2023

Tricritical Point As A Crossover Between Type-Is And Type-Iis Bifurcations, Prabakaran Rajamanickam, Joel Daou

Progress in Scale Modeling, an International Journal

A tricritical point as a crossover between (stationary finite-wavelength) type-Is and (stationary longwave) type-IIs bifurcations is identified in the study of diffusive-thermal (Turing) instability of flames propagating in a Hele-Shaw channel in a direction transverse to a shear flow. Three regimes exhibiting different scaling laws are identified in the neighbourhood of the tricritical point. For these three regimes, sixth-order partial differential equations are obtained governing the weakly nonlinear evolution of unstable solutions near the onset of instability. These sixth-order PDES may be regarded as the substitute for the classical fourth-order Kuramoto­­­­­­–­­Sivashinsky equation which is not applicable near the …


Multiexciton Quintet State Populations In A Rigid Pyrene-Bridged Parallel Tetracene Dimer, Liang-Chun Lin, Tanner Smith, Qianxiang Ai, Brandon K. Rugg, Chad Risko, John E. Anthony, Niels H. Damrauer, Justin C. Johnson Oct 2023

Multiexciton Quintet State Populations In A Rigid Pyrene-Bridged Parallel Tetracene Dimer, Liang-Chun Lin, Tanner Smith, Qianxiang Ai, Brandon K. Rugg, Chad Risko, John E. Anthony, Niels H. Damrauer, Justin C. Johnson

UK CARES Faculty Publications

The multiexciton quintet state, 5 TT, generated as a singlet fission intermediate in pairs of molecular chromophores, is a promising candidate as a qubit or qudit in future quantum information science schemes. In this work, we synthesize a pyrene-bridged parallel tetracene dimer, TPT, with an optimized interchromophore coupling strength to prevent the dissociation of 5 TT to two decorrelated triplet (T1) states, which would contaminate the spin-state mixture. Long-lived and strongly spin-polarized pure 5 TT state population is observed via transient absorption spectroscopy and transient/pulsed electron paramagnetic resonance spectroscopy, and its lifetime is estimated to be >35 ms, with the …


Overview Of Hil Co-Simulation For Very Large Distribution Systems And Power Electronic Converters With A Dc Fast Charging Ev Benchmark Study On An Ieee Test Feeder, Rosemary E. Alden, Donovin D. Lewis, Dan M. Ionel Oct 2023

Overview Of Hil Co-Simulation For Very Large Distribution Systems And Power Electronic Converters With A Dc Fast Charging Ev Benchmark Study On An Ieee Test Feeder, Rosemary E. Alden, Donovin D. Lewis, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Current development towards implementation of the future smart grid includes advanced controller and power hardware-in-the-loop (CHIL/PHIL) testing of new technology. The impact of new loads, distributed energy resources (DER) equipment, and controls spans two fields, both electric distribution power systems modeling, typically completed in the phasor domain, and electromagnetic transient (EMT) analysis across the frequency domain. The co-simulation of distribution power systems and power electronic converter controls is a growing field of research for improved design using real-time HIL capability. Within this paper, over fifty references are reviewed to summarize the current state of HIL technology, specifically with co-simulation in …


Distribution System Optimal Operation Of Smart Homes With Battery And Equivalent Hvac Energy Storage For Virtual Power Plant Controls, Steven B. Poore, Rosemary E. Alden, Evan S. Jones, Dan M. Ionel Oct 2023

Distribution System Optimal Operation Of Smart Homes With Battery And Equivalent Hvac Energy Storage For Virtual Power Plant Controls, Steven B. Poore, Rosemary E. Alden, Evan S. Jones, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Battery energy storage systems (BESS) that can be utilized for demand response (DR) and load shifting are limited in adoption by high capital cost. Large residential loads such as electric water heaters (EWH) and heating, ventilation and air-conditioning (HVAC) may be controlled using distributed energy resource management systems (DERMS) to perform functions like batteries, such as reducing cost and decreasing energy storage capacity requirements when implemented at the aggregate level. Increasing levels of renewable generation further incentivizes shifting loads in time through controls and energy storage to reduce curtailment and carbon footprint. This paper proposes techniques for the optimization and …


Elongation Of Very Long Chain Fatty Acids-3 (Elovl3) Is Activated By Zhx2 And Is A Regulator Of Cell Cycle Progression, Kate Townsend Creasy, Hui Ren, Jieyun Jiang, Martha L. Peterson, Brett T. Spear Oct 2023

Elongation Of Very Long Chain Fatty Acids-3 (Elovl3) Is Activated By Zhx2 And Is A Regulator Of Cell Cycle Progression, Kate Townsend Creasy, Hui Ren, Jieyun Jiang, Martha L. Peterson, Brett T. Spear

Markey Cancer Center Faculty Publications

Zinc fingers and homeoboxes 2 (Zhx2) are transcriptional regulators of liver gene expression with key functions in embryonic development as well as tissue regeneration in response to damage and disease, presumably through its control of target genes. Previous microarray data suggested that elongation of very long chain fatty acids-3 (Elovl3), a member of the ELOVL family of enzymes that synthesize very long chain fatty acids (VLCFAs), is a putative Zhx2 target gene. VLCFAs are core component of ceramides and other bioactive sphingolipids that are often dysregulated in diseases and regulate key cellular processes including proliferation. Since several previously identified Zhx2 …


Stat3 Modulates Cd4+ T Mitochondrial Dynamics And Function In Aging, Emelia Zukowski, Marco Sannella, Jack Donato Rockhold, Gabriella Kalantar, Jingting Yu, Sara Santacruz-Calvo, Madison K. Kuhn, Nasun Hah, Ling Ouyang, Tzu-Wen Wang, Lyanne Murphy, Heather Marszalkowski, Kaleigh Gibney, Micah J. Drummond, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath Oct 2023

Stat3 Modulates Cd4+ T Mitochondrial Dynamics And Function In Aging, Emelia Zukowski, Marco Sannella, Jack Donato Rockhold, Gabriella Kalantar, Jingting Yu, Sara Santacruz-Calvo, Madison K. Kuhn, Nasun Hah, Ling Ouyang, Tzu-Wen Wang, Lyanne Murphy, Heather Marszalkowski, Kaleigh Gibney, Micah J. Drummond, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath

Markey Cancer Center Faculty Publications

Aging promotes numerous intracellular changes in T cells that impact their effector function. Our data show that aging promotes an increase in the localization of STAT3 to the mitochondria (mitoSTAT3), which promotes changes in mitochondrial dynamics and function and T-cell cytokine production. Mechanistically, mitoSTAT3 increased the activity of aging T-cell mitochondria by increasing complex II. Limiting mitoSTAT3 using a mitochondria-targeted STAT3 inhibitor, Mtcur-1 lowered complex II activity, prevented age-induced changes in mitochondrial dynamics and function, and reduced Th17 inflammation. Exogenous expression of a constitutively phosphorylated form of STAT3 in T cells from young adults mimicked changes in mitochondrial dynamics and …


2023 Final Report For Databases In The 2022 Traffic Records Improvement Plan: Facilitating The Development Of Projects To Attain The Goals In The Implementation Plan For The 2022-26 Traffic Records Strategic Plan, Lenahan O'Connell, Samantha Wright, Reginald Souleyrette Oct 2023

2023 Final Report For Databases In The 2022 Traffic Records Improvement Plan: Facilitating The Development Of Projects To Attain The Goals In The Implementation Plan For The 2022-26 Traffic Records Strategic Plan, Lenahan O'Connell, Samantha Wright, Reginald Souleyrette

Kentucky Transportation Center Research Report

During fiscal year 2023, with financial support (Grant #M3Da-2022-04) from the Kentucky Office of Highway Safety, the Kentucky Transportation Center (KTC)-continued its work with traffic database officials to facilitate successful attainment of the remaining goals from the 2017-21 Traffic Records Strategic Plan (TRSP), which goals are in the 2022-26 TRSP Transportation Records Improvement Plan (TRIP). For most databases, some new goals were developed; this required further refinement of some projects or strategies to improve database performance. Projects to complete the goals in the TRIP were continued and some completed for the following databases: CRASH, Citation/Adjudication, Injury Surveillance (KIPRC and EMS), …


Bridging The Gap Between Academic Research And Reduction To Practice: Manufacturing Scale-Up Of Polymeric Membranes For Water Treatment, David Lu, Isabel C. Escobar Sep 2023

Bridging The Gap Between Academic Research And Reduction To Practice: Manufacturing Scale-Up Of Polymeric Membranes For Water Treatment, David Lu, Isabel C. Escobar

Kentucky Water Resources Annual Symposium

No abstract provided.


Modeling, Managing, And Mitigating Stormwater Flooding Using A Real-Time Monitoring Network And Environmental Equity Approach, Ben Hauschild, Jason S. Polk, Trayson Lawler, Adam Desloge Sep 2023

Modeling, Managing, And Mitigating Stormwater Flooding Using A Real-Time Monitoring Network And Environmental Equity Approach, Ben Hauschild, Jason S. Polk, Trayson Lawler, Adam Desloge

Kentucky Water Resources Annual Symposium

No abstract provided.


Stormwater Management Advances Using Smart Sensing Network Architecture For Precipitation Monitoring, Brittany Pekara, Jason S. Polk, James Adam Shelley Sep 2023

Stormwater Management Advances Using Smart Sensing Network Architecture For Precipitation Monitoring, Brittany Pekara, Jason S. Polk, James Adam Shelley

Kentucky Water Resources Annual Symposium

No abstract provided.


Development Of A Spatial And Statistical Diagnostic Tool To Prioritize Pfas Sample Locations In Kentucky Surface Waters, Ariel Robinson, Angela Gutierrez, Kelly G. Pennell Sep 2023

Development Of A Spatial And Statistical Diagnostic Tool To Prioritize Pfas Sample Locations In Kentucky Surface Waters, Ariel Robinson, Angela Gutierrez, Kelly G. Pennell

Kentucky Water Resources Annual Symposium

No abstract provided.


A Flood Of Consequences In Louisville, Kentucky: Using Hgis To Track Refugees Impacted By The 1937 Ohio River Flood, Trevor Harry, Margaret M. Gripshover Sep 2023

A Flood Of Consequences In Louisville, Kentucky: Using Hgis To Track Refugees Impacted By The 1937 Ohio River Flood, Trevor Harry, Margaret M. Gripshover

Kentucky Water Resources Annual Symposium

No abstract provided.


Sewer Gas, Siphons And Long-Term Stewardship For Community Interventions, Hong Cheng Tay, Kelly G. Pennell Sep 2023

Sewer Gas, Siphons And Long-Term Stewardship For Community Interventions, Hong Cheng Tay, Kelly G. Pennell

Kentucky Water Resources Annual Symposium

No abstract provided.


Perceptions And Visual Awareness Of Urban Karst Flooding To Inform Preparedness Planning And Management Actions, Grace Herrmann, Jason Polk Sep 2023

Perceptions And Visual Awareness Of Urban Karst Flooding To Inform Preparedness Planning And Management Actions, Grace Herrmann, Jason Polk

Kentucky Water Resources Annual Symposium

No abstract provided.


Contaminant Transport Mechanisms And Source Tracking In Karst Groundwater Systems Under Agriculture Land Use, Shreya Pandley, Jason S. Polk Sep 2023

Contaminant Transport Mechanisms And Source Tracking In Karst Groundwater Systems Under Agriculture Land Use, Shreya Pandley, Jason S. Polk

Kentucky Water Resources Annual Symposium

No abstract provided.


Identifying Controls On Sediment Hysteresis Patterns Using Interpretable Machine Learning, Arlex Marin-Ramirez, David Tyler Mahoney, Brendan Riddle, Leonie Bettel, James Fox Sep 2023

Identifying Controls On Sediment Hysteresis Patterns Using Interpretable Machine Learning, Arlex Marin-Ramirez, David Tyler Mahoney, Brendan Riddle, Leonie Bettel, James Fox

Kentucky Water Resources Annual Symposium

No abstract provided.


Modifying The Cop Karst Groundwater Vulnerability Model Using Spring Storm Response, Benjamin Tobin, Sara Arpin, Solomon Nketsia, Chelsea Parada, Maaz Fareedi, Will Hemenover, Charlies Taylor Sep 2023

Modifying The Cop Karst Groundwater Vulnerability Model Using Spring Storm Response, Benjamin Tobin, Sara Arpin, Solomon Nketsia, Chelsea Parada, Maaz Fareedi, Will Hemenover, Charlies Taylor

Kentucky Water Resources Annual Symposium

No abstract provided.


Exploring Water Quality On The Reclaimed Surface Mines Lands In Eastern Kentucky, Whitney Tara Maynard, Buddhi Gyawali, George Antonious Sep 2023

Exploring Water Quality On The Reclaimed Surface Mines Lands In Eastern Kentucky, Whitney Tara Maynard, Buddhi Gyawali, George Antonious

Kentucky Water Resources Annual Symposium

No abstract provided.


Modeling Moisture Content Variations In The Shallow Subsurface Soil Under Rainfall Infiltration And Different Atmospheric Conditions, Omid Ghasemi-Fare, Mohammadreza Mir Tamizdoust, Fereydoun Najafian Jazi, Amin Mohammadzadeh, Tom Rockaway Sep 2023

Modeling Moisture Content Variations In The Shallow Subsurface Soil Under Rainfall Infiltration And Different Atmospheric Conditions, Omid Ghasemi-Fare, Mohammadreza Mir Tamizdoust, Fereydoun Najafian Jazi, Amin Mohammadzadeh, Tom Rockaway

Kentucky Water Resources Annual Symposium

No abstract provided.


Karst Watershed Planning For The Jennings Creek/Lost River Watershed In South-Central Kentucky To Improve Water Quality And Community Awareness, Jason S. Polk, Adam Desloge, Brittany Pekara, Trayson Lawler, Shreya Pandey, Kara Brunot, Mara Neace, Meghan Forbes, Matt Powell Sep 2023

Karst Watershed Planning For The Jennings Creek/Lost River Watershed In South-Central Kentucky To Improve Water Quality And Community Awareness, Jason S. Polk, Adam Desloge, Brittany Pekara, Trayson Lawler, Shreya Pandey, Kara Brunot, Mara Neace, Meghan Forbes, Matt Powell

Kentucky Water Resources Annual Symposium

No abstract provided.


River And Conduit Stage Tomography For Characterizing Karst Aquifers, Junfeng Zhu, Steven Webb, James Fox Sep 2023

River And Conduit Stage Tomography For Characterizing Karst Aquifers, Junfeng Zhu, Steven Webb, James Fox

Kentucky Water Resources Annual Symposium

No abstract provided.


Antibiotic-Resistant E.Coli In Kentucky Watersheds Impacted By Various Land Uses, Jayden Hamlet, Jason Marion, Travis Altheide Sep 2023

Antibiotic-Resistant E.Coli In Kentucky Watersheds Impacted By Various Land Uses, Jayden Hamlet, Jason Marion, Travis Altheide

Kentucky Water Resources Annual Symposium

No abstract provided.


Investigating The Impact Of Stream Restoration On Sediment Transport At A Karst Spring Using Hydrograph Unmixing, Sediment Transport Modeling And Multi-Source Hysteresis, Leonie Bettel, Jimmy Fox, Admin Husic, Tyler Mahoney, Arlex Marin, Zunfeng Zhu, Benjamin Tobin, Nabil Al Aamer, Chloe Osborne Sep 2023

Investigating The Impact Of Stream Restoration On Sediment Transport At A Karst Spring Using Hydrograph Unmixing, Sediment Transport Modeling And Multi-Source Hysteresis, Leonie Bettel, Jimmy Fox, Admin Husic, Tyler Mahoney, Arlex Marin, Zunfeng Zhu, Benjamin Tobin, Nabil Al Aamer, Chloe Osborne

Kentucky Water Resources Annual Symposium

No abstract provided.


Methane Dynamics Of Kentucky Bottomland Hardwood Forested Systems, Marissa Miles, Jessica B. Moon, Skylar Ross, Jarred Asselta, Niklas Klauss, Rosie Carey, Kabi Raj Khatiwada, Bassil El Masri, Gary Stinchcomb, Benjamin R. K. Runkle Sep 2023

Methane Dynamics Of Kentucky Bottomland Hardwood Forested Systems, Marissa Miles, Jessica B. Moon, Skylar Ross, Jarred Asselta, Niklas Klauss, Rosie Carey, Kabi Raj Khatiwada, Bassil El Masri, Gary Stinchcomb, Benjamin R. K. Runkle

Kentucky Water Resources Annual Symposium

No abstract provided.


A Critical Review Of Vegetation Issues In So-Called “Stream Restoration” On Daniel Boone National Forest, Julian J. N. Campbell Sep 2023

A Critical Review Of Vegetation Issues In So-Called “Stream Restoration” On Daniel Boone National Forest, Julian J. N. Campbell

Kentucky Water Resources Annual Symposium

No abstract provided.


Floating Vegetation As A Driver Of Ch4 Emissions In Small Ponds Across Louisville, Ky, Mark Tierney, C. Jalink, J. H. Loughrin, S. W. Antle, Andrew S. Mehring Sep 2023

Floating Vegetation As A Driver Of Ch4 Emissions In Small Ponds Across Louisville, Ky, Mark Tierney, C. Jalink, J. H. Loughrin, S. W. Antle, Andrew S. Mehring

Kentucky Water Resources Annual Symposium

No abstract provided.