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The Association Of Circulating Amylin With Β-Amyloid In Familial Alzheimer's Disease, Han Gia Ly, Nirmal Verma, Savita Sharma, Deepak Kotiya, Sanda Despa, Erin L. Abner, Peter T. Nelson, Gregory A. Jicha, Donna M. Wilcock, Larry B. Goldstein, Rita Guerreiro, José Brás, Angela J. Hanson, Suzanne Craft, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Alzheimer’S Disease Exome Sequencing Group, Florin Despa

Pharmacology and Nutritional Sciences Faculty Publications

Introduction

This study assessed the hypothesis that circulating human amylin (amyloid‐forming) cross‐seeds with amyloid beta (Aβ) in early Alzheimer's disease (AD).

Methods

Evidence of amylin‐AD pathology interaction was tested in brains of 31 familial AD mutation carriers and 20 cognitively unaffected individuals, in cerebrospinal fluid (CSF) (98 diseased and 117 control samples) and in genetic databases. For functional testing, we genetically manipulated amylin secretion in APP/PS1 and non‐APP/PS1 rats.

Results

Amylin‐Aβ cross‐seeding was identified in AD brains. High CSF amylin levels were associated with decreased CSF Aβ42 concentrations. AD risk and amylin gene are not correlated. Suppressed amylin secretion protected …

Breeding And Utilization Of Poa Pratensis L. Cv. Daqingshan, Suying Wen

IGC Proceedings (1977-2023)

No abstract provided.

Conversion Of A Degraded Urban Area To Golf‐School Course In Central Italy, Andrea Pardini, R. Tallarico, D. Parrini

IGC Proceedings (1977-2023)

No abstract provided.

Beef Cattle Performance In A Silvopastoral System Fertilized With N And K, In Brazilian Cerrado, F. S. Bernardino, R. Garcia, J. C. L. Neves, R. G. Tonucci

IGC Proceedings (1977-2023)

No abstract provided.

Nitrogen Release From Turfgrass Clippings With Different Fertilization Rates, Karin Kauer, Tiina Köster, H. Raave, R. Viiralt, A. Selge

IGC Proceedings (1977-2023)

No abstract provided.

The Study On Cross‐Breeding Of Zoysia Willd., Hailin Guo, Jianxiu Liu, Aigui Guo

IGC Proceedings (1977-2023)

No abstract provided.

Preliminary Research On Root Characteristics Of Some Turfgrasses In Kunming, Fucheng Luo, Yun Chen, Zhenzhong Sun

IGC Proceedings (1977-2023)

No abstract provided.

Studies On The Wild Dichondra Repen Forst. In Southwest Of China, Yan Chen, Youmin Gan, Kunlei Wang, Ling Fei

IGC Proceedings (1977-2023)

No abstract provided.

Green Turf Quality And Evapotranspiration Rate In Summer Of Agrostis Stolonifera L. Cv. Yuexuan No. 1 In Guangzhou Area, P. Chen, X. L. Shi, P. Liu, Y. L. Zhou, A. Liu

IGC Proceedings (1977-2023)

No abstract provided.

Nalfurafine Reduces Neuroinflammation And Drives Remyelination In Models Of Cns Demyelinating Disease, Lisa Denny, Afnan Al Abadey, Katharina Robichon, Nikki Templeton, Thomas E. Prisinzano, Bronwyn M. Kivell, Anne C. La Flamme

Pharmaceutical Sciences Faculty Publications

Objectives: Multiple sclerosis (MS) is a neurodegenerative disease characterised by inflammation and damage to the myelin sheath, resulting in physical and cognitive disability. There is currently no cure for MS, and finding effective treatments to prevent disease progression has been challenging. Recent evidence suggests that activating kappa opioid receptors (KOR) has a beneficial effect on the progression of MS. Although many KOR agonists like U50,488 are not suitable for clinical use because of a poor side-effect profile, nalfurafine is a potent, clinically used KOR agonist with a favorable side-effect profile.

Methods: Using the experimental autoimmune encephalomyelitis (EAE) model, the effect …

Alleviating Poverty And Managing Natural Resources Through Integrated Crop‐Livestock Systems Research In Western China, William D. Bellotti, Z. B. Nan, Y. Y. Shen, F. J. Hou, S. Pain, Lihua Li, Xiaoyan Wang

IGC Proceedings (1977-2023)

No abstract provided.

Simulating Options For Managing Seasonal And Annual Variations In Feed Supply Of Mixed Crop/Livestock Systems In Sub‐Tropical Australia, Lindsay W. Bell

IGC Proceedings (1977-2023)

No abstract provided.

Impact Of Preceding Cropping And Cutting Height On Stand Uniformity Of Corn, Souichiro Morita, Tsutomu Kanno, Shunji Kurokawa, S. Sato, Y. Yoshimura

IGC Proceedings (1977-2023)

No abstract provided.

Integrating Dual‐Purpose Wheat Crops Into Different Sheep Production Systems In Southern Australia: Impacts On Livestock, Economic Returns And Risk, Andrew D. Moore, H. Dove, W. M. Kelman

IGC Proceedings (1977-2023)

No abstract provided.

Intake And Nutritional Value Of Brachiaria Brizantha Cv. Marandu In A Silvopastoral System, Rogerio M. Mauricio, N. M. Rodriguz, L. F. Sousa, E. O. S. Saliba, L. C. Gonçalves, G. R. Moreira

IGC Proceedings (1977-2023)

No abstract provided.

Salt Tolerance Of Some New Selections Of Warm Season Turfgrasses And Their Salt Tolerance Mechanisms, Jingbo Chen, Tingting Zhang, Jun Yan, Yanqin Jiang, Hailin Guo, Jianxiu Liu

IGC Proceedings (1977-2023)

No abstract provided.

Evaluating Turfgrass Color Using Hyperspectral Vegetation Indices, Gong Chen, W. Zhang, G. D. Li

IGC Proceedings (1977-2023)

No abstract provided.

Exploitation Enhancement Of Buffaloes Manure Application Vs Conventional Cultivation In Intensive Two Forage Cropping Models Per Year--Results On Agronomic Purposes, Pasquale Martiniello, E. Sabia, E. Rossi, S. Concetti

IGC Proceedings (1977-2023)

No abstract provided.

The Impact Of A Wide-Spread Insect Outbreak And Subsequent Timber Harvesting On Forested Rangelands, Matthew D. Braun

IGC Proceedings (1977-2023)

No abstract provided.

From Forages To Perennial Grain Polycultures: Illinois Bundleflower‐Intermediate Wheatgrass Dual Purpose Mixtures, V. D. Picasso, E. C. Brummer, M. Liebman

IGC Proceedings (1977-2023)

No abstract provided.

Lipid Metabolism As A Targetable Metabolic Vulnerability In Colorectal Cancer, Yekaterina Y. Zaytseva

Toxicology and Cancer Biology Faculty Publications

No abstract provided.

The Effects Of Kindergarten And First Grade Schooling On Executive Function And Academic Skill Development: Evidence From A School Cutoff Design, Matthew H. Kim, Sammy F. Ahmed, Frederick J. Morrison

Psychology Faculty Publications

Early executive function (EF) skills reliably predict school readiness and future academic success. While children’s skills undergo rapid development during the transition to formal schooling, it remains unclear the extent to which schooling exerts a unique influence on the accelerated development of EF and academic skills during the early years of schooling. In the present study, a quasi-experimental technique known as the school cutoff design was used to examine whether same-aged children who made vs. missed the age cutoff for school entry significantly differed on EF, reading, and math outcomes. Data from 166 pre-k, kindergarten, and first grade children (Range …

High-Density Lipoproteins And Serum Amyloid A (Saa), Nancy R. Webb

Pharmacology and Nutritional Sciences Faculty Publications

PURPOSE OF REVIEW: Serum amyloid A (SAA) is a highly sensitive acute phase reactant that has been linked to a number of chronic inflammatory diseases. During a systemic inflammatory response, liver-derived SAA is primarily found on high-density lipoprotein (HDL). The purpose of this review is to discuss recent literature addressing the pathophysiological functions of SAA and the significance of its association with HDL.

RECENT FINDINGS: Studies in gene-targeted mice establish that SAA contributes to atherosclerosis and some metastatic cancers. Accumulating evidence indicates that the lipidation state of SAA profoundly affects its bioactivities, with lipid-poor, but not HDL-associated, SAA capable of …

Metabolomics-Based Analysis Of Miniature Flask Contents Identifies Tobacco Mixture Use Among The Ancient Maya, Mario Zimmermann, Korey J. Brownstein, Luis Pantoja Díaz, Iliana Ancona Aragón, Scott R. Hutson, Barry Kidder, Shannon Tushingham, David R. Gang

Anthropology Faculty Publications

A particular type of miniature ceramic vessel locally known as “veneneras” is occasionally found during archaeological excavations in the Maya Area. To date, only one study of a collection of such containers successfully identified organic residues through coupled chromatography–mass spectrometry methods. That study identified traces of nicotine likely associated with tobacco. Here we present a more complete picture by analyzing a suite of possible complementary ingredients in tobacco mixtures across a collection of 14 miniature vessels. The collection includes four different vessel forms and allows for the comparison of specimens which had previously formed part of museum exhibitions with recently …

Adaptation To Water‐Poor Conditions: An Experimental Study With Buchloe Dactyloides, X. L. Sun, J. Z. Niu, He Zhou

IGC Proceedings (1977-2023)

No abstract provided.

Pasture Management Strategies To Support Sustainable Production Of Dual Purpose Farms In Western Venezuela, Dario Osechas, Ligia Becerra

IGC Proceedings (1977-2023)

No abstract provided.

Traditional Uses Of Wild Grasses Amongst Three Kenyan Farming Communities, N. M. Nganga, F. N. Muyekho, Z. R. Khan, R. S. Copeland

IGC Proceedings (1977-2023)

No abstract provided.

Arginase 1 Insufficiency Precipitates Amyloid-Β Deposition And Hastens Behavioral Impairment In A Mouse Model Of Amyloidosis, Chao Ma, Jerry B. Hunt, Maj-Linda B. Selenica, Awa Sanneh, Leslie A. Sandusky-Beltran, Mallory Watler, Rana Daas, Andrii Kovalenko, Huimin Liang, Devon Placides, Chuanhai Cao, Xiaoyang Lin, Michael B. Orr, Bei Zhang, John C. Gensel, David J. Feola, Marcia N. Gordon, Dave Morgan, Paula C. Bickford, Daniel C. Lee

Sanders-Brown Center on Aging Faculty Publications

Alzheimer’s disease (AD) includes several hallmarks comprised of amyloid-β (Aβ) deposition, tau neuropathology, inflammation, and memory impairment. Brain metabolism becomes uncoupled due to aging and other AD risk factors, which ultimately lead to impaired protein clearance and aggregation. Increasing evidence indicates a role of arginine metabolism in AD, where arginases are key enzymes in neurons and glia capable of depleting arginine and producing ornithine and polyamines. However, currently, it remains unknown if the reduction of arginase 1 (Arg1) in myeloid cell impacts amyloidosis. Herein, we produced haploinsufficiency of Arg1 by the hemizygous deletion in myeloid cells using Arg1 …

Characteristics And Turf Quality Traits Of Native Poa Pratensisin Humid Subtropical Sichuan, Yan Peng, Ying Qiu, Youmin Gan, Xia Liu

IGC Proceedings (1977-2023)

No abstract provided.

Breeding To Adapt Annual Ryegrass (Lolium Multiflorum Lam.) From A Forage To A Dwarf Turfgrass For Overseeding Sports Fields, L. R. Nelson, Jimmy Crowder

IGC Proceedings (1977-2023)

No abstract provided.