Digital Commons Network^™

Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction In Tauopathy, Shon A. Koren, Matthew J. Hamm, Ryan Cloyd, Sarah N. Fontaine, Emad Chishti, Chiara Lanzillotta, Jennifer Rodriguez-Rivera, Alexandria Ingram, Michelle Bell, Sara M. Galvis-Escobar, Nicholas Zulia, Fabio Di Domenico, Duc Duong, Nicholas T. Seyfried, David K. Powell, Moriel Vandsburger, Tal Frolinger, Anika M. S. Hartz, John Koren Iii, Jeffrey M. Axten, Nicholas J. Laping, Jose F. Abisambra

Sanders-Brown Center on Aging Faculty Publications

Tauopathies are a group of more than twenty known disorders that involve progressive neurodegeneration, cognitive decline and pathological tau accumulation. Current therapeutic strategies provide only limited, late-stage symptomatic treatment. This is partly due to lack of understanding of the molecular mechanisms linking tau and cellular dysfunction, especially during the early stages of disease progression. In this study, we treated early stage tau transgenic mice with a multi-target kinase inhibitor to identify novel substrates that contribute to cognitive impairment and exhibit therapeutic potential. Drug treatment significantly ameliorated brain atrophy and cognitive function as determined by behavioral testing and a sensitive imaging …

Differential Responses Of Antioxidant Metabpolism To Heat Stress For Warm‐Season And Cool‐Season Turfgrass Species, H. Du, Z. Wang, B. Huang

IGC Proceedings (1977-2023)

No abstract provided.

Cool‐Season Turfgrass Evaluation And Analysis Of Effectors Inhibiting Turfgrass Growth Under Camphor Trees In Shanghai China, Yali He, J. F. Guo, C. Wang, J. Chen, M. Lv, Y. M. Liu

IGC Proceedings (1977-2023)

No abstract provided.

Effects Of Different Nitrogen Supply Forms On The Growth And Quality Of Seashore Paspalum (Paspalum Vaginatum Sw.), Herong Guo, J. J. Wang, X. L. Lu

IGC Proceedings (1977-2023)

No abstract provided.

Bhlh Iridoid Synthesis 3 Is A Member Of A Bhlh Gene Cluster Regulating Terpenoid Indole Alkaloid Biosynthesis In Catharanthus Roseus, Sanjay Kumar Singh, Barunava Patra, Priyanka Paul, Yongliang Liu, Sitakanta Pattanaik, Ling Yuan

Kentucky Tobacco Research and Development Center Faculty Publications

Basic helix‐loop‐helix (bHLH) transcription factors (TFs) are key regulators of plant specialized metabolites, including terpenoid indole alkaloids (TIAs) in Catharanthus roseus. Two previously characterized subgroup‐IVa bHLH TFs, BIS1 (bHLH Iridoid Synthesis 1) and BIS2 regulate iridoid biosynthesis in the TIA pathway. We reanalyzed the recently updated C. roseus genome sequence and discovered that BIS1 and BIS2 are clustered on the same genomic scaffold with a previously uncharacterized bHLH gene, designated as BIS3. Only a few bHLH gene clusters have been studied to date. Comparative analysis of 49 genome sequences from different plant lineages revealed the presence of analogous …

Tomato Chlorosis Virus Infection Facilitates Bemisia Tabaci Med Reproduction By Elevating Vitellogenin Expression, Liping Huang, Xiaobin Shi, Jizhe Shi, Zhuo Zhang, Yong Fang, Zhanhong Zhang, Qiuyi Pan, Limin Zheng, Yang Gao, Deyong Zhang, Xinqiu Tan, Yong Liu, Xuguo Zhou

Entomology Faculty Publications

Transmission of plant pathogenic viruses mostly relies on insect vectors. Plant virus could enhance its transmission by modulating the vector. Previously, we showed that feeding on virus infected plants can promote the reproduction of the sweet potato whitefly, Bemisia tabaci MED (Q biotype). In this study, using a whitefly-Tomato chlorosis virus (ToCV)-tomato system, we investigated how ToCV modulates B. tabaci MED reproduction to facilitate its spread. Here, we hypothesized that ToCV-infected tomato plants would increase B. tabaci MED fecundity via elevated vitellogenin (Vg) gene expression. As a result, fecundity and the relative expression of B. tabaci MED Vg …

Visit-To-Visit Blood Pressure Variability And Sleep Architecture, Xiaoyue Liu, Jeongok Logan, Younghoon Kwon, Jennifer M. Lobo, Hyojung Kang, Min-Woong Sohn

Health Management and Policy Faculty Publications

Visit‐to‐visit blood pressure (BP) variability (BPV) is an independent risk factor of cardiovascular disease (CVD). Sleep architecture characterizes the distribution of different stages of sleep and may be important in CVD development. We examined the association between visit‐to‐visit BPV and sleep architecture using in‐lab polysomnographic data from 3,565 patients referred to an academic sleep center. BPV was calculated using the intra‐individual coefficient of variation of BP measures collected 12 months before the sleep study. We conducted multiple linear regression analyses to assess the association of systolic and diastolic BPV with sleep architecture—rapid eye movement (REM) and non‐rapid eye movement (NREM) …

Nitrogen Status In Leaves Of Poapratensis In Relation To Nitrogen Fertilization Strategy In Intensive Lawn Utilization, Piotr Goliński, Barbara Golińska

IGC Proceedings (1977-2023)

No abstract provided.

Lead Hyperaccumulation And Tolerance In Eremochloa Ophiuroides And Paspalum Vaginatum, Yanhua Zhu, Zhaolong Wang, Bingru Huang

IGC Proceedings (1977-2023)

No abstract provided.

Identification Of Centipedegrass Hybrids And Selection Of Polymorphic Primer Combinations By Sequence‐Related Amplified Polymorphism, Yiqi Zheng, Jianxiu Liu

IGC Proceedings (1977-2023)

No abstract provided.

Appalachian Caregiver Perspectives On Childhood Gun Safety In The Home, Dannell Boatman

Journal of Appalachian Health

Background: Childhood gun injuries pose a critical public health challenge. For children, unintentional gun injury deaths primarily occur in the home where parents or other adult guardians, referred to as caregivers hereafter, are responsible for safety. While the American Academic of Pediatrics recommends not having guns in areas where children live and play, firearms are often viewed as normative and fill an important role in many homes. This is particularly true in more rural areas, such as Appalachia, where there is a high density of gun ownership. Additional research is needed to understand rural caregivers’ current gun safety practices in …

Impacts Of Cold Stress On Stringy Stonecrop And Linear Stonecrop In Northern China, Bo Zhao, Jijun Li

IGC Proceedings (1977-2023)

No abstract provided.

Genetic Diversity Of Wild Cynodon Dactylon Germplasm Detected By Srap Markers, Yangjie Yi, Xinquan Zhang, Linkai Huang, Yao Ling, Xiao Ma, Wei Liu

IGC Proceedings (1977-2023)

No abstract provided.

Turf Performance Of 19 Tall Fescue Varieties During Summer Stress, Zhiming Yang, Zhihua Li

IGC Proceedings (1977-2023)

No abstract provided.

Cloning Of Dreb Transcription Factor From Buffalo Grass, Qingchuan Yang, Xiaoyan Hu, Junmei Kang, Houcong Jin

IGC Proceedings (1977-2023)

No abstract provided.

Establishing An Abundant And Efficient Explant System For The Agrobacterium‐Mediated Transformation Of Zoysiagrass, X. Wang, Y. Hoshino, T. Yamada

IGC Proceedings (1977-2023)

No abstract provided.

Seeding Rate And Cultivar Effect On Bahiagrass Establishment, Y. C. Newman, Jason A. Ferrell, Ann R. Blount, Lynn E. Sollenberger

IGC Proceedings (1977-2023)

No abstract provided.

Farmer‐Participatory Evaluation Of Summer Feeding Strategies In Afghanistan: Growth Of Cow‐Calf Pairs Grazing Native Pasture Supplemented With Oil‐Seed Cake, A. Larbi, S. Nezamuddin, S. Mahmood, M. Najibulla, K. Amegbeto

IGC Proceedings (1977-2023)

No abstract provided.

Factors Affecting Pasture Growth In A Densely Planted Willow Browse Block, Z. Hussain, Peter D. Kemp, David J. Horne, I. K. D. Jaya

IGC Proceedings (1977-2023)

No abstract provided.

A Successful Approach To Integrating Wildlife Management Into Grassland And Rangeland Conservation In The United States, L. Peter Heard, Terrell Erickson, Wendell Gilgert, Dennis Thompson

IGC Proceedings (1977-2023)

No abstract provided.

N Mineralization In Soil From 5‐And 9‐Year Lucerne Stands On The Loess Plateau, Fanghu Han, Yuying Shen

IGC Proceedings (1977-2023)

No abstract provided.

Morphological And Anatomical Characteristics Of Forage Peanut Under Shade, K. F. Gobbi, R. Garcia, A. F. Garcez Neto, M. C. Ventrella, O. G. Pereira, G. C. Rocha

IGC Proceedings (1977-2023)

No abstract provided.

Saltbush Alley Cropping Effects On Crop And Livestock Production On‐Farm In The Dry Areas Of Northern Syria, F. Ghassali, A. E. Osman, A. Larbi, M. Singh, J. Tiedeman, B. Norton

IGC Proceedings (1977-2023)

No abstract provided.

Beef Cattle Performance In A Silvopastoral System In Brazilian Cerrado, R. Garcia, F. S. Bernardino, J. C. L. Neves, R. G. Tonucci, K. F. Gobbi

IGC Proceedings (1977-2023)

No abstract provided.

Characterization Of Soil Properties Under Legume And Non‐Legume Tree Canopies Occurring In Signal Grass (Brachiaria Decumbens Stapf.) Pastures, José C. B. Dubeux Jr., M. A. Lira, M. V. F. Santos, D. M. Barros, M. A. Silva, Alexandre C. L. De Mello

IGC Proceedings (1977-2023)

No abstract provided.

Comprehensive Analysis Of Nac Transcription Factor Family Uncovers Drought And Salinity Stress Response In Pearl Millet (Pennisetum Glaucum), Ambika Dudhate, Harshraj Shinde, Pei Yu, Daisuke Tsugama, Shashi Kumar Gupta, Shenkui Liu, Tetsuo Takano

Pharmaceutical Sciences Faculty Publications

BACKGROUND: Pearl millet (Pennisetum glaucum) is a cereal crop that possesses the ability to withstand drought, salinity and high temperature stresses. The NAC [NAM (No Apical Meristem), ATAF1 (Arabidopsis thaliana Activation Factor 1), and CUC2 (Cup-shaped Cotyledon)] transcription factor family is one of the largest transcription factor families in plants. NAC family members are known to regulate plant growth and abiotic stress response. Currently, no reports are available on the functions of the NAC family in pearl millet.

RESULTS: Our genome-wide analysis found 151 NAC transcription factor genes (PgNACs) in the pearl millet genome. Thirty-eight …

Finnish Adolescent Girls’ Activity Patterns And The Effects Of An Activity-Based Homework Intervention On Their Physical Activity, Mari Kääpä, Sanna Palomäki, Henri Vähä-Ypyä, Tommi Vasankari, Mirja Hirvensalo, Alicia Fedewa

Educational, School, and Counseling Psychology Faculty Publications

Purpose: The insufficient physical activity (PA) of adolescents is a global challenge, and there is a need to find opportunities to engage youth in active lifestyles. The majority of adolescents do not meet the recommended guidelines of physical activity, and especially females have low levels of activity as they approach adolescence. The goal of this study was to obtain insight into Finnish adolescent girls’ objectively measured physical activity by evaluating the effects of an activity-based homework intervention on low, medium, and high-active girls during after-school hours.

Method: A physical activity homework intervention was put into place for female adolescent girls. …

Effects Of Salinity On Growth, Water Status, And Ion Accumulation In Two Cool‐Season Turfgrass Species, Ran Xu, M. Oka, H. Fujiyama

IGC Proceedings (1977-2023)

No abstract provided.

Study On Winter‐Green Technology For Sports Field Turf In Tropic And Subtropic Region Of China, J. B. Xi, Y. Li

IGC Proceedings (1977-2023)

No abstract provided.

Genetic Approach To Elucidate The Role Of Cyclophilin D In Traumatic Brain Injury Pathology, Ryan D. Readnower, W. Brad Hubbard, Olivia J. Kalimon, James W. Geddes, Patrick G. Sullivan

Spinal Cord and Brain Injury Research Center Faculty Publications

Cyclophilin D (CypD) has been shown to play a critical role in mitochondrial permeability transition pore (mPTP) opening and the subsequent cell death cascade. Studies consistently demonstrate that mitochondrial dysfunction, including mitochondrial calcium overload and mPTP opening, is essential to the pathobiology of cell death after a traumatic brain injury (TBI). CypD inhibitors, such as cyclosporin A (CsA) or NIM811, administered following TBI, are neuroprotective and quell neurological deficits. However, some pharmacological inhibitors of CypD have multiple biological targets and, as such, do not directly implicate a role for CypD in arbitrating cell death after TBI. Here, we reviewed the …