Digital Commons Network^™

Hpv Vaccination And Cervical Cancer Screening Promotion Among Black Individuals: Social Ecological Perspectives From Key Informants Interviews, Adebola Adegboyega, Desmennu Adeyimika, Obielodan Omoadoni, Dignan Mark

UK CARES Faculty Publications

Objectives: Rates of HPV infection and HPV-related cancers are elevated in the Black population of the US. Efforts to promote HPV vaccination and cervical cancer screening are important to reducing the cancer burden among Black populations. The purpose of this qualitative descriptive study guided by social ecological model (SEM) was to describe from the perspective of key informants, the challenges and opportunities for HPV vaccination and cervical cancer screening promotion among Black adults.

Design: Twenty-three key informants participated in individual interviews over zoom video conferencing. The sessions were audio- recorded, transcribed verbatim, and checked for accuracy prior to data analysis. …

Magnetic Nanocomposites For The Remote Activation Of Sulfate Radicals For The Removal Of Rhodamine B, Pranto Paul, Marissa Nicholson, J. Zach Hilt

UK CARES Faculty Publications

The widespread presence of numerous organic contaminants in water poses a threat to the ecological environment and human health. Magnetic nanocomposites exposed to an alternating magnetic field (AMF) have a unique ability for magnetically mediated energy delivery (MagMED) resulting from the embedded magnetic nanoparticles; this localized energy delivery and associated chemical and thermal effects are a potential method for removing contaminants from water. This work developed a novel magnetic nanocomposite—a polyacrylamide-based hydrogel loaded with iron oxide nanoparticles. For this magnetic nanocomposite, persulfate activation and the contamination removal in water were investigated. Magnetic nanocomposites were exposed to AMF with a model …

Forage News [2023-03], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.

Association Of Symptoms And Mode Of Transportation To Emergency Department In Patients With Acute Coronary Syndrome, Leslie L. Davis, Thomas P. Mccoy, Barbara Riegel, Sharon Mckinley, Lynn V. Doering, Debra K. Moser

UK CARES Faculty Publications

Background: Patients with acute coronary syndrome (ACS) with symptoms matching their expectations of a heart attack are more likely to use emergency medical services (EMS) than not.

Objective: To determine whether presenting symptom clusters are associated with EMS use in ACS patients and if EMS use or symptom clusters are associated with prehospital delay.

Methods: This secondary analysis used data from the PROMOTION trial, a randomized clinical trial that enrolled 3522 subjects with a history of or at risk for ACS from 5 sites in the United States, Australia, and New Zealand. Subjects were randomized to usual care or an …

Body Mass Index Percentiles Versus Body Composition Assessments: Challenges For Disease Risk Classifications In Children, Jody L. Clasey, Elizabeth Ann Easley, Margaret O'Bryan Murphy, Stefan G. Kiessling, Arnold Stromberg, Aric Schadler, Hong Huang, John A. Bauer

UK CARES Faculty Publications

Background: Identifying at-risk children with optimal specificity and sensitivity to allow for the appropriate intervention strategies to be implemented is crucial to improving the health and well-being of children. We determined relationships of body mass indexes for age and sex percentile (BMI%) classifications to actual body composition using validated and convenient methodologies and compared fat and non-fat mass estimates to normative cut-off reference values to determine guideline reliability. We hypothesized that we would achieve an improved ability to identify at-risk children using simple, non-invasive body composition and index measures.

Methods: Cross-sectional study of a volunteer convenience sample of 1,064 (537 …

Incorporating Environmental Impacts Into Short-Term Mine Planning: A Literature Survey, Milad Rahnema, Bahar Amirmoeini, Ali Moradi Afrapoli

Mining Engineering Faculty Publications

This paper aims to address the significant financial, environmental, and social risks posed by climate change to the mining industry, which is responsible for approximately 8% of global greenhouse gas emissions. With 70% of mining projects for the six largest mining companies located in water-stressed regions, the industry is facing increasing pressure to reduce its impact. Our study investigates the applicability of multi-objective optimization to integrate environmental impact considerations into short-term planning for mining operations. To achieve this, we have reviewed similar studies in various industries and developed an integrated planning framework that incorporates environmental considerations into production planning for …

Exposure To Pcb126 During The Nursing Period Reversibly Impacts Early-Life Glucose Tolerance, Brittany Breon Rice, Keegan W. Sammons, Sara Y. Ngo Tenlep, Madeline T. Weltzer, Leryn J. Reynolds, Cetewayo S. Rashid, Hollie I. Swanson, Kevin J. Pearson

Markey Cancer Center Faculty Publications

Polychlorinated biphenyls (PCBs) are persistent environmental organic pollutants known to have detrimental health effects. Using a mouse model, we previously demonstrated that PCB126 exposure before and during pregnancy and throughout the perinatal period adversely affected offspring glucose tolerance and/or body composition profiles. The purpose of this study was to investigate the glucose tolerance and body composition of offspring born to dams exposed to PCB126 during the nursing period only. Female ICR mice were bred, and half of the dams were exposed to either vehicle (safflower oil) or 1 μmole PCB126 per kg of body weight via oral gavage on postnatal …

Chronic Environmental Circadian Disruption Increases Atherosclerosis And Dyslipidemia In Female, But Not Male, Apolipoproteine-Deficient Mice, Jeffrey M. Chalfant, Deborah A. Howatt, Victoria B. Johnson, Lisa R. Tannock, Alan Daugherty, Julie S. Pendergast

Saha Cardiovascular Research Center Faculty Publications

Shift work chronically disrupts circadian rhythms and increases the risk of developing cardiovascular disease. However, the mechanisms linking shift work and cardiovascular disease are largely unknown. The goal of this study was to investigate the effects of chronically shifting the light-dark (LD) cycle, which models the disordered exposure to light that may occur during shift work, on atherosclerosis. Atherosclerosis is the progressive accumulation of lipid-filled lesions within the artery wall and is the leading cause of cardiovascular disease. We studied ApolipoproteinE-deficient (ApoE−/−) mice that are a well-established model of atherosclerosis. Male and female ApoE−/− mice were housed in control 12L:12D …

Cervical Spinal Cord Injury Leads To Injury And Altered Metabolism In The Lungs, Emily E. Huffman, Brittany E. Dong, Harrison A. Clarke, Lyndsay E. A. Young, Matthew S. Gentry, Derek B. Allison, Ramon C. Sun, Christopher M. Waters, Warren J. Alilain

Saha Cardiovascular Research Center Faculty Publications

High-cervical spinal cord injury often disrupts respiratory motor pathways and disables breathing in the affected population. Moreover, cervically injured individuals are at risk for developing acute lung injury, which predicts substantial mortality rates. While the correlation between acute lung injury and spinal cord injury has been found in the clinical setting, the field lacks an animal model to interrogate the fundamental biology of this relationship. To begin to address this gap in knowledge, we performed an experimental cervical spinal cord injury (N = 18) alongside sham injury (N = 3) and naïve animals (N = 15) to assess lung injury …

Chalcone Derivative Cx258 Suppresses Colorectal Cancer Via Inhibiting The Top2a/Wnt/Β-Catenin Signaling, Xi Chen, Xiaocheng Lv, Lijie Gao, Jiawei Liu, Wei Wang, Lichao Guo, Mykhaylo S. Frasinyuk, Wen Zhang, David S. Watt, Chunming Liu, Xifu Liu

Markey Cancer Center Faculty Publications

The deregulation in the Wnt/β-catenin signaling pathway is associated with many human cancers, particularly colorectal cancer (CRC) and, therefore, represents a promising target for drug development. We have screened over 300 semisynthetic and natural compounds using a Wnt reporter assay and identified a family of novel chalcone derivatives (CXs) that inhibited Wnt signaling and CRC cell proliferation. Among them, we selected CX258 for further in vitro and in vivo study to investigate the molecular mechanisms. We found that CX258 significantly inhibited β-catenin expression and nuclear translocation, inducing cell cycle arrest at the G2/M phase in CRC cells. Additionally, CX258 reduced …

Endogenous Glycoprotein Gpm6a Is Involved In Neurite Outgrowth In Rat Dorsal Root Ganglion Neurons, Gabriela I. Aparicio, Antonella León, Rocío Gutiérrez Fuster, Baylen Ravenscraft, Paula V. Monje, Camila Scorticati

Markey Cancer Center Faculty Publications

The peripheral nervous system (PNS) has a unique ability for self-repair. Dorsal root ganglion (DRG) neurons regulate the expression of different molecules, such as neurotrophins and their receptors, to promote axon regeneration after injury. However, the molecular players driving axonal regrowth need to be better defined. The membrane glycoprotein GPM6a has been described to contribute to neuronal development and structural plasticity in central-nervous-system neurons. Recent evidence indicates that GPM6a interacts with molecules from the PNS, although its role in DRG neurons remains unknown. Here, we characterized the expression of GPM6a in embryonic and adult DRGs by combining analysis of public …

Kegg_Pull: A Software Package For The Restful Access And Pulling From The Kyoto Encyclopedia Of Gene And Genomes, Erik D. Huckvale, Hunter N. B. Moseley

Markey Cancer Center Faculty Publications

Background: The Kyoto Encyclopedia of Genes and Genomes (KEGG) provides organized genomic, biomolecular, and metabolic information and knowledge that is reasonably current and highly useful for a wide range of analyses and modeling. KEGG follows the principles of data stewardship to be findable, accessible, interoperable, and reusable (FAIR) by providing RESTful access to their database entries via their web-accessible KEGG API. However, the overall FAIRness of KEGG is often limited by the library and software package support available in a given programming language. While R library support for KEGG is fairly strong, Python library support has been lacking. Moreover, there …

Existing Transportation Infrastructure In The Central Appalachian Basin To Support Core-Cm, Bryan Gibson, Robin Baskette, Doug Kreis

Kentucky Transportation Center Research Report

Stretching from Tennessee northeastward through southwestern Pennsylvania, the Central Appalachian Basin’s economic fortunes have long depended on coal production. However, as the U.S. has increasingly turned toward new forms of energy to generate electricity, the region’s economy has faced inexorable headwinds. Yet, what is clear is that the extractive industries are likely to play a key role in shaping the basin’s economy in the years to come. Taking this assumption as a starting point, this paper discusses how well current transportation infrastructure can support expanded us of the basin’s carbon ore, rare earth, and critical minerals (CORE-CM), other minerals, and …

Analysis Of Silage Fermentation Characteristics Using Transflectance Measurements By Near Infrared Spectroscopy, A. Martínez, A. Soldado, R. Garcia, D. Sánchez, B. De La Roza-Delgado

IGC Proceedings (1977-2023)

The fermentation end products as lactic acid, volatile fatty acids and ammonia-nitrogen, are important indicators of the efficiency of silage fermentation and are closely related to nutritive value of them (Jaster, 1995). Drying is problematic in the case of silage as many fermentation products are volatile and may get lost during the drying process. This may be a reason why NIR technology is being little used for the evaluation of silage fermentation characteristics. The feasibility of using near infrared transflectance spectroscopy to evaluate the content in fermentation end products of grass and maize fresh silage was investigated in this study.

Prediction Of Red Clover Content In Mixed Swards By Near-Infrared Reflectance Spectroscopy, B. Deprez, D. Stilmant, C. Clément, C. Decamps, A. Peeters

IGC Proceedings (1977-2023)

Because of the legume fixation capacity, their high protein content, digestibility and intake characteristics, more and more attention is paid to grassland clover content. In field experiments, clover content must often be determined, for example to quantify nitrogen flux or the best practices to manage such species (Stilmant et al., 2004). However hand sorting of clover and grass, even if accurate, is time-consuming and has a high labour cost. In comparison, accuracy of visual estimation of clover content, directly in the field, varies according to training and experience. Near-infrared reflectance spectroscopy (NIRS) has been proposed as a method for …

Modelling The Digestibility Decrease Of Three Grass Species During Spring Growth According To The Age Of The Grass, The Thermal Age And The Yield, M. E. Salamanca, R. Lambert, M. Gomez, A. Peeters

IGC Proceedings (1977-2023)

The nutritive value of forage changes during growth. For the protein content, a general evolution curve was found with the yield increase (Salette & Lemaire, 1984). The digestibility of the organic matter decreases during growth as cellulose and lignin content increase. Regrowth age is the main factor, which explains the digestibility decrease (Demarquilly & Jarrige, 1981). The crop age can be expressed in number of growth days but also in thermal age (cumulated temperature). We compared the digestibility change of three grass species during spring growth for two years as a function of yield increase, thermal age or number of …

A New Agro-Meteorological Simulation Model For Predicting Daily Grass Growth Rates Across Ireland, R. P. O. Schulte

IGC Proceedings (1977-2023)

Grass growth rates and herbage yields depend on weather conditions, soil characteristics and grassland management and differ from year to year and from site to site. In the past, grass growth has been predicted using both mechanistic and statistical models. The accuracy of mechanistic models is commonly insufficient for practical application, while statistical models generally apply to one test site only (e.g. Han et al., 2003). In this paper a semi-empirical grass growth model is presented which is numerically accurate, but which can be applied to contrasting sites across Ireland at the same time.

Effect Of Farm Grass Cover At Turnout On The Grazing Management Of Spring Calving Dairy Cows, M. O'Donovan, L. Delaby, P. Defrance

IGC Proceedings (1977-2023)

Early spring grazing is an objective for most Irish dairy farmers. If more grass is included in the diet of the cow in early lactation, the profitability of the farm system can be increased. Post turnout, dairy cow feeding management varies with the amount of farm grass cover (FC) available. Experiments on the consequences of different FC at turnout require large resources and all scenarios cannot be accounted for. Consequently, a decision support system, Pâtur’IN (Delaby et al., this volume), was used to describe the effects of various FC at turnout on grazing management in spring.

Objectives And Benefits Of Molecular Breeding In Forage Species, T. Lübberstedt

IGC Proceedings (1977-2023)

1. The amount of resources and information provided by forage crop genomic programs has dramatically increased during the past few years.
2. Trait-based forward genetic procedures such as mapping and expression profiling have successfully provided new candidate genes or genome regions affecting forage quality. Respective information can easily be transferred across related forage species.
3. Since several genes in major biochemical pathways related to forage traits have been isolated, gene-based reverse genetic approaches (transformation, association studies) are promising.
4. Most genetic experiments are conducted under simplified "artificial" conditions such as on single-spaced plants. Therefore, transferability of respective genetic information to breeding practice needs to …

Update On Options For Managing Thin Alfalfa Stands, Jimmy C. Henning

Kentucky Alfalfa and Stored Forage Conference

Alfalfa is the highest yielding, highest quality hay crop grown in Kentucky. Well cured alfalfa and alfalfa‐grass hay is in high demand for dairy and in particular, horse owners. Alfalfa stands in Kentucky remain productive from four to as long as 8 years or more depending on several factors. Long stand life is favored by:

1. Using an improved variety with high resistance to the major diseases of Kentucky and that is proven to be high yielding in relevant trials such as conducted at the University of Kentucky.

2. Deep, well drained soils,

3. Soils that have been limed to …

Hay Production In The Deep South: Bermudagrass And Alfalfa A Perfect Combination, Jennifer J. Tucker

Kentucky Alfalfa and Stored Forage Conference

No abstract provided.

National Producer And Consumer Survey: Increasing Alfalfa Hay Sales To Horse Owners, Krista Lea, Bob Coleman, Laurie Lawrence, Jen Zimmerman, Ray Smith

Kentucky Alfalfa and Stored Forage Conference

Horse owners were surveyed regarding their hay feeding choices. Unique factors of this market are discussed.

Participatory Approach To Common Use Grazing Management In Dry Area Developing Countries, J. Tiedeman, A. Larbi, F. Ghassali, N. Battikha

IGC Proceedings (1977-2023)

Key points

1. Range restoration technology is available but useless when not followed by management.

2. Institutional mechanisms for grazing management are needed for communal range.

3. Community participatory approaches help pastoralists better manage rangeland grazing.

Recent Developments In Methods To Characterise The Chemical And Biological Parameters Of Grass Silage, R. S. Park, R. E. Agnew, M. G. Porter

IGC Proceedings (1977-2023)

Key points

1. Chemical analysis of forages is expensive, time consuming, environmentally unfriendly and relates poorly to the feed value for production purposes.
2. In vivo characterisation of animal feed is not a feasible option in terms of cost and analysis time.
3. NIRS is a rapid, non destructive, environmentally friendly, multi-analytical technique which can estimate the nutritive value of the feed.
4. NIRS predictive equations developed on a master instrument can be transferred to local and international sites.
5. Future assessment of forages necessitates rapid, stable, instrumentation for ‘in field’ studies.

Fermentation Characteristics Of Maize/Sesbania Bi-Crop Silage, M. Kondo, J. Yanagisawa, K. Kita, H. Yokota

IGC Proceedings (1977-2023)

Maize is one of the main forages for dairy production and is a suitable material for silage making because of high fermentable carbohydrates, high counts of lactic acid bacteria (LAB) and low buffering capacity (BC) (Nishino et al. 2003; McDonald et al. 1991). Whole crop maize silage is high in energy but low in crude protein (CP). On the other hand, legumes are high in CP but difficult to conserve because of their low water soluble carbohydrates (WSC) and high BC. It might be possible that maize/legume bi-crop silage compensate for their negative points. Sesbania is a legume originated …

Silage Production From Tropical Forages, Luiz Gustavo Nussio

IGC Proceedings (1977-2023)

Key Points

1. The determination of overall DM recovery is important in tropical grass silage systems
2. Silage fermentation profile and aerobic stability: trends and additional effects
3. Combinations of chemical and microbial additives might be useful for control of losses
4. Fermentation products should be considered in order to better predict animal performance
5. A critical points database would be a helpful management tool for the development of a set of HACCP principles for the production and utilisation of tropical grass silages

Effect Of Perennial Ryegrass Cultivars On The Fatty Acid Composition In Milk Of Stall-Fed Cows, A. Elgersma, H. J. Smit, G. Ellen, S. Tamminga

IGC Proceedings (1977-2023)

Herbage provides bulk feed for ruminants and plant lipids, especially C18:3, are a major source of benefical fatty acids (FA) in milk. There are very few direct comparisons allowing a precise evaluation of the effects of the basal forage diet on milk FA composition. Grass quality differences can affect rumen metabolism and there could be opportunities to change the composition of ruminant products through choice of grass cultivar. To test this hypothesis, six cultivars were fed to dairy cows in a stall-feeding trial with fresh grass to evaluate the effect of grass cultivar on rumen VFA and milk FA composition …

Recent Developments In Feeding Beef Cattle On Grass Silage-Based Diets, M. Mcgee

IGC Proceedings (1977-2023)

Key points:

1. High digestibility grass silage with moderate concentrate supplementation can sustain a large proportion of the cattle performance achieved on high concentrate diets.
2. Increasing concentrate supplementation reduces the importance of grass silage nutritional value.
3. Subsequent compensatory growth diminishes the advantage of concentrate supplementation of young cattle.
4. Meat quality and fatty acid composition can be influenced by grass silage-based diets.

Effect Of Biological Additives In Red Clover – Timothy Conservation, A. Olt, H. Kaldmäe, E. Songisepp, O. Kärt

IGC Proceedings (1977-2023)

Red clover at early flower bud formation is difficult to ensile. For efficient improvement of the quality of leguminous silages, chemical additives are used. The present research focuses on the effectiveness of biological additives with different composition on the fermentation and quality of clover silage.

Paying For Our Keep: Grasslands Decision Support In More-Developed Countries, Andrew D. Moore

IGC Proceedings (1977-2023)

Key points

1. A survey of decision support (DS) tools in grassland agriculture illustrates the diversity of decisions supported and of delivery technologies that are used. Larger, whole-enterprise planning tools are undergoing a period where their user interfaces are being adapted to better reflect the requirements and practice of advisory users.

2. The history of use of GrassGro, a ‘versatile simulator’, is used to illustrate how versatile tools attract a diverse range of users and uses. Lessons learnt by the GrassGro team are discussed.

3. Uptake rates of DS tools in grasslands are generally lower than was expected a decade …