Digital Commons Network^™

Institutional Lending Models, Mission Drift, And Microfinance Institutions, Bethany L. Paris

Theses and Dissertations--Public Policy and Administration

Microfinance is a development tool used to reduce poverty among extremely poor households. Impoverished households can access lines of credit through microfinance institutions (MFIs), in order to create a new business, smooth household consumption, fund medical emergencies, etc. Many authors postulate that MFIs are drifting from a welfarist to an institutionalist approach to lending.

Using MIXMarket data on specific MFIs in 118 countries between 1995 and 2011, the average loan balance of these organizations will be regressed against measure of outreach and sustainability of these institutions by charter type through a series of four, fixed effects models. The main research …

A Novel Selective Lipid Uptake Pathway Contributing To Ldl-Induced Macrophage Foam Cell Formation, Jason M. Meyer

Theses and Dissertations--Molecular and Cellular Biochemistry

Atherosclerosis is a disease characterized by cholesterol-rich plaques within the intima of medium and large arteries. Cholesterol deposition is thought to occur by infiltration of low-density lipoprotein (LDL) into lesions followed by uptake into macrophages, generating lipid-loaded “foam cells.” Foam cells can also be generated in vitro by treatment of macrophages with LDL or oxidized LDL (oxLDL). The purpose of the current investigation was to determine the contribution of selective cholesteryl ester (CE) uptake versus whole-particle uptake during LDL-induced foam cell formation in cultured macrophages. Murine bone marrow-derived macrophages (BMMs) exhibited significant cholesterol accumulation when treated with LDL as indicated …

Validation And Descriptive Analysis Of The System For Observing Dance Activities In The Classroom Environment (Sodance), Meredith E. Sims

Theses and Dissertations--Kinesiology and Health Promotion

The first part of this study sought to validate the System for Observing Dance Activities in the Classroom Environment (SODANCE) based off the System for Observing Fitness Instructional Time (SOFIT). Female students age 11-17 years (N=42) participated in an activity protocol of SOFIT activities and common dance activities to validate appropriate coding categories. Each student wore a heart rate monitor and accelerometer while participating in the activities lying, sitting, standing, walking, running, single leg balances, leg swings, pirouettes, and leaps. Heart rate, maximum heart rate percentage, heart rate reserve percentage, vertical axis accelerometer counts, and vector magnitude accelerometer counts for …

An Update On Vitamin D: The Role In Chronic Disease, Clinical Practice Implications, And The Current Status Of Nurse Practitioner Knowledge, Sara E. Robertson

DNP Projects

The discovery that a large portion of the United States population is vitamin D deficient, has led to hundreds of studies in the last decade which aim to discover the role of vitamin D in overall health and to determine what clinical consequences occur in a deficient state. The current clinical knowledge regarding vitamin D deficiency is reviewed, including the definition of vitamin D insufficiency and deficiency and its correlation to chronic disease states; the risk factors and epidemiology of vitamin D deficiency; and appropriate clinical screening and treatment of vitamin D deficiency. A research study completed in 2012 to …

Educational Materials And Brief Counseling Improve Diabetes Knowledge And Self-Efficacy, Tamara K. Wellman

DNP Projects

Purpose: The purpose of this study was to see if education and counseling of the Appalachian individual with diabetes and a family member/friend would improve knowledge of the disease and self-efficacy of the patient in regard to their diabetes care.

Setting: The setting was one of eight primary care offices of Our Lady of Bellefonte Hospital, Bon Secours, located in the Ashland, Kentucky.

Design: A pilot study of descriptive, comparative design was used.

Subjects: Data were collected from a convenience sample of patients with type 2 diabetes (n=15) that were established at the primary care office and their family members/friends …

Calendula Officinalis Growth And Production Of Secondary Compounds In Greenhouse And Soil-Based Herbal Organic Production Systems, Victoria M. Anderson

Theses and Dissertations--Plant and Soil Sciences

Calendula officinalis is a useful model crop because calendula flowers are used both ornamentally and medicinally. Organic production systems have many challenges; among these is the synchrony of nitrogen mineralization with the requirements of the crop. Organic greenhouse substrates have significantly different initial nitrogen levels which influence the performance of calendula, the highest initial N and plant performance was found in the organic compost peat substrate (OCP). The addition of supplemental nitrogen improved performance, but only OCP performed as well as the conventionally fertilized peat-based substrate. The nitrogen mineralization patterns in a soil-based greenhouse pot experiment showed that highly processed …

Understanding Multidrug Resistance In Gram-Negative Bacteria -- A Study Of A Drug Efflux Pump Acrb And A Periplasmic Chaperone Sura, Meng Zhong

Theses and Dissertations--Chemistry

Multiple drug resistance (MDR) has been a severe issue in treatment and recovery from infection.Gram-negative bacteria intrinsically exhibit higher drug tolerance than Gram-positive microbes. In this thesis, two proteins involved in Gram-negative bacterial MDR were studied, AcrB and SurA.

Resistance-nodulation-cell division pump AcrAB-TolC is the major MDR efflux system in Gram-negative bacteria and efficiently extrudes a broad range of substances from the cells. To study subtle conformational changes of AcrB in vivo, a reporter platform was designed. Cysteine pairs were introduced into different regions in the periplasmic domain of the protein, and the extents of disulfide bond formation were …

Examining The Interaction Of Neonatal Alcohol And Hypoxia In Vitro, Megan L. Carter

Theses and Dissertations--Psychology

Exposure to ethanol (ETOH) during fetal development results in a range of cognitive/behavioral deficits. There are differences in sensitivity to the effects of ETOH that could be explained by other factors, such as hypoxia. Similar mechanisms of damage underlie both ETOH, more specifically ETOH withdrawal, and hypoxia. Based on this overlap, it was hypothesized that sub threshold levels of these insults may interact to produce increased damage in sensitive brain regions. This study used a rodent organotypic hippocampal slice culture model to investigate the interaction of hypoxia and ETOH withdrawal and to determine possible developmental differences in the sensitivity to …

The Impact Of Acculturation And Labeling On African Americans' Stigmatization Of Mental Illness, Tahirah Abdullah

Theses and Dissertations--Psychology

Although African Americans endorse more stigma towards those with mental illnesses than European Americans and are quite susceptible to stigma’s detrimental effects on help-seeking for mental health problems, stigma has not been adequately studied for African Americans. Given that stigma is a key barrier to obtaining help for mental health problems, it is imperative that we gain a more nuanced understanding of stigma. This study used experimental design and vignettes to examine the influence of acculturation and labeling on African Americans’ stigmatization of depression, social phobia, alcohol dependence, and schizophrenia. Results indicated that schizophrenia was generally the most stigmatized disorder …

Ovarian Cancer Screening As A Teachable Moment For Health Behavior Change: Determining The Role Of Positive Affect And Self-Efficacy, Rachel F. Steffens

Theses and Dissertations--Psychology

In medical settings, a teachable moment (TM) has been described as an event which may lead to psychological changes prompting individuals to engage in health promoting behaviors. A cancer screening (CS) has been suggested as a potential TM because several types of positive health behavior change (HBC), ranging from dietary changes to smoking cessation, have been linked to CS. However, most research has examined the TM in CS settings using cross-sectional and prospective methodologies and has lacked a theory-driven model. Moreover, few intervention studies have attempted to capitalize on the potential TM in CS settings. In light of this, the …

Advice, Influence, And Independence: Adolescent Nutritional Practices And Outcomes In Belfast, Northern Ireland, Jennifer L. Williams

Theses and Dissertations--Anthropology

The goal of this dissertation is to discuss relationships between the sociocultural environment and nutritional status outcomes in an urban industrialized city with high rates of poverty. The purpose is to highlight the complex web of factors shaping nutritional status outcomes and move beyond cause and effect approaches to nutrition in an environment where obesity is a central nutritional concern. To accomplish this goal, I examine a range of factors that relate to adolescent nutritional practices and nutritional status outcomes in a sample population of adolescents living in Belfast, Northern Ireland. I discuss connections between social locations such as age, …

Missing "Links": Investigating The Age And Gender Dimensions Of Development, Conservation, And Environmental Change In A Southern Zambian Frontier, Allison Harnish

Theses and Dissertations--Anthropology

This dissertation focuses on the lived, material realities of rural women, men, girls, and boys struggling to make a living in the context of changing national development priorities and changing environmental conditions in Southern Province, Zambia.

Over the last 20 years, Gwembe Tonga migrants living in the frontier farming area of Kulaale have witnessed significant declines in non-cultivated “bush” resources due to the conversion of forest and grassland to agricultural uses. This dissertation seeks to understand how women, men, boys, and girls differently experience these declines according to local gender- and age-based divisions of subsistence labor. Drawing on a variety …

Elevated Cardiovascular Risk Among Adults With Obstructive And Restrictive Airway Functioning In The United States: A Cross-Sectional Study Of The National Health And Nutrition Examination Survey From 2007-2010, Earl S. Ford, Anne G. Wheaton, David M. Mannino, Letitia Presley-Cantrell, Chaoyang Li, Janet B. Croft

Preventive Medicine and Environmental Health Faculty Publications

BACKGROUND: Reasons for the excess risk for cardiovascular disease among people with chronic obstructive pulmonary disease remain unclear. Our objective was to examine the cardiovascular risk profile for adults with obstructive and restrictive impairments of lung functioning in a representative sample of adults from the United States.

METHODS: We used data from adults aged 20-79 years who participated in the National Health and Nutrition Examination Survey from 2007 to 2010 and had a pulmonary function test. The severity of obstructive impairment was defined by adapting the Global Initiative for Chronic Obstructive Lung Disease criteria.

RESULTS: Among 7249 participants, 80.9% had …

Doublesex Target Genes In The Red Flour Beetle, Tribolium Castaneum, Jayendra Nath Shukla, Subba Reddy Palli

Entomology Faculty Publications

Sex determination cascade in insects terminates with the production of sex-specific protein, Doublesex (Dsx). We identified the dsx homolog (Tcdsx) in Tribolium castaneum. The pre-mRNA of Tcdsx is sex-specifically spliced into three female (Tcdsxf1, Tcdsxf2 and Tcdsxf3) and one male-specific (Tcdsxm) isoforms. Cis-regulatory elements potentially involved in sex-specific splicing of the Tcdsx pre-mRNA were identified in the female-specific exon and the adjoining intronic sequences. All the three female-specific TcDsx proteins share common OD1 and OD2 domains and differ in their C-terminal sequences. Knockdown of Tcdsx resulted in a reduction in the oocyte development, egg production and hatching of eggs laid. …

Reactive Oxygen Species Production And Brugia Pahangi Survivorship In Aedes Polynesiensis With Artificial Wolbachia Infection Types, Elizabeth S. Andrews, Philip R. Crain, Yuqing Fu, Daniel K. Howe, Stephen L. Dobson

Entomology Faculty Publications

Heterologous transinfection with the endosymbiotic bacterium Wolbachia has been shown previously to induce pathogen interference phenotypes in mosquito hosts. Here we examine an artificially infected strain of Aedes polynesiensis, the primary vector of Wuchereria bancrofti, which is the causative agent of Lymphatic filariasis (LF) throughout much of the South Pacific. Embryonic microinjection was used to transfer the wAlbB infection from Aedes albopictus into an aposymbiotic strain of Ae. polynesiensis. The resulting strain (designated "MTB") experiences a stable artificial infection with high maternal inheritance. Reciprocal crosses of MTB with naturally infected wild-type Ae. polynesiensis demonstrate strong bidirectional incompatibility. Levels of reactive …

Is There More To Food Insecurity Among Children Than Poverty? The Importance Of Measurement, Neeraj Kaushal, Jane Waldfogel, Irwin Garfinkel, Vanessa Wight

University of Kentucky Center for Poverty Research Discussion Paper Series

This paper examines the association between poverty and food insecurity among children using the official measure of poverty and the newsupplemental poverty measure of the Census Bureau based on a more inclusive definition of family resources and needs. Our objective is to study whether the association between food insecurity and poverty improves with a more comprehensive measure of income and needs. We find a strong and statistically significant association between income-to-needs ratio based on the official poverty metric and food insecurity among children—particularly very low food security among children. A more inclusive measure of income-to-needs-ratio, based on the supplemental poverty …

Does Economic Decline Contribute To A Decline In Children’S Food Security?, Kimberly Groover, Bradford Mills, George Davis

University of Kentucky Center for Poverty Research Discussion Paper Series

Most Americans believe that children should not experience persistent worry about the quality or quantity of food consumed due to low household resources. Since 1995, the USDA has tracked children’s food security based upon household responses to the annual Current Population Survey Food Security Supplement (CPS-FSS). During this time, a small, but recently growing, share of U.S. households report multiple indicators of reduced food intake and disrupted eating patterns among children due to inadequate resources to obtain food (Coleman- Jenson et al, 2012). The USDA classifies children as food secure, low food secure, or very low food secure based upon …

Morphological And Genetic Changes Induced By Excess Zn In Roots Of Medicago Truncatula A17 And A Zn Accumulating Mutant, Ricky W. Lewis, Guiliang Tang, David H. Mcnear

Plant and Soil Sciences Faculty Publications

BACKGROUND: Nutrient fluxes associated with legume-rhizobia symbioses are poorly understood and little is known regarding the influence of abiotic stresses on development and maintenance of N-fixing nodules and root system architecture (RSA). We examined effects of Zn on nodule development and structure, root architecture, and expression of nodulation-related miRNAs in Medicago truncatula and the mutant, raz (requires additional Zn).

FINDINGS: Excess Zn increased root and shoot associated Zn in both genotypes, however, raz plants had lower root associated Zn than WT plants. Roots of raz plants exposed to excess Zn had less volume, surface area, and total length compared to …

Biochemical Pathways In Cancer, Eun-Kyoung Yim Breuer, Mandi M. Murph, Rolf J. Craven

Pharmacology and Nutritional Sciences Faculty Publications

No abstract.

Multigenerational Families And Food Insecurity, James P. Ziliak, Craig Gundersen

University of Kentucky Center for Poverty Research Discussion Paper Series

The prevalence of multigenerational families is on the rise in the United States, as is food insecurity. We estimate the effect of resident grandchildren on the risk of and transitions in food insecurity using repeated cross sections and longitudinally linked two-year panels of the Current Population Survey from 2001-2010. We find that rates of food insecurity in families with a grandchild present are at least twice as high in a typical year compared to families without a resident grandchild, and the extent of very low food security increased substantially faster among these households over the past decade. The rise in …

Forage News [2012-11], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky Grazing Conference
• KFGC Presents Awards
• Alfalfa Intensive Training Seminar
• Kentuckian Featured at National Hay Convention
• AFGC Conference in Covington
• Kentucky's 2012 National Forage Spokesman to speak at Farm Bureau Forage Commodity Conference
• Dr. Peter Ballerstedt to Speak at Forages at KCA During the KCA Convention
• Neutral Detergent Fiber Digestibility (NDFD): A Good Predictor of Forage Quality
• Where Does Nitrogen Fertilizer Come From?
• The Cost of Pasture vs. Hay

Noninvasive Optical Characterization Of Muscle Blood Flow, Oxygenation, And Metabolism In Women With Fibromyalgia, Yu Shang, Katelyn Gurley, Brock Symons, Douglas Long, Ratchakrit Srikuea, Leslie J. Crofford, Charlotte A. Peterson, Guoqiang Yu

Biomedical Engineering Faculty Publications

INTRODUCTION: Women with fibromyalgia (FM) have symptoms of increased muscular fatigue and reduced exercise tolerance, which may be associated with alterations in muscle microcirculation and oxygen metabolism. This study used near-infrared diffuse optical spectroscopies to noninvasively evaluate muscle blood flow, blood oxygenation and oxygen metabolism during leg fatiguing exercise and during arm arterial cuff occlusion in post-menopausal women with and without FM.

METHODS: Fourteen women with FM and twenty-three well-matched healthy controls participated in this study. For the fatiguing exercise protocol, the subject was instructed to perform 6 sets of 12 isometric contractions of knee extensor muscles with intensity steadily …

Regional Variation In Aortic At1b Receptor Mrna Abundance Is Associated With Contractility But Unrelated To Atherosclerosis And Aortic Aneurysms, Aruna Poduri, A. Phillip Owens, Deborah A. Howatt, Jessica J. Moorleghen, Anju Balakrishnan, Lisa A. Cassis, Alan Daugherty

Pharmacology and Nutritional Sciences Faculty Publications

BACKGROUND: Angiotensin II (AngII), the main bioactive peptide of the renin angiotensin system, exerts most of its biological actions through stimulation of AngII type 1 (AT1) receptors. This receptor is expressed as 2 structurally similar subtypes in rodents, termed AT1a and AT1b. Although AT1a receptors have been studied comprehensively, roles of AT1b receptors in the aorta have not been defined.

METHODOLOGY/RESULTS: We initially compared the regional distribution of AT1b receptor mRNA with AT1a receptor mRNA in the aorta. mRNA abundance of both subtypes increased from the proximal to the distal aorta, with the greatest abundance in the infra-renal region. Corresponding …

Food Insecurity Across The First Five Years: Triggers Of Onset And Exit, Alison Jacknowitz, Taryn W. Morrissey

University of Kentucky Center for Poverty Research Discussion Paper Series

Very low food security among young children is associated with developmental deficiencies. However, little is known about the factors that predict entry into or exit from very low food security during early childhood. This study seeks to: (1) Understand the triggers that explain movements into or out of very low food security among children from birth to age five; (2) Examine the first aim using different definitions of food insecurity. The analysis relies on the Early Childhood Longitudinal Study-Birth Cohort (ECLS-B), a longitudinal, nationally representative dataset of approximately 10,700 children, to estimate linear probability models. Results suggest that residential moves …

Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth By Targeting Vegfr- 2 Regulated Akt/Mtor/P70s6k Signaling Pathways, Poyil Pratheeshkumar, Amit Budhraja, Young-Ok Son, Xin Wang, Zhuo Zhang, Songze Ding, Lei Wang, Andrew Hitron, Jeong-Chae Lee, Mei Xu, Gang Chen, Jia Luo, Xianglin Shi

Toxicology and Cancer Biology Faculty Publications

Angiogenesis is a crucial step in the growth and metastasis of cancers, since it enables the growing tumor to receive oxygen and nutrients. Cancer prevention using natural products has become an integral part of cancer control. We studied the antiangiogenic activity of quercetin using ex vivo, in vivo and in vitro models. Rat aortic ring assay showed that quercetin at non-toxic concentrations significantly inhibited microvessel sprouting and exhibited a significant inhibition in the proliferation, migration, invasion and tube formation of endothelial cells, which are key events in the process of angiogenesis. Most importantly, quercetin treatment inhibited ex vivo angiogenesis …

Child Maltreatment Outpatient Visits To Kentucky Non-Federal Acute Care Hospitals, 2008-2010, Marjorie Stanek, Michael Singleton, Svetla Slavova, Terry Bunn

Kentucky Injury Prevention and Research Center Special Report

No abstract provided.

The Impact Of Incarceration On Food Insecurity Among Households With Children, Sally Wallace, Robynn Cox

University of Kentucky Center for Poverty Research Discussion Paper Series

This study seeks to determine the role that parental incarceration plays on the probability of food insecurity among families with children and very low food security of children using micro-level data from the Fragile Families and Child Well Being Study (FFCWS). The data set contains the 18-question food security module which allows us to explore the link between incarceration and food insecurity and very low food security among children, families, and adults. The incidence of very low food security in our data is somewhat higher than the national average, but the incidence of other levels of food security is similar …

The Effect Of Safety Net Programs On Food Insecurity, Lucie Schmidt, Lara Shore-Sheppard, Tara Watson

University of Kentucky Center for Poverty Research Discussion Paper Series

Does the safety net reduce food insecurity in families? In this paper we investigate how the structure of benefits for five major safety net programs – TANF, SSI, EITC, SNAP, and Medicaid – affects low food security in families and very low food security among children. We build a calculator for the years 2001-2009 to impute eligibility and benefits for these programs in each state, taking into account cross-program eligibility rules. To identify a causal effect of the safety net, we instrument for imputed eligibility and benefits using simulated eligibility and benefits for a nationally representative sample. Focusing on non-immigrant, …

Family Structure, Work Patterns And Time Allocations: Potential Mechanisms Of Food Insecurity Among Children, Kelly Balistreri

University of Kentucky Center for Poverty Research Discussion Paper Series

Over 469 thousand households in the U.S. experienced very low food security among children, a severe condition characterized by reductions in food intake due to an inability to afford enough food. But food insecurity is not simply about economic resources. There exists a paradox in which some poor households with children are food secure while some non-poor households with children are food insecure. This study moves beyond a singular focus on income and considers how the family context may protect or generate risk of food insecurity for children. The goals of the proposed project were to: 1) to provide a …

Identifying The Effect Of Wic On Very Low Food Security Among Infants And Children, Brent Kreider, John V. Pepper, Manan Roy

University of Kentucky Center for Poverty Research Discussion Paper Series

The Women, Infants, and Children Program (WIC) is considered a crucial component of the social safety net in the United States, yet there is limited supporting evidence on the effects of WIC on the nutritional well-being and food security of infants and young children. Two key identification problems have been especially difficult to address. First, the decision to take up WIC is endogenous as households are not randomly assigned to the program; recipients are likely to differ from nonrecipients in unobserved ways (e.g., prior health) that are related to associated outcomes. Second, survey respondents often fail to report receiving public …