Digital Commons Network^™

Global Change, Domestic Policy, And Life Course Influences On Perceptions Of Health Equity Among Older Cubans, James Lester Schwar

University of Kentucky Doctoral Dissertations

Cubas provision of free health services to the entire population via neighborhood-based family doctors produced dramatic health gains and achieved a relative state of health equality. Since 1989, however, the termination of Soviet trade, a grave economic crisis, intensification of the US embargo, welfare reductions, and population aging have placed Cubas health successes and elder care services in jeopardy. Little independent research, though, has focused on the influence of post-Cold War circumstances on citizen attitudes about health programs and resources targeting Cubas older population. This research examined global and domestic factors since 1989 that have most influenced perceptions of the …

Impaired Antigen Receptor Induced Calcium Mobilization In A Phospholipase C-Gamma1 Deficient B Cell Line., Natarajan Muthusamy, Do Joon Park, Hei-Won Rho, Sue Goo Rhee, Subbarao Bondada

Microbiology, Immunology, and Molecular Genetics Faculty Publications

B lymphocytes express phospholipase C-gamma(1) (PLC-gamma(1)) and phospholipase C-gamma(2) (PLC-gamma(2)) isozymes. However, the relative importance of these two isozymes in B cell signaling is not known. We report here the identification and analysis of a B cell line deficient in PLC-gamma(1). Mature splenic B lymphocytes and a panel of cell lines representing pre-B, immature and mature B cell stages expressed phospholipase C-gamma (PLC-gamma), but not the beta or delta isoforms of phospholipase C (PLC). While all the tested B cell lines and primary splenic B cells expressed PLC-gamma(1) and PLC-gamma(2) isozymes, the L1.2 B cell line exclusively expressed PLC-gamma(2), but …

Protection Against Ischemia And Reperfusion Injury, Peter R. Oeltgen, Paul D. Bishop, Mark S. Kindy, Juan A. Sanchez

Molecular and Cellular Biochemistry Faculty Patents

A compound and method for using compound-D SEQ ID NO:1 to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.

Method Of Solubilizing Single-Walled Carbon Nanotubes In Organic Solutions, Robert C. Haddon, Jian Chen

Chemistry Faculty Patents

Naked single-walled nanotube carbon metals and semiconductors are dissolved in various organic solutions.

Beyond The Shelf: Serving Historic Kentuckiana Through Digital Access [October 2003], Becky Ryder, Eric Weig, Kopana Terry, Peter Hesseldenz

Library Presentations

No abstract provided.

Evaluation Of Methods To Protect Water Quality In Karst Areas: Phase I, Jennifer Webster, Dhandayudhapani Ramalingam, Sudhir Palle

Kentucky Transportation Center Research Report

The primary focus of this report is two-fold; to provide a literature review on what has been previously learned about highway runoff in relation to karsts aquifers and to characterize a karsts highway site in Kentucky that can be used to evaluate a variety of best management practices. From research findings, the main sources of pollutants in highway runoff came from vehicles, atmospheric fallout, and precipitation. The behavior of pollutants and their interaction with the environment can dictate where they will be found and how to best minimize their effects. Although it would seem that traffic volumes would greatly influence …

A Neuronal-Specific Differentiation Protein That Directly Modulates Retinoid Receptor Transcriptional Activation, Kenneth W. Henry Ii, Michael L. Spencer, Maria Theodosiou, Dingyuan Lou, Daniel J. Noonan

Molecular and Cellular Biochemistry Faculty Publications

BACKGROUND: The specificity of a nuclear receptor's ability to modulate gene expression resides in its ability to bind a specific lipophilic ligand, associate with specific dimerization partners and bind specific DNA sequences in the promoter regions of genes. This sequence of events appears to be the basis for targeting an additional regulatory complex composed of a variety of protein and RNA components that deliver signals for facilitation or inhibition of the RNA polymerase complex. Characterization of the tissue and cell-specific components of these coregulatory complexes appear to be integral to our understanding of nuclear receptor regulation of transcription.

RESULTS: A …

La Influencia Regional Y El Apoyo Ciudadano A Las Reformas Neoliberales Mexicanas, Charles L. Davis, Jorge E. Figueroa

Political Science Faculty Publications

Por medio de encuestas de opinión pública llevadas a cabo en México en los años de 1991 y 1996, el presente estudio examina empíricamente las bases regionales de apoyo popular a las reformas neoliberales (privatizaciones y el TLC). Se encontró que el apoyo ciudadano a estas reformas fue mayor en las regiones económicamente más avanzadas como el norte y el Distrito Federal y menor en los estados sureños y centrales, a pesar de que el nivel de este apoyo declinó en todas las regiones entre 1991 y 1996. Se analizan dos hipótesis alternativas para explicar las variaciones regionales de apoyo …

Evaluation Of Kentucky’S “Buckle Up Kentucky: It’S The Law & It’S Enforced” Campaign, Kenneth R. Agent, Eric R. Green, Ronald E. Langley

Kentucky Transportation Center Research Report

The objective of this report was to document the results of the “Buckle Up Kentucky: It’s the Law & It’s Enforced” campaign in Kentucky. The campaign involved a combination of earned media, paid media, and enforcement. The earned media started about three weeks prior to Memorial Day 2003 and continued through the enforcement period. The paid media started about two weeks prior to Memorial Day. The enforcement period was a two-week period including the week before and the week of Memorial Day.

The evaluation of the campaign included documenting the activities associated with the program (publicity and enforcement) and evaluating …

Southeastern Law Librarian Summer 2003, Seaall

Newsletters

No abstract provided.

Exit Routes From Welfare: Examining Barriers To Employment, Demographic And Human Capital Factors, Colleen Heflin

University of Kentucky Center for Poverty Research Discussion Paper Series

This paper investigates how barriers to employment, human capital, and demographic characteristics affect women’s exit routes off welfare. Specifically, I address two questions. First, what are the avenues through which women leave welfare? Second, are mental and physical health problems, domestic violence, and lack of access to transportation, characteristics that have been ignored in other studies of welfare dynamics, associated with different welfare exit routes? Using multinomial logistic regression and data from the Women’s Employment Survey, this project examines the specific exit route chosen in detail and goes beyond general dynamics associated with welfare exit in order to capture the …

Adiponectin Expression From Human Adipose Tissue: Relation To Obesity, Insulin Resistance, And Tumor Necrosis Factor-Α Expression, Philip A. Kern, Gina B. Di Gregorio, Tong Lu, Negah Rassouli, Gouri Ranganathan

Clinical and Translational Science Faculty Publications

Adiponectin is a 29-kDa adipocyte protein that has been linked to the insulin resistance of obesity and lipodystrophy. To better understand the regulation of adiponectin expression, we measured plasma adiponectin and adipose tissue adiponectin mRNA levels in nondiabetic subjects with varying degrees of obesity and insulin resistance. Plasma adiponectin and adiponectin mRNA levels were highly correlated with each other (r = 0.80, P < 0.001), and obese subjects expressed significantly lower levels of adiponectin. However, a significant sex difference in adiponectin expression was observed, especially in relatively lean subjects. When men and women with a BMI2were compared, women had a twofold higher percent body fat, yet their plasma adiponectin levels were 65% higher (8.6 ± 1.1 and 14.2 ± 1.6 μg/ml in men and women, respectively; P < 0.02). Plasma adiponectin had a strong association with insulin sensitivity index (S_I) (r = 0.67, P < 0.0001, n = 51) that was not affected by sex, but no relation with insulin secretion. To separate the effects of obesity (BMI) from S_I, subjects who were discordant for S_I were matched for BMI, age, and sex. Using this approach, insulin-sensitive subjects demonstrated a twofold higher plasma level of …

Highway Crash Site Management, Monica L. Barrett, Jennifer R. Walton

Kentucky Transportation Center Research Report

Traveler delay is the problem most often associated with highway crashes, but by far the most serious problem is the resulting secondary crashes that occur. Another related issue is the danger posed to response personnel serving the public at the scene of a crash. The longer a crash is in place, the longer the responders are vulnerable and exposed to injury.

The Kentucky Transportation Center, in cooperation with the Kentucky Transportation Cabinet, developed a checklist and interagency workshop to address ways to secure and coordinate the resources necessary to restore the roadway’s operation in a safe and timely manner. The …

Psychosocial Stress And Cervical Neoplasia Risk, Ann L. Coker, Sharon M. Bond, Margaret M. Madeleine, Kathryn J. Luchok, Lucia Pirisi

CRVAW Faculty Journal Articles

OBJECTIVE: We assessed the association between psychosocial stress and preinvasive cervical neoplasia development controlling for HR-HPV infection.

METHODS: This case-control study enrolled low-income women receiving family planning services at health department clinics. There were 59 cases with biopsy confirmed HSIL and 163 with low-grade SIL and 160 controls with normal cervical cytology. A modified SLE scale was used to measure stressful events and the perceived impact of the event in the prior 5 years. Unconditional logistic regression was used to assess SIL risk and stressful events scores and by subscales.

RESULTS: After adjusting for age, HR-HPV infection, and lifetime number …

Adolescent Violence Prevention: A Case Presentation, Hatim A. Omar, Joan Griffith

Pediatrics Faculty Publications

Violence in adolescence has seen an increase since the 1990s with dramatic statistics on violent death and risk behaviors. School violence has been focused upon by a huge media coverage of especially violent cases that could have had some endemic consequences worldwide. We present a case of a 14 year old white male with change in school behavior, strategies for the case investigation, its results, and long term prevention. Other research has shown that preventive measures during pregnancy, infancy and childhood can prevent adolescent and adult delinquency.

Statistical Implications Of Pooling Rna Samples For Microarray Experiments, Xuejun Peng, Constance L. Wood, Eric M. Blalock, Kuey Chu Chen, Philip W. Landfield, Arnold J. Stromberg

Statistics Faculty Publications

BACKGROUND: Microarray technology has become a very important tool for studying gene expression profiles under various conditions. Biologists often pool RNA samples extracted from different subjects onto a single microarray chip to help defray the cost of microarray experiments as well as to correct for the technical difficulty in getting sufficient RNA from a single subject. However, the statistical, technical and financial implications of pooling have not been explicitly investigated.

RESULTS: Modeling the resulting gene expression from sample pooling as a mixture of individual responses, we derived expressions for the experimental error and provided both upper and lower bounds for …

Neuronal Cell Model And Methods Of Use Thereof, Craig S. Miller, Robert J. Jacob, Robert J. Danaher

Microbiology, Immunology and Molecular Genetics Faculty Patents

We previously described a novel in vitro model of a non-productive herpes simplex virus type 1 (HSV-1) infection in neurally-differentiated (ND)-PC12 cells that allows for inducible virus replication upon forskolin and heat stress (HS) treatment. In this research, we further characterized the model with respect to HSV-2 strain 333. We found that: (i) ND-PC12 cells are non-permissive to HSV-2 replication; (ii) HSV-2 can establish a quiescent infection, like HSV-1, in ND-PC12 cells with the transient use of acycloguanosine (ACV); however unlike HSV-1, anti-viral conditions are not obligatory to establish and maintain a quiescent state; (iii) the quiescent state is maintained …

Intelligent Transportation Systems Statewide Architecture, Joseph D. Crabtree, Jennifer R. Walton

Kentucky Transportation Center Research Report

This report describes the development of Kentucky’s Statewide Intelligent Transportation Systems (ITS) Architecture. The process began with the development of an ITS Strategic Plan in 1997-2000. A Business Plan, developed in 2000-2001, translated the goals of the Strategic Plan into specific project recommendations. To develop the Statewide Architecture, the project team first inventoried all existing and planned ITS projects in the state. A project architecture was developed for each identified project, and these project architectures were then merged to form the Statewide Architecture. This report describes the background work that set the stage for the architecture, the actual architecture development …

Developing The Next Generation Of Technological Aids To Effective Public Involvement In Public Transportation Planning & Design, C. Anneta Arno Anneta, Keiron Bailey, Ted H. Grossardt

Kentucky Transportation Center Faculty and Researcher Publications

Problem

Public involvement in the design of complex public infrastructure solutions, such as a new light rail line, including stops, stations and transit centers, and associated Transit- Oriented Developments (TOD), often relies on lengthy public meetings during which the complexities and subtleties of design preferences, their articulation and communication is overwhelming to both participants and design professionals. Such gatherings can produce more confusion than clarity for the public and design professional alike, especially when strong personalities highlight differences and discourage compromise and consensus. More effective methods of discerning, developing and evaluating the nature of the public’s different preferences and perspectives, …

Beyond The State: The Return To Anarchy, Jeff Shantz

disClosure: A Journal of Social Theory

No abstract provided.

Editor's Preface, Jessica Hollis

disClosure: A Journal of Social Theory

No abstract provided.

Urban Fabric: Lexington's New Courthouse Plaza, Beth Diamond, Krista L. Schneider

disClosure: A Journal of Social Theory

No abstract provided.

Discourse And Civil Repair: Disclosure Interviews Jeffrey C. Alexander, Jessica Hollis, Natalia Ruiz-Junco, Brett Smith

disClosure: A Journal of Social Theory

No abstract provided.

Method Of Preparing A Composite Polymer And Silica-Based Membrane, Dibakar Bhattacharyya, Stephen M. Ritchie, Leonidas G. Bachas, Jamie A. Hestekin, Subhas K. Sikdar

Chemical and Materials Engineering Faculty Patents

A method for preparing a chemically activated or polyamino acid functionalized membrane includes the steps of permeating a silica-based membrane with a solution of silane and a solvent so as to react methoxy groups of the silane with silanol groups of the membrane to incorporate epoxide groups and attaching a polyamino acid to the membrane by reacting a terminal amine group of the polyamino acid with one of the epoxide groups on the membrane.

Preparing And Regenerating A Composite Polymer And Silica-Based Membrane, Dibakar Bhattacharyya, Stephen M. Ritchie, Leonidas G. Bachas, Jamie A. Hestekin, Subhas K. Sikdar

Chemical and Materials Engineering Faculty Patents

A method for preparing and regenerating a chemically activated or polyamino acid functionalized membrane includes the steps of permeating the silica-based membrane with a solution of silane and a solvent so as to react methoxy groups of the silane with silanol groups of the membrane to incorporate epoxide groups and attaching a polyamino acid to the membrane by reacting a terminal amine group of the polyamino acid with one of the epoxide groups on the membrane. The membrane is regenerated after metal entrapment by utilizing helix-coil properties of polyamino acids.

23rd Annual Conference On Legal Issues For Financial Institutions, Office Of Continuing Legal Education At The University Of Kentucky College Of Law

Continuing Legal Education Materials

Materials from the 23rd Annual Conference on Legal Issues for Financial Institutions held by UK/CLE in April of 2003.

What Gets Judges In Trouble, Richard H. Underwood

Law Faculty Scholarly Articles

I wrote this article to collect some cautionary material about “what gets judges in trouble.” I wanted something I could offer to our state judges, practitioners, and my legal ethics students. While I have never been a judge, and while I have never worked for a judicial conduct organization, I have been a law professor for almost twenty-five years and the chairman of a state bar association ethics committee for fourteen. I am not the kind of person who would refrain from holding forth just because I may not know what I am talking about.

When I started out, I …

Method Of Solubilizing Carbon Nanotubes In Organic Solutions, Robert C. Haddon, Mark A. Hamon

Chemistry Faculty Patents

Carbon nanotubes are dissolved in organic solutions by attaching an aliphatic carbon chain (which may contain aromatic residues) so as to render the carbon nanotubes soluble.

Environmental Impacts Of Bridge Cleaning Operations, Theodore Hopwood Ii, Sudhir Palle, Rick Younce

Kentucky Transportation Center Research Report

Cleaning (washing) operations of existing leaded paints on bridges were studied to determine the level of lead contamination in the resulting wastewater. Twelve experimental overcoating projects were let on bridges with various types of existing paint in varying states of deterioration. The projects employed different washing pressures ranging from 2500 psi to 10000 psi and various wash nozzles (fan and 0o spinner tips). KYTC standard filtration was used on 10 projects and 2 projects used an experimental filtration unit having a sand filter and two types of chemical filter media.

Prior to painting, the existing paint was analyzed for thickness, …

[Review Of] The Baseball Filmography, 1915 Through 2001, Robert A. Aken

Library Faculty and Staff Publications

No abstract provided.