Digital Commons Network^™

Hiv Protease Inhibitors Promote Atherosclerotic Lesion Formation Independent Of Dyslipidemia By Increasing Cd36-Dependent Cholesteryl Ester Accumulation In Macrophages, James Dressman, Jeanie Kincer, Sergey V. Matveev, Ling Guo, Richard N. Greenberg, Theresa Guerin, David Meade, Xiang-An Li, Weifei Zhu, Annette M. Uittenbogaard, Melinda E. Wilson, Eric J. Smart

Physiology Faculty Publications

Protease inhibitors decrease the viral load in HIV patients, however the patients develop hypertriglyceridemia, hypercholesterolemia, and atherosclerosis. It has been assumed that protease inhibitor–dependent increases in atherosclerosis are secondary to the dyslipidemia. Incubation of THP-1 cells or human PBMCs with protease inhibitors caused upregulation of CD36 and the accumulation of cholesteryl esters. The use of CD36-blocking antibodies, a CD36 morpholino, and monocytes isolated from CD36 null mice demonstrated that protease inhibitor–induced increases in cholesteryl esters were dependent on CD36 upregulation. These data led to the hypothesis that protease inhibitors induce foam cell formation and consequently atherosclerosis by upregulating CD36 and …

Lower Class Mobilization And State Welfare Policy In The Era Of Welfare Reform, James M. Avery, Mark Peffley

University of Kentucky Center for Poverty Research Discussion Paper Series

The 1990s played host to the most significant changes in the American welfare system in the last fifty years— in particular, states were granted much wider latitude in deciding who is eligible to receive welfare. Taking advantage of these changes, we examine the linkage between lower class turnout and state adoption of restrictive welfare eligibility requirements after the passage of the historic welfare reform legislation of 1996. We find that in states where lower class turnout was relatively high, lawmakers were much less likely to pass a range of “get tough” welfare rules. Our findings provide novel support for the …

Poverty And Macroeconomic Performance Across Space, Race, And Family Structure, Craig Gundersen, James P. Ziliak

University of Kentucky Center for Poverty Research Discussion Paper Series

Understanding the link between poverty and economic growth is of long-standing interest, but heretofore it has not received much attention within the context of the dramatic changes in recent business-cycle conditions and social policies. In this paper we use state-level panel data from the 1981–2000 waves of the Current Population Survey to examine the impacts of the macroeconomy and welfare reform on family poverty. We estimate models of before-tax and after-tax poverty rates and squared poverty gaps for all families, by family structure, and by race. Our results indicate that a strong macroeconomy at both the state and national levels …

Pharmaceutical Patents And Trips: A Comparison Of India And South Africa, Stephen Barnes

Kentucky Law Journal

No abstract provided.

Innovation In A University Social System: The Adoption Of Electronic Theses And Dissertations Digital Libraries, Suzanne Lorraine Allard

University of Kentucky Doctoral Dissertations

The "digital library" (DL) is a communication technology that has the potential to improve communication by removing temporal and geographic barriers and by introducing interactivity. This research focused on the adoption of digital libraries for electronic theses and dissertations (ETD-DL) at universities worldwide. ETD-DLs provide a means for universities to learn about implementing digital libraries in a networked environment.This research used diffusion of innovation theory to explore what has influenced ETD-DL adoption among Networked Digital Library of Theses and Dissertations (NDLTD) member universities. Communication channels were categorized as being either interpersonal or mediated. The perceived importance of these channels was …

Why Are Victims Of Domestic Violence Still Dying At The Hands Of Their Abusers? Filling The Gap In State Domestic Violence Gun Laws, Sharon L. Gold

Kentucky Law Journal

No abstract provided.

Reforming Business Entity Law To Stimulate Economic Growth Among The Marginalized: The Modern South African Experienc, Johan J. Henning

Kentucky Law Journal

No abstract provided.

A Comment On The Litigation Strategy, Judicial Politics And Political Context Which Produced Grutter And Gratz, Sheryl G. Snyder

Kentucky Law Journal

No abstract provided.

Anthropological Research On Homosexuality In Latin America And The Lesbian Drought, Angela M. Meyer

Kaleidoscope

The goal of this paper is to document the significant contributors, contents, methodologies, developments, and theoretical frameworks relevant to the anthropological study of homosexuality in Latin America. Among other data, this research project yields regional accounts of gay / lesbian liberation movements, transvestitism, HIV I AIDS, and the intersections of gender and power in countries such as Mexico, Brazil, Cuba, and Argentina. Also included in this review are critical assessments of academic sources, ethical dilemmas faced by ethnographers, and spaces available for original research on homosexuality in Latin America. Though this documentation is not totally comprehensive, one can conclude the …

Oswald Research And Creativity Program, Uk Office Of Undergraduate Research

Kaleidoscope

No abstract provided.

Undergraduate Awards And Honors, Uk Office Of Undergraduate Research

Kaleidoscope

No abstract provided.

Our Adolescents--Our Future, Hatim A. Omar

Pediatrics Faculty Publications

No abstract provided.

Bazin On Early Fellini: Three Original Reviews, Bert Cardullo

The Kentucky Review

No abstract provided.

Sex Education In The Schools: What Role Does It Play?, Darby H. Mcelderry, Hatim A. Omar

Pediatrics Faculty Publications

Information regarding pubertal development, sex, pregnancy, and contraception should be provided to children and adolescents in an age-appropriate manner from parents, health care providers, and schools. This article reviews the medical literature on school sex education programs, adolescents' perception of these programs, and the role played by the media, parents, and health care professionals in sexual education of teens.

Modification Of The Nucleotide Cofactor-Binding Site Of Cytochrome P450 Reductase To Enhance Turnover With Nadh In Vivo, Calvin Lee Elmore

University of Kentucky Doctoral Dissertations

NADPH-cytochrome P450 reductase is the electron transfer partner for the cytochromes P450, heme oxygenase, and squalene monooxygenase, and is a component of the nitric oxide synthases and methionine synthase reductase. P450 reductase shows very high selectivity for NADPH and uses NADH only poorly. Substitution of tryptophan 677 with alanine (W677A) has been shown by others to yield a 3-fold increase in turnover with NADH, but profound inhibition by NADP+ makes the enzyme unsuitable for in vivo applications. In the present study site-directed mutagenesis of amino acids in the 2'-phosphate-binding site of the NADPH domain, coupled with the W677A substitution, was …

Democracy, Not Deference: An Egalitarian Theory Of Judicial Review, Ronald C. Den Otter

Kentucky Law Journal

No abstract provided.

Exploring The Sarbanes-Oxley Act: Will Government Intervention In The Public Accounting Profession Prevent Another Enron?, Sally S. Spielvogel

Kentucky Law Journal

No abstract provided.

Modeling The Infrared Emission From Dust In Active Galactic Nuclei, Maia M. Nenkova

University of Kentucky Doctoral Dissertations

Active Galactic Nuclei (AGN) are compact regions in the centers of some galaxies. They emit significantly in the whole range of the electromagnetic spectrum and show variability at different timescales. Observational evidence suggests the presence of a dusty torus obscuring the central radiation source of AGN. According to the Unified Model the observed general properties of AGN emission can be understood on the basis of orientation of this torus toward an observer. Two main types of AGN are distinguished: Type 1, with detected emission from the inner torus cavity viewed pole-on, and Type 2, viewed through the obscuring torus. There …

Are These Queer Times? Gay Male Representation On The American Stage In The 1920'S And 1990'S, James Russell Couch

University of Kentucky Master's Theses

Utilizing a model based on Queer theory and comprising four relational paradigms, this thesis examines specific dramas of Mae West and Terrence McNally in an effort to understand the multiple relationships between the text, the society and the culture in the production of a gay male identity and its representation on the American stage in the 1920s and the 1990s. Each relational paradigm is the product of a different twentieth century scholar and can be viewed as an individual lens through which one aspect of a drama or culture can be magnified, illuminated or distorted. These paradigms are: culture and …

Minimum Inhibitory Concentrations Of Two Common Food Phenolic Compounds And Their Effect On The Microbial Ecology Of Swine Feces In Vitro, Jennifer I. Zaffarano

University of Kentucky Master's Theses

Feeding sub-therapeutic levels of antibiotics to livestock has been associated withdevelopment and spread of antibiotic resistant bacteria. The present experiment was conductedto investigate the effect of antibiotic alternatives (caffeic acid, chlorogenic acid, and carbadox)on the microbial ecology of swine feces in vitro.Minimum inhibitory concentrations of caffeic and chlorogenic acids were determined forseveral pathogens using macrobroth and agar dilution techniques. Gram-negative bacteria werenot inhibited. Caffeic acid inhibited four Staphylococcus aureus strains at 200 ppm or less, andtwo Clostridium perfringens strains at 300 ppm. Chlorogenic acid inhibited all S. aureus strainsat 500 ppm, and one C. perfringens strain at 400 ppm.Effects of …

Transmission Electron Microscopy And Flow Field-Flow Fractionation: Exploration Of The Nanoscopic Components In Partially Reduced Polyoxomolybdates By Kinetic Precipitation With De Novo Organic Molecules, Yan Zhu

University of Kentucky Doctoral Dissertations

Although molybdenum blue solutions have been known for more than twocenturies, an understanding of their chemical nature is only beginning to emerge.This dissertation aimed at elucidating the structural nature of the polydisperse,nanoscopic components in the solution phases and the solid states of partiallyreduced polyoxomolybdate (Mo-POM). The study offered at least fourcontributions to the area: (1) a rational protocol for the molecular recognition ofMo-POM with de novo organic hosts. (2) demonstration of kinetic precipitation ofa dynamic mixture of polyoxomolybdates and application of the technique to thestudy of the dynamic mixture by TEM (3) characterization of the Mo-POMnanostructures by an unusual combination …

Inhibitory Properties Of Microplitis Croceipes Teratocyte Secretory Products And The Recombinant Protein Tsp14 On Protein Synthesis, Francis Anthony Diluna

University of Kentucky Master's Theses

Microplitis croceipes is a solitary endoparasitic wasp that oviposits in the hemocoel of Heleothis virescens larvae. Upon parasitization, the host larvaes physiology is altered; resulting in a compromised immune system and a decrease in the production of some vital proteins resulting in a terminal post-wandering prepupal state. Teratocytes, cells derived from the extraembryonic serosa of the parasitic wasp, mimic symptoms of parasitization when injected into host larvae, independent of other factors like polydnavirus and venom. Some of the inhibition of protein synthesis can be attributed to proteins secreted by the teratocytes (teratocyte secretory proteins or TSP). A fraction of TSP …

Design Of A Lorentz, Slotless Self-Bearing Motor For Space Applications, Barrett Alan Steele

University of Kentucky Master's Theses

The harsh conditions of space, the stringent requirements for orbiting devices, and the increasing precision pointing requirements of many space applications demand an actuator that can provide necessary force while using less space and power than its predecessors. Ideally, this actuator would be able to isolate vibrations and never fail due to mechanical wear, while pointing with unprecedented accuracy. This actuator has many space applications from satellite optical communications and satellite appendage positioning to orbiting telescopes. This thesis presents the method of design of such an actuator a self-bearing motor. The actuator uses Lorentz forces to generate both torque and …

“Private” Crime In Public Housing: Violent Victimization, Fear Of Crime And Social Isolation Among Women Public Housing Residents, Claire M. Renzetti, Shana L. Maier

CRVAW Faculty Journal Articles

Although public housing is typically associated with high crime rates, little research has been done on fear of crime or violent victimization experiences among public housing residents. Moreover, there are few studies that look specifically at women’s fear of crime or violent victimization experiences in public housing, despite the fact that women constitute the majority of public housing residents. These issues were examined in the present study through interviews with female public housing residents in Camden, New Jersey (NJ). The interviews reveal high rates of violent victimization, especially at the hands of intimates and acquaintances. Fear of crime is also …

Plasma Pge-2 Levels And Altered Cytokine Profiles In Adherent Peripheral Blood Mononuclear Cells In Non-Small Cell Lung Cancer (Nsclc), Giovanna E. Hidalgo, Li Zhong, Dennis E. Doherty, Edward A. Hirschowitz

Internal Medicine Faculty Publications

INTRODUCTION: PGE-2 is constitutively produced by many non-small cell lung cancers (NSCLC) and its immunosuppressive effects have been linked to altered immune responses in lung cancer. We asked whether elevated levels of plasma PGE-2 correlated with monocyte IL10 production in the NSCLC environment. Looking for correlation in NSCLC patient blood we assayed plasma from NSCLC patients for PGE2 and IL10; we further evaluated production of IL10 by adherent mononuclear cells from a subset of these patients looking for an altered cytokine profile.

RESULTS: Our initial in vitro experiments show that monocyte IL10 induction correlates with tumor cell PGE-2 production, confirming …

Use Of Bacterial Acetate Kinase And Their Genes For Protection Of Plants Against Different Pathogens, Arthur G. Hunt, Glenn B. Collins, Qingshun Li, Santanu Dasgupta

Kentucky Tobacco Research and Development Center Faculty Patents

An isolated gene fragment that encodes for acetate kinase, which confers disease resistance in plants is disclosed. The gene can be cloned into an expression vector to produce a recombinant DNA expression system suitable for insertion into cells to form a transgenic plant transformed with the gene fragment. A method for conferring disease resistance in plants that consists of growing plant host cells transformed with the expression system and expressing the gene conferring disease resistance to impart such resistance to host cells is also disclosed.

4th Annual Computer & Technology Law Institute, Office Of Continuing Legal Education At The University Of Kentucky College Of Law

Continuing Legal Education Materials

Materials from the 4th Annual Computer & Technology Law Institute held by UK/CLE in November 2002.

Southeastern Law Librarian Fall 2002, Seaall

Newsletters

No abstract provided.

Evaluation Of Kentucky’S You Drink And Drive. You Lose”, Kenneth R. Agent, Eric R. Green, Ronald E. Langley

Kentucky Transportation Center Research Report

Alcohol and drug related crashes continue to be one of the highest priority problem identification areas and considerable emphasis is being placed on programs to impact those types of crashes. Various types of campaigns have been used over the years in an attempt to reduce the number of alcohol-related crashes. Kentucky was selected within the Southeast Region of the United States by the National Highway Traffic Safety Administration to conduct a comprehensive impaired driving campaign entitled “You Drink & Drive. You Lose”. The campaign was conducted around the 2002 Labor Day holiday. The objective of this report was to document …

A Mechanical System For Soil Reconstruction, John Patrick Fulton, Larry G. Wells, Timothy D. Smith

Biosystems and Agricultural Engineering Faculty Publications

One of the most perplexing problems associated with reclaiming surface–mined lands is excessive compaction of soil due to the heavy earthmoving equipment used during the reclamation process. Over the years, some innovative material handling schemes have been devised to limit vehicle traffic during reclamation on reconstructed soil. However, final grading operations can often create root–limiting bulk densities, which affect plant growth and yield. The purpose of this article is to describe a mechanism designed at the University of Kentucky whereby mine soil can be reconstructed without introducing compaction caused by surface traffic in order for the soil to sustain desirable …