Digital Commons Network^™

Design Optimization And Comparison Of Direct-Drive Outer-Rotor Srms Based On Fast Current Profile Estimation And Transient Fea, Vandana Rallabandi, Peng Han, Jie Wu, Aaron M. Cramer, Dan M. Ionel, Ping Zhou

Power and Energy Institute of Kentucky Faculty Publications

Outer-rotor switched reluctance machines (SRMs) have drawn much attention as promising candidates for in-wheel direct-drive motors of future electric vehicles. This article presents a systematic performance comparison of three outer-rotor SRM topologies for in-wheel traction applications in terms of the specific torque, electromagnetic efficiency, torque ripple, radial force, and mechanical aspects. A generalized design optimization framework for SRMs is proposed to enable the fast evaluation of large numbers of designs generated from the differential evolution by incorporating an analytical current profile estimation into the transient finite element analysis. The relationship between the saliency ratio and converter volt-ampere rating is also …

Role Reversal Of Functional Identity In Host Factors: Dissecting Features Affecting Pro-Viral Versus Antiviral Functions Of Cellular Dead-Box Helicases In Tombusvirus Replication, Cheng-Yu Wu, Peter D. Nagy

Plant Pathology Faculty Publications

Positive-stranded (+)RNA viruses greatly exploit host cells to support viral replication. However, unlike many other pathogens, (+)RNA viruses code for only a limited number of genes, making them highly dependent on numerous co-opted host factors for supporting viral replication and other viral processes during their infections. This excessive dependence on subverted host factors, however, renders (+)RNA viruses vulnerable to host restriction factors that could block virus replication. Interestingly, cellular ATP-dependent DEAD-box RNA helicases could promote or inhibit the replication of Tomato bushy stunt virus (TBSV) replication. However, it is currently unknown what features make a particular DEAD-box helicase either pro-viral …

Relation Between Vegetation And Soil In West Azarbaijan Rangelands Of Iran, J. Torkan, S. Gholinejad, A. Alijanpoor

IGC Proceedings (1977-2023)

No abstract provided.

Liposomal Delivery Of Azithromycin Enhances Its Immunotherapeutic Efficacy And Reduces Toxicity In Myocardial Infarction, Ahmed Al-Darraji, Renée R. Donahue, Himi Tripathi, Hsuan Peng, Bryana M. Levitan, Lakshman Chelvarajan, Dalia Haydar, Erhe Gao, David Henson, John C. Gensel, David J. Feola, Vincent J. Venditto, Ahmed K. Abdel-Latif

Gill Heart & Vascular Institute Faculty Publications

A growing body of evidence shows that altering the inflammatory response by alternative macrophage polarization is protective against complications related to acute myocardial infarction (MI). We have previously shown that oral azithromycin (AZM), initiated prior to MI, reduces inflammation and its negative sequelae on the myocardium. Here, we investigated the immunomodulatory role of a liposomal AZM formulation (L-AZM) in a clinically relevant model to enhance its therapeutic potency and avoid off-target effects. L-AZM (40 or 10 mg/kg, IV) was administered immediately post-MI and compared to free AZM (F-AZM). L-AZM reduced cardiac toxicity and associated mortality by 50% in mice. We …

Microglia Prevent Beta-Amyloid Plaque Formation In The Early Stage Of An Alzheimer's Disease Mouse Model With Suppression Of Glymphatic Clearance, Weixi Feng, Yanli Zhang, Ze Wang, Hanrong Xu, Ting Wu, Charles Marshall, Junying Gao, Ming Xiao

Physical Therapy Faculty Publications

BACKGROUND: Soluble beta-amyloid (Aβ) can be cleared from the brain through various mechanisms including enzymatic degradation, glial cell phagocytosis, transport across the blood-brain barrier, and glymphatic clearance. However, the relative contribution of each clearance system and their compensatory effects in delaying the pathological process of Alzheimer's disease (AD) are currently unknown.

METHODS: Fluorescent trace, immunofluorescence, and Western blot analyses were performed to compare glymphatic clearance ability and Aβ accumulation among 3-month-old APP695/PS1-dE9 transgenic (APP/PS1) mice, wild-type mice, aquaporin 4 knock out (AQP4^−/−) mice, and AQP4^−/−/APP/PS1 mice. The consequence of selectively eliminating microglial cells, or downregulating apolipoprotein …

Evaluation Of Bearing Voltage Reduction In Electric Machines By Using Insulated Shaft And Bearings, Peng Han, Greg Heins, Dean Patterson, Mark Theile, Dan M. Ionel

Power and Energy Institute of Kentucky Faculty Publications

Bearing voltages and corresponding currents in electric machines driven by pulse width modulation (PWM) converters with fast switching and high dv/dt can cause premature bearing failures. This paper evaluates the bearing voltage reduction by using insulated shafts and bearings. An equivalent circuit representation of electric machines taking into account high-frequency effects is developed to show the production mechanism of bearing voltage, based on which simulations are performed with detailed finite element models for transient and simplified equivalent circuit for steady-state analysis. The steady-state equivalent circuit is then calibrated, by combined numerical calculations and experimental measurements, and used to predict the …

Southeastern Law Librarian Fall 2020, Seaall

Newsletters

No abstract provided.

Facing Others: Ray Johnson’S Portrait Of A Curator As A Network, Miriam Kienle

Art and Visual Studies Faculty Publications

Deploying various forms of art world communication (commercial, bureaucratic, and interpersonal), Ray Johnson made a portrait of the curator Samuel J. Wagstaff during the mid-1960s that unworked the singular and unified image of his subject and emphasized identity as contingent upon a person’s position in their social network. Although many have noted the networked character of Johnson’s mail art practice—wherein participants were connected to each other with and through continually circulated collaged correspondence—few have explored it in relation to contemporary network theory and none have examined how it relates to portraiture of the period. By analyzing the remains of Johnson’s …

Combined Numerical And Experimental Determination Of Ball Bearing Capacitances For Bearing Current Prediction, Peng Han, Greg Heins, Dean Patterson, Mark Theile, Dan M. Ionel

Electrical and Computer Engineering Faculty Publications

High-frequency voltages across the steel ball bearings and the corresponding currents can cause premature bearing failures in electric machines driven by PWM converters. The bearing voltage, one of the most commonly-used failure indicators, depends heavily on the bearing capacitance. This paper presents a combined numerical and experimental approach for the calculation of ball bearing capacitances to address the uncertainty introduced by lubricant property, lubrication status and other metal parts, such as seals and ball retainers. Based on the obtained capacitance breakdown, the influences of temperature, speed and bearing load (radial, axial or combined) on the capacitance are studied. Measurements and …

Electric Drives With Wide Bandgap Devices For Two-Phase Very Low Inductance Machines, Yibin Zhang, Damien Lawhorn, Peng Han, Aaron M. Cramer, Dan M. Ionel

Power and Energy Institute of Kentucky Faculty Publications

Slotless and coreless machines with low inductance and low core losses are attractive for high speed and high power density applications. With the increase in fundamental frequency, typical drive implementations using conventional silicon-based devices are performance limited and also produce large current and torque ripples. This paper presents a systematic study of proposed drive configurations implemented with wide bandgap (WBG) devices in order to mitigate such issues for 2-phase very low inductance machines. Two inverter topologies, i.e., a dual H-bridge inverter with maximum redundancy and survivability and a 3-leg inverter for reduced cost, are considered. Feasible modulation schemes are derived …

Pregnant Violence In Post-3.11 Fiction, Doug Slaymaker

Modern and Classical Languages, Literatures and Cultures Faculty Publications

This essay explores the violence and the threat of violence associated with pregnancy in Japanese fiction after the triple disasters—the earthquake, tsunami, and nuclear meltdown—of March 11, 2011. There is hardly a female character in this fiction that is not confronted with questions about pregnancy and childbirth. The queries are surely motivated by genuine concern about the humans involved, but they are just as often about control, about a woman’s body as a public item, about responsibility to the child, and then to society at large. Childbearing in a disaster zone is profoundly anxiety-producing; but it is also worth examining …

Federal Student Loan Servicing Accountability And Incentives In Contracts, Rajeev Darolia, Andrew Sullivan

Institute for the Study of Free Enterprise Working Papers

Student loan servicers play a critical and underappreciated role in federal student loan programs. The federal government contracts out to servicers an array of many of the most critical functions related to student loan repayment, including account management, payment processing, and the provision of information about payment plans and solutions for distressed borrowers. In fact, most borrowers’ interactions with federal student loan repayment are almost exclusively with their servicer. We aim to improve upon the scarce research literature about federal student loan servicers by exploring the complicated set of measures that determine how servicers are compensated for servicing each debtor …

Measuring The Spread Of Covid-19 In Kentucky: Do We Have The Right Data?, Kenneth R. Troske, Paul A. Coomes

Institute for the Study of Free Enterprise Working Papers

We examine various measures of COVID-19 infections, hospitalizations and deaths, with an emphasis on data for Kentucky. We find that: Data on the number of new reported cases of the disease obtained from convenience samples (as opposed to representative random samples) is an inaccurate measure of the spread of the disease in the State. Using CDC data and national studies, it appears that there were ten times the number of infections in March than reported for Kentucky at the time and by September the State is still capturing only one out of two people infected.

A better measure of new …

Environmental Conservation, Jennifer A. Bartlett

Library Faculty and Staff Publications

No abstract provided.

The Sources And Consequences Of Political Rhetoric: Issue Importance, Collegial Bargaining, And Disagreeable Rhetoric In Supreme Court Opinions, Michael A. Zilis, Justin Wedeking

Political Science Faculty Publications

How do political actors use rhetoric after an initial policy battle? We explore factors that lead Supreme Court justices to integrate disagreeable rhetoric into opinions. Although disagreeable language has negative consequences, we posit that justices pay this cost for issues with high personal significance. At the same time, we argue that integrating disagreeable rhetoric has a deleterious effect on the institution by reducing majority coalition size. Examining opinions from 1946 to 2011 using text-based measures of disagreeable rhetoric, we model the language of opinion writing as well as explore the consequences for coalition size. Our findings suggest serious implications for …

Optimal Study Of A High Specific Torque Vernier-Type Axial-Flux Pm Machine With Two Different Stators And A Single Winding, Murat G. Kesgin, Peng Han, Narges Taran, Dan M. Ionel

Power and Energy Institute of Kentucky Faculty Publications

This paper presents the optimal study of a verniertype axial-flux permanent-magnet (AFPM) machine, which has a high-polarity spoke-type PM rotor, a wound stator with a low number of coils, and a profiled stator. Both stators have profiled teeth to enhance the magnetic interaction between the rotor PM array and stator windings for torque production. Compared to the topology with two wound stators, the studied one has a smaller total axial length and is expected more suitable for applications where the space is limited in axial direction. Both topologies are optimized through 3-dimensional (3D) finite element analysis (FEA) by the combined …

Demand Response Of Hvacs In Large Residential Communities Based On Experimental Developments, Huangjie Gong, Evan S. Jones, Rosemary E. Alden, Andrew G. Frye, Donald G. Colliver, Dan M. Ionel

Power and Energy Institute of Kentucky Faculty Publications

Heating, ventilation, and air-conditioning (HVAC) systems contribute the largest electricity usage for a residential community. Modeling of the HVAC systems facilitate the study of demand response (DR) at both the residential and the power system level. In this paper, the equivalent thermal model of a reference house was proposed. Parameters for the reference house were determined based on the systematic study of experimental data obtained from fully instrumented field demonstrators. The aggregated HVAC load was modeled based on the reference house while considering a realistic distribution of HVAC parameters derived from data that was provided by one of the largest …

Electric Power System Studies For A Multi-Mw Pv Farm And Large Rural Community With Net Zero Energy And Microgrid Capabilities, Evan S. Jones, Oluwaseun M. Akeyo, Keith Waters, Dan M. Ionel

Power and Energy Institute of Kentucky Faculty Publications

Solar photovoltaic (PV) systems are currently being deployed at an accelerated rate because of their cost-competitiveness and environmental benefits, which make them a prime candidate for local renewable energy generation in communities. Microgrids can help accommodate for the problems that accompany PV systems, such as intermittency due to weather, by coordinating different distributed energy resources (DERs), while islanded or by drawing power from the utility while in grid-connected mode. An islanding option is also important for resilience and grid fault mitigation, even if other DERs are not present within the system. This paper studies the potential benefits that a multi-MW …

Design Optimization Of Coreless Axial-Flux Pm Machines With Litz Wire And Pcb Stator Windings, Murat G. Kesgin, Peng Han, Narges Taran, Damien Lawhorn, Donovin Lewis, Dan M. Ionel

Electrical and Computer Engineering Faculty Publications

Coreless axial-flux permanent-magnet (AFPM) machines may be attractive options for high-speed and high-power-density applications due to the elimination of core losses. In order to make full use of the advantages offered by these machines and avoid excessive eddy current losses in windings, advanced technologies for winding conductors need to be employed to suppress the eddy effect, such as the Litz wire and printed circuit board (PCB). In this paper, the best practices for designing Litz wire/PCB windings are discussed and a brief survey of state of the art PCB winding technology is provided. Three coreless AFPM machines are mainly considered. …

Analysis Of Traffic Crash Data In Kentucky 2015-2019, Eric R. Green, Paul A. Ross, Christopher L. Blackden, Michael A. Fields, William Nicholas Staats

Kentucky Transportation Center Research Report

Executive Summary and Introduction

This report documents an analysis of traffic crash data in Kentucky. A primary objective of this study was to determine average crash statistics for Kentucky highways. Where used, rates were calculated for various types of highways and for counties and cities. Difference criteria were used for exposure.

Average and critical numbers, SPFs, and rates of crashes were calculated for various types of highways in rural and urban areas. These use crashes identified on highways where Annual Average Daily Traffic (AADT) volumes were available. The data in this report may be used to help identify problem areas. …

Cardioplastic Approach To Omental Flap Coverage For Severe Aortic Root Infections In The Opioid Era, Alisha R. Bonaroti, R. Wesley Edmunds, Ryan C. Decoster, James Y. Liau, Michael E. Sekela, Henry C. Vasconez

Surgery Faculty Publications

Aortic root abscesses are severe sequelae of endocarditis that clinically manifest as life-threatening infection. As the opioid epidemic continues to yield a national crisis, the incidence and severity of this disease process have increased. Reconstruction of the aortic root is a challenging undertaking and carries the risk of recurrent infection. The omentum has an established reputation as a reliable flap in thoracic reconstruction, given its amorphous form and immunogenic properties, but it has not been utilized for aortic root infections. We present a novel indication for the omental flap using a cardioplastic approach in coverage of aortic root reconstruction. Four …

Sod2 Deficiency In Cardiomyocytes Defines Defective Mitochondrial Bioenergetics As A Cause Of Lethal Dilated Cardiomyopathy, Sudha Sharma, Susmita Bhattarai, Hosne Ara, Grace Sun, Daret K. St. Clair, Md Shenuarin Bhuiyan, Christopher Kevil, Megan N. Watts, Paari Dominic, Takahiko Shimizu, Kevin J. Mccarthy, Hong Sun, Manikandan Panchatcharam, Sumitra Miriyala

Toxicology and Cancer Biology Faculty Publications

Electrophilic aldehyde (4-hydroxynonenal; 4-HNE), formed after lipid peroxidation, is a mediator of mitochondrial dysfunction and implicated in both the pathogenesis and the progression of cardiovascular disease. Manganese superoxide dismutase (MnSOD), a nuclear-encoded antioxidant enzyme, catalyzes the dismutation of superoxide radicals (O2^•-) in mitochondria. To study the role of MnSOD in the myocardium, we generated a cardiomyocyte-specific SOD2 (SOD2Δ) deficient mouse strain. Unlike global SOD2 knockout mice, SOD2Δ mice reached adolescence; however, they die at ~4 months of age due to heart failure. Ultrastructural analysis of SOD2Δ hearts revealed altered mitochondrial architecture, with prominent disruption of the …

Haiti's Hiv Surveillance System: Past, Present, And Future, Chris Delcher, Ermane G. Robin, Daniella Myriam Pierre

Pharmacy Practice and Science Faculty Publications

No abstract provided.

Nlrp3 Inflammasome Signaling Regulates The Homing And Engraftment Of Hematopoietic Stem Cells (Hspcs) By Enhancing Incorporation Of Cxcr4 Receptor Into Membrane Lipid Rafts, Mateusz Adamiak, Ahmed K. Abdel-Latif, Kamila Bujko, Arjun Thapa, Krzysztof Anusz, Michał Tracz, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Magda Kucia, Mariusz Z. Ratajczak

Internal Medicine Faculty Publications

Fast and efficient homing and engraftment of hematopoietic stem progenitor cells (HSPCs) is crucial for positive clinical outcomes from transplantation. We found that this process depends on activation of the Nlrp3 inflammasome, both in the HSPCs to be transplanted and in the cells in the recipient bone marrow (BM) microenvironment. For the first time we provide evidence that functional deficiency in the Nlrp3 inflammasome in transplanted cells or in the host microenvironment leads to defective homing and engraftment. At the molecular level, functional deficiency of the Nlrp3 inflammasome in HSPCs leads to their defective migration in response to the major …

Simulation Tools And Pastoral Resources Dynamics In Sahelian Area: The Senegalese Example, Alassane Bah, Ibra Touré, Alexandre Ickowicz, Amadou Tamsir Diop

IGC Proceedings (1977-2023)

No abstract provided.

Integrated Multiparametric Radiomics And Informatics System For Characterizing Breast Tumor Characteristics With The Oncotypedx Gene Assay, Michael A. Jacobs, Christopher B. Umbricht, Vishwa S. Parekh, Riham H. El Khouli, Leslie Cope, Katarzyna J. Macura, Susan Harvey, Antonio C. Wolff

Radiology Faculty Publications

Optimal use of multiparametric magnetic resonance imaging (mpMRI) can identify key MRI parameters and provide unique tissue signatures defining phenotypes of breast cancer. We have developed and implemented a new machine-learning informatic system, termed Informatics Radiomics Integration System (IRIS) that integrates clinical variables, derived from imaging and electronic medical health records (EHR) with multiparametric radiomics (mpRad) for identifying potential risk of local or systemic recurrence in breast cancer patients. We tested the model in patients (n = 80) who had Estrogen Receptor positive disease and underwent OncotypeDX gene testing, radiomic analysis, and breast mpMRI. The IRIS method was trained …

Rho Gtpases: Big Players In Breast Cancer Initiation, Metastasis And Therapeutic Responses, Brock Humphries, Zhishan Wang, Chengfeng Yang

Toxicology and Cancer Biology Faculty Publications

Rho GTPases, a family of the Ras GTPase superfamily, are key regulators of the actin cytoskeleton. They were originally thought to primarily affect cell migration and invasion; however, recent advances in our understanding of the biology and function of Rho GTPases have demonstrated their diverse roles within the cell, including membrane trafficking, gene transcription, migration, invasion, adhesion, survival and growth. As these processes are critically involved in cancer initiation, metastasis and therapeutic responses, it is not surprising that studies have demonstrated important roles of Rho GTPases in cancer. Although the majority of data indicates an oncogenic role of Rho GTPases, …

Mesencephalic Astrocyte-Derived Neurotrophic Factor (Manf) Regulates Neurite Outgrowth Through The Activation Of Akt/Mtor And Erk/Mtor Signaling Pathways, Wen Wen, Yongchao Wang, Hui Li, Hong Xu, Mei Xu, Jacqueline A. Frank, Murong Ma, Jia Luo

Pharmacology and Nutritional Sciences Faculty Publications

Neurite outgrowth is essential for brain development and the recovery of brain injury and neurodegenerative diseases. In this study, we examined the role of the neurotrophic factor MANF in regulating neurite outgrowth. We generated MANF knockout (KO) neuro2a (N2a) cell lines using clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 and demonstrated that MANF KO N2a cells failed to grow neurites in response to RA stimulation. Using MANF siRNA, this finding was confirmed in human SH-SY5Y neuronal cell line. Nevertheless, MANF overexpression by adenovirus transduction or addition of MANF into culture media facilitated the growth of longer neurites in RA-treated N2a …

A Digital Ethnography Of Teach For America: Analysis Of Counternarrative From The Truth For America Podcast, Julian Vasquez Heilig, T. Jameson Brewer, Amber K. Kim, Miguel Sanchez

Educational Policy Studies and Evaluation Faculty Publications

To analyze the counternarrative in the public discourse surrounding Teach For America (TFA), this paper represents the first digital ethnography in education policy. We conduct a qualitative analysis of Truth For America, an education policy podcast. We found four overarching themes that arose from conversations with respondents: (1) problematic practice, preparation, and pedagogy; (2) concerns linked to critiquing TFA and the organization’s responses to that critique; (3) issues related to race and diversity; and (4) disconcerting funding practices and political power. We conclude by discussing the implications of how individual-level stakeholder experiences inform the public discourse about TFA.

Neurotropic Lineage Iii Strains Of Listeria Monocytogenes Disseminate To The Brain Without Reaching High Titer In The Blood, Taylor E. Senay, Jessica L. Ferrell, Filip G. Garrett, Taylor M. Albrecht, Jooyoung Cho, Katie L. Alexander, Tanya Myers-Morales, Olivia F. Grothaus, Sarah E. F. D'Orazio

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Listeria monocytogenes is thought to colonize the brain using one of three mechanisms: direct invasion of the blood-brain barrier, transportation across the barrier by infected monocytes, and axonal migration to the brain stem. The first two pathways seem to occur following unrestricted bacterial growth in the blood and thus have been linked to immunocompromise. In contrast, cell-to-cell spread within nerves is thought to be mediated by a particular subset of neurotropic L. monocytogenes strains. In this study, we used a mouse model of foodborne transmission to evaluate the neurotropism of several L. monocytogenes isolates. Two strains preferentially colonized the brain …