Digital Commons Network^™

Nek1 Phosphorylation Of Yap Promotes Its Stabilization And Transcriptional Output, Md Imtiaz Khalil, Ishita Ghosh, Vibha Singh, Jing Chen, Haining Zhu, Arrigo De Benedetti

Molecular and Cellular Biochemistry Faculty Publications

Most prostate cancer (PCa) deaths result from progressive failure in standard androgen deprivation therapy (ADT), leading to metastatic castration-resistant PCa (mCRPC); however, the mechanism and key players leading to this are not fully understood. While studying the role of tousled-like kinase 1 (TLK1) and never in mitosis gene A (NIMA)-related kinase 1 (NEK1) in a DNA damage response (DDR)-mediated cell cycle arrest in LNCaP cells treated with bicalutamide, we uncovered that overexpression of wt-NEK1 resulted in a rapid conversion to androgen-independent (AI) growth, analogous to what has been observed when YAP1 is overexpressed. We now report that overexpression of wt-NEK1 …

Manf Is Neuroprotective Against Ethanol-Induced Neurodegeneration Through Ameliorating Er Stress, Yongchao Wang, Wen Wen, Hui Li, Marco Clementino, Hong Xu, Mei Xu, Murong Ma, Jacqueline A. Frank, Jia Luo

Pharmacology and Nutritional Sciences Faculty Publications

Fetal alcohol spectrum disorders (FASD) are a spectrum of developmental disorders caused by prenatal alcohol exposure. Neuronal loss or neurodegeneration in the central nervous system (CNS) is one of the most devastating features in FASD. It is imperative to delineate the underlying mechanisms to facilitate the treatment of FASD. Endoplasmic reticulum (ER) stress is a hallmark and an underlying mechanism of many neurodegenerative diseases, including ethanol-induced neurodegeneration. Mesencephalic astrocyte-derived neurotrophic factor (MANF) responds to ER stress and has been identified as a protein upregulated in response to ethanol exposure during the brain development. To investigate the role of MANF in …

Synthesis, Characterization, And Antiproliferative Activity Of Novel Chiral [Quinoxp*Aucl2]+ Complexes, Adedamola S. Arojojoye, R. Tyler Mertens, Samuel Ofori, Sean R. Parkin, Samuel G. Awuah

Chemistry Faculty Publications

Herein is reported the synthesis of two Au(III) complexes bearing the (R,R)-(–)-2,3-Bis(tert-butylmethylphosphino)quinoxaline (R,R-QuinoxP*) or (S,S)-(+)-2,3-Bis(tert-butylmethylphosphino)quinoxaline (S,S-QuinoxP*) ligands. By reacting two stoichiometric equivalents of HAuCl₄.3H₂O to one equivalent of the corresponding QuinoxP* ligand, (R,R)-(–)-2,3-Bis(tert-butylmethylphosphino)quinoxalinedichlorogold(III) tetrachloroaurates(III) (1) and (S,S)-(+)-2,3-Bis(tert-butylmethylphosphino)quinoxalinedichlorogold(III) tetrachloroaurates(III) (2) were formed, respectively, in moderate yields. The structure of (S,S)-(+)-2,3-Bis(tert-butylmethylphosphino)quinoxalinedichlorogold(III) tetrachloroaurates(III) (2) was further confirmed by X-ray crystallography. The antiproliferative activities of the two compounds were evaluated in a panel of cell lines and exhibited promising results comparable to auranofin and cisplatin with …

Cross-Cultural Analysis Of Gamer Identity: A Comparison Of The United States And Poland, Małgorzata Ćwil, William T. Howe

Communication Faculty Publications

Who is a gamer? What kind of people are perceived to be gamers? And finally – who perceives themselves as a gamer? In this article the authors attempt to answer these three questions from a multinational perspective.

Background. Games are nowadays one of the most frequently encountered forms of entertainment and constitute an ever-increasing part of many people’s day-to-day lives. With the rising popularity of video games, there is a need to conduct a research concerning gamer identity and to find out who perceives themselves as a gamer. The aim of this study is to compare the results of …

Multicultural Competencies Of Healthcare Professionals And Disability-Inclusive In Telehealth During The Covid-19 Pandemic, Si-Yi Chao, Keith B. Wilson, Carrie L. Acklin

Early Childhood, Special Education, and Counselor Education Faculty Publications

There is evidence that people with disabilities are more likely to be discriminated against and to have disproportionate health care disparities compared to people who are able-bodied during the devastating COVID-19 pandemic. In light of COVID-19, telehealth has been transformed to the primary health care delivery due to social restrictions of most, globally. Disability-inclusive telehealth design can promote culturally diverse groups access and more accurate COVID-19 information, knowledge, public health measures, and guidelines of preventive strategies for acquiring COVID-19. Applying multicultural competencies is required for healthcare providers to maximize health engagement and outcomes of PWD. In many areas of health …

Governing The Gold Rush Into Emerging Markets: A Case Study Of Indonesia’S Regulatory Responses To The Expansion Of Chinese-Backed Online P2p Lending, Angela Tritto, Yujia He, Victoria Amanda Junaedi

Patterson School of Diplomacy and International Commerce Faculty Publications

Peer-to-peer (P2P) lending has the potential to boost financial inclusion in emerging markets. This paper contributes to the literature on fintech governance in emerging Asian markets. It examines the case of the Indonesian government’s approach in regulating the P2P lending sector using both primary interviews and secondary firm-level data. Driven by regulation tightening in China and regulatory gaps in Indonesia, Chinese investments became the largest in this sector contributing, however, to growing risks from illegal business practices. The Indonesian government responded by creating new regulations and institutions, mitigating risks without stifling the potential for financial inclusion. We conclude a proactive …

Hooked On A Feeling: Influence Of Brief Exposure To Familiar Music On Feelings Of Emotion In Individuals With Alzheimer's Disease, Alaine E. Reschke-Hernández, Amy M. Belfi, Edmarie Guzmán-Vélez, Daniel Tranel

Music Faculty Publications

BACKGROUND: Research has indicated that individuals with Alzheimer's-type dementia (AD) can experience prolonged emotions, even when they cannot recall the eliciting event. Less is known about whether music can modify the emotional state of individuals with AD and whether emotions evoked by music linger in the absence of a declarative memory for the eliciting event.

OBJECTIVE: We examined the effects of participant-selected recorded music on self-reported feelings of emotion in individuals with AD, and whether these feelings persisted irrespective of declarative memory for the emotion-inducing stimuli.

METHODS: Twenty participants with AD and 19 healthy comparisons (HCs) listened to two 4.5-minute …

Compact Low-Cost Fiberless Diffuse Speckle Contrast Flow-Oximeter, Guoqiang Yu, Chong Huang, J. Todd Hastings

Biomedical Engineering Faculty Patents

A low-cost compact fiberless diffuse speckle contrast flow-meter includes a small laser diode and a 2-dimensional imaging device such as a charge coupled device (CCD) or complementary metal oxide semiconductor (CMOS) for directly contacting the tissue and measuring a parameter such as blood flow in a deep/thick volume of tissue (up to 10 mm depth). The small laser diode is fixed at a certain distance (0 to 20 mm) from the imaging device and directly contacts the tissue. Light emitted from the laser diode penetrates through the tissue and reflects back to the imaging device without passing through any lenses …

Review Of: From The Front Lines Of The Appalachian Addiction Crisis Healthcare Providers Discuss Opioids, Meth And Recovery, Carl G. Leukefeld

Journal of Appalachian Health

The Journal of Appalachian Health is dedicated to reviewing various types of media related to contemporary concepts that affect the health of Appalachia. As the opioid-related overdose deaths ravish Appalachia, now more than ever, we each must devote energy to understanding addiction and pathways to recovery. Dr. Carl Leukefeld reviews the book From the Front Lines of the Appalachian Addiction Crisis: Healthcare Providers Discuss Opioids, Meth and Recovery.

The Landscape Of Connected Cancer Symptom Management In Rural America: A Narrative Review Of Opportunities For Launching Connected Health Interventions, Ming-Yuan Chih, Anna Mccowan, Sadie Whittaker, Melinda Krakow, David K. Ahern, Eliah Aronoff-Spencer, Bradford W. Hesse, Timothy W. Mullett, Robin C. Vanderpool

Journal of Appalachian Health

Background: The 2016 President’s Cancer Panel called for projects focusing on improving cancer symptom management using connected health technologies (broadband and telecommunications). However, rural communities, like those in Appalachia, may experience a “double burden” of high cancer rates and lower rates of broadband access and adoption necessary for connected health solutions.

Purpose: To better understand the current landscape of connected health in the management of cancer symptoms in rural America.

Methods: A literature search was conducted using four academic databases (PubMed, CINAHL, MEDLINE, and PsycINFO) to locate articles published from 2010 to 2019 relevant to connected cancer symptom management in …

Leveraging Electronic Health Records Data For Enhanced Colorectal Cancer Screening Efforts, Adam D. Baus, Lauren E. Wright, Stephenie Kennedy-Rea, Mary E. Conn, Susan Eason, Dannell Boatman, Cecil Pollard, Andrea Calkins, Divya Gadde

Journal of Appalachian Health

Introduction: Colorectal cancer is the third most common type of cancer in the United States for men and women combined. While the current threat of disease nationally is significant, the majority of colorectal cancer cases and deaths could be prevented through established screening tests and guidelines. Within the Appalachian region and West Virginia in particular, colorectal cancer is a significant public health problem. A more systematic, comprehensive approach to preventing and controlling cancer is essential.

Methods: Through the West Virginia Program to Increase Colorectal Cancer Screening, primary care systems across the state received data-informed practice facilitation designed to increase screening …

In Their Own Words: How Opioids Have Impacted The Lives Of “Everyday” People Living In Appalachia, Patricia Nola Eugene Roberson, Gina Cortez, Laura H. Trull, Katherine Allison Lenger

Journal of Appalachian Health

Introduction: The opioid epidemic is ravaging people, families, and communities in Appalachia. However, limited research has examined how “everyday” people (e.g., not chronic pain patients, not medical professionals) living in these communities how opioids have impacted their lives.

Objective: Identify the perception of the opioid epidemic on individuals, families, and communities from people living in region most impacted regions.

Methods: Patients were recruited at Remote Area Medical clinics throughout Central and Southern Appalachia to complete interviews online (N = 169) or over the phone (N = 26), including one open-ended question about how opioids have impacted their lives.

Results: Using …

Rural Community Toolbox To Help Battle Opioid Epidemic, Liz Carey

Journal of Appalachian Health

An online data repository and toolbox created by the Office of National Drug Control Policy is designed to provide communities with knowledge and resources to fight the opioid epidemic according to their unique needs.

Cost Minimization Of Battery-Supercapacitor Hybrid Energy Storage For Hourly Dispatching Wind-Solar Hybrid Power System, Pranoy Roy, Jiangbiao He, Yuan Liao

Electrical and Computer Engineering Faculty Publications

This study demonstrates a dispatching scheme of wind-solar hybrid power system (WSHPS) for a one-hour dispatching period for an entire day utilizing battery and supercapacitor hybrid energy storage subsystem (HESS). A frequency management approach is deployed to extend the longevity of the batteries through extensively utilizing the high energy density property of batteries and the high power density property of supercapacitors in the HESS framework. A low-pass filter (LPF) is employed to decouple the power between a battery and a supercapacitor (SC). The cost optimization of the HESS is computed based on the time constant of the LPF through extensive …

Viral Data, Agnieszka Leszczynski, Matthew Zook

Geography Faculty Publications

We are experiencing a historical moment characterized by unprecedented conditions of virality: a viral pandemic, the viral diffusion of misinformation and conspiracy theories, the viral momentum of ongoing Hong Kong protests, and the viral spread of #BlackLivesMatter demonstrations and related efforts to defund policing. These co-articulations of crises, traumas, and virality both implicate and are implicated by big data practices occurring in a present that is pervasively mediated by data materialities, deeply rooted dataist ideologies that entrench processes of datafication as granting objective access to truth and attendant practices of tracking, data analytics, algorithmic prediction, and data-driven targeting of individuals …

Modeling The Impact Of Grazing On Water Budgets, Ying Zhao, Stephan Peth, Julia Krümmelbein, Bettina Ketzer, Yingzhi Gao, Christian Bernhofer, Rainer Horn

IGC Proceedings (1977-2023)

No abstract provided.

Nmr Spectroscopy Analysis Reveals Differential Metabolic Responses In Arabidopsis Roots And Leaves Treated With A Cytokinesis Inhibitor, Thomas E. Wilkop, Minmin Wang, Angelo Heringer, Jaideep Singh, Florence Zakharov, Viswanathan V. Krishnan, Georgia Drakakaki

Physiology Faculty Publications

In plant cytokinesis, de novo formation of a cell plate evolving into the new cell wall partitions the cytoplasm of the dividing cell. In our earlier chemical genomics studies, we identified and characterized the small molecule endosidin-7, that specifically inhibits callose deposition at the cell plate, arresting late-stage cytokinesis in arabidopsis. Endosidin-7 has emerged as a very valuable tool for dissecting this essential plant process. To gain insights regarding its mode of action and the effects of cytokinesis inhibition on the overall plant response, we investigated the effect of endosidin-7 through a nuclear magnetic resonance spectroscopy (NMR) metabolomics approach. In …

Exercise For Weight Loss: Further Evaluating Energy Compensation With Exercise, Kyle D. Flack, Harry M. Hays, Jack Moreland, Douglas E. Long

Dietetics and Human Nutrition Faculty Publications

PURPOSE: This study assessed how individuals compensate for energy expended during a 12-wk aerobic exercise intervention, elucidating potential mechanisms and the role exercise dose plays in the compensatory response.

PARTICIPANTS AND DESIGN: Three-arm, randomized controlled trial among sedentary adults age 18 to 40 yr, body mass index of 25 to 35. Groups included six exercise sessions per week, two sessions per week, and sedentary control.

METHODS: Rate of exercise energy expenditure was calculated from a graded exercise test averaged across five heart rate zones. Energy compensation was calculated as the difference between expected weight loss (based on exercise energy expenditure) …

Some Regional Economic Perspectives On Covid-19 Impacts, Paul A. Coomes

Institute for the Study of Free Enterprise Working Papers

It has been about eight months since the Covid-19 pandemic began sweeping across America, causing the well-known health care emergency, and major economic and fiscal distortions. Presumably, we are in the last stages of the damage, as activity has picked up in most realms of daily life. However, recovery problems linger in many areas, including air travel, cruises, hotels, conventions, concerts, and schools. While not over, enough information has emerged to start documenting the regional economic impacts around Kentucky. This note examines the latest public data to study the apparent economic and fiscal damage related to Covid responses, public and …

Multi-Ancestry Genome-Wide Association Study Accounting For Gene-Psychosocial Factor Interactions Identifies Novel Loci For Blood Pressure Traits, Daokun Sun, Melissa A. Richard, Soloman K. Musani, Yun Ju Sung, Thomas W. Winkler, Karen Schwander, Jin Fang Chai, Xiuqing Guo, Tuomas O. Kilpeläinen, Dina Vojinovic, Hugues Aschard, Traci M. Bartz, Lawrence F. Bielak, Michael R. Brown, Kumaraswamy Chitrala, Fernando P. Hartwig, Andrea R. V. R. Horimoto, Yongmei Liu, Alisa K. Manning, Raymond Noordam, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP, taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to 128,894 adults from five ancestry groups. In the combined meta-analyses of stages 1 and 2, we identified 59 loci (p value < 5e−8), including nine novel BP loci. The novel associations were observed mostly with pulse pressure, with fewer observed with mean arterial pressure. Five novel loci were identified in African ancestry, and all but one showed patterns of interaction with at least one psychosocial factor. Functional annotation of the novel loci supports a major role for genes implicated in the immune response (PLCL2), synaptic function and neurotransmission (LIN7A …

Spiny Mice (Acomys) Exhibit Attenuated Hallmarks Of Aging And Rapid Cell Turnover After Uv Exposure In The Skin Epidermis, Wesley Wong, Austin Kim, James R. Monaghan, Ashley W. Seifert, Malcolm Maden, Justin D. Crane

Biology Faculty Publications

The study of long-lived and regenerative animal models has revealed diverse protective responses to stressors such as aging and tissue injury. Spiny mice (Acomys) are a unique mammalian model of skin wound regeneration, but their response to other types of physiological skin damage has not been investigated. In this study, we examine how spiny mouse skin responds to acute UVB damage or chronological aging compared to non-regenerative C57Bl/6 mice (M. musculus). We find that, compared to M. musculus, the skin epidermis in A. cahirinus experiences a similar UVB-induced increase in basal cell …

An Experimental Investigation Into Promoting Mental Health Service Use On Social Media: Effects Of Source And Comments, Zhaomeng Niu, Lun Hu, David C. Jeong, Jared Brickman, Jerod L. Stapleton

Health, Behavior & Society Faculty Publications

Mental health is an increasingly prevalent topic of public interest, but remains a complex area requiring focused research that must account for negative perceptions surrounding mental health issues. The current work explores the roles of social media information source credibility and valence of social media comments on health outcomes in such a mental health context. We used a 2 (message source: professional vs. layperson) × 3 (valence of comments: positive vs. negative vs. mixed) online experiment to examine the effects of source and valence of comments on trust, attitudes and intentions related to mental health information and services among 422 …

Legacy Missions In Times Of Change: Defining And Shaping Collections In The 21st Century, Antje Mays, Oya Y. Rieger

Library Faculty and Staff Publications

Despite the rapidly changing information and technology landscape, collections remain at the heart of academic libraries, signifying their enduring importance in providing access to our cultural heritage. Given broader trends in research and the current information ecology of an increasingly networked, distributed, and licensed environment, building collections and developing collection polices is increasingly ambiguous. These trends impact librarians in form of ever-expanding portfolios, diffusion of effort, weakened sense of focus, and a rising sense of persistent yet unmet needs for developing new skills. This paper outlines current research on collection trends and summarizes the interactive exchanges from the 2019 Charleston …

An Overview Of Methods And A New Three-Dimensional Fea And Analytical Hybrid Technique For Calculating Ac Winding Losses In Pm Machines, Narges Taran, Dan M. Ionel, Vandana Rallabandi, Greg Heins, Dean Patterson

Power and Energy Institute of Kentucky Faculty Publications

This article proposes a new hybrid analytical and numerical finite element (FE) based method for calculating ac eddy current losses in wire windings and demonstrates its applicability for axial flux permanent magnet electric machines. The method takes into account three-dimensional (3-D) field effects in order to achieve accurate results and yet greatly reduce computational efforts. The new 3-D FE-based method is advantageous as it employs minimum simplifications and considers the end turns in the eddy current path, the magnetic flux density variation along the effective length of coils, and the field fringing and leakage, which ultimately increases the accuracy of …

An Update Of Seismic Monitoring And Research In The Vicinity Of The Paducah Gaseous Diffusion Plant: January 2018–December 2019, Zhenming Wang, N. Seth Carpenter, Edward W. Woolery

Report of Investigations--KGS

From January 2018 to December 2019, the Kentucky Geological Survey monitored earthquakes and conducted research on seismic hazards in the vicinity of the Paducah Gaseous Diffusion Plant, a former uranium enrichment facility, in McCracken County, western Kentucky. Six hundred forty-four earthquakes with magnitude between 0.5 and 3.7 were recorded in the area during this period. Research focused on the influence of the thick sediments on earthquake ground motion, the so-called site response, through theoretical and data analysis of borehole seismic records. Our research has shown that the National Earthquake Hazards Reduction Program site classification, which is based on Vs30, and …

Toward A Century Of Language Attitudes Research: Looking Back And Moving Forward, Marko Dragojevic, Fabio Fasoli, Jennifer Cramer, Tamara Rakić

Communication Faculty Publications

The study of language attitudes is concerned with the social meanings people assign to language and its users. With roots in social psychology nearly a century ago, language attitudes research spans several academic disciplines and draws on diverse methodological approaches. In an attempt to integrate this work and traverse disciplinary boundaries and methodological proclivities, we propose that language attitudes—as a unified field—can be organized into five distinct—yet interdependent and complementary—lines of research: documentation, explanation, development, consequences, and change. After highlighting some of the key findings that have emerged from each area, we discuss several opportunities and challenges for future research.

Changes Of Persistent Soil Seed Bank In Degraded Seriphidium Transillens Desert Grassland, Guili Jin, Jinzhong Zhu, Honglai Liu

IGC Proceedings (1977-2023)

No abstract provided.

Strategy And Issues Of Ecological Grass Construction In Jilin Province, F. G. Du, W. W. Lu

IGC Proceedings (1977-2023)

No abstract provided.

Study On Root System Morphology Of Creeping‐Rooted Alfalfa And Related Analysis Of Soil Physical Factor, Jinpeng Zhang

IGC Proceedings (1977-2023)

No abstract provided.

A User Study Of A Wearable System To Enhance Bystanders’ Facial Privacy, Alfredo J. Perez, Sherali Zeadally, Scott Griffith, Luis Y. Matos Garcia, Jaouad A. Mouloud

Information Science Faculty Publications

The privacy of users and information are becoming increasingly important with the growth and pervasive use of mobile devices such as wearables, mobile phones, drones, and Internet of Things (IoT) devices. Today many of these mobile devices are equipped with cameras which enable users to take pictures and record videos anytime they need to do so. In many such cases, bystanders’ privacy is not a concern, and as a result, audio and video of bystanders are often captured without their consent. We present results from a user study in which 21 participants were asked to use a wearable system called …