Digital Commons Network^™

What You Do Or What You Say? An Examination Of Analyst Reactions To Prototypical And Non-Prototypical Ceos Linguistic And Competitive Behaviors, Courtney Hart

Theses and Dissertations--Management

Non-prototypical CEOs are those that process different demographic characteristics from a target reference group. In the US, a non-prototypical CEO is both white and male. While the negative responses to non-prototypical leaders based on race and gender have been well documented, we know less on what these leaders do that may influence biased evaluations. In this dissertation I took an impression management view to examine analysts’ evaluative bias (AEB) on prototypical and non-prototypical CEOs hiding linguistic behaviors and competitive aggressiveness. Specifically, I examined hiding linguistic behaviors on quarterly conference calls and two attributes of competitive repertoire will be researched. Drawing …

Finance And Economic Performance Across Countries, Monika Islam Khan

Theses and Dissertations--Economics

My dissertation consists of three papers on finance and economic performance across countries. The first paper applies the gravity model of international trade to quantify the impact of the banking sector and the stock market on bilateral trade patterns. Following the study of capital structure, I evaluate the mix of external financing sources used for real investment at the macroeconomic level by differentiating between the relative roles of the banking sector and stock market development in determining trade patterns. Using aggregate bilateral trade data for 87 countries over 1976-2012, I find that stock market development has a substantial impact on …

Dimension Reduction Techniques In Regression, Pei Wang

Theses and Dissertations--Statistics

Because of the advances of modern technology, the size of the collected data nowadays is larger and the structure is more complex. To deal with such kinds of data, sufficient dimension reduction (SDR) and reduced rank (RR) regression are two powerful tools. This dissertation focuses on these two tools and it is composed of three projects. In the first project, we introduce a new SDR method through a novel approach of feature filter to recover the central mean subspace exhaustively along with a method to determine the dimension, two variable selection methods, and extensions to multivariate response and large p …

Novel Nonparametric Testing Approaches For Multivariate Growth Curve Data: Finite-Sample, Resampling And Rank-Based Methods, Ting Zeng

Theses and Dissertations--Statistics

Multivariate growth curve data naturally arise in various fields, for example, biomedical science, public health, agriculture, social science and so on. For data of this type, the classical approach is to conduct multivariate analysis of variance (MANOVA) based on Wilks' Lambda and other multivariate statistics, which require the assumptions of multivariate normality and homogeneity of within-cell covariance matrices. However, data being analyzed nowadays show marked departure from multivariate normal distribution and homoscedasticity. In this dissertation, we investigate nonparametric testing approaches for multivariate growth curve data from three aspects, i.e., finite-sample, resampling and rank-based methods.

The first project proposes an approximate …

Novel Methods For Characterizing Conditional Quantiles In Zero-Inflated Count Regression Models, Xuan Shi

Theses and Dissertations--Statistics

Despite its popularity in diverse disciplines, quantile regression methods are primarily designed for the continuous response setting and cannot be directly applied to the discrete (or count) response setting. There can also be challenges when modeling count responses, such as the presence of excess zero counts, formally known as zero-inflation. To address the aforementioned challenges, we propose a comprehensive model-aware strategy that synthesizes quantile regression methods with estimation of zero-inflated count regression models. Various competing computational routines are examined, while residual analysis and model selection procedures are included to validate our method. The performance of these methods is characterized through …

Interactions Of Post-Pks Enzymes Of The Mithramycin Biosynthetic Pathway, Ryan Wheeler

Theses and Dissertations--Pharmacy

Combinatorial biosynthesis is a powerful tool for generating new, more active drug analogues to combat disease. But in order for combinatorial biosynthesis to be employed to its full potential, a deep understanding of the enzymes that produce the parent molecule must be had. The goals of the work presented in this thesis are to characterize the reaction catalyzed by MtmW, the final enzyme in the mithramycin (MTM) biosynthetic pathway, and to discover the interaction between MtmW and MtmOIV.

MtmW is an aldol-ketoreductase responsible for reducing the most distal carbonyl on the MTM pentyl side chain. It forms an octamer that …

Understanding The Impact Of Solvents In Oral Solid Dosage Formulation And Process Development, Matthew Kyle Defrese

Theses and Dissertations--Pharmacy

The successful delivery of chemical compounds for the purpose of therapeutic treatments and prophylactics is a substantial undertaking in modern drug development. Notably, the adoption of high throughput screening techniques has led to the proliferation of poorly water soluble and/or highly potent molecules which further complicate development activities. Spray dried amorphous solid dispersions are an increasingly important formulation strategy to overcome solubility issues while wet granulation approaches are the method of choice for the preparation of highly potent APIs in oral solid dosage forms.

A common connection between these critical techniques is their reliance on solvent-based processing that can often …

Human Regulatory T Cells Control Inflammation From Effector T Cells In Prediabetes, Rui Liu

Theses and Dissertations--Pharmacy

Type 2 diabetes (T2D) is a chronic low-grade inflammatory disease. A T cell cytokine profile (Th17) from PBMCs can distinguish obese T2D from obese non-diabetes subjects. Individual T cell subsets interact with each other and the diverse subsets jointly determine overall inflammation. Cellular metabolism drives cytokine production of CD4⁺ T cells, and therefore contributes to inflammation in T2D. However, specific changes in metabolism and function of CD4⁺ T cells during the progression from lean healthy to obese and diabetic stages in people have not been clarified.

We hypothesize that human regulatory T cells (Treg) impact metabolism of effector …

Abc Transporters In Glioblastoma: Anticancer Drug Transport And Transporter Regulation At The Blood-Brain Barrier, Julia A. Schulz

Theses and Dissertations--Pharmacy

Glioblastoma is one of the deadliest cancers, with a median survival of only one year. Even after aggressive treatment consisting of surgical resection, radiation, and chemotherapy, most glioblastoma patients suffer from tumor recurrence within 6-9 months. One reason for treatment failure of anticancer drugs is the blood-brain barrier that protects the brain by impeding xenobiotic uptake from the blood. To this end, efflux transporters at the human blood-brain barrier, such as P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2), prevent many compounds, including anticancer drugs, from entering the brain. Thus far, approaches to deliver anticancer drugs across the blood-brain barrier …

Investigation Of The Biosynthesis Of The Nucleoside Antibiotic Sphaerimicin, Jonathan Overbay

Theses and Dissertations--Pharmacy

Antibiotic-resistance has become a widespread problem in the United States and across the globe. Meanwhile, new antibiotics are entering the clinic at an alarmingly low rate. Highly-modified nucleosides, a class of natural products often produced by actinobacteria, target MraY bacterial translocase I. MraY is a clinically unexploited enzyme target that is ubiquitous and essential to peptidoglycan cell wall biosynthesis. The nucleoside antibiotics known vary in efficacy and the functionalities contributing to improved activity is poorly understood. Sphaerimicin, a newly discovered modified nucleoside, has potent inhibitory activity with an IC50 of 13.65 nM against MraY. In general, sphaerimicin is primarily effective …

Pharmacist Provision Of Contraception Services In Kentucky: Opinions And Policy Interventions, Dustin K. Miracle

Theses and Dissertations--Pharmacy

Unintended pregnancy continues to be a prevalent issue across the United States, impacting millions of women annually. While several states have enacted policies expanding pharmacist services to allow for provision of hormonal contraception, Kentucky has yet to do so. Likewise, although provision of nonprescription hormonal contraception could be authorized under Kentucky regulation, prior to this study, this had yet to be done. The objectives of this study were to 1) understand the opinions of Kentucky pharmacists and student pharmacists regarding provision of hormonal contraception services through a board-authorized protocol, 2) understand the opinions of Kentucky pharmacists and student pharmacists regarding …

Identification And Characterization Of Epitope Specific Immune Responses In Humans And Mice, David Henson

Theses and Dissertations--Pharmacy

Cardiovascular disease (CVD) is a major cause of morbidity and mortality around the world causing approximately 14% of total disease burden. A major factor in the progression to major CVD within patients is immune activation, which led to the study of various immune products as potential biomarkers for the prediction of cardiovascular events, including antigen-specific antibodies and immune complexes. One focus of this biomarker research is IgG autoantibodies targeting apolipoprotein A-I (ApoA-I), and several studies of these antibodies have found an association with increased CVD events. Based on the encouraging results from these studies and previous research which has identified …

Examining Childhood Outcomes In Neonatal Abstinence Syndrome, Kailyn Conner

Theses and Dissertations--Pharmacy

Rates of neonatal abstinence syndrome have been rising over the past several years, alongside rising rates of opioid use disorder, propelled by the continuing Opioid Epidemic ravaging the country. Children born withdrawing from opioids they were exposed to in utero have known health complications through the first year of life that have been studied in the current literature. Less is known, however, about the outcomes these children face in childhood. As many of these children are progressing to childhood, there is an urgent need for healthcare system to prepare to handle the health needs of these children; outcomes related to …

Elucidating The Role Of The Tyrosine Phosphatase, Shp-2, In Regulation Of Pd-L1 Expression In Non-Small Lung Cancer Using Both Biochemical Analyses And Real-World Genomic Information, Keller Toral

Theses and Dissertations--Pharmacy

Immune checkpoint inhibitors (ICIs), especially those that target programmed cell death protein 1 (PD-1) and programmed cell death ligand-1 (PD-L1), have been shown to provide substantial clinical benefit in many patients with non-small cell lung cancer (NSCLC). While these therapeutic agents can be highly effective in the correct context, the biological systems that malignant cells draft from normal activities of the cell are poorly characterized. Tumor cell-specific expression of PD-L1 is likely important for clinical benefit from PD-1 and PD-L1 inhibitors. It is known that PD-L1 is inappropriately expressed in many cancers harboring mutations in the RAS family of genes. …

Towards A Holistic Risk Model For Safeguarding The Pharmaceutical Supply Chain: Capturing The Human-Induced Risk To Drug Quality, Heather R. Campbell

Theses and Dissertations--Pharmacy

Counterfeit, adulterated, and misbranded medicines in the pharmaceutical supply chain (PSC) are a critical problem. Regulators charged with safeguarding the supply chain are facing shrinking resources for inspections while concurrently facing increasing demands posed by new drug products being manufactured at more sites in the US and abroad. To mitigate risk, the University of Kentucky (UK) Central Pharmacy Drug Quality Study (DQS) tests injectable drugs dispensed within the UK hospital. Using FT-NIR spectrometry coupled with machine learning techniques the team identifies and flags potentially contaminated drugs for further testing and possible removal from the pharmacy. Teams like the DQS are …

Delineating The Biosynthesis Of Capuramycin-Type Antibiotics, Ashley L. Biecker

Theses and Dissertations--Pharmacy

New antibiotic scaffolds with novel drug targets are needed to combat the rise of drug-resistant, infectious microorganisms. The bacterial translocase I is a ubiquitous enzyme in the peptidoglycan biosynthetic pathway that has yet to be targeted by clinically used antibiotics. It catalyzes the transfer of N-acetylmuramoyl-pentapeptide to undecaprenylphosphate in order to generate lipid I during cell wall biosynthesis. A screening of bacterial translocase I inhibitors led to the discovery of the novel compound capuramycin and its analogues: A-500359s, A-503083s, and A-102395, produced by various species of actinomycetes. The capuramycins show potent activity against the bacterial translocase I with IC50s …

Multiple Proteinopathies And Their Role In Cognitive Impairment And Neurodegenerative Diseases, Shama D. Karanth

Theses and Dissertations--Epidemiology and Biostatistics

Most age-related neurodegenerative disorders are associated with the aggregation of misfolded and aberrant proteins. Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders and is highly prevalent in older adults. Neuropathologically, AD is characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs). Other misfolded proteins, including α-synuclein and transactive response DNA-binding protein 43 (TDP-43), are also commonly observed in aged brains. Aberrant α-synuclein has been associated with Parkinson's disease, Dementia with Lewy bodies, and multiple system atrophy, whereas TDP-43 has been associated with multiple neurological diseases, the most common of which was designated as limbic-predominant, …

Enhancing Drug Overdose Mortality Surveillance Through Natural Language Processing And Machine Learning, Patrick J. Ward

Theses and Dissertations--Epidemiology and Biostatistics

Epidemiological surveillance is key to monitoring and assessing the health of populations. Drug overdose surveillance has become an increasingly important part of public health practice as overdose morbidity and mortality has increased due in large part to the opioid crisis. Monitoring drug overdose mortality relies on death certificate data, which has several limitations including timeliness and the coding structure used to identify specific substances that caused death. These limitations stem from the need to analyze the free-text cause-of-death sections of the death certificate that are completed by the medical certifier during death investigation. Other fields, including clinical sciences, have utilized …

Environmental Respiratory Exposures And Pulmonary Function Among Residents Of Rural Appalachia, Kentucky, John C. Flunker

Theses and Dissertations--Epidemiology and Biostatistics

Introduction

Resource extraction exposures are hypothesized to promote adverse respiratory health outcomes among residents of rural Appalachia, yet no studies to date have simultaneously quantified small-scale geographic variation in residential exposure, individual level health factors, and respiratory health outcomes.

Methods

The Mountain Air Project (MAP) is a community engaged cross-sectional study based in Harlan and Letcher counties of Southeastern Kentucky. MAP utilized a novel small-scale method to define residential exposure boundaries: hydrologic unit code (HUC), which represents distinct drainages (AKA “hollows”) where residents cluster. We assigned the HUC level density of active and abandoned surface and underground mining, oil/gas wells, …

Enhancing Evidence-Based Tobacco Treatment Services For Clients With Mental Illnesses, Janet Otachi

Theses and Dissertations--Social Work

Tobacco users with mental illnesses (MI) have continued to experience disparate rates of tobacco use, related illnesses and mortality. Despite higher rates of tobacco use among clients with MI, few providers in mental health settings deliver evidence based tobacco treatment. If tobacco use is not addressed, clients with MI will continue to experience disproportionate rates of tobacco use and related burden. Utilizing the theory of planned behavior (TPB), this study examined factors associated with provider intentions to deliver tobacco treatment, and their tobacco treatment delivery practices. Based on the main constructs of the TPB, providers’ attitudes about tobacco treatment delivery, …

Hospital Nurses' Moral Distress And Coping During Covid-19: A Pilot Study, Abigail Latimer

Theses and Dissertations--Social Work

The COVID-19 pandemic caused a wave of critically ill patients, overwhelming hospitals, and creating unprecedented conditions for hospital employees, particularly bedside nurses. Concerns about the emotional and mental well-being of nurses have already been raised prior to the pandemic and depression, anxiety, and PTSD symptoms among nurses during the pandemic have been observed. Given the increased infection and safety risks, staffing shortages, inadequate personal protective equipment and resources, and hospital restrictions causing many nurses to be patients’ only support, there is also a growing concern about how these institutional and personal restrictions to providing best care and practicing ethically have …

The Role Of Adverse Childhood Experiences (Aces) In The Military And Predicting Current Distress, Douglas A. Foote

Theses and Dissertations--Social Work

The United States has been in continuous military conflicts for the past two decades. The importance of having a fully capable fighting force is unquestionable, but too often, military units are not at full capacity due to service members (SMs) within a unit being unable to deploy due to mental health impediments. The surge of non-deployable SMs is a national security concern as it affects the SMs’ quality of life and Department of Defense’s (DoD) ability to fight today’s conflicts.

This study bolsters military ACE research because it sampled more female and officer participants compared to extant military ACE studies. …

Development Of An Autonomous Navigation System For The Shuttle Car In Underground Room & Pillar Coal Mines, Vasileios Androulakis

Theses and Dissertations--Mining Engineering

In recent years, autonomous solutions in the multi-disciplinary field of the mining engineering have been an extremely popular applied research topic. The growing demand for mineral supplies combined with the steady decline in the available surface reserves has driven the mining industry to mine deeper underground deposits. These deposits are difficult to access, and the environment may be hazardous to mine personnel (e.g., increased heat, difficult ventilation conditions, etc.). Moreover, current mining methods expose the miners to numerous occupational hazards such as working in the proximity of heavy mining equipment, possible roof falls, as well as noise and dust. As …

Investigation Of Coal Burst Potential Using Numerical Modeling And Rock Burst Indices, Cristian David Cardenas Triana

Theses and Dissertations--Mining Engineering

Coal bursts are typically defined as a rapid failure of coal or surrounding rock producing a violent release of energy and ejection of rock particles. This phenomenon is extremely complex and dynamic, and this has made it very difficult to predict. In the last decades, different researchers have aimed to understand the sources and mechanisms of failure of coal bursts. Various indices have been developed to assess the burst potential such as the Burst Potential Index (BPI), Energy Storage Rate, and the Strain Energy Density. Lately, numerical modeling has also been used as a tool to examine the rock deformation …

An Approach For Predicting Flow Characteristics At The Continuous Miner Face, Kayla Henderson

Theses and Dissertations--Mining Engineering

As coal and rock are mined, dust is dispersed into the air. This dust, among other contaminants, poses a serious health and safety risk to mineworkers. Very fine dust known as respirable dust can infiltrate the deepest part of the lungs, and long-term exposure to these particles leads to a disease called coal worker’s pneumoconiosis (CWP). Occurrence of this disease declined steadily over the latter half of the 20^th century; however, a recent study indicates that CWP has reemerged with an upward trend beginning at the turn of the century. To combat dust exposure, mine operators use a combination …

Application Of A Novel Ventilation Simplification Algorithm, Caitlin V. Strong

Theses and Dissertations--Mining Engineering

Ventilation network analysis is an integral part of maintaining a safe mine environment. Despite its important role, liberties are often taken with the representation of networks in ventilation network analysis software. In order to provide an alternative to heuristic methods used by ventilation engineers, a simplification algorithm has been developed. This algorithm is designed to work as a compliment to ventilation software. Comparisons of original ventilation networks and simplified networks show little to no change in fan operating point. The program utilizing this algorithm provides an alternative to reducing networks with a parallel factor. It can also be used in …

Capture Of Respirable Dust Using Maintenance Free Impingement Screen, Neeraj Kumar Gupta

Theses and Dissertations--Mining Engineering

Dust produced during mining activities has a detrimental effect on both miners’ health and operations’ safety. There is no definitive treatment for coal miners’ pneumoconiosis (CWP), which is caused by prolonged inhalation of respirable dust. Elevated coal dust concentrations have also been shown to cause several disastrous explosions in the United States and worldwide, resulting in the death of miners and loss of operations. Flooded-bed dust scrubbers are used on all modern-day continuous miners. These devices cleanse the dust-laden air and assist in bringing fresh air towards the mining face. Scrubbers use a multi-layered fibrous screen to capture airborne particles. …

Concepts For Development Of Shuttle Car Autonomous Docking With Continuous Miner Using 3-D Depth Camera, Sibley Miller

Theses and Dissertations--Mining Engineering

In recent years, a great deal of work has been conducted in automating mining equipment with the goals of increasing worker health and safety and increasing mine productivity. Automating vehicles such as load-haul-dumps been successful even in underground environments where the use of global positioning systems are unavailable. This thesis addresses automating the operation of a shuttle car, specifically focusing on positioning the shuttle car under the continuous miner coal-discharge conveyor during cutting and loading operations. This task requires recognition of the target and precise control of the tramming operation because a specific orientation and distance from the coal discharge …

Measurements Of Wind Turbine Wake Evolution And Trajectory During Morning Boundary Layer Transition And Under Wake Steering Conditions Via Unmanned Aerial Vehicles, Stewart Nelson

Theses and Dissertations--Mechanical and Aerospace Engineering

In July of 2019, a flight campaign was conducted using semi-autonomous Unmanned Aerial Vehicles (UAVs) at the Port Alma Kruger Energy wind farm in Ontario, Canada, to study various aspects of wind turbine wake evolution. Horizontal transects across the wakes were measured using modified fixed-wing aircraft fitted with a five-hole probe to measure the wind velocity vector. Reference boundary layer conditions were measured by an octocopter with an assortment of mounted sensors flying vertical profiles upstream of the turbines. Three experiments were conducted during the campaign, which consisted of a study on wake behavior during the morning boundary layer transition, …

Balancing Trade-Offs In One-Stage Production With Processing Time Uncertainty, Jingjing You

Theses and Dissertations--Mechanical and Aerospace Engineering

Stochastic production scheduling faces three challenges, first the inconsistencies among key performance indicators (KPIs), second the trade-offs between the expected return and the risk for a portfolio of KPIs, and third the uncertainty in processing times. Based on two inconsistent KPIs of total completion time (TCT) and variance of completion times (VCT), we propose our trade-off balancing (ToB) heuristic for one-stage production scheduling. Through comprehensive case studies, we show that our ToB heuristic with preference =0.0:0.1:1.0 efficiently and effectively addresses the three challenges. Moreover, our trade-off balancing scheme can be generalized to balance a number of …