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The Impact Of The 2018 Kentucky Cigarettes Taxes On Tobacco Use Among Youth, Claire W. Mampunza Jan 2021

The Impact Of The 2018 Kentucky Cigarettes Taxes On Tobacco Use Among Youth, Claire W. Mampunza

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Introduction: In the Commonwealth of Kentucky, cigarette smoking results in 1.92 billion dollars spent every year on medical costs, the death of approximately 9,000 Kentuckians, and 34 percent of all cancer cases. In 2017, 14.3 percent of high school students in Kentucky declared being current cigarette smokers, compared to 8.8 percent nationally. Tobacco use among youth is a public health concern because 88 percent of adult smokers initiate smoking before age 18. Youth nicotine use can damage the growing brain, which continues to develop until 25 years of age. In July 2018, the excise tax on cigarettes increased from …

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Covid Mitigation Strategies And Safety Perceptions Among Workers During Spring 2020 Shutdown, William Mciver Jan 2021

Covid Mitigation Strategies And Safety Perceptions Among Workers During Spring 2020 Shutdown, William Mciver

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

A novel coronavirus pandemic radically shifted the working environment of the population in the United States in the spring of 2020. Studies have examined the difference between healthcare workers and the general population, but there exists a gap when looking at mitigation strategies between healthcare workers and other workers that continued working outside the home. This study surveyed workers and asked about employment status, employment field, COVID safety precautions taken in the workplace, and feelings of safety. This study examined that and found statistically significant differences in the mitigation strategies used by healthcare workplaces and all other non-healthcare workplaces. This …

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Educational Intervention To Change Knowledge And Attitudes Regarding Sexual Behaviors To Reduce Rates Of Sexually Transmitted Infections Among University Of Kentucky’S Sorority Life Students., Julianna Maita Jan 2021

Educational Intervention To Change Knowledge And Attitudes Regarding Sexual Behaviors To Reduce Rates Of Sexually Transmitted Infections Among University Of Kentucky’S Sorority Life Students., Julianna Maita

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Sexually transmitted infections disproportionally affect young adults. Within this age group, women are at an increased risk for contracting and STI and face more severe long-term adverse consequences than men. College aged individuals are at an increased risk for contracting an STI due to risky sexual behaviors such as unprotected sex with multiple partners. College students involved in Greek Life have been found to engage in risker sexual behaviors than non-Greek life students. These individuals perceive themselves to be at a higher risk for contracting an STI and have an increased number of unprotected sexual encounters under the influence of …

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Novel Tools For Analysis Of Disordered Sleep And Motor Behavior In Preclinical Models Of Disease, Dillon M. Huffman Jan 2021

Novel Tools For Analysis Of Disordered Sleep And Motor Behavior In Preclinical Models Of Disease, Dillon M. Huffman

Theses and Dissertations--Biomedical Engineering

Subtle changes in sleep architecture can accompany and be symptomatic of various diseases or disorders. Understanding the complex interactions between sleep and health requires the ability to characterize sleep, probe its underlying mechanisms through perturbation, and quantify dependent physiological outcomes. Rodent models have come to be accepted as a valuable tool for preclinical investigations. However, experimental tools to accomplish such research typically rely on laborious methods that limit throughput and flexibility. Thus, research tools that minimize workload could be of great value to the research community and expedite investigation of the underlying mechanisms of sleep and further the development of …

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Changes In Cardiovascular, Respiratory, And Neural Activity By Music: Effects Of Breathing Pathway On Feeling Emotions, Mohammad Javad Mollakazemi Jan 2021

Changes In Cardiovascular, Respiratory, And Neural Activity By Music: Effects Of Breathing Pathway On Feeling Emotions, Mohammad Javad Mollakazemi

Theses and Dissertations--Biomedical Engineering

Listening to music can induce emotional and physiological changes. Increasing recognition of the palliative effects of music has led to its use as an adjuvant therapeutic tool in the treatment of various diseases. It is also well known that autonomic nervous activities and some cardiorespiratory rhythms change in correspondence with music. However, less is known about how these effects triggered by music come about. Listening to music affects synchronization between electroencephalograms (EEGs) and cardiac rhythmic activity. This interaction between cardiac and electrical responses led us to investigate whether EEG segments synchronized to different portions of the cardiac cycle can better …

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Facilitating Analysis Of Toxoplasma Gondii Bradyzoite Metabolic Activity Via Image Processing And Multivariate Logistic Regression For High Throughput Classification Of Mitochondrial Morphologies, Brooke Place Jan 2021

Facilitating Analysis Of Toxoplasma Gondii Bradyzoite Metabolic Activity Via Image Processing And Multivariate Logistic Regression For High Throughput Classification Of Mitochondrial Morphologies, Brooke Place

Theses and Dissertations--Biomedical Engineering

Approximately a third of the population worldwide is chronically infected by the parasite Toxoplasma gondii. During chronic infection the parasite resides within tissue cysts as the poorly understood bradyzoite form. Observation of these bradyzoites via microscopic imaging within tissue cyst purified from infected mouse brains has shown metabolic activity with heterogeneous replication potential. With fluorescence microscopy imaging targeting the parasite’s actively respiring mitochondria, the parasite’s metabolic state can be further investigated as the morphology of mitochondria can be associated with specific physiologic states. However, manually classifying mitochondrial morphologies from these images can be tedious and prone to error as …

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Life Cycle Assessment Of Polylactic Acid Biopolymer Industrial Waste Management Techniques In Belize, Dennis J. Newby Jan 2021

Life Cycle Assessment Of Polylactic Acid Biopolymer Industrial Waste Management Techniques In Belize, Dennis J. Newby

Theses and Dissertations--Civil Engineering

In January 2020, the Government of Belize enacted an Implementation Strategy and Action Plan to phase-out single-use plastics and to transition to products like bioplastics. This work investigated the environmental effects of using alternative waste management techniques to manage polylactic acid biopolymer (PLA) waste by using life cycle assessment (LCA). The following treatment options were compared: landfill, landfill expansion, cogeneration, and anaerobic digestion. The landfill and landfill expansion processes both had a global warming potential of 0.01 kg of CO2 eq. per kg of PLA waste managed compared to the cogeneration and anaerobic digestion processes -0.03 and -0.06 kg …

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Investigation Of Nitrate Transfer In Karst Basins During Storm Events Using Submersible Underwater Nutrient Analyzers, John Pike Jan 2021

Investigation Of Nitrate Transfer In Karst Basins During Storm Events Using Submersible Underwater Nutrient Analyzers, John Pike

Theses and Dissertations--Civil Engineering

Knowledge of nitrate sources and pathways in karst basins remains incomplete and hinders management of nutrients that cause algae blooms and degrade municipal water supply. However, the increased availability of optical, ultraviolet nitrate sensors allows advancement of nitrate source and transfer for water managers. A concept model is hypothesized for nitrate transfer during hydrologic events and baseflow that considers the multiple porosity of karst. To test the concept model, 15-minute nitrate sensor data is collected with submersible underwater nutrient analyzers over a multi-year period from two locations in a karst basin in the inner bluegrass region of central Kentucky, USA. …

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Localization Of Stationary Source Of Floor Vibration Using The Steered Response Power Method, Mohammad Royvaran Jan 2021

Localization Of Stationary Source Of Floor Vibration Using The Steered Response Power Method, Mohammad Royvaran

Theses and Dissertations--Civil Engineering

If the generated vibration in a building exceeds the acceptable limit design for a floor system, it is necessary to identify the source of vibration, a process known as localization. The objective of this study is the localization of stationary vibration sources, and the approach used is the steered response power (SRP) method. This method has already been shown to work well for wireless and acoustical applications to locate transmitter and sound sources, respectively. To the writer’s knowledge, this study is the first application of the SRP method to locate vibration sources using floor vibration measurements. However, because waves behave …

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Artificial Intelligence And Soft Computing In Smart Structural Systems, Sajad Javadinasab Hormozabad Jan 2021

Artificial Intelligence And Soft Computing In Smart Structural Systems, Sajad Javadinasab Hormozabad

Theses and Dissertations--Civil Engineering

Next-generation smart cities are the key feature in the next chapter of human life. Cities that employ innovative and technology-driven solutions to improve the sustainability, resilience, prosperity, and amenity of the community are considered smart cities. Development of smart cities requires fundamental innovations in many technical and technological aspects including those contributing to smart structures. Smart technologies improve the structural performance against natural disasters like earthquakes, hurricanes, tornados, and promote the sustainability of structural systems. Next-generation smart structures encompass a variety of technologies including Structural Control (SC) and Structural Health Monitoring (SHM). SC covers methodologies and technologies that modify the …

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Multi-Stream Longitudinal Data Analysis Using Deep Learning, Sajjad Fouladvand Jan 2021

Multi-Stream Longitudinal Data Analysis Using Deep Learning, Sajjad Fouladvand

Theses and Dissertations--Computer Science

Longitudinal healthcare data encompasses all tasks where patients information are collected at multiple follow-up times. Analyzing this data is critical in addressing many real world problems in healthcare such as disease prediction and prevention. In this thesis, technical challenges in analyzing longitudinal administrative claims data are addressed and novel deep learning based models are proposed for multi-stream data analysis and disease prediction tasks. These algorithms and frameworks are assessed mainly on substance use disorders prediction tasks and specifically designed to tackled these disorders. Substance use disorder is a public health crisis costing the US an estimated $740 billion annually in …

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Impact Of Short Meditation On Attentional Performance, Lauren E. Guerriero Jan 2021

Impact Of Short Meditation On Attentional Performance, Lauren E. Guerriero

Theses and Dissertations--Biology

Meditation describes a large variety of traditions that all include the conscious focus of attention. By maintaining attention, meditators experience both acute and long-term changes in physiology, anatomy, and cognitive performance. The type of performance benefit is believed to depend, at least in part, on the specific type of mental training. What is much less clear in the literature is the impact of a single session of meditation on the brain and how the acute changes could impact performance. Studies in advanced meditators show an increase in neuronal coordination and slowing of neuronal firing across many regions in the brain, …

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The Use Of Distraction: Doomscrolling, Losing Time, And Digital Well-Being In Pandemic Space-Times, Jacob Saindon Jan 2021

The Use Of Distraction: Doomscrolling, Losing Time, And Digital Well-Being In Pandemic Space-Times, Jacob Saindon

Theses and Dissertations--Geography

In the space-times of the COVID-19 global health crisis, how have our relationships with smartphones changed? How do popular discourses designate mundane engagements with digital technologies as healthy or unhealthy, and how are these notions of wellness practiced? This thesis draws upon an online survey of smartphone users residing in Kentucky, and a review of marketing, journalistic, and academic literature to establish current understandings of ‘digital well-being’. The paper then analyzes interviews with Kentucky smartphone users who were asked to track their screen time for a one-week period. This project reveals normative conceptions of well-being and the role of smartphone …

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Uncovering Frontier Mythologies: Memorial Landscapes In Minneapolis, Mn, Corrin Turkowitch Jan 2021

Uncovering Frontier Mythologies: Memorial Landscapes In Minneapolis, Mn, Corrin Turkowitch

Theses and Dissertations--Geography

This thesis analyzes the relationship between settler colonialism and public memory in B.F. Nelson Park, a downtown park in Minneapolis. My focus is the Pioneer statue, a large granite memorial depicting a frontier family in the middle of the park, which I examine through the lenses of race, gender, power, and violence. Using archival and landscape analysis I examine the historical and present built environment of the park and how it relates to white supremacy. Through interviews of two municipal constituencies, I evaluate how these organizations maintain present narratives of European settlement and in turn uphold the monument. This research …

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Gentrification And The Black Church: Mitigating Black Suburban Displacement In A Post Covid-19 World, Jordan Mccray Jan 2021

Gentrification And The Black Church: Mitigating Black Suburban Displacement In A Post Covid-19 World, Jordan Mccray

Theses and Dissertations--Geography

Black churches have been playing an important, stabilizing and supportive role for their members, their neighborhoods, and their communities more broadly. However, these churches’ memberships, community functions, and abilities to support their members have been threatened by the accelerating displacement of African Americans due to the ongoing effects of gentrification, defined by massive economic investment in low-income areas leading to the displacement of low-income residents. At the same time, COVID-19 has also changed the ways churches are able to deliver their support and outreach, with some moving their services to be completely virtual, and many outreach programs having to be …

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Almost Heaven: Religious Arguments In Appalachian Extractive Fiction, Darby Lane Campbell Jan 2021

Almost Heaven: Religious Arguments In Appalachian Extractive Fiction, Darby Lane Campbell

Theses and Dissertations--English

Appalachia is a national sacrifice zone that hosts extractive industries directly responsible for many social problems in the region, however, many attribute these issues to the moral failings of Appalachians themselves. Activism in the area is heavily focused on opposing both extraction and the negative perceptions which contribute to its domination. One way this activism is conducted is through extractive fiction—novels which expose the destruction caused by extractive industries. Appalachian extractive fiction utilizes religion and spirituality to argue against extraction. This research examines how fiction can be an effective mode of activism and how the use of Christian arguments in …

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Building Public Health In A Rural State: Strategies For Preventing Disease In Kentucky, 1883-1914, Abigail Stephens Jan 2021

Building Public Health In A Rural State: Strategies For Preventing Disease In Kentucky, 1883-1914, Abigail Stephens

Theses and Dissertations--History

During the period from 1883-1914, the Kentucky State Board of Health developed strategies for preventing disease in the state by enforcing hard power measures of vaccination, quarantine, and isolation of disease suspects, and through the soft power measures of written and spoken communication. Throughout this period their efforts to prevent and contain disease were limited by inadequate funding as well as opposition from the public, local authorities, and the state legislature, demonstrating that while hard power measures can be effective in combating disease, they cannot be fully successful without support from the people they aim to protect.

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Appalachia On The Airwaves: A History Of Public And Educational Television In The Southern Mountains, Carson Benn Jan 2021

Appalachia On The Airwaves: A History Of Public And Educational Television In The Southern Mountains, Carson Benn

Theses and Dissertations--History

Through a series of historical case studies of individual states within the multi-state region of the Appalachian mountain range, as well as the region as a whole, this dissertation examines educational television (ETV) operations, both at the network level and that of individual stations. Though mostly thought of as “public television”—an educational and noncommercial alternative to mainstream broadcast media—these ETV networks offered, I argue, something more analogous to present-day understandings of distance education and the use of instructional media and technology. Station directors, philanthropic benefactors, and school administrators took different approaches to providing the service of ETV, but all were …

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Making Sense Of The Divinely Beautiful: Essays On Friendship, Love, And Attraction, Michelle Catlin Jan 2021

Making Sense Of The Divinely Beautiful: Essays On Friendship, Love, And Attraction, Michelle Catlin

Theses and Dissertations--Philosophy

Essay 1: As interpersonal communication has changed with the proliferation of technology-based forms of meeting and interacting with others, philosophers have begun considering ways in which these new types of communication have altered the landscape of our relationships. Although philosophers are split on whether online friendships can measure up to the Aristotelean standard of virtue friendship, none have questioned the importance of truth telling or accurate representation of oneself in the context of online sharing. The underlying assumption is that in a virtuous friendship, there is no role whatsoever for anything other than strict honestly. I disagree with this …

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Spinoza's Methodology: A Genetic Account Of Fundamental Concepts In His Early Writings, Clay Graham Jan 2021

Spinoza's Methodology: A Genetic Account Of Fundamental Concepts In His Early Writings, Clay Graham

Theses and Dissertations--Philosophy

Spinoza’s magnum opus, the Ethics, is written in a very peculiar, “geometrical” style, one that builds metaphysical and ethical doctrines out of mathematical, deductive proofs. These proofs rely on a series of definitions, axioms, propositions, and demonstrations. Nowhere in the Ethics does Spinoza explain his fundamental definitions and axioms, nor does he proffer a defense of his manner of presentation. I claim that by a thorough and systematic investigation of his earliest writings we can peel back the mystery of this geometrical garb and grasp why Spinoza presents his philosophy with formal, mathematical structure. I argue for the view …

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Stress, Burnout, And Well-Being In New Veterinary Graduates: Evaluating A Pilot Online Professional Development Program, Addie Rose Reinhard Jan 2021

Stress, Burnout, And Well-Being In New Veterinary Graduates: Evaluating A Pilot Online Professional Development Program, Addie Rose Reinhard

Theses and Dissertations--Community & Leadership Development

Suicide, stress, and burnout are occurring at high rates among veterinary professionals, and the transition from student to practicing veterinarian has been shown to be a particularly stressful time. The aim of this study was to evaluate an online professional development program for new veterinary graduates incorporating peer social support and training in professional skills important for success in the transition to practice. In this mixed methods study, the program was evaluated qualitatively with focus group data and quantitatively by assessing knowledge gained and levels of stress, burnout, social support, and well-being. Seven new veterinary graduates participated in the program, …

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The “Case” For Assessments: An Evaluation Of Case End Of Course Assessments And Teacher Motivation, Andrew Lawrence Hauser Jan 2021

The “Case” For Assessments: An Evaluation Of Case End Of Course Assessments And Teacher Motivation, Andrew Lawrence Hauser

Theses and Dissertations--Community & Leadership Development

Curriculum for Agricultural Science Education (CASE) End of Course (EoC) assessments are summative assessments used to evaluate the CASE curriculum. This quantitative study explored the effects teacher motivation has on student performance on CASE EoC assessments. CASE teachers (n= 55) who participated in the study responded to the 28-item CASE End of Course Assessment Teacher Motivation Questionnaire on a 5-point Likert-type scale. The researcher conducted a Pearson r Correlation test to determine a relationship between questionnaire mean values and secondary student assessment data. Results from the study outline frequency of responses, perceived value and expectancy mean values, and correlations …

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Understanding Perspectives Of Clinical And Non-Clinical Healthcare Administrators On Culture And Diversity In The Healthcare Workplace, Katherine Counts Jan 2021

Understanding Perspectives Of Clinical And Non-Clinical Healthcare Administrators On Culture And Diversity In The Healthcare Workplace, Katherine Counts

Theses and Dissertations--Community & Leadership Development

The racial and ethnic composition of the U.S. population is becoming increasingly more diverse. The 2010 U.S. Census reported a 29% increase in minority groups other than non-Hispanic Whites. In response to these changing demographics, healthcare organizations have struggled to keep pace with these trends in their hiring of a diverse staff. Healthcare leaders appear to be lagging in their efforts to make adequate changes to increase diversity in their organizations. What factors may be contributing to this inequity? One possible explanation is a limited knowledge of healthcare leaders regarding culture and diversity within the workplace. To this end, this …

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Acl Injury, A Time Course Study Of Transcriptional Changes, Thomas Carter Jan 2021

Acl Injury, A Time Course Study Of Transcriptional Changes, Thomas Carter

Theses and Dissertations--Medical Sciences

ACL tear is a common injury in the United States with a significant cost and time burden during recovery; reconstructive surgery often results in weakened quadricep muscle and higher risk of posttraumatic osteoarthritis. Prior research has highlighted cellular derangements within the quadriceps after ACL injury and reconstruction, but the early molecular effectors of cellular dysfunction remain to be identified. To further understand the molecular effectors of quadriceps dysfunction following ACL injury, this study aims to quantify the timing and magnitude of transcriptional differences between the quadriceps muscle of injured and contralateral non-injured limbs. These data will provide insight into the …

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The Role Of Vascular Endothelial Growth Factor In Leukemia Trafficking, Shaw Powell Jan 2021

The Role Of Vascular Endothelial Growth Factor In Leukemia Trafficking, Shaw Powell

Theses and Dissertations--Medical Sciences

Vascular endothelial growth factor (VEGF) is a signaling protein involved in inducing and regulating endothelial cell proliferation and function (Duffy et al 2000). VEGF is also involved in cancer progression, as it induces vascular permeability and promotes angiogenesis to tumor laden areas, giving cancer cells critical oxygen and nutrients (Hoeppner et al.,2012. Studies indicate VEGF prevents lymphoblast apoptosis, which may contribute to leukemia formation and enable the proliferation of leukemic cells (Duffy et al 2000). Ongoing research seeks to further examine VEGF in leukemia, using a rag2:GFP-Myc expressing transgenic zebrafish as the animal model of T-cell Acute Lymphoblastic Leukemia (T-ALL). …

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S. Gordonii-Produced Hydrogen Peroxide Modulates Mir-663a And Ccl20 Expression In Oral Epithelial Cells, Marshall Houston Maynard Jan 2021

S. Gordonii-Produced Hydrogen Peroxide Modulates Mir-663a And Ccl20 Expression In Oral Epithelial Cells, Marshall Houston Maynard

Theses and Dissertations--Medical Sciences

The mechanisms through which a persistent recognition of commensal bacteria by oral epithelial cells (OECs) mitigates an uncontrolled inflammatory response of the oral mucosa remain unknown. CCL20 secretion by OECs in response to pathogenic bacteria is regulated by S. gordonii (Sg)-induced miR-663a; nevertheless, the mechanisms involved in these Sg-modulated responses remain to be elucidated. Since Sg is a hydrogen peroxide (H2O2) producer, and H2O2 has been shown to stimulate miRNA expression, we hypothesized that H2O2 could be involved in Sg-induced miR663a and CCL20 responses. Expression of miR663a …

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Application Of Genetic Techniques To Investigate Chlamydia Trachomatis Type Iii Secretion Effector Biology, Gabrielle Keb Jan 2021

Application Of Genetic Techniques To Investigate Chlamydia Trachomatis Type Iii Secretion Effector Biology, Gabrielle Keb

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Chlamydia trachomatis is the causative agent of the most reported bacterial sexually transmitted disease in the United States. The establishment of an intracellular niche within mucosal epithelium is sufficient to drive immunopathology and disease sequela. As obligate intracellular bacteria, Chlamydia spp. have evolved numerous mechanisms for establishing an intracellular growth environment. The type III secretion system (T3SS) delivers effector proteins to the host cytosol and is essential for C. trachomatis invasion and development. The effectors TmeA, TmeB, and TarP, are all secreted during C. trachomatis invasion. TarP and TmeA have been associated with manipulation of actin networks and are …

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Carnosic Acid Differentially Modulates The Nrf2- Antioxidant Response In Male And Female Mice Following Experimental Traumatic Brain Injury, Jacob A. Dunkerson Jan 2021

Carnosic Acid Differentially Modulates The Nrf2- Antioxidant Response In Male And Female Mice Following Experimental Traumatic Brain Injury, Jacob A. Dunkerson

Theses and Dissertations--Neuroscience

Traumatic brain injury (TBI) is a leading cause of death and disability in the United States. Each year, an estimated 2.8 million Americans are diagnosed with a TBI due to falling, motor vehicle collisions, gun violence, and sports related concussions. Although inflicted by a single event, the post-traumatic effects of TBI often develop into a life-long disease. Survivors often experience cognitive decline, memory loss, emotional instability, changes in personality, and physical disabilities. A single TBI, and more-so repetitive TBI's, place an individual at a greater risk of developing chronic neurological disorders, such as dementia or Alzheimer’s disease, earlier in life. …

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Examining Human Apoe Genotype And Sex As Modulators Of Respiratory Plasticity In The Presence And Absence Of Spinal Cord Injury, Lydia Ella Strattan Jan 2021

Examining Human Apoe Genotype And Sex As Modulators Of Respiratory Plasticity In The Presence And Absence Of Spinal Cord Injury, Lydia Ella Strattan

Theses and Dissertations--Neuroscience

There are over 17,000 new spinal cord injuries (SCIs) every year in the Unites States alone. Almost 60% of these injuries occur at the cervical level, potentially leading to loss of function in a variety of sensory and motor systems including upper and lower limbs, respiratory, and autonomics. In addition to the physical and emotional costs, individuals who experience these higher level injuries also face a massive financial burden, incurring over $1 million in expenses during the first year after injury in addition to substantial yearly costs for the rest of their lifetime. A myriad of therapeutic approaches targeting plasticity …

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Characterizing The Physiology And Genetics Of Contact Dependent Growth Inhibiton Systems In Burkholderia Species, Alice Elizabeth Oates Jan 2021

Characterizing The Physiology And Genetics Of Contact Dependent Growth Inhibiton Systems In Burkholderia Species, Alice Elizabeth Oates

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Contact-dependent growth inhibition (CDI) systems mediate interbacterial competition. The genes encoding these systems are widespread among Gram-negative bacteria, including Burkholderia pathogens. CDI systems of Burkholderia species are composed of two-partner secretion pathway proteins and function to deliver the toxic C-terminus of a polymorphic surface-exposed exoprotein BcpA (Burkholderia CDI protein A) to the cytoplasm of neighboring recipient bacteria upon cell-cell contact. Specific outer and inner membrane proteins facilitate BcpA translocation both out of the donor bacterium and into the recipient cell cytoplasm. Most Burkholderia species-specific CDI translocation factors in recipient cells are unknown. BcpA intoxication functions as a mechanism by …

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