Digital Commons Network^™

“Adopt-A-Tissue” Initiative Advances Efforts To Identify Tissue-Specific Histone Marks In The Mare, N. B. Kingsley, Natasha A. Hamilton, Gabriella Lindgren, Ludovic Orlando, Ernest Bailey, Samantha Brooks, Molly Mccue, Theodore S. Kalbfleisch, James N. Macleod, Jessica L. Petersen, Carrie J. Finno, Rebecca R. Bellone

Maxwell H. Gluck Equine Research Center Faculty Publications

No abstract provided.

Comparative Effects Of Event Detection Methods On The Analysis And Interpretation Of Ca2+ Imaging Data, Austin Neugornet, Bernadette O’Donovan, Pavel I. Ortinski

Neuroscience Faculty Publications

Calcium imaging has gained substantial popularity as a tool to profile the activity of multiple simultaneously active cells at high spatiotemporal resolution. Among the diverse approaches to processing of Ca²⁺ imaging data is an often subjective decision of how to quantify baseline fluorescence or F₀. We examine the effect of popular F₀ determination methods on the interpretation of neuronal and astrocyte activity in a single dataset of rats trained to self-administer intravenous infusions of cocaine and compare them with an F₀-independent wavelet ridgewalking event detection approach. We find that the choice of the processing …

Long Non-Coding Rna Zfas1 Is A Major Regulator Of Epithelial-Mesenchymal Transition Through Mir-200/Zeb1/E-Cadherin, Vimentin Signaling In Colon Adenocarcinoma, Stephen J. O'Brien, Casey Fiechter, James Burton, Jacob Hallion, Mason Paas, Ankur Patel, Ajay Patel, Andre Rochet, Katharina Scheurlen, Sarah Gardner, Maurice Eichenberger, Harshini Sarojini, Sudhir Srivastava, Shesh Rai, Theodore S. Kalbfleisch, Hiram C. Polk, Susan Galandiuk

Veterinary Science Faculty Publications

Colon adenocarcinoma is a common cause of cancer-related deaths worldwide. Epithelial-mesenchymal transition is a major regulator of cancer metastasis, and increased understanding of this process is essential to improve patient outcomes. Long non-coding RNA (lncRNA) are important regulators of carcinogenesis. To identify lncRNAs associated with colon carcinogenesis, we performed an exploratory differential gene expression analysis comparing paired colon adenocarcinoma and normal colon epithelium using an RNA-sequencing data set. This analysis identified lncRNA ZFAS1 as significantly increased in colon cancer compared to normal colon epithelium. This finding was validated in an institutional cohort using laser capture microdissection. ZFAS1 was also found …

How Well Can We Assess The Validity Of Non-Randomised Studies Of Medications? A Systematic Review Of Assessment Tools, Elvira D'Andrea, Lydia Vinals, Elisabetta Patorno, Jessica M. Franklin, Dimitri Bennett, Joan A. Largent, Daniela C. Moga, Hongbo Yuan, Xuerong Wen, Andrew R. Zullo, Thomas P. A. Debray, Grammati Sarri

Pharmacy Practice and Science Faculty Publications

OBJECTIVE: To determine whether assessment tools for non-randomised studies (NRS) address critical elements that influence the validity of NRS findings for comparative safety and effectiveness of medications.

DESIGN: Systematic review and Delphi survey.

DATA SOURCES: We searched PubMed, Embase, Google, bibliographies of reviews and websites of influential organisations from inception to November 2019. In parallel, we conducted a Delphi survey among the International Society for Pharmacoepidemiology Comparative Effectiveness Research Special Interest Group to identify key methodological challenges for NRS of medications. We created a framework consisting of the reported methodological challenges to evaluate the selected NRS tools.

STUDY SELECTION: Checklists …

Space-Occupying Brain Lesions, Trauma-Related Tau Astrogliopathy, And Artag: A Report Of Two Cases And A Literature Review, Adam D. Bachstetter, Filip G. Garrett, Gregory A. Jicha, Peter T. Nelson

Spinal Cord and Brain Injury Research Center Faculty Publications

Astrocytes with intracellular accumulations of misfolded phosphorylated tau protein have been observed in advanced-stage chronic traumatic encephalopathy (CTE) and in other neurodegenerative conditions. There is a growing awareness that astrocytic tau inclusions are also relatively common in the brains of persons over 70 years of age-affecting approximately one-third of autopsied individuals. The pathologic hallmarks of aging-related tau astrogliopathy (ARTAG) include phosphorylated tau protein within thorn-shaped astrocytes (TSA) in subpial, subependymal, perivascular, and white matter regions, whereas granular-fuzzy astrocytes are often seen in gray matter. CTE and ARTAG share molecular and histopathologic characteristics, suggesting that trauma-related mechanism(s) may predispose to the …

Nutraceutical Intervention With Colostrum Replacer: Can We Reduce Disease Hazard, Ameliorate Disease Severity, And Improve Performance In Preweaned Dairy Calves?, Melissa C. Cantor, D. L. Renaud, Joao H. C. Costa

Animal and Food Sciences Faculty Publications

The objective of this randomized clinical trial was to determine if an intervention with colostrum replacer (CR; Premolac Plus, Zinpro; 125 g/d fed for 3 d) or a placebo milk replacer (Cows Match, Land O'Lakes Inc.; 125 g/d for 3 d) following a triggered alarm could ameliorate disease bouts in dairy calves. The alarm was set to detect negative deviations of milk intake (20% reduction) or drinking speed (30% reduction) in relation to a calf's 12-d rolling average feeding behavior. Calves were enrolled on this study (n = 42 CR, n = 42 placebo) when they triggered an alarm from …

Corporate Officer Liability As An "Operator" Under Cercla: The Kelley V. Tiscornia Analysis, Clay M. Stevens

Journal of Natural Resources & Environmental Law

No abstract provided.

Posner Reigns In Cercla: Amcast Industrial Corp. & Elkhart Products Corp. V. Detrex Corp, T. Christopher Daniel

Journal of Natural Resources & Environmental Law

No abstract provided.

Lender Liability Under Cercla: Death Of The Epa Rule And Resurrection Of Uncertainty, Stephen D. Stoltz

Journal of Natural Resources & Environmental Law

No abstract provided.

Attorney Fees: Does Cercla Include Them As Part Of A Private Cost Recovery Action?, Russell B. Morgan

Journal of Natural Resources & Environmental Law

No abstract provided.

Federal Sovereign Immunity And Cercla: When Is The United States Liable For Costs?, Holly Everett

Journal of Natural Resources & Environmental Law

No abstract provided.

Institutional Controls--An Expedited And Cost-Effective Means For Returning A Superfund Site To Beneficial Use, Anne D. Weber

Journal of Natural Resources & Environmental Law

No abstract provided.

The Superfund Liability Scheme: A Goal-Based Approach To Reauthorization, Jason D. Topp

Journal of Natural Resources & Environmental Law

No abstract provided.

Compulsory Licensing Of Critical Patents Under Cercla?, Kenneth J. Nunnenkamp

Journal of Natural Resources & Environmental Law

No abstract provided.

Does Minimizing Expenditures For Cercla Site Remediation Increase The Future Public Abatement Costs?, Carl B. Meyer

Journal of Natural Resources & Environmental Law

No abstract provided.

Cleaning Up Superfund: A Proposal For Permanent Cleanups And Returning Land Back To Nature--With Applications To The Petroleum Industry, Itzchak E. Kornfeld

Journal of Natural Resources & Environmental Law

No abstract provided.

Reforming Retroactive And Current Owner Liability Standards In Cercla To Increase Fairness And Efficiency, Bruce Howard

Journal of Natural Resources & Environmental Law

No abstract provided.

Cercla Reauthorization 1994: Insuring The Cleanup Of Hazardous Substance Pollution, Katherine Taylor Eubank

Journal of Natural Resources & Environmental Law

No abstract provided.

Closing The Circle: Tribal Implementation Of The Superfund Program In The Reservation Environment, Richard A. Du Bey, James M. Grijalva

Journal of Natural Resources & Environmental Law

No abstract provided.

And The Meek Shall Inherit Cleaner Earth, Frank Cross, Scott Segal

Journal of Natural Resources & Environmental Law

No abstract provided.

Sara's Offspring: Some First Principles For Superfund Reform In The 1990s, Robert F. Blomquist

Journal of Natural Resources & Environmental Law

No abstract provided.

How To Save The National Priorities List From The D.C. Circuit--And Itself, John S. Applegate

Journal of Natural Resources & Environmental Law

No abstract provided.

Arkansas V. Oklahoma: Downstream States Left Without A Paddle, Neil Fairweather

Journal of Natural Resources & Environmental Law

No abstract provided.

Anilca Under Attack: Will The Right To Travel Wreak Havoc With Subsistence Rights?, Kathy A. Gudgell

Journal of Natural Resources & Environmental Law

No abstract provided.

Severance Taxes As An Offensive Weapon: The Forbidding Legacy Of Wyoming V. Oklahoma, Judy Jones Lewis

Journal of Natural Resources & Environmental Law

No abstract provided.

"Taking" A Walk On A Winter's Night, James E. Brookshire

Journal of Natural Resources & Environmental Law

No abstract provided.

Lucas V. South Carolina Coastal Council: The Remaking Of Takings Law And The Re-Emergence Of Lochner, Jerry Mitchell

Journal of Natural Resources & Environmental Law

No abstract provided.

"Ownership" Of Underground Storage Tanks, Gary W. Napier, Samuel L. Perkins

Journal of Natural Resources & Environmental Law

No abstract provided.

Correction To Some Statements About Aluminum In Sulaiman Et Al., Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

No abstract provided.

Leveraging Online Learning To Promote Systems Thinking For Sustainable Food Systems Training In Dietetics Education, Marie Spiker, Amanda Hege, Janice Giddens, Joanna Cummings, Jasia Steinmetz, Angie Tagtow, Erin Bergquist, Lauren Burns, Christina Campbell, Diane Stadler, Elizabeth Combs, Nancy Prange, Aaron Schwartz, Katie Brown, Kevin Sauer

Dietetics and Human Nutrition Faculty Publications

Educating and training a multisectoral food systems workforce is a critical part of developing sustainable, resilient, and healthy food and water systems. This paper shares perspectives from a working group of educators, learners, and food systems subject matter experts that collaborated over the course of a year to develop, pilot test, and evaluate two interactive webinar series with a multi-site cohort of dietetics interns and graduate students. The three-part webinar series format included a training webinar, a practice activity, and a synthesis webinar. In reflecting on the effectiveness of this format, we provide direct assessments of student learning from subject …