Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (8643)
- Life Sciences (4317)
- Social and Behavioral Sciences (3121)
- Medical Specialties (2709)
- Physical Sciences and Mathematics (2177)
-
- Public Health (2087)
- Law (1835)
- Engineering (1399)
- Plant Sciences (1356)
- Medical Sciences (1220)
- Earth Sciences (1112)
- Pharmacy and Pharmaceutical Sciences (1065)
- Soil Science (996)
- Agronomy and Crop Sciences (892)
- Plant Pathology (885)
- Agricultural Science (853)
- Plant Biology (848)
- Weed Science (828)
- Oncology (763)
- Sociology (762)
- Education (727)
- Arts and Humanities (722)
- Psychology (695)
- Nursing (693)
- Public Affairs, Public Policy and Public Administration (554)
- Biochemistry, Biophysics, and Structural Biology (490)
- Economics (488)
- Genetics and Genomics (479)
- Diseases (463)
- Civil and Environmental Engineering (427)
- Keyword
-
- Humans (1002)
- Kentucky (752)
- Animals (604)
- Female (578)
- Male (557)
-
- Appalachia (330)
- Mice (305)
- Public health (246)
- Adult (231)
- Obesity (208)
- Middle Aged (204)
- Adolescent (200)
- United States (187)
- Aged (185)
- Aging (177)
- COVID-19 (149)
- Inflammation (149)
- Public Health (138)
- Aluminum in foods (134)
- Cancer (132)
- Accidents (127)
- Education (123)
- Brain (116)
- Rural (114)
- University of Kentucky (111)
- Rats (105)
- Injury prevention (97)
- Treatment (96)
- Young Adult (96)
- Diabetes (95)
- Publication Year
- Publication
-
- Kentucky Law Journal (1034)
- IGC Proceedings (1977-2023) (821)
- DNP Projects (522)
- Markey Cancer Center Faculty Publications (507)
- Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.) (487)
-
- University of Kentucky Doctoral Dissertations (349)
- Pediatrics Faculty Publications (335)
- MPA/MPP/MPFM Capstone Projects (318)
- Internal Medicine Faculty Publications (292)
- Law Faculty Scholarly Articles (290)
- Theses and Dissertations--Psychology (255)
- Pharmaceutical Sciences Faculty Publications (220)
- University of Kentucky Master's Theses (219)
- Sanders-Brown Center on Aging Faculty Publications (216)
- Journal of Appalachian Health (211)
- Physiology Faculty Publications (206)
- Kentucky Journal of Equine, Agriculture, & Natural Resources Law (204)
- Microbiology, Immunology, and Molecular Genetics Faculty Publications (203)
- Kentucky Transportation Center Research Report (201)
- Pharmaceutical Sciences Faculty Patents (194)
- Journal of Natural Resources & Environmental Law (190)
- Aluminum in Beverages and Foods: A Compilation (186)
- World of Coal Ash Proceedings (181)
- Epidemiology and Environmental Health Faculty Publications (170)
- Theses and Dissertations--Pharmacy (164)
- Frontiers in Public Health Services and Systems Research (161)
- Biostatistics Faculty Publications (155)
- Molecular and Cellular Biochemistry Faculty Publications (146)
- Pharmacology and Nutritional Sciences Faculty Publications (139)
- Health Management and Policy Presentations (138)
- Publication Type
- File Type
Articles 4261 - 4290 of 18293
Full-Text Articles in Entire DC Network
Mental Health In The Courtroom: How Victim Mental Illness Impacts Juror Decision-Making In A Rape Case, Mary M. Levi
Mental Health In The Courtroom: How Victim Mental Illness Impacts Juror Decision-Making In A Rape Case, Mary M. Levi
Theses and Dissertations--Psychology
The influence of mental illness on jury decision-making has rarely been investigated, and even fewer studies have examined how jurors perceive a victim with mental illness. The present study investigated the effect of victim mental illness on jury decision-making in a rape trial using a 3 (victim mental health status: schizophrenia, depression, no illness) x 2 (participant gender: female, male) between-subjects design. I hypothesized that mock jurors would render fewer guilty verdicts in the schizophrenia condition compared to the depression condition, and render fewer guilty verdicts in the schizophrenia and depression conditions compared to the control. I also hypothesized that …
"Think Of The Situation In A Positive Light": A Look At Cognitive Reappraisal, Affective Reactivity And Health, Jessica Chloe Maras
"Think Of The Situation In A Positive Light": A Look At Cognitive Reappraisal, Affective Reactivity And Health, Jessica Chloe Maras
Theses and Dissertations--Psychology
How individuals regulate their emotions is critical for maintaining health and well-being. For example, reframing a stressful situation in a positive light, a form of cognitive reappraisal, is beneficial for health and well-being outcomes. However, it is currently unclear why this relationship exists. One potential mechanism could be how one emotionally reacts to stressors in daily life, termed affective reactivity. The current study examined longitudinal associations that spanned 20 years between cognitive reappraisal and health outcomes and subjective well-being and if affective reactivity mediated this relationship. Participants completed waves 1-3 of the Midlife in the United States (MIDUS) Survey series …
Self-Monitoring And The Dsm-5 Section Iii Alternative Model Of Personality Disorder, Gillian Mccabe
Self-Monitoring And The Dsm-5 Section Iii Alternative Model Of Personality Disorder, Gillian Mccabe
Theses and Dissertations--Psychology
The Alternative Model of Personality Disorder (AMPD) was introduced in Section III (“Emerging Measures and Models”) of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) to address many of the challenges inherent to the categorical system of personality disorder diagnosis. According to the AMPD, personality disorders can be identified by the extent to which impairment in personality functioning (i.e., Criterion A) and pathological personality traits (Criterion B) are present. Researchers have divided over the distinction between Criterion A and Criterion B, with one side favoring the current AMPD conceptualization of personality traits and functioning as independent constructs and the …
Experiential-Based Feedback During Alcohol Intoxication And Its Effect On Drinkers’ Risk Awareness, Alexandra R. Kelly
Experiential-Based Feedback During Alcohol Intoxication And Its Effect On Drinkers’ Risk Awareness, Alexandra R. Kelly
Theses and Dissertations--Psychology
The prevalence of alcohol-impaired driving injuries and fatalities has not decreased for over a decade despite strategies to reduce and prevent driving under the influence of alcohol (DUI). In 2019, 10,142 people died in alcohol-impaired driving crashes in the United States, which totaled to 28% of all traffic fatalities for the year. DUI interventions have been found to have moderate effects on reducing DUI recidivism. Prevention research has identified a lack of risk awareness in DUI offenders and this could be a target to motivate behavioral change. However, the training to increase levels of risk awareness needs to occur in …
A Pilot Randomized Controlled Trial Of Smoking Cessation Induction Treatment For Rural, Underserved Cancer Survivors Across The Continuum Of Motivation To Quit, William Bowling
Theses and Dissertations--Psychology
The United States’ smoking prevalence has decreased substantially, but this public health improvement is unevenly distributed across the population. A promising individual-level approach to cancer control equity is to develop more acceptable and efficacious interventions that are widely disseminated to rural and other disadvantaged cancer survivors. Smoking cessation induction focuses not on long-term abstinence, but on engaging people in the process of making quit attempts and may be ideal for hard-to-reach populations. The aim of this pilot randomized controlled trial was to evaluate the feasibility and acceptability of a smoking cessation induction intervention designed for rural cancer survivors. The treatment …
Effects Of An Online Insomnia Intervention On Sleep And Alcohol Consumption, Justin Verlinden
Effects Of An Online Insomnia Intervention On Sleep And Alcohol Consumption, Justin Verlinden
Theses and Dissertations--Psychology
Alcohol use disorder (AUD) and insomnia are highly comorbid, due in part to the use of alcohol as a sleep aid among individuals with insomnia. Initial studies have shown that cognitive behavioral therapy for insomnia (CBT-I), the first-line treatment for insomnia, is moderately successful at improving both sleep and drinking outcomes in heavy drinkers with insomnia. However, CBT-I is expensive and not widely available. Online CBT-I could be a more accessible alternative. One online CBT-I program, Sleep Healthy Using the Internet (SHUTi), is especially promising due to its high efficacy in treating insomnia and its individualized and interactive platform. Here …
Latent Classes Of Symptom Trajectory In A Brief Treatment For Borderline Personality Disorder, Doug Terrill
Latent Classes Of Symptom Trajectory In A Brief Treatment For Borderline Personality Disorder, Doug Terrill
Theses and Dissertations--Psychology
It is likely that patients with BPD progress through treatment in different ways. Characterizing symptom trajectories during treatment can facilitate the identification of distinct treatment responses, which may be shared by subgroups of patients. Researchers have consistently identified multiple distinct symptom trajectories among individuals with common psychopathological conditions, but no research to date has attempted to do so among patients with BPD. This study used latent growth mixture modeling to identify and characterize distinct classes of symptom trajectories among patients receiving an 18-week cognitive-behavioral treatment for BPD. Two distinct BPD symptom trajectories were identified in this sample, which were primarily …
Assessing Stress Biomarkers As Embodied Identity In Kentucky’S Green River Archaic, Anna-Marie Casserly
Assessing Stress Biomarkers As Embodied Identity In Kentucky’S Green River Archaic, Anna-Marie Casserly
Theses and Dissertations--Anthropology
The primary goal of this bioarchaeology dissertation research is to investigate the relationship between evidence of social identity and indicators of biological stress in the Green River region of Kentucky during the Late Archaic period (5,000-3,000 BP). Utilizing a biocultural perspective, I examine the ways that aspects of identity and social organization are embodied through the experience of biological stress. This research explores how social differences influence the patterning of osteological stress markers in an Archaic population while problematizing categories of difference that are often naturalized in bioarchaeology, such as gender or age cohorts. In so doing, it contributes to …
‘I Went To The One Game In Town’: Obstetric And Maternity Unit Closures, Dwindling Birth Choices, And Resilience In Rural Appalachia, Sia Beasley
Theses and Dissertations--Anthropology
Obstetric and maternity health services are being rapidly eliminated in the rural United States, making maternal care more difficult to access and causing negative birth outcomes. Service closures have a magnified impact in Appalachia due to histories of systemic regional and state policy practices which devalue the lives of people living rural areas, local economic marginalization, geographic barriers, and insufficient health infrastructures. This research investigates how women living in rural Appalachia navigate pregnancy and birth amidst constant care closures. The Sunflower Mountain Region is a seven-county area in rural Southern Appalachia. The region has experienced ongoing obstetric closures over the …
Data Acquisition, Analysis And Simulations For The Fermilab Muon G−2 Experiment, Fang Han
Data Acquisition, Analysis And Simulations For The Fermilab Muon G−2 Experiment, Fang Han
Theses and Dissertations--Physics and Astronomy
The goal of the new Muon g-2 E989 experiment at Fermi National Accelerator Laboratory (FNAL) is a precise measurement of the muon anomalous magnetic moment, aμ ≡ (g-2)/2. The previous BNL experiment measured the anomaly aμ(BNL) with an uncertainty of 0.54 parts per million (ppm). The discrepancy between the current standard model calculation of the aμ(SM) and the previous measurement aμ(BNL) is over 3σ. The FNAL Muon g-2 experiment aims at increasing the precision to 140 parts per billion (ppb) to resolve the discrepancy between the theoretical …
Impacting Website Visitor Engagement Through Information Provision, Will Buntin
Impacting Website Visitor Engagement Through Information Provision, Will Buntin
Theses and Dissertations--Educational Leadership Studies
Enrollment in library science programs has been on a downward trend for several years (Association for Library and Information Science Education, n.d.). At the School of Information Science in the College of Communication and Information at the University of Kentucky, enrollment in the online library science master's program dropped 28% from 2012 to 2018. With a student population in fall 2018 of 177 and a targeted enrollment (set by program faculty) of 240, the program administration has been exploring ways to recruit more students without further stressing the resources available to the School. The Director and Assistant Director of the …
The Power Of Connections: An Online Doctoral Program's Use Of Strategic Onboarding To Enhance The Doctoral Experience, Jeri Heileman
The Power Of Connections: An Online Doctoral Program's Use Of Strategic Onboarding To Enhance The Doctoral Experience, Jeri Heileman
Theses and Dissertations--Educational Leadership Studies
A positive doctoral experience is rooted in an understanding of the expectations and reality of doctoral–level work. Students need specific knowledge, skills, and mindsets to complete coursework, critically analyze research, and write and defend a research dissertation. Despite a mutual commitment to academic achievement and graduation by faculty and students, attrition in doctoral programs remains high. This rate is even higher for those in online programs. Additionally, there are many challenges doctoral students experience outside of the core curriculum. The challenges facing students vary depending on the phase of the doctoral journey and the individual development of each student.
This …
Career Development And Employability Skill Integration Within The Equine Science And Management Undergraduate Program At The University Of Kentucky, Savannah Faye Robin
Career Development And Employability Skill Integration Within The Equine Science And Management Undergraduate Program At The University Of Kentucky, Savannah Faye Robin
Theses and Dissertations--Educational Leadership Studies
College graduates need to be equipped with career and employability skills that are necessary to be meaningfully and gainfully employed in their future. These skills consist of self-management, career-management, essential-employability, and discipline-specific skills. More responsibility is being placed on college and university academic programs to ensure that students are graduating with these skills when they enter the workforce. However, students are growing less likely to participate in out of course career development activities and resources. Integrating these skills into program curriculum can be an effective way to ensure that all students have the ability to develop these necessary skills.
While …
Housewives To Heroines: Continuing Education For Women At The University Of Kentucky, 1964-1988, Allison L. Elliott
Housewives To Heroines: Continuing Education For Women At The University Of Kentucky, 1964-1988, Allison L. Elliott
Theses and Dissertations--Educational Policy Studies and Evaluation
Beginning in the early 1960s, the movement for the continuing education for women (CEW) brought together a seemingly unlikely alliance of American activists, educators, philanthropists, and government agencies. Fueled by philanthropic funds, accelerated by the quest for “womanpower” to bolster national defense, and aligned with regional workforce needs as well as the personal goals of individual women, CEW programs pioneered new models of academic advising and student support that continue to influence higher education practitioners today. By studying the experiences of both administrators and students involved with CEW at the University of Kentucky, this study sheds light on how one …
Evaluation Of Air Consumption And Work Efficiency In Structural Firefighters, Emily Lynn Langford
Evaluation Of Air Consumption And Work Efficiency In Structural Firefighters, Emily Lynn Langford
Theses and Dissertations--Kinesiology and Health Promotion
INTRODUCTION: For safe and efficient fireground performance, firefighters (FF) must consume air supplied by the self-contained breathing apparatus (SCBA) efficiently while sustaining high work rates. Firefighter research and fire department physical ability assessments typically quantify performance solely on task completion time (i.e., work rate), failing to consider the critical element of air consumption efficiency, which subsequently impacts the SCBA’s functional work duration. PURPOSES: (Arm 1, Aim #1) To examine variability in air consumption (AC) between FF during standardized pace tasks; (Arm 1, Aim #2) To evaluate AC efficiency (ACE) against a recognized metabolic-work rate concept of economy; (Arm …
Etiology Of Firefighter Injuries: A Health Care Practitioner Perspective, Alyssa Quinn Eastman
Etiology Of Firefighter Injuries: A Health Care Practitioner Perspective, Alyssa Quinn Eastman
Theses and Dissertations--Kinesiology and Health Promotion
BACKGROUND: Structural firefighting involves the performance of rigorous occupational tasks in unpredictable, dynamic, and hot environments which increases firefighters’ risk of injury. Specifically, the National Fire Protection Association reported that musculoskeletal injuries account for 56% of non-fireground and 41% of fireground injuries. Furthermore, physical training is the most common cause of injury, accounting for one-third of all injuries and resulting in 41% of post-injury absences from work. There is limited research identifying occupational and exercise injury risk factors among firefighters. However, experienced health care practitioners working with fire departments may provide critical insight into potential mechanisms of these common injuries. …
The Correlation Between Acl Injury & Concussion, Brandon Michael Phillips
The Correlation Between Acl Injury & Concussion, Brandon Michael Phillips
Theses and Dissertations--Kinesiology and Health Promotion
Concussion (also known as mild traumatic brain injury) is a neurological injury that occurs after a blow to the head or neck area and can have affects to movement based on the severity of the injury. Mild traumatic brain injury has possible linkage to an increased risk of anterior cruciate ligament (ACL) injury. The purpose of this thesis was to assess the impact of prior concussion on lower extremity mechanics that are associated with risk of ACL injury. A total of 11 individuals with prior history of concussion and 11 healthy individuals without prior history of concussion (56.5 months since …
Role Strain And Role Satisfaction Of Academic Program Coordinators At A Southern Research-Intensive Doctoral Granting University, Samer R. Jan
Theses and Dissertations--Educational Policy Studies and Evaluation
The research dissertation examined, through a self-administered survey, the activities academic program coordinators perform at a US research-intensive university and whether they suffered from role strain during the 2020-2021 academic year. The dissertation also explored what academic program coordinators found satisfying in performing their roles. The research contributes to the field of higher education by providing a better understanding of the roles and activities academic program coordinators perform, along with factors that cause role strain among program coordinators. A total of 47 program coordinators responded to the survey representing a 20% response rate.
The research found that program coordinators perform …
The Appalachian Commitment Of Berea College: A Review Of Historical Figures, Narratives, And An Analysis Of Programmatic Outcomes, Rebecca E. Tucker
The Appalachian Commitment Of Berea College: A Review Of Historical Figures, Narratives, And An Analysis Of Programmatic Outcomes, Rebecca E. Tucker
Theses and Dissertations--Education Sciences
Since its founding in 1855 Berea College has continuously defined and redefined itself based on eight Great Commitments that collectively shape Berea’s mission. All Bereans, from students to alums to Presidents, have a responsibility to review and evaluate the ways in which Berea College is acting on each of its eight Commitments. This study offers a review of Berea’s Appalachian Commitment, “To engage Appalachian communities, families, and students in partnership for mutual learning, growth, and service” (Berea College, 2017). The following three articles seek to understand some of the ways in which Berea College leaders have interpreted and acted on …
Exploring The Use Of Rasch Models To Construct Measures Of Firms’ Profitability With Multiple Discretization Ratio-Type Data, Chen Qiu
Theses and Dissertations--Education Sciences
Ratio-type data plays an important role in real-world data analysis. Mass ratios have been created for different purposes, depending on time and people’s needs. Then, it is necessary to create a comprehensive score to extract information from those mass ratios when they measure the same concept from different perspectives. Therefore, this study adopts the same logic of psychometrics to systematically conduct scale development on ratio-type data under the Rasch model. However, it is first necessary to discretize the ratio-type data for use in the Rasch model. Therefore, this study also explores the effect of different data discretization methods on scale …
Development Of The Elementary Teachers’ Commitment To Outdoor Education Survey: A Mixed Methods Study, Sagan Goodpaster
Development Of The Elementary Teachers’ Commitment To Outdoor Education Survey: A Mixed Methods Study, Sagan Goodpaster
Theses and Dissertations--Education Sciences
As the Green Schoolyards Movement continues to grow throughout North America, outdoor education (OE) is gaining more attention in the formal K-12 curriculum (Dyment, 2005; Sterrett & Imig, 2015). Rooted in the pedagogies of place-based and experiential learning, outdoor instruction provides social, psychological, physical, and academic benefits for students, and fosters their sense of connection to the natural environment (Dubel & Sobel, 2008; Robertson, 2017). In particular, outdoor learning opportunities have been shown to promote greater gains in students’ scientific content knowledge (Carrier et al., 2014; Cronin-Jones, 2000; Dirks & Orvis, 2005; Kenney et al., 2003). Outdoor instruction involves students …
Investigating Discussion Forum Impact On Students’ Social Justice Beliefs In Online Undergraduate Mathematics Courses: A Mixed Methods Study, Ashlee Lynn Akin Matney
Investigating Discussion Forum Impact On Students’ Social Justice Beliefs In Online Undergraduate Mathematics Courses: A Mixed Methods Study, Ashlee Lynn Akin Matney
Theses and Dissertations--Education Sciences
While teaching math for social justice and equity has become a heavily researched topic in recent decades with Jo Boaler (2008, 2015, 2016), Rochelle Gutiérrez (2009, 2013), and Eric (Rico) Gutstein (2003, 2006, 2007, 2013) emerging as recent leaders in the charge, the focus has consistently remained on traditional classroom teaching (e.g. Boaler, 2008; Gutiérrez, 2009; Gutstein, 2003). This convergent design mixed methods study investigated the impact of teaching math for social justice in the online learning environment, specifically, the impact of discussion forums on students’ social justice beliefs in fully online undergraduate math courses.
Quantitatively, 56 students completed pre- …
Validation Of An Early Childhood Emotional And Social Competence Instrument Using A Rasch Partial Credit Model, Nan Li
Theses and Dissertations--Education Sciences
The release of the Every Student Succeeds Act (ESSA) started a new chapter of education in the United States. The ESSA emphasizes the importance of preschool education; the act states that more resources will be devoted to preschool education, which lays the foundation for children’s school learning process. The goal of the act is to make sure children enter kindergarten education with equal preparatory. School, family, and researchers are paying more attention to developing preschool children’s social and emotional competency before entering Kindergarten. For understanding preschool children’s social and emotional skill development situation, instrument is the mostly widely adopted method …
Knitting Code: Examining The Relationship Between Knitting And Computational Thinking Skills Using The Nexus Of Practice, Emily Rose Dodson-Snowden
Knitting Code: Examining The Relationship Between Knitting And Computational Thinking Skills Using The Nexus Of Practice, Emily Rose Dodson-Snowden
Theses and Dissertations--Education Sciences
Due to the rise of careers in STEM-related fields, there is a growing need for schools to produce people to fill these positions. One area of STEM that is growing is computer science/coding. Due to this demand, schools need to be intentional about exposing students to computer science/coding. There are a variety of new tools to introduce students to this field. One growing belief is that knitting can teach computer science/coding to students.
The goal of this study was to see if knitting can serve as an introduction to teach students computation skills. Kitting has historically been used to code …
Pray And Play: The Impact Of Fellowship Of Christian Athletes Among Di African American Collegiate Football Players In Kentucky, Rasheed Flowers
Pray And Play: The Impact Of Fellowship Of Christian Athletes Among Di African American Collegiate Football Players In Kentucky, Rasheed Flowers
Theses and Dissertations--Educational Policy Studies and Evaluation
Participation in athletics provides student-athletes with opportunities to further themselves outside of athletics through academic assistance, educational opportunities and experiences, physical wellness, and personal/professional development. One often overlooked portion of this holistic development is spiritual development. As demonstrated in the name student-athlete, it implies a dual identity. Few student-athletes navigate multiple identities and a myriad of additional challenges in their collegiate journey than African American football student-athletes (AAFSAs). Spiritual development is vital for student-athletes; the literature validates that student-athletes growing in their faith may be better equipped to navigate the tension of multiple identity roles and cope with various circumstances. …
Authorship & Agency: Exploring Coaching As A Tool For Student Success, Allison Rebecca Lake
Authorship & Agency: Exploring Coaching As A Tool For Student Success, Allison Rebecca Lake
Theses and Dissertations--Educational Policy Studies and Evaluation
Coaching has emerged as a new, innovative practice within higher education. However, we have only begun to understand the true impact of coaching for college students. Research from individual coaching programs has shown that students who participate in coaching sessions are more likely to be retained, have higher GPAs, and engage in self-regulated learning. However, little research has been done to explore coaching from the student perspective. We do not yet understand how students utilize coaching as a tool to optimize their student experience. The goal of this project was to explore how coaching impacts the student experience and to …
A Survey Of Elementary Educators' Self-Efficacy Related To Stem Education, Elizabeth Mckenzie Johnson
A Survey Of Elementary Educators' Self-Efficacy Related To Stem Education, Elizabeth Mckenzie Johnson
Theses and Dissertations--Science, Technology, Engineering, and Mathematics (STEM) Education
While the call for STEM and engineering design has increased since the release of the Next Generation Science Standards, the implementation of STEM in elementary grades has been slow. A variety of factors play a role in why educators, schools, or districts make the informed decisions they do regarding curriculum and instruction. Identifying strengths and challenges elementary educators face in implementing STEM into the curriculum can guide schools and districts in creating supports for increasing STEM in the elementary grades. This study sought to create and test a survey instrument for use with elementary educators in a large urban district …
Long Term Observation Of The Grassland Vegetation Used Intensively Or Extensively And Ecologically, H.-D. Matthes, J. Matthes, W. Jentsch, V. Pastushenko
Long Term Observation Of The Grassland Vegetation Used Intensively Or Extensively And Ecologically, H.-D. Matthes, J. Matthes, W. Jentsch, V. Pastushenko
IGC Proceedings (1977-2023)
The aim of the present paper was to study alterations of the grassland flora from 55 plots following a more extensive management under long term observation within 6 years. Extensification of grassland use leads to an increase of the numbers of plant species by 32%, “Red-list-species” included. The moisture number of the soils slightly increased and the reaction and nitrogen numbers decreased. Results are presented for different vegetation units.
Single-Cell Analysis Of Aneurysmal Aortic Tissue In Patients With Marfan Syndrome Reveals Dysfunctional Tgf-Β Signaling, Ashley Dawson, Yanming Li, Yang Li, Pingping Ren, Hernan G. Vasquez, Chen Zhang, Kimberly R. Rebello, Waleed Ageedi, Alon R. Azares, Aladdein Burchett Mattar, Mary Burchett Sheppard, Hong S. Lu, Joseph S. Coselli, Lisa A. Cassis, Alan Daugherty, Ying H. Shen, Scott A. Lemaire
Single-Cell Analysis Of Aneurysmal Aortic Tissue In Patients With Marfan Syndrome Reveals Dysfunctional Tgf-Β Signaling, Ashley Dawson, Yanming Li, Yang Li, Pingping Ren, Hernan G. Vasquez, Chen Zhang, Kimberly R. Rebello, Waleed Ageedi, Alon R. Azares, Aladdein Burchett Mattar, Mary Burchett Sheppard, Hong S. Lu, Joseph S. Coselli, Lisa A. Cassis, Alan Daugherty, Ying H. Shen, Scott A. Lemaire
Saha Cardiovascular Research Center Faculty Publications
The molecular and cellular processes leading to aortic aneurysm development in Marfan syndrome (MFS) remain poorly understood. In this study, we examined the changes of aortic cell populations and gene expression in MFS by performing single-cell RNA sequencing (scRNA seq) on ascending aortic aneurysm tissues from patients with MFS (n = 3) and age-matched non-aneurysmal control tissues from cardiac donors and recipients (n = 4). The expression of key molecules was confirmed by immunostaining. We detected diverse populations of smooth muscle cells (SMCs), fibroblasts, and endothelial cells (ECs) in the aortic wall. Aortic tissues from MFS showed alterations …
Inhibition Of Bruton Tyrosine Kinase Reduces Neuroimmune Cascade And Promotes Recovery After Spinal Cord Injury, Chen Guang Yu, Vimala Bondada, Hina Iqbal, Kate L. Moore, John C. Gensel, Subbarao Bondada, James W. Geddes
Inhibition Of Bruton Tyrosine Kinase Reduces Neuroimmune Cascade And Promotes Recovery After Spinal Cord Injury, Chen Guang Yu, Vimala Bondada, Hina Iqbal, Kate L. Moore, John C. Gensel, Subbarao Bondada, James W. Geddes
Physiology Faculty Publications
Microglia/astrocyte and B cell neuroimmune responses are major contributors to the neurological deficits after traumatic spinal cord injury (SCI). Bruton tyrosine kinase (BTK) activation mechanistically links these neuroimmune mechanisms. Our objective is to use Ibrutinib, an FDA-approved BTK inhibitor, to inhibit the neuroimmune cascade thereby improving locomotor recovery after SCI. Rat models of contusive SCI, Western blot, immunofluorescence staining imaging, flow cytometry analysis, histological staining, and behavioral assessment were used to evaluate BTK activity, neuroimmune cascades, and functional outcomes. Both BTK expression and phosphorylation were increased at the lesion site at 2, 7, 14, and 28 days after SCI. Ibrutinib …