Digital Commons Network^™

Predictors And Outcomes Of Acute Pulmonary Embolism In Covid-19; Insights From Us National Covid Cohort Collaborative, Muhammad H. Gul, Zin Mar Htun, Vinicio De Jesus Perez, Muhammad Suleman, Samiullah Arshad, Muhammad Imran, Mahender Vyasabattu, Jeremy P. Wood, Michael I. Anstead, Peter E. Morris

Saha Cardiovascular Research Center Faculty Publications

Objectives To investigate whether COVID-19 patients with pulmonary embolism had higher mortality and assess the utility of d-dimer in predicting acute pulmonary embolism.

Patients and methods Using the National Collaborative COVID-19 retrospective cohort, a cohort of hospitalized COVID-19 patients was studied to compare 90-day mortality and intubation outcomes in patients with and without pulmonary embolism in a multivariable cox regression analysis. The secondary measured outcomes in 1:4 propensity score-matched analysis included length of stay, chest pain incidence, heart rate, history of pulmonary embolism or DVT, and admission laboratory parameters.

Results Among 31,500 hospitalized COVID-19 patients, 1117 (3.5%) patients were diagnosed …

Relative Adrenal Insufficiency Is A Risk Factor And Endotype Of Sepsis - A Proof-Of- Concept Study To Support A Precision Medicine Approach To Guide Glucocorticoid Therapy For Sepsis, Chia-Hua Wu, Ling Guo, Dan Hao, Qian Wang, Xiang Ye, Misa Ito, Bin Huang, Chieko Mineo, Philip W. Shaul, Xiang-An Li

Saha Cardiovascular Research Center Faculty Publications

Introduction: 25-60% of septic patients experience relative adrenal insufficiency (RAI) and glucocorticoid (GC) is frequently used in septic patients. However, the efficacy of GC therapy and whether GC therapy should be based on the status of RAI are highly controversial. Our poor understanding about the pathogenesis of RAI and a lack of RAI animal model present significant barriers to address these critical issues.

Methods: Scavenger receptor BI (SR-BI) regulates stress-induced GC (iGC) production in response to stress. We generated SF1CreSR-BIfl/fl mice and utilized the mice as a RAI model to elucidate the pathogenesis of RAI and GC therapy in sepsis. …

Utilizing Precision Technologies To Validate A Real-Time Location System For Dairy Cattle And Monitor Calf Behaviors During Heat Stress, Emily Rice

Theses and Dissertations--Animal and Food Sciences

With the increase in on-farm precision dairy technologies (PDT) utilization, large quantities of information are readily available to producers. A more recently available technology for use in livestock species is the real-time location system. These technologies offer dairy producers the opportunity to monitor and track real-time locations of cows, track locomotion patterns, and summarize specific area usage. However, the usefulness of these insights is heavily dependent on the performance of the technology. Therefore, the first objective of this dissertation was to assess the positioning recording performance and the usefulness of the data recorded of a real-time location system (Smartbow GmbH; …

Effects Of Biosynthesized Bromoform On Enteric Methane Production, Animal Performance And Tissue Residues In Cattle, Sydney Davis

Theses and Dissertations--Animal and Food Sciences

Greenhouse gas (GHG) emissions have been implicated in global warming and extreme climate change conditions. The Environmental Protection Agency (EPA) has identified agriculture, more specifically cattle production, as a major contributor to global GHG production. When expressed as liters of gas, CO2 is considered the primary GHG produced, however, in terms of global warming potential (GWP), CH4 has 25-times greater potential than that of CO2. Due to the elevated GWP of CH4, we have constructed a series of experiments to investigate the use of a halogenated CH4 analogue derived from kelp (i.e., bromoform) as an inhibitor of enteric CH4 production …

Interface: Technology & Portraiture, Mullins Sydney

Graduate Thesis Exhibition Catalogue Gallery, 2023

In Interface, five Kentucky-area artists explore a new language of representation with the aid of digital tools like Artificial Intelligence (AI) and Automatic Facial Recognition Software (AFR). Some artists use algorithms to alter celebrity faces beyond recognition, others feed data sets of existing art to AI models in an attempt to generate portraits of no one in particular. Others still create tools for understanding the very act of facial recognition or obfuscation. All have one thing in common: they wish to stretch the limits of and critique the genre of portraiture, as well as to cause viewers to question …

“Who Do You Love, And Are You For Sure?”: Black Relationship Attitudes And Partner Preferences, Chesmore Simon Montique

Theses and Dissertations--Educational, School, and Counseling Psychology

Historically, research has identified Black relationships as deviant, unstable, and pathological as compared to White relationships (Frazier, 1966; Moynihan, 1965). This outlook centers on White experiences as a baseline for comparison and dismisses the cultural nuance within Black relationships. Examining intraracial Black relationship formation dynamics – specifically romantic partner preferences – using an intersectional framework seems more relevant as Black people are least likely of all races to date White people (Batson et al., 2006; Yancey, 2009). As Black immigrants continue to increase their presence in the U.S. (Anderson & López, 2018), the current research examines how cultural factors influence …

An Investigation Of Individualized Education Programs For Students With Autism, Jordan Findley

Theses and Dissertations--Educational, School, and Counseling Psychology

Autism is one of the fastest growing educational disability groups (U.S. Department of Education, Office of Special Education Programs, 2021). The Individuals with Disabilities Education Improvement Act (IDEIA, 2004) ensures all students have access to a free and appropriate public education. Individualized Education Programs (IEP) have been described as central to IDEIA (2004) and are the most common service received by children with autism (Berrcera et al., 2017; Yell et al., 2003). Despite the frequent use of the IEP in service provision for students with autism, there is relatively little research on the content and quality of IEPs for students …

Microglia Proliferation Underlies Synaptic Dysfunction In The Prefrontal Cortex: Implications For The Pathogenesis Of Hiv-1- Associated Neurocognitive And Affective Alterations, Hailong Li, Kristen A. Mclaurin, Charles F. Mactutus, Rosemarie M. Booze

Neuroscience Faculty Publications

Microglia, which are productively infected by HIV-1, are critical for brain development and maturation, as well as synaptic plasticity. The pathophysiology of HIV-infected microglia and their role in the pathogenesis of HIV-1-associated neurocognitive and affective alterations, however, remains understudied. Three complementary aims were undertaken to critically address this knowledge gap. First, the expression of HIV-1 mRNA in the dorsolateral prefrontal cortex of postmortem HIV-1 seropositive individuals with HAND was investigated. Utilization of a combined RNAscope multiplex fluorescent and immunostaining assay revealed prominent HIV-1 mRNA in microglia of postmortem HIV-1 seropositive individuals with HAND. Second, measures of microglia proliferation and neuronal …

Clustering States To Improve The Strategic Highway Safety Plan, Victoria Cambron

Theses and Dissertations--Civil Engineering

Each update to a Strategic Highway Safety Plan (SHSP) can require a large amount of time, resources, and funding. From the requirements in U.S.C.148(a)(13)(E-F), in the SHSP update process states must consider the results of other transportation planning processes and develop a list of strategies to reduce or eliminate fatal and serious injury crashes (United States, 2023). To fulfill these requirements more efficiently and to gain the largest amount of benefit from said research, this thesis asks the question: how do we select other state transportation plans to study for ideas on improving our own SHSP? In this thesis, a …

Value Propositions, Adoption Factors, And Implementation Considerations: Building A Path Towards Construction Innovation, Makram Bou Bou Hatoum

Theses and Dissertations--Civil Engineering

The construction industry has been influenced by a wave of technological advancements and trends that were introduced by the fourth industrial revolution or Industry 4.0. Mapped as Construction 4.0, these technologies are disrupting the way projects are designed, planned, constructed, delivered, and operated. While existing research has predominantly focused on technology adoption and use cases across the project lifecycle, limited attention has been given to the organizational perspective and explored Construction 4.0 as a transformative vision. As such, there is a significant need for decision science research to support decision-makers in understanding the value of Construction 4.0, gaining leadership buy-in, …

Creating Change In Pediatric Health Disparities: Utilizing Systemsbased Thinking To Overcome Disparities Affecting Pediatric Type 1 Diabetes In Kentucky, Sydney Speed

Lewis Honors College Thesis Collection

Healthcare disparities are perpetuated and upheld for patients with type 1 diabetes (T1D) in rural and underserved urban areas of Kentucky. By adopting systems-based thinking, we can identify areas of the healthcare system to change to eliminate these disparities. Namely, key leverage points of this system include distribution and utilization of resources, finances and the movement of money, and communication pathways. To address the disparities surrounding pediatric T1D in Kentucky, a state-wide medical event called Kentucky Diabetes Family Day (KDFD) was hosted. The focus of this event was to lessen the effects of these specific healthcare disparities by altering key …

Early Childhood Language And Literacy Development Programs For Autism Spectrum Disorder And D/Deaf And Hard-Of-Hearing Students, Mayson Spillman

Lewis Honors College Thesis Collection

This paper examines several popular approaches in the United States for enhancing early childhood literacy and language development in two special education populations— d/Deaf or hard-of-hearing (d/DHH) students and students with autism spectrum disorder (ASD). In addition to examining the effectiveness of these approaches, I adopt an educational equity lens to describe how variability in implementation can impact outcomes for these children. Based on my critical reading of the literature, I offer three broad recommendations for school psychologists: (1) Carefully consider dosage and fidelity of implementation, (2) Use caution when modifying existing interventions for these populations, and (3) Increase in-service …

Evaluation Of Academic Detailing To Educate Clinicians Regarding Childhood Lead Poisoning Prevention: A Pilot Study, Nicholas C. Newman, Jacqueline M. Knapke, Rachael Kiniyalocts, John Belt, Erin N. Haynes

UK CARES Faculty Publications

Context: Environmental exposures are associated with approximately 19% of disease globally, and exposure to neurotoxic chemicals is estimated to cost the United States $50 billion per year. Despite calls from the Institute of Medicine to increase training for clinicians regarding environmental health since the 1990s, there is still little instruction in environmental health for clinicians. This leaves gaps in knowledge that need to be bridged through outreach and education to practicing clinicians. Academic detailing (AD) is an educational intervention associated with improved prescribing practices in healthcare professionals but has not been applied to preventive or environmental health. Childhood lead exposure …

Asynchronous E-Training And Coaching To Indonesian Parents: Naturalistic Strategies To Support Language Development Of Children With Social-Communication Delays, Ndaru Prapti

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

The study is about virtual training and coaching to Indonesian parents of preschool-age children with social-communication delays to implement naturalistic intervention. These intercontinental coaching sessions were delivered asynchronously because of the time difference between the coach and the participants and internet bandwidth barrier in some rural areas in Indonesia. Multiple-baseline design across behaviors was utilized to determine the effect of asynchronous training and coaching program to teach three Indonesian parents three naturalistic strategies (i.e., modeling, mand-model, and time delay) during natural routines. Parent-child dyads video-recorded their interaction before and after intervention.

The intervention was started by learning the strategies, video-recorded …

Evaluating Trends In K-12 Teachers’ Well-Being And Career Plans Throuhgout The Covid-19 Pandemic, Madeline Dunfee

Theses and Dissertations--Epidemiology and Biostatistics

The COVID-19 pandemic has had far reaching effects on school communities, which will continue to affect the teaching profession for years to come. As K-12 teachers worked to meet the educational, social, emotional and health needs of students and families, their personal well-being was taxed. It is critical to understand the experiences of K-12 teachers during the COVID-19 pandemic and to leverage this understanding to develop effective strategies for supporting K-12 teachers in the future. This research leveraged data from the School Staff Health and Wellness Study to examine teachers’ well-being and career outlook during the COVID-19 pandemic. The central …

The Future Is Electric: Nuclear Energy’S Role In Combating Climate Change And The Regulatory Measures To Enable Its Advancement, Autumn Clark

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

An Agricultural Plastic Crisis: How Federally Endorsed Biodegradable Plastics Could Liberate The Industry In The Eleventh Hour, Samantha Davenport

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Is The Russian-Ukrainian Conflict Finally The Tipping Point For Criminal Liability When The Environmental And Natural Resources Are Weaponized In Armed Conflict? An Analysis Of The Karachun Dam Attack, Mary Jocelyn

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Changing The Conversation Around Big Oil Climate Commitments, Hannah Thompson

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

A Legislative Call-To-Action: Applying Capture Theory To Combat The Risk Of Private Industry’S Excess Influence Over The Fda’S Regulation Of Livestock Antibiotics, Nathaniel Richey

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Examining A Blood Biomarker Approach To Blood-Brain Barrier Disruption, Samantha Ford

Theses and Dissertations--Medical Sciences

Blood-brain barrier disruption has been identified to associate with the pathogenesis several neurological diseases such as dementia [1, 2], multiple sclerosis[3, 4], acute or chronic cerebral ischemia[5], brain trauma[5], meningitis[5], encephalitis[5], stroke[6], and seizures[7]. Being able to effectively identify blood-brain barrier disruption is limited in methodology. The current standard is using a cerebrospinal fluid (CSF) albumin to serum albumin index, which requires the use of a lumbar puncture. A novel method of identifying blood-brain barrier disruption utilizing blood biomarkers is proposed in this study. Participants in this study had previously collected blood and CSF samples, which were analyzed to compare …

Comparing Indirect Assessment Results To A Direct Function Focused Preference Assessment To Identify Potential Reinforcers To Increase Task Completion In A School Setting, Kailee Joy Matthews

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

In the present study, a concurrent operant analysis (COA) was conducted for one elementary aged student in a publicly funded school to determine if the results yielded an interpretable outcome to identify a potential reinforcer to increase work completion. A simultaneous treatments design was used during the COA to assess choice making behavior. The results of the COA indicated the student’s choice making behavior was maintained by access to attention. An indirect measure of motivation was used as a secondary assessment to identify a potential reinforcer to increase work completion and to determine if the results would align with the …

Rnai-Mediated Gene Silencing In The Exotic Redbay Ambrosia Beetle, Xyleborus Glabratus, And Insect-Fungal Interactions Within The Laurel Wilt Complex, Morgan Christine Knutsen

Theses and Dissertations--Entomology

Laurel wilt disease (LWD) is a lethal vascular disease impacting lauraceous hosts caused by Harringtonia lauricola, the fungal symbiont of the redbay ambrosia beetle (Xyleborus glabratus Eichoff) (RAB) (Coleoptera: Curculionidae). LWD has caused tree mortality throughout the southeastern United States and is continuing to spread into new regions. Current management methods have not been successful in preventing spread, warranting investigation into innovative techniques including RNA interference (RNAi).

Elongation factor-1 alpha (ef1a) and actin (act) were established as stably expressed reference genes after exposing beetles to different photoperiod, temperature, and dsRNA exposure. After RAB oral …

Linking Previous Experiences To Behavior And Health In The Honey Bee (Apis Mellifera), Rebecca R. Westwick

Theses and Dissertations--Entomology

An organism’s ability to respond to changing conditions can be vital to its success. Indeed, plasticity is a common feature of living organisms. Much of the research in this area, though, has focused on effects caused by environmental conditions. What has received relatively less attention is how social experiences and broader features of an organism’s social environment can lead to long-lasting changes in health and behavior. This knowledge gap exists despite the well-documented existence of health and behavioral effects after social interactions in certain taxa such as humans.

Social insects such as honey bees provide an excellent opportunity to better …

Epigenetic Regulation Of Insect Development, Yaoyu Jiao

Theses and Dissertations--Entomology

Insects undergo a series of distinct life stages such as egg, larva and pupa to develop into mature adults capable of reproduction throughout their life cycle. In the larval stage, insects experience the fastest growth with voracious feeding and multiple cuticle shedding resulting in hundreds-of-fold increasing of size. During metamorphosis, insects stop increasing body size but go through dramatic tissue transformation, developing wings and other adult features. The characteristic mode of insect development, especially the metamorphosis, makes insects the most successful group of animals on the earth. However, the epigenetic mechanisms behind insect development remain elusive. Studying the epigenetic regulation …

A Laboratory And Numerical Investigation Of The Strength Of Irregularly Shaped Pillars, Zachary Wedding

Theses and Dissertations--Mining Engineering

Underground mining operations utilize the room-and-pillar mining method that extracts the orebody and creates ‘rooms’ and leaves the remaining in-situ material as ‘pillars’ to support the overburden. Room-and-pillar mines are traditionally designed in square or rectangular-shaped pillars. This work presents laboratory experiments testing the compressive strengths of specimens modeled after square and parallelogram-shaped pillars and numerical models of square and -parallelogram-shaped pillar systems. The uniaxial compressive strength of the specimens’ shape and the observations of the extent of the specimen core post-failure were analyzed. There was insufficient evidence from the laboratory experiments to conclude that there is a difference in …

Manipulation Of Components Of The Renin Angiotensin System In Renal Proximal Tubules Fails To Alter Atherosclerosis In Hypercholesterolemic Mice, Masayoshi Kukida, Naofumi Amioka, Dien Ye, Hui Chen, Jessica J. Moorleghen, Ching-Ling Liang, Deborah A. Howatt, Yuriko Katsumata, Motoko Yanagita, Hisashi Sawada, Alan Daugherty, Hong S. Lu

Saha Cardiovascular Research Center Faculty Publications

Background and objective: Whole body manipulation of the renin-angiotensin system (RAS) consistently exerts profound effects on experimental atherosclerosis development. A deficit in the literature has been a lack of attention to the effects of sex. Also, based on data with gene-deleted mice, the site of RAS activity that influences lesion formation is at an unknown distant location. Since angiotensin (AngII) concentrations are high in kidney and the major components of the RAS are present in renal proximal tubule cells (PTCs), this study evaluated the role of the RAS in PTCs in atherosclerosis development.

Methods and results: Mice with an LDL …

Nutritional & Colorectal Health, Tariq A. Alam, Brittany R. Rice, Sara B. Police

Journal of Pharmacology & Nutritional Sciences

Kentucky has the highest incidence and mortality rate of all site cancers, and Kentuckians residing in the Appalachian region often have worse outcomes, where cancer is a leading cause of death. Focusing on colorectal cancer (CRC) specifically, Kentucky ranks first nationwide for incidence (50 cases per 100,000 people) and fifth for mortality (about 17 deaths per 100,000 people). The Kentucky Colon Cancer Screening Program increased screening rates and reduced mortality since its launch. Yet, CRC remains a leading cause of death for Kentuckians. Risk factors for CRC include increasing age as well as a history of inflammatory bowel disease (IBD) …

Local News Deserts In China: The Role Of Social Media And Personal Communication Networks, Zixue Tai, Bai He, Jianping Liu

Journalism and Media Faculty Publications

The field of local news is often associated with news deserts, commonly defined as geo‐based communities without news‐ papers or other legacy media as providers of locally oriented news and civic information. This phenomenon is expanding in global society due to the diminishing presence of newspapers at moments of accelerated digitization. This study examines the multiplex nature of news deserts in rural and suburban areas in China. Data were collected through a multi‐methods approach combining two focus groups and 44 semi‐structured in‐depth interviews. Patterns of engagement among inter‐ viewees reveal that smartphone‐based social media applications and digital platforms function as …

Organizational Access Points And Substance Use Disorder Treatment Utilization Among Black Women: A Longitudinal Cohort Study, Sugy Choi, Amanda Bunting, Talia Nadel, Charles J. Neighbors, Carrie B. Oser

Sociology Faculty Publications

Introduction Health and social service organizations, including the emergency department (ED) and public assistance programs, constitute a social safety net that may serve as an “access point” for substance use treatment utilization. Racialization of substance use disorder (SUD) and gender disparities in access to treatment contribute to differences in health and social service utilization, including substance use treatment for Black women. We therefore explored the role of various access points in facilitating the use of substance use treatment among Black women with substance use and involvement in the criminal justice system.

Methods We used data from the Black Women in …