Digital Commons Network^™

Intentions To Seek Mental Health Services Among Arabs In The United States: The Effect Of A Tailored Web-Based Educational Video, Ohoud Alosais

Theses and Dissertations--Nursing

Arabs in the United States (U.S.) are exposed to different stressors that place them at high risk of developing adverse mental health outcomes. Compared to other minority groups, Arabs in the U.S. have reported significantly higher levels of anxiety and depression. Researchers have found disparities between the need for mental health services (MHS) and actual utilization among Arabs in the U.S. Understanding the intrapersonal factors involved in MHS’ help-seeking behavior among Arabs in the U.S. is essential to reduce the burdens caused by untreated mental health disorders in this population. Therefore, the purpose of this dissertation was to enhance our …

Southeastern Law Librarian 2023 Special Election Edition, Seaall

Newsletters

No abstract provided.

Offshoring And Subordinate Financialization In Developing Countries, Logan Kuegel

Undergraduate Public Policy Capstone Projects

This study will investigate the relationship between global value chain integration and financialization in the Global South. It is intended for policy research committees in international organizations such as the United Nations (Commission on Trade and Development Special Committee on Cization), the International Monetary Fund (Development Committee), the World Trade Organization, and World Bank. The global production network represents the international division of production through intermediate offshoring, while financialization represents the entrance of traditionally nonfinancial actors (namely firms, governments/banks, and households) into the financial system.

Attempting to use a heterodox framework, this paper builds upon literature that synthesizes the two …

Bolstering Resistance To Misinformation Through K-12 Education, Allison Johnson

Undergraduate Public Policy Capstone Projects

Misinformation online and in news media is a problem because it degrades truth and hinders legitimate democratic discourse. As misinformation becomes more prevalent, we need to start finding ways to limit the extent of the problem. To do so, I recommend a policy solution based on inoculation theory. Inoculation theory, as the name suggests, uses the metaphor of a vaccine. When receiving the flu shot, we get a weakened dose of the virus, which in turn helps us to create antibodies and later be more effective at fighting the real flu. In this instance, people are exposed to weakened doses …

Curbing Diabetes Prevalence And Reducing Risk Through Policy, Grayson Blount

Undergraduate Public Policy Capstone Projects

The purpose of this policy brief is to illuminate the dire circumstances surrounding the ongoing diabetes epidemic in Kentucky. Type II diabetes mellitus, a preventable and manageable chronic illness, affects nearly 465,000 Kentuckians currently. Beyond the daily struggle associated with diabetes, many acute complications can arise that are severly detrimental to quality of life, such as blindness or lower extremeity amputation. Additionally, the costs associated with diabetes are tremendous, to patients, to providers, and to the state. It is in the best interest of all stakeholders to do whatever we can in order to reduce prevalence and improve management of …

Child Welfare And The Opioid Crisis In The Bluegrass State, Irina Mohler

Undergraduate Public Policy Capstone Projects

This brief discusses the challenges facing Kentucky's child welfare system, particularly due to the opioid epidemic, childhood adversity, mental health needs, and limited social services. Kentucky has one of the highest child neglect rates and opioid dispensing rates in the nation. The state's child welfare system includes services like the Child and Family Services Plan, Independent Living Program, and Sobriety Treatment and Recovery Team (START), but it faces issues such as high caseloads and data gaps. It aims to emphasizes the importance of providing the highest standard of care for children in Kentucky and seeking effective recommendations by examining similar …

Macrophage Polarization Status Impacts Nanoceria Cellular Distribution But Not Its Biotransformation Or Ferritin Effects, Uschi M. Graham, Alan K. Dozier, David James Feola, Michael T. Tseng, Robert Yokel

Nanobiotechnology Center Faculty Publications

The innate immune system is the first line of defense against external threats through the initiation and regulation of inflammation. Macrophage differentiation into functional pheno- types influences the fate of nanomaterials taken up by these immune cells. High-resolution electron microscopy was used to investigate the uptake, distribution, and biotransformation of nanoceria in human and murine M1 and M2 macrophages in unprecedented detail. We found that M1 and M2 macrophages internalize nanoceria differently. M1-type macrophages predominantly sequester nanoceria near the plasma membrane, whereas nanoceria are more uniformly distributed throughout M2 macrophage cytoplasm. In contrast, both macrophage phenotypes show identical nanoceria biotransformation …

Interbranch Equity, Jonathan Shaub

Law Faculty Scholarly Articles

In recent years, Congress has increasingly turned to the courts to challenge executive actions. In these suits, the executive branch has strenuously pressed several distinct doctrinal arguments that interbranch cases are nonjusticiable and must be dismissed. These arguments, though expressed in the relevant language of each individual justiciability doctrine, are all centered on a single fundamental point—the judiciary should not be involved in refereeing a dispute that is solely between the legislative and executive branches. The briefs and judicial opinions explicitly identify a coherent category of cases—interbranch cases. But these cases are treated haphazardly as a matter of doctrine. Within …

Opioid Lawsuits: Is There Any End In Sight?, Richard C. Ausness

Law Faculty Scholarly Articles

Numerous lawsuits have been filed since 2014 against opioid manufacturers, distributors and retail pharmacies by state and local governments and other plaintiffs. Unfortunately, although some settlements with some defendants have been negotiated, a comprehensive “global” resolution of the opioid controversy remains elusive. This article traces the history of opioid litigation and considers whether there is a better way to deal with such a massive problem.

Beneficiaries As Trustees: Here's The State Of Things, Richard C. Ausness

Law Faculty Scholarly Articles

It is not unusual for settlors to appoint beneficiaries as trustees. However, there are serious risks associated with this practice. This Article will examine some of these risks and suggest ways to reduce them. Part II describes why settlors appoint beneficiaries as trustees. Part III identifies some of the cases that have arisen where other trust beneficiaries have charged trustee beneficiaries with breach of fiduciary duties such as the duty of loyalty, impartiality, and prudence, as well as the duty to inform and report. Part IV explores a number of cases which have involved common trust arrangements such as revocable …

Low-Head Dams (Aka Drowning Machines) Are Deadly: An Analysis Of Liability For Landowners And States, And Recommendations For Legislation And Warning Signs, Forrest R. Hansen, Rollin H. Hotchkiss

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Making Sense Of “Commence” In The Clean Water Act’S Diligent Prosecution Bar, Isa Harrison

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

50 Shades Of Green: How Inconsistencies In State Regulatory Regimes Threaten To Doom The Legal Cannabis Market In The United States, Shawn Harkins

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

A New Rule: Why Broad Jurisdiction Under § 404 Of The Clean Water Act Will Protect Wetlands, Gracie Sandlin

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Delta-Late: How The Contentious And Hazy Legal Status Of Delta-8 Thc Reveals Kentucky’S Need For Federal Regulatory Guidance, Georgiana Ledford

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Let Kids Be Kids: Why The Fair Labor Standards Act Of 1938 Desperately Needs A Revision, Cori Agnoni

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Horsing Around With Protecting The Horse Industry: Should California Adopt An Equine Activity Liability Act?, Kara Legg

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Companies Over Countries: A More Pointed Approach To International Climate Treaties, Alex G. Woodward

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Assessing Compressed Air Energy Storage (Caes) Potential In Kentucky To Augment Energy Production From Renewable Resources, J Richard Bowersox, John B. Hickman

Report of Investigations--KGS

Fossil fuel power plants in Kentucky have some of the highest emissions of greenhouse gasses in the United States. One potential strategy for mitigating greenhouse gasses from electric power generation is the co-installation of Compressed Air Energy Storage (CAES) and a renewable source such as photovoltaic solar electricity generation (PV solar generation). CAES with complementary co-installed PV solar generation enhances stand-alone PV solar generation because CAES power is available at night.

CAES, however, requires both a site where large volumes of compressed air can be stored in the subsurface, and a heat source to prepare the stored air prior to …

Artificial Intelligence And The Practice Of Law Part 1: Lawyers Must Be Professional And Responsible Supervisors Of Ai, Michael D. Murray

Law Faculty Popular Media

No abstract provided.

Promoting Resilience For Children And Families With Adverse Childhood Experiences, Laken Albrink

Law Faculty Popular Media

No abstract provided.

Arbitration Of Erisa Statutory Claims, Kathryn L. Moore

Law Faculty Books and Chapters

In light of the flood of fiduciary litigation in recent years, some plan sponsors have considered amending their plans to include provisions requiring mandatory arbitration of claims and waivers of class action or collective claims. All things being equal, arbitration is potentially more efficient and less costly than litigation, and plan sponsors hope that mandatory arbitration and class action waivers may save them time and money in the current litigious environment. In fact, however, under the current state of the law, arbitration provisions may lead to protracted litigation and additional costs, including the cost of litigating the enforceability of the …

Development And Biological Evaluation Of Selective Small-Molecule Inhibitors Of The Human Cytochrome P450 1b1, Austin Hachey

Theses and Dissertations--Chemistry

The human cytochrome P450 1B1 (CYP1B1) is an emerging target for small- molecule therapeutics. Several solid tumors overexpress CYP1B1 to the degree that it has been referred to as a universal tumor antigen. Conversely, its expression is low in healthy tissues. CYP1B1 may drive tumorigenesis through promoting the formation of reactive toxins from environmental pollutants or from endogenous hormone substrates. Additionally, the expression of CYP1B1 in tumors is associated with resistance to several common chemotherapies and with poor prognoses in cancer patients. However, inhibiting CYP1B1 with small molecules has been demonstrated in cellular and murine model systems to reverse this …

Paper Gowns, Cold Hands, Or Something Else? Black Women's Barriers To Gynecologic Screening, Nadia Ayesha Sesay

Theses and Dissertations--Communication

Cervical cancer mortality burden is carried disproportionately by African American women. Early indicators of cervical cancer are identified through prevention screening, a procedure typically performed by a gynecologist. Ideally, the patient group with the most severe mortality would likewise be the group with the most robust communication exchange with their physician to prevent cervical cancer incidence. However, a slew of factors contributes to continued mortalities among Black women. This study uses semi-structured interviews (n=10) and the health belief model to examine one barrier to Black women’s prosocial behaviors regarding routine gynecologic care—awkwardness, which here is conceptualized as social anxiety. The …

Identity And Perception Among Aspec Consumers Of Mass Media, Jericho Franke

Theses and Dissertations--Communication

The portrayals of sex and romance, as well as asexuality and aromanticism, in mass media can have a profound impact on the way asexual and aromantic media consumers view relationships and their own identities, and affect the perception and treatment of the aspec community as a whole. This study uses mixed qualitative methods of online discourse analysis and participant interviews to examine the how mass media has shaped the self-perception and life experiences relating to sex and romance among aspec audience members.

‘It’S Like Flipping A Switch’: Understanding The Challenges, Expectations, And Identity Of High School Wrestlers, Aubree Herman

Theses and Dissertations--Communication

This study aims to understand the challenges and expectations of high school wrestlers, and how they are managing their social identities within the parameters of the sport. The rise of female wrestlers within the last decade and the hegemonic masculine roots of the sport show how imperative it is that research shed light into the unique experiences of high school wrestlers. Social identity theory was used as a theoretical framework and participants answered interview questions that discussed the three components of their social identity (i.e., cognitive, affective, and evaluative). They also identified challenges that they faced, the kind of expectations …

Leadership In Nonprofit Organizations: Best Practices For Volunteer Retention, Jennifer Lawrence

DSW Capstone Projects

While there is a significant amount of research focusing on organizational leadership in business and for-profit organizations, comparatively little data has been collected and studied to address the role of leadership in volunteer organizations. By closing this gap in research and providing context around leadership, nonprofit organizations can enhance leadership, culture and climate, and volunteer engagement and retention. Fewer Americans are engaging in volunteerism in their community than any other time in the past twenty years. The Systemic Literature Review will aid in recognizing and addressing this decline which is important as volunteer organizations provide needed services to people and …

Impact Of Insurance Payer On Stage At Diagnosis Of Prostate Cancer, Hunter M. Stiff

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Objectives: Prostate cancer (CaP) is the most common site of cancer in men in the United States and is very treatable when diagnosed in localized and regional stages. While there are widely available forms of screening that can detect CaP in its early stages, factors that can affect healthcare access such as health insurance, race, and Appalachian residency have been linked with differences in rates of distant-stage CaP diagnosis. This study aimed to explore the relationships between health insurance, race, Appalachian residency, and late-stage CaP diagnosis in the state of Kentucky.

Methods: A sample of 26,622 men from the state …

Hmgb2 Regulates The Differentiation And Stemness Of Exhausted Cd8+ T Cells During Chronic Viral Infection And Cancer, Emily N. Neubert, Julia M. Derogatis, Sloan A. Lewis, Karla M. Viramontes, Pedro Ortega, Monique L. Henriquez, Rémi Buisson, Ilhem Messaoudi, Roberto Tinoco

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Chronic infections and cancers evade the host immune system through mechanisms that induce T cell exhaustion. The heterogeneity within the exhausted CD8⁺ T cell pool has revealed the importance of stem-like progenitor (Tpex) and terminal (Tex) exhausted T cells, although the mechanisms underlying their development are not fully known. Here we report High Mobility Group Box 2 (HMGB2) protein expression is upregulated and sustained in exhausted CD8⁺ T cells, and HMGB2 expression is critical for their differentiation. Through epigenetic and transcriptional programming, we identify HMGB2 as a cell-intrinsic regulator of the differentiation and maintenance of Tpex cells during …

A Mor Antagonist With High Potency And Antagonist Efficacy Among Diastereomeric C9-Alkyl-Substituted N-Phenethyl-5-(3-Hydroxy)Phenylmorphans, Dana R. Chambers, Agnieszka Sulima, Dan Luo, Thomas E. Prisinzano, Arthur E. Jacobson, Kenner C. Rice

Pharmaceutical Sciences Faculty Publications

The 5-(3-hydroxy)phenylmorphan structural class of compounds are unlike the classical morphinans, 4,5-epoxymorphinans, and 6,7-benzomorphans, in that they have an equatorially oriented aromatic ring rather than the axial orientation of that ring found in the classical opioids. This modified and simplified opioid-like structure has been shown to retain antinociceptive activity, depending on its stereochemistry and substituents, and some of them have been found to be much more potent than morphine. A simple C9-hydroxy-5-(3-hydroxy)phenylmorphan enantiomer was found to be about 500 times more potent than morphine in vivo. We have previously examined C9-alkenyl and hydroxyalkyl substituents in the N-phenethyl-5-(3-hydroxy)phenylmorphan class of compounds. …