Digital Commons Network^™

Effects Of Elevated Extracellular Dopamine On Astrocytes In The Nucleus Accumbens, Mengfan Xia

Theses and Dissertations--Pharmacology and Nutritional Sciences

Nucleus accumbens is involved in processing of motivational and affective behaviors and plays a significant role in development and maintenance of substance use. Released from the ventral tegmental area into the nucleus accumbens, the mesolimbic dopamine controls incentive salience and facilitates learning of reinforcement and reward-related motor functions. Recent studies reveal that, in the context of cocaine exposure, dopamine transmission in the ventromedial striatum is pivotal to the regulation of initial drug use. Astrocytes, a major subpopulation of the brain glial cells, are an active component of the so-called tripartite synapse and communicate with neurons through the release of transmitters …

Maternal Occupation And Pediatric Brain Cancer In Kentucky, Mary Begley

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Pediatric brain cancer is a rare and potentially deadly diagnosis that affects children in Kentucky at a higher incidence than those nationally. Limited exposures in children early in life to warrant the development and progression of brain cancer point to the role parental exposures experienced in the period prior to conception and throughout pregnancy may play in its development. Many of these exposures may be experienced through occupation. Data on a subset of pediatric brain cancer cases in Kentucky was compared to all cases diagnosed in the state from 1995 to 2019. Survey data of the study sample was collected …

Cardinal's Blues: Implementation Of A School-Based Cognitive Behavioral Therapy Program For Jefferson County Public Schools In Louisville, Kentucky, Loui Chang

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

With the increasing rate of adolescent depression and anxiety1 2, developing mental health interventions is necessary. Many adolescents’ times spent in schools increased compared to 20 years ago5, which makes school-based intervention programs suitable for reaching adolescent population effectively. Though there are numerous treatment providers available in Jefferson County, Kentucky, the school-based prevention programs addressing adolescent’s negative mental health outcomes have never been implemented. The Blueprints for Healthy Youth Development developed a program called the Blues Program24. The Blues Program provides an adapted version of group Cognitive Behavioral Therapy sessions to train and educate adolescents coping skills and cognitive restructuring24. …

Deep Community Partnerships: The Future Of Community-Based Senior Care In A Value-Driven Era, Diana Wilcox

DSW Capstone Projects

This capstone reviews three scholarly products that examine how chronically ill older adults interact with healthcare systems and senior service delivery systems in the United States. The systematic literature review examines how community-based senior programs that are funded by the Older Americans Act (OAA) positively impact health outcomes and promote health and wellness among the older adult population. The conceptual paper examines how Accountable Care Organizations (ACOs), Managed Care Organizations (MCOs), Area Agencies on Aging (AAA) interact with the patient and with one another using the lens of Systems Theory. The practice application paper examines best practices regarding care coordination …

"It's All Lateral Violence": How Sexual Minority Men Cope With Appearance Discrimination, Matthew T. Richardson

Theses and Dissertations--Educational, School, and Counseling Psychology

Sexual minority men experience higher rates of body dissatisfaction (BD) than heterosexual men (Frederick & Essayli, 2016). BD is associated with negative health outcomes in this population, including eating disorders (Yean et al., 2013), depression (Blashill et al., 2016), suicidality (Grunewald, Calzo, et al., 2021), and risky sexual behavior (Goedel et al., 2017). Sexual minority men who use dating apps may be at greater risk of experiencing BD via exposure to appearance-based discrimination (Tran et al., 2020), sexual objectification, and weight stigma (Filice et al., 2019). Little is known about sexual minority men’s experiences of appearance discrimination on dating apps …

The Role Of Authenticity In The Link Between Self-Determination, Gender Minority Stress, Psychological Well-Being And Distress In Transgender, Nonbinary, And Gender Expansive Individuals, Zakary Alexander Clements

Theses and Dissertations--Educational, School, and Counseling Psychology

Transgender, nonbinary, and gender expansive individuals (TNB and GE) have the same basic psychological needs (BPN) for self-determination as their cisgender counterparts yet face unique gender minority stressors (GMS) that may impact psychological distress and well-being. Authenticity is an important factor that may also affect psychological well-being and distress in TNB and GE people. Few research studies have examined BPN attainment or GMS factors and psychological well-being and distress. The role of authenticity, which is associated with psychological well-being in cisgender samples, has yet to be examined in TNB and GE people on the context of BPN attainment or GMS. …

Exploration Of Factors Associated With Rural Appalachian Women's Use Of Buprenorphine Prior To Incarceration, Kelsey A. Redmayne

Theses and Dissertations--Educational, School, and Counseling Psychology

The Gelberg-Anderson Behavioral Model for Vulnerable Populations was used to identify factors related to buprenorphine use in general and through diversion (versus formal treatment) among rural Appalachian women using substances in the six months prior to their incarceration. This study is a secondary analysis of data from interviews completed with rural Appalachian women (N=400) residing in rural Kentucky jails. Independent variables were analyzed using chi square and independent t-tests for buprenorphine use generally and diverted buprenorphine use. The significant predictors were then evaluated through hierarchical logistic regression to explore which factors account for the most variance in general …

The Effect Of Exceptionality Label On School Psychologists During The Evaluation Process, Rachel Jacob

Theses and Dissertations--Educational, School, and Counseling Psychology

School psychologists often lead the evaluation process that is responsible for identifying students with an education-based disability. They are also responsible for providing recommendations for the student following the evaluation. The current study is focusing on the variable of exceptionality label as it is a universally present variable that has the potential to affect all evaluations. Two recent studies have examined and found labeling bias on preservice educators (Allday et al., 2011; Fisher et al., 2022). This study sought to expand this research by looking at labeling bias in school psychologists. The study measured the effect of exceptionality label on …

An Examination Of Factors Impacting Home-School Collaboration In Head Start Populations, Madison Mei-Mei Yee

Theses and Dissertations--Educational, School, and Counseling Psychology

Two essential pillars in a preschool-age student’s life include their caregiver and their teacher. In turn, it is unsurprising that a more cohesive relationship between these two figures can promote better wellbeing, academic skills, and overall developmental growth in young children. Unfortunately, a multitude of barriers impede home-school collaboration, such as socioeconomic status, non-English speaking households, and caregiver mental health, just to name a few. Head Start, a federally funded preschool program, targets underserved populations who often relate to these named barriers. Head Start works out of the Parent, Family, and Community Engagement (PFCE) Framework, a framework specifically geared toward …

The Spread Of Nuclear Technology: The Difficulty Of Arms Control And The Consequences Of Nuclear Proliferation, Bryce Allen Beschorner

Theses and Dissertations--Political Science

The potential impact of nuclear technology on international relations raises a number of important questions for scholars and policymakers. This dissertation focuses on different aspects of nuclear-related cooperation and competition and attempts to answer some of these questions. In this dissertation, I address three main puzzles related to nuclear politics using a mixed methods approach. First, I examine the consequences of the spread of nuclear technology on the outcomes of international crises, specifically focusing on the impact of nuclear weapons tests on crisis outcomes. Using data on nuclear weapons tests, I argue and find support for the notion that nuclear …

Conserved Novel Interactions Between Post-Replicative Repair And Mismatch Repair Proteins Have Differential Effects On Dna Repair Pathways, Anna K. Miller

Theses and Dissertations--Toxicology and Cancer Biology

DNA mismatch repair (MMR) is the DNA repair mechanism that repairs base-base mispairs and small insertions and deletions remaining after replication. MMR is also required for apoptosis after certain types of exogenous DNA damage that result in damage-associated mispairs. The basic MMR mechanism is well understood; however, proteins associated with MMR continue to be identified. The roles of these interacting proteins in MMR are largely unknown. We have identified the yeast protein Rad5 as a novel interactor of the critical MMR proteins Msh2 and Mlh1. Rad5 is a DNA helicase and E3 ubiquitin ligase involved in post-replicative repair. However, to …

Elucidating The Functional Importance Of Peroxiredoxin Iv In Prostate Cancer And Its Secretion Mechanism, Na Ding

Theses and Dissertations--Toxicology and Cancer Biology

Prostate cancer is the most common and second leading cause of cancer death in men. Prevailing theories state that inflammation may drive prostate carcinogenesis via oxidative stress and the generation of reactive oxygen species (ROS) that induce somatic mutagenesis. Since high proliferating cells or cancer cells exhibit aberrant metabolism to satisfy the needs of energy for rapid cell proliferation, they also generate high levels of ROS which stimulates the expression of cellular antioxidants to overcome the dysregulation of redox homeostasis through the regulation of redox-sensitive transcription factors. Among different antioxidants, peroxiredoxin (Prx) family proteins are the highly conserved and mostly …

Beyond Mitosis, Plk1-Mediated Phosphorylation Re-Wires Cancer Metabolism And Promotes Cancer Progression, Qiongsi Zhang

Theses and Dissertations--Toxicology and Cancer Biology

Polo-like kinase 1 (PLK1) is a well- characterized regulator of cell division and is known to be highly expressed in certain types of tumors. It has been demonstrated the multifaceted roles of PLK1 in regulation of transcription, translation, epigenetics, DNA damage and cellular metabolism et al. Despite these findings, the precise mechanisms by which PLK1 regulates these processes beyond mitosis remain unclear. PLK1-mediated phosphorylation and misregulation of its substrates has been linked to tumorigenesis, cancer progression, drug resistance and worse prognosis. In this study, we investigated the non-canonical functions of PLK1 in cancer metabolism and drug resistance. We found that …

Disparities In Mental Health Technology Among African Americans: Breaking Cultural Inclusion Barriers, Nyoki Cosey-Brown

DSW Capstone Projects

Mental health technology is a healthcare delivery model of the future. The engagement in virtual healthcare was intensified when traditional healthcare methods were inaccessible during the federal restrictions implemented due to the COVID-19 pandemic. Utilizing digital apparatuses for healthcare improved the convenience, efficiency, and accessibility of various mental health services that were inoperable in past healthcare models. However, the historical constructs of stigma, discrimination, inequity, exclusion, and structural racism in mental healthcare were prevalent problems that remained present in virtual mental health platforms concerning the experiences of African-American patients and professionals who utilized the spaces.

This research explored mental health …

Technology As A Change Agent For Social Work Supervision, Hermaya Onunwor

DSW Capstone Projects

The COVID-19 pandemic has had a critical impact on the social work profession, with social workers relying heavily on technology to deliver services. There have been concerns about the effectiveness of these evolved practices, and practitioners are questioning whether they are acceptable as emergency orders caused by the pandemic begin to lapse. To address these concerns, a systematic literature review was conducted to synthesize scholarly literature on the effectiveness of telesupervision in social work practice. This capstone project aims to provide valuable insights into the effectiveness of telesupervision in social work practice

When evaluating the training and development of social …

Substance Use And Trauma Among Adult Education Students In The United States, Brittany Miller-Roenigk, Michael Awad, Maria C. Crouch, Derrick M. Gordon

Educational, School, and Counseling Psychology Faculty Publications

Adult basic education (ABE) programs in the United States serve millions of students annually to help them achieve high school equivalency, English proficiency, and other skills. These skills are necessary for upward mobility and competitiveness in the labor market, which is important for ABE students who are disproportionately affected by racial/ethnic disparities and poverty. Among learners who are not in ABE programs, substance use and trauma affect student outcomes. Similar research is limited among ABE students. Understanding the influence of these factors among ABE students can better inform interventions. The current study, grounded in Stress and Coping Theory, examined rates, …

Writing New Normals: A Study Of American Pandemic Fiction In The Wake Of Covid-19, Riley E. Droppleman

Gaines Fellow Senior Theses

The purpose of this thesis is to explore the aspects of pandemic fiction that extend beyond the illness itself. In this thesis, I show that while the disease that spreads is a large focus of pandemic fiction, the truths that spring from these novels reveal larger societal issues, such as class hierarchies, racial inequalities, and failings of the government to fight the pandemic. In fact, pandemics act as catalysts for the uncovering of these societal ills, and the authors of pandemic fictions bring these greater faults of society to the forefront of their novels. I analyze three novels from the …

The People We Carry, Abigail E. Eplin

Gaines Fellow Senior Theses

No abstract provided.

Revitalization Through Reuse: A Proposed Repositioning Of A 1960s Shopping Mall In Balcones Heights, Texas - Site History And Literature Review, Sophie Gershtenson

Gaines Fellow Senior Theses

No abstract provided.

Restorative Landscapes And Their Potential Application To The University Of Kentucky Campus, Felix Lowery

Gaines Fellow Senior Theses

Exposure to natural environments has been shown to have significant positive impacts on both mood and attention, as well as the potential to decrease stress and other negative emotions. Hospitals and other healthcare settings have been on the forefront of implementing spaces designed with the intent of improving mental health. However, this is not the only setting in which restorative landscapes are needed. Implementing restorative landscapes on college campuses would be an innovative way for colleges to address their students’ mental health needs. The objective of this thesis is to understand what aspects of a natural landscape promote cognitive restoration, …

Cyborgs, Dolls And Passing Narratives: Trans-Femininity In Popular Music, Quinn J. Troia

Lewis Honors College Thesis Collection

The Cyborg is a figure that has been used by feminist scholars as a metaphor for feminist issues and transgender identity because the embodiment of both transgender people and cyborgs challenges binary understandings of male/femaleness and human/nonhumanness respectively. This comparison has also suggested the potential of reading cyborgs as passing figures who attempt to perform normative social identities; however, scholarship analyzing Cyborg figures has not explored this in ways that are specific to trans-feminine people. By combining contributions from the theory of gender performativity and research on transgender linguistic practices and identity construction, I perform a visual and textual analysis …

Data For "Linking Previous Experiences To Behavior And Health In The Honey Bee (Apis Mellifera)"", Rebecca R. Westwick, Clare C. Rittschof, Gavin P. Brackett, Cameron E. Brown, Bethany J. Ison, Zainulabbeudin Syed, Anna M. Foose

Entomology Research Data

An organism’s ability to respond to changing conditions can be vital to its success. Indeed, plasticity is a common feature of living organisms. Much of the research in this area, though, has focused on effects caused by environmental conditions. What has received relatively less attention is how social experiences and broader features of an organism’s social environment can lead to long-lasting changes in health and behavior. This knowledge gap exists despite the well-documented existence of health and behavioral effects after social interactions in certain taxa such as humans.

Social insects such as honey bees provide an excellent opportunity to better …

Cross-Tailoring Integrative Alcohol And Risky Sexual Behavior Feedback For College Students: Protocol For A Hybrid Type 1 Effectiveness-Implementation Trial, Anne E. Ray, Eun-Young Mun, Melissa A. Lewis, Dana M. Litt, Jerod L. Stapleton, Lin Tan, David B. Buller, Zhengyang Zhou, Heather M. Bush, Seth Himelhoch

UK CARES Faculty Publications

Background: Underage drinking and related risky sexual behavior (RSB) are major public health concerns on United States college campuses. Although technology-delivered personalized feedback interventions (PFIs) are considered a best practice for individual-level campus alcohol prevention, there is room for improving the effectiveness of this approach with regard to alcohol-related RSB.

Objective: The aims of this study are to (1) evaluate the impact of a brief PFI that integrates content on alcohol use and RSB and is adapted to include a novel cross-tailored dynamic feedback (CDF) component for at-risk first-year college students and (2) identify implementation factors critical to the CDF’s …

Effect Of Reflex And Mechanical Decreases In Skin Perfusion On Thermal- And Agonist-Induced Eccrine Sweating In Humans, Kristen Metzler-Wilson, Milie M. Fang, Kenan Alibegovic, James W. Daggett, Seetharam C. Narra, Robert P. Dazé, Olivia G. Miller, Thad E. Wilson

UK CARES Faculty Publications

In humans, skin blood flux (SkBF) and eccrine sweating are tightly coupled, suggesting common neural control and regulation. This study was designed to separate these two sympathetic nervous system end-organ responses via nonadrenergic SkBF- decreasing mechanical perturbations during heightened sudomotor drive. We induced sweating physiologically via whole body heat stress using a high-density tube-lined suit (protocol 1; 2 women, 4 men), and pharmacologically via forearm intradermal microdialysis of two steady-state doses of a cholinergic agonist, pilocarpine (protocol 2; 4 women, 3 men). During sweating induction, we decreased SkBF via three mechanical perturbations: arm and leg dependency to engage the cutaneous …

Massachusetts Prevalence Of Opioid Use Disorder Estimation Revisited: Comparing A Bayesian Approach To Standard Capture-Recapture Methods, Jianing Wang, Nathan Doogan, Katherine L. Thompson, Dana Bernson, Daniel Feaster, Jennifer Villani, Redonna Chandler, Laura F. White, David Kline, Joshua A. Barocas

Statistics Faculty Publications

Background: The National Survey on Drug Use and Health (NSDUH) estimated the prevalence of opioid use disorder (OUD) among the civilian, noninstitutionalized people aged 12 years or older in Massachusetts as 1.2% between 2015 and 2017. Accurate estimation of the prevalence of OUD is critical to the success of treatment and resource planning. Various indirect estimation approaches have been used but are subject to data availability and infrastructure-related issues.

Methods: We used 2015 data from the Massachusetts Public Health Data Warehouse (PHD) to compare the results of two approaches to estimating OUD prevalence in the Massachusetts population. First, we used …

Cannabinoid Poisoning-Related Emergency Department Visits And Inpatient Hospitalizations In Kentucky, 2017 To 2019, Stevie C. Britch, Sharon L. Walsh, Rachel Vickers-Smith, Shanna Babalonis, Svetla Slavova

Center on Drug and Alcohol Research Faculty Publications

Background and objectives: Cannabis is the most used federally illicit substance. Due to widespread medicinal use and state-level legalization, public perceptions of cannabis have shifted toward the assumption that cannabis is safe. However, cannabinoids can cause adverse medical complications that may lead people to seek treatment. This study characterized cannabinoid poisoning-related medical encounters, poisoning involving cannabinoids and other psychoactive substances, and cannabinoid poisoning-related cardiac complications. Methods: Administrative billing data for emergency department visits and inpatient hospitalizations in acute care facilities with a discharge date from January 1, 2017 to December 31, 2019 were used to characterize cannabinoid poisoning events in …

Evaluating A Rapid Coaching Intervention That Includes Interdisciplinary Collaboration: Teaching A Parent Naturalistic Strategies, Lauren Reiss

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

Parents of young children with or at risk for disabilities face added stress and challenges every day. This study implemented a rapid coaching intervention to teach a parent naturalistic language interventions such as mapping language onto their child's play, narrating their own play, and arranging the environment. In addition, parents were trained to use a milieu teaching procedure. In addition, a pre-service behavior interventionist and speech-language pathologist collaborated on selecting instructional targets for the child.

An Exploration Of Athlete Thoughts And Perceptions Of Cohesion In Coacting Sports, Jared Scott Hrabcak

Theses and Dissertations--Kinesiology and Health Promotion

Cohesion is a central element in group dynamics that contributes to a team’s functioning and performance. Most of the cohesion research to date has focused on the dynamic within interacting sport teams (i.e., football, basketball, soccer) but has looked past coacting teams (i.e., golf, tennis, cross-country running). While interacting sports command worldwide popularity, a significant portion of student athletes compete in coacting sports and represent the bulk of NCAA affiliated participants on the world stage at the Olympics. Thus, with such status on the world stage of competition, the investigation of coacting sports is justified. Therefore, the purpose of this …

Food Insecurity On College Campuses: Addressing The Issue Through A Student-Centered Perspective, Thomas Ard

Theses and Dissertations--Kinesiology and Health Promotion

Research indicates food insecurity (FI) has become a consistent challenge for college students. However, more is needed regarding the students' lived experiences of food insecurity following the COVID-19 pandemic. Universities play a vital role in assisting students with food insecurity through food assistance programs, on-campus resources, and financial help, which impacts their physiological needs and academic performance. A better understanding of what influences students' perceptions and decisions about whether to engage in these resources is essential.

This dissertation's purpose was to explore how college students living with food insecurity experience engaging in food assistance programs (FAP). The study used a …

Association Of Notch3 With Elastic Fiber Dispersion In The Infrarenal Abdominal Aorta Of Cynomolgus Monkeys, Sohei Ito, Naofumi Amioka, Michael K. Franklin, Pengjun Wang, Ching-Ling Liang, Yuriko Katsumata, Lei Cai, Ryan E. Temel, Alan Daugherty, Hong S. Lu, Hisashi Sawada

Saha Cardiovascular Research Center Faculty Publications

BACKGROUND: The regional heterogeneity of vascular components and transcriptomes is an important determinant of aortic biology. This notion has been explored in multiple mouse studies. In the present study, we examined the regional heterogeneity of aortas in nonhuman primates.

METHODS: Aortic samples were harvested from the ascending, descending thoracic, suprarenal, and infrarenal regions of young control monkeys and adult monkeys with high fructose consumption for 3 years. The regional heterogeneity of aortic structure and transcriptomes was examined by histological and bulk RNA sequencing analyses, respectively.

RESULTS: Immunostaining of CD31 and αSMA (alpha-smooth muscle actin) revealed that endothelial and smooth muscle …