Digital Commons Network^™

Insulin-Like Growth Factor Ii Signaling In Neoplastic Proliferation Is Blocked By Transgenic Expression Of The Metalloproteinase Inhibitor Timp-1, David C. Martin, John L. Fowlkes, Bojana Babic, Rama Khokha

Pediatrics Faculty Publications

Insulin-like growth factor (IGF) II is overexpressed in many human cancers and is reactivated by, and crucial for viral oncogene (SV40 T antigen, [TAg])-induced tumorigenesis in several tumor models. Using a double transgenic murine hepatic tumor model, we demonstrate that tissue inhibitor of metalloproteinase 1 (TIMP-1) blocks liver hyperplasia during tumor development, despite TAg-mediated reactivation of IGF-II. Because the activity of IGFs is controlled by IGF-binding proteins (IGFBPs), we investigated whether TIMP-1 overexpression altered the IGFBP status in the transgenic liver. Ligand blotting showed that IGFBP-3 protein levels were increased in TIMP-1-overexpressing double transgenic littermates, whereas IGFBP-3 mRNA levels were …

Method Of Protecting Against Neuron Loss, Philip W. Landfield

Pharmacology and Nutritional Sciences Faculty Patents

The present invention pertains to a method of protecting against neuron loss in a subject by administering a compound that protects against neuron loss by acting through a vitamin D receptor. Some of these compounds may prevent or retard neuron loss by regulating intraneuronal and/or peripheral calcium and phosphate levels. Other compounds of the invention act through a vitamin D receptor to protect against neuron loss through mechanisms not involving calcium or phosphate regulation. A preferred compound is a biologically active form of vitamin D, a precursor, metabolite, or analog of vitamin D. A preferred form of vitamin D is …

Polynucleotides Related To Monoclonal Antibody 1a7 And Use For The Treatment Of Melanoma And Small Cell Carcinoma, Malaya Chatterjee, Kenneth A. Foon, Sunil K. Chatterjee

Microbiology, Immunology and Molecular Genetics Faculty Patents

The present invention relates to monoclonal antibody 1A7. This is an anti-idiotype produced by immunizing with an antibody specific for ganglioside GD2, and identifying a hybridoma secreting antibody with immunogenic potential in a multi-step screening process. Also disclosed are polynucleotide and polypeptide derivatives based on 1A7, including single chain variable region molecules and fusion proteins, and various pharmaceutical compositions. When administered to an individual, the 1A7 antibody overcomes immune tolerance and induces an immune response against GD2, which comprises a combination of anti-GD2 antibody and GD2-specific T cells. The invention further provides methods for treating a disease associated with altered …

The Hidden Work Of The Farm Homemaker, Deborah B. Reed, Susan C. Westneat, Steven R. Browning, Lana Skarke

Preventive Medicine and Environmental Health Faculty Publications

Despite women’s involvement in agricultural production, the work role of women residing in farm households has not been thoroughly examined. Data collected in 1994-1995 as part of the NIOSH-sponsored Farm Family Health and Hazard Surveillance Project were used to address task issues and health status of farm women in Kentucky. In 1996, the farm woman component of the Kentucky study was replicated in five counties in west Texas, allowing an examination of farm women in two large agricultural states. The Kentucky study employed a two-stage cluster design;the Texas study was based on a systematic quota sample of farms. Both studies …

Conversion Of New Circle Road To A Limited Access Highway, Steven M. Henderson, Nikiforos Stamatiadis

Kentucky Transportation Center Research Report

The objectives of this study were to first evaluate the existing traffic conditions along the NE part of New Circle Road and investigate the use of unconventional left turn treatments, as well as other access restrictions to improve the operating conditions of New Circle Road. The alternatives examined include a do-nothing alternative, the addition of one through lane per direction, the use of median U-turns at various locations, and combinations of them. Restrictive left turn strategies proved to be a more successful tool for traffic management on New Circle Road than simply adding a lane in each direction. Using median …

Laser Skin Graft Harvesting Apparatus And Related Method, David S. Kirn

Surgery Faculty Patents

A laser dermatome is disclosed for harvesting and meshing grafts of skin. A roller driven by a motor lifts the leading edge of a portion of skin for cutting by a beam of light generated by a laser. Adhesive tape attached to the roller aids in lifting the portion of skin and is further utilized to secure the severed portion of skin to the roller. A stage mounted atop an axle supports the laser or a beam director. The movement of the stage is controlled by second and third motors which drive the stage along or rotate it about the …

Methods Of Treating Eye Conditions With Human Leukocyte Elastase (Hle) Inhibitory Agents, George A. Digenis, Charles Khouri

Pharmaceutical Sciences Faculty Patents

A method of reducing corneal scarring or fibroblast proliferation comprises applying to an area of a subject's eye afflicted with the condition a corneal scar-fibroblast proliferation-reducing amount of a free or polymer-bound HLE inhibitory agent under conditions and for a period of time effective to attain the desired effect. A method of reducing neovascularization of corneal scar tissue comprises applying to an area of a subject's eye afflicted with the condition a neovascularization-inhibitory amount of a free or polymer-bound HLE inhibitory agent under conditions and for a period of time effective to attain the desired effect.

26th Annual Midwest/Midsouth Estate Planning Institute, Office Of Continuing Legal Education At The University Of Kentucky College Of Law, Turney P. Berry, Jerold I. Horn, David Ackerman, Sheldon G. Gilman, Cassie Spencer, Theodore B. Atlass, John T. Bondurant, Eric A. Manterfield, Norvie L. Lay, James W. Turner, Jeffrey M. Yussman, Homer Parrent Iii, David Tachau

Continuing Legal Education Materials

Materials from the 26th Annual Midwest/Midsouth Estate Planning Institute held by UK/CLE in July 1999.

Street-Based Female Adolescent Puerto Rican Sex Workers: Contextual Issues And Health Needs, Margarita Burgos, Donna L. Richter, Belinda Reininger, Ann L. Coker, Ruth Saunders, Margarita Alegria, Mildred Vera

CRVAW Faculty Journal Articles

Adolescent sex workers potentially have many health needs but are included rarely in health assessments; therefore, little is known about their needs or how to reach them. This study examines the motivations, social context, and health needs of street-based adolescent sex workers. The results show these youths are more likely to experience negative health outcomes, such as unintended pregnancies and sexually transmitted infections, when they are using drugs or are depressed. These findings suggest the need for comprehensive programming to include individual, interpersonal, and greater environmental interventions. Examples for reaching adolescent sex workers are discussed.

Library Notes: Selected Acquisitions [V. 14, No. 2]

The Kentucky Review

No abstract provided.

Kentucky's Road Fund Tax Structure, Ron Zimmer, Merl Hackbart, Steve Calabrese, Susana Luzuriaga

Kentucky Transportation Center Research Report

In recent years, there has been a great deal of discussion of whether the incoming Road Fund revenue is sufficient to meet the needs of Kentucky's Highways System. Many have suggested a policy of raising the current tax rates on motor fuels as a way of enhancing the financial health of the Road Fund. This current study examines the sources of the Road Fund and evaluates the sources of revenue in terms of stability, equity, competitiveness, and adequacy. Finally, the study examines the impact various changes in motor fuel taxes would have on revenue.

Adolescent Violence As Viewed By High School Students, Hatim A. Omar

Pediatrics Faculty Publications

On April 20^th, 1999 two high school students from Columbine High School in Littleton, Colorado armed with a variety of firearms managed to kill 15 persons and injure many others in their school. Following this incident, a wave of bomb threats to schools throughout the country erupted and several adolescents and adults were arrested. Ten days following the incident we surveyed a total of 412 students from urban area high schools. All students have heard of the shooting, 80% felt sad about the incident, 90% felt hate for the shooters and sad for the victims. 3% felt indifferent …

A Report On County Road Program Finance (Fiscal Year 1997-98), Patsy Anderson, Kris Koehler

Kentucky Transportation Center Research Report

This report reflects the findings of a study of county road finance in Kentucky. Statistics contained in the report were derived from financial statements submitted by the counties to the Kentucky Department of Local Government.

Physical Violence During Pregnancy: Maternal Complications And Birth Outcomes, Vilma E. Cokkinides, Ann L. Coker, Maureen Sanderson, Cheryl Addy, Lesa Bethea

CRVAW Faculty Journal Articles

Objective: To assess the association between physical violence during the 12 months before delivery and maternal complications and birth outcomes.

Methods: We used population-based data from 6143 women who delivered live-born infants between 1993 and 1995 in South Carolina. Data on women's physical violence during pregnancy were based on self-reports of partner-inflicted physical hurt and being involved in a physical fight. Outcome data included maternal antenatal hospitalizations, labor and delivery complications, low birth weights, and preterm births. Odds ratios and 95% confidence intervals were calculated to measure the associations between physical violence, maternal morbidity, and birth outcomes.

Results: The prevalence …

19th Annual Conference On Legal Issues For Financial Institutions, Office Of Continuing Legal Education At The University Of Kentucky College Of Law, M. Thurman Senn, Michael Whiteman, Garry Throckmorton, James H. Newberry, Benjamin Cowgill Jr., R. Gregg Hovious, Victor B. Maddox, S. Tracy Jefferson, J. Mark Grundy, Erin N. O'Daniel, Lea Pauley Goff, Walter R. Byrne, Debra K. Stamper, John T. Mcgarvey, J. Rick Jones

Continuing Legal Education Materials

Materials from the 19th Annual Conference on Legal Issues For Financial Institutions held by UK/CLE in May 1999.

Tort & Sweet: An Occasional Law Library Newsletter, May 1999, University Of Kentucky Law Library

Tort & Sweet: An Occasional Law Library Newsletter

No abstract provided.

Hygiene Of The Optical, Peter Gray

disClosure: A Journal of Social Theory

No abstract provided.

Southeastern Law Librarian Spring 1999, Seaall

Newsletters

No abstract provided.

Seaall Chapter Handbook And Procedures Manual, April 1999, Seaall

Administrative Materials

This handbook is a revised and updated version of the March 1998 SEAALL Chapter Handbook and Procedures Manual.

Aluminum And Phosphorus Separation: Application To Preparation Of Target From Brain Tissue For 26Al Determination By Accelerator Mass Spectrometry, Russell D. Brauer, J. David Robertson, Pankaj Sharma, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

Acid digested brain containing 4 mg added ²⁷Al was ashed at 1000°C to prepare an Al₂O₃ target for accelerator mass spectrometry (AMS) analysis of ²⁶Al. A glass-like material usually resulted which was thought to be aluminum (Al) oxyphosphate. The separation of Al and phosphate was investigated. Al, but not phosphate, was bound by a cation exchange resin (AG 50-X8). Hydrofluoric acid eluted the Al from the resin. Removal of phosphate from acid digested brain by this method produced an amorphous material after ashing that was easier to recover from the porcelain crucible and had a …

When Warnings Alone Won’T Do: A Reply To Professor Phillips, Richard C. Ausness

Law Faculty Scholarly Articles

In his paper, Professor Phillips contends that questions about the adequacy of a product's design should be resolved by the use of a risk-utility test and that the existence of an adequate warning should merely be one factor for the jury to take into account. This is essentially the position espoused by the Restatement (Third) of Torts: Products Liability (hereinafter Third Restatement), section 2, comment l. On the other hand, Professor PhiIlips is very critical of subsections 6(c) and 6(d). These provisions establish liability for the sellers of prescription drugs and medical devices. Section 6(c), which is concerned …

Role Of Protein Kinase C In The Translational Regulation Of Lipoprotein Lipase In Adipocytes, Gouri Ranganathan, Rami Kaakaji, Philip A. Kern

Clinical and Translational Science Faculty Publications

The hypertriglyceridemia of diabetes is accompanied by decreased lipoprotein lipase (LPL) activity in adipocytes. Although the mechanism for decreased LPL is not known, elevated glucose is known to increase diacylglycerol, which activates protein kinase C (PKC). To determine whether PKC is involved in the regulation of LPL, we studied the effect of 12-O-tetradecanoyl phorbol 13-acetate (TPA) on adipocytes. LPL activity was inhibited when TPA was added to cultures of 3T3-F442A and rat primary adipocytes. The inhibitory effect of TPA on LPL activity was observed after 6 h of treatment, and was observed at a concentration of 6 nM. …

Formulations And Methods To Treat And Prevent Equine Protozoal Myeloencephalitis, David E. Granstrom, Thomas Tobin

Veterinary Science Faculty Patents

The present invention provides formulations useful to treat EPM. It also provides methods to treat EPM in a horse in need of such treatment, comprising administering a pharmaceutically effective amount of a triazine-based anti-coccidial. Preferred are methods to treat EPM using clazuril, diclazuril, toltrazuril or letrazuril. The present invention also provides methods to prevent S. neurona infection in horses comprising administering a prophylactic amount of a triazine-based anticoccidial. Preferred is a method to prevent S. neurona infection by using clazuril, diclazuril, toltrazuril or letrazuril, alone or in combination with other known therapeutics.

Knotted Log Rolls Off Truck And Kills Logger At Sawmill, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 42-year-old logger (the victim) was killed when he was struck by a log rolling off a loaded truck at a sawmill. At about 6:10 a.m., the victim and the truck driver arrived at the sawmill with a load of logs on the 20-foot flatbed truck. The stack of logs was rounded above the height of the 53-inch standards and secured by only one chain on the middle of the load. When they arrived, the victim got out of the truck and assisted the driver in backing the vehicle into place for unloading. The victim was in view of the …

Portocaval-Right Atrial Shunt, Bradley B. Hill

Surgery Faculty Patents

A shunt includes a tubular body having first and second legs at a proximal end and a third leg at a distal end. A fluid distensible balloon and cooperating insufflation conduit are carried on the tubular body. The first leg of the tubular body includes a longitudinal slit for receiving the second leg whereby the first and second legs may be positioned substantially coaxial so as to allow easier introduction of the shunt into the blood vessel of a patient. Similarly, the second leg having a longitudinally slit for receiving a portion of the cooperating insufflation conduit and also holding …

Implant Pre-Treated For Reducing The Generation Of Wear Particulates, David A. Pienkowski, Kwon-Yong Lee

Biomedical Engineering Faculty Patents

A method is provided for reducing the amount of wear particulates generated by a total joint orthopaedic implant. The implant consists of two matched articulating components wherein at least one of the components is made of polymer or other material with similar physical properties. The method includes the steps of placing the total joint orthopaedic implant in a fluid bath and articulating the implant in the fluid bath for at least 1,000 cycles. The articulation may be performed in three stages. In the first, the implant is articulated under a load of substantially 0.1-500 Newtons with sliding speeds of substantially …

15th Annual Environmental Law Institute, Office Of Continuing Legal Education At The University Of Kentucky College Of Law, W. Blaine Early Iii, Timothy J. Hagerty, E. Allen Kyle, Lee Colten, Tom C. Van Arsdall, John R. Leathers, Clinton J. Elliott, Thomas J. Fitzgerald, Jeffrey M. Sanders, Richard H. Underwood, Bradley E. Diillon, Henry L. Stephens, Lauren Anderson, David A. Smart

Continuing Legal Education Materials

Materials from the 15th Annual Environmental Law Institute held by UK/CLE in March 1999.

Kentucky Transportation Cabinet: Employee Satisfaction Survey Report, Bennett Tepper, Patsy Anderson

Kentucky Transportation Center Research Report

The purpose of this survey was to establish the baseline attitude of Kentucky Transportation Cabinet employees concerning work environment and morale.

Nebulized Nitroglycerin In Children With Pulmonary Hypertension Secondary To Congenital Heart Disease, Hatim Omar, Fangqi Gong, Mei Y. Sun, Stanley Einzig

Pediatrics Faculty Publications

Pulmonary hypertension continues to be a major cause of morbidity and mortality, despite new treatments. Since inhaled nitric oxide has been reported to be effective in some cases, we investigated using nebulized nitroglycerine to treat pulmonary hypertension in children with congenital heart disease. Four children (ages 6-72 months) with severe pulmonary hypertension secondary to congenital heart disease (all with membranous ventricular septal defect, undergoing cardiac catheterization) were given 3 cc of nebulized normal saline over 10 min as placebo control, followed by nebulized nitroglycerine (20 micrograms/Kg in 3 cc normal saline). Normal saline administration did not elicit any change, but …

How I Produce And Market Alfalfa Hay, John Nowak

Kentucky Alfalfa and Stored Forage Conference

John Nowak was born March 22, 1947, in New York City and was raised in Westchester County, just north of New York City. After graduating from Colorado State University with a B.S. degree in farm and ranch management, he entered the U.S. Army. John served on active duty from 1969 until 1978. In 1975, his Army career brought him to Fort Campbell, Kentucky, and he began farming part-time in Christian County in 1976. As with many "start-from-scratch" farmers, John's first farming efforts involved producing burley tobacco during the years 1976 through 1979. In 1979, he began a cow-calf and backgrounding …