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Bulldozer Owner/Operator Drowns While Trying To Repair A Pond, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

The Kentucky Fatality Assessment and Control Evaluation program was notified July 31, 2003, via newspaper surveillance, of an occupational fatality involving a 55-year-old bulldozer owner/operator. On July 29, 2003, a bulldozer owner / operator drowned in the cab of his machine as he was trying to find a leak in a pond dam. The operator had been hired by a local farm owner to find and repair a leak in one of the ponds on her farm. As the operator dug a trench through the earthen dam, a section at the top collapsed sending sludge into the trench. The water/sludge …

Filling The Poverty Gap, Then And Now, James P. Ziliak

University of Kentucky Center for Poverty Research Discussion Paper Series

The extent to which means-tested transfers, social insurance, and tax credits fill the gap between a family’s private resources and the poverty threshold is a periodic barometer of the social safety net. Using data on families from the Current Population Survey I examine how the level and composition of before- and after-tax and after-transfer poverty gaps changed in response to changes in the policy and economic landscapes over the past two decades. The estimates presented here indicate not only dramatic changes in the level and sources of income maintenance programs filling the poverty gap, but also dramatic changes in which …

Evaluation Of Methods To Protect Water Quality In Karst Areas: Phase I, Jennifer Webster, Dhandayudhapani Ramalingam, Sudhir Palle

Kentucky Transportation Center Research Report

The primary focus of this report is two-fold; to provide a literature review on what has been previously learned about highway runoff in relation to karsts aquifers and to characterize a karsts highway site in Kentucky that can be used to evaluate a variety of best management practices. From research findings, the main sources of pollutants in highway runoff came from vehicles, atmospheric fallout, and precipitation. The behavior of pollutants and their interaction with the environment can dictate where they will be found and how to best minimize their effects. Although it would seem that traffic volumes would greatly influence …

Flexible Recording/High Energy Electrode Catheter With Anchor For Ablation Of Atrial Flutter By Radio Frequency Energy, Chien-Suu Kuo, John G. Gurley

Internal Medicine Faculty Patents

An electrode catheter is provided having a predetermined flexibility throughout the entire length or at least at the contact portion, such as the electrode region, to allow for the molding of the contact portion such that it conforms to the shape of the heart at a preselected desired target area, such as the isthmus between the inlet of inferior vena cava and posterior tricuspid annulus. The catheter also includes a guiding sheath that is preferably semirigid and may be pre-shaped with at least one bend or angulation to assist in molding to ensure that the electrode region overlies the desired …

Transgenic Mice Expressing Lipoprotein Lipase In Adipose Tissue: Absence Of The Proximal 3′-Untranslated Region Causes Translational Upregulation, Lori L. Hensley, Gouri Ranganathan, Elke M. Wagner, Brian D. Wells, Joseph C. Daniel, Diane Vu, Clay F. Semenkovich, Rudolf Zechner, Philip A. Kern

Clinical and Translational Science Faculty Publications

Lipoprotein lipase (LPL) is a key enzyme in lipoprotein and adipocyte metabolism. Defects in LPL can lead to hypertriglyceridemia and the subsequent development of atherosclerosis. The mechanisms of regulation of this enzyme are complex and may occur at multiple levels of gene expression. Because the 3′-untranslated region (UTR) is involved in LPL translational regulation, transgenic mice were generated with adipose tissue expression of an LPL construct either with or without the proximal 3′-UTR and driven by the aP2 promoter. Both transgenic mouse colonies were viable and expressed the transgene, resulting in a 2-fold increase in LPL activity in white adipose …

System And Method For Intranasal Administration Of Lorazepam, Daniel Wermeling

Pharmacy Practice and Science Faculty Patents

A therapeutic composition of lorazepam and its pharmaceutically acceptable derivatives are provided for intranasal administration of at least one predetermined volumetric unit dose in the form of a spray by means that delivers one or more therapeutically prescribed unit doses that are highly accurate as to the volume discharged and which leave no significant quantity of the composition in the delivery means.

Chinese Immigrant Restaurant Owner Electrocuted, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On August 12, 2002, at 6:40 pm, a Chinese immigrant restaurant owner (decedent) died after being electrocuted by 110 volts of electricity. The restaurant owner and his wife were refurbishing a restaurant they had recently purchased. They spent the day cleaning the kitchen area while waiting for a washing machine repairman to arrive. Earlier in the day, the decedent had removed the electric cord to a single door, glass-fronted vertical cooler on rollers. He replaced the electrical cord from the unit with an electrical cord he had fabricated himself by attaching one end of a 10 foot length of 10/2 …

Pathogen- Or Elicitor-Inducible Transcription Regulatory Element From The Tobacco 5-Epi-Aristolochene Synthase Gene And Plants Transformed Therewith, Joseph Chappell, Shaohui Yin, Catherine Cornett

Pharmaceutical Sciences Faculty Patents

A tobacco epi-5-aristolochene synthase transcriptional regulatory element functional in plants, plant tissue and in plant cells for pathogen inducible gene expression and a method for increasing the transcriptional expression of downstream genetic information in plants, plant tissue and plant cells are disclosed.

Vegf164-Mediated Inflammation Is Required For Pathological, But Not Physiological, Ischemia-Induced Retinal Neovascularization, Susumu Ishida, Tomohiko Usui, Kenji Yamashiro, Yuichi Kaji, Shiro Amano, Yuichiro Ogura, Tetsuo Hida, Yoshihisa Oguchi, Jayakrishna Ambati, Joan W. Miller, Evangelos S. Gragoudas, Yin-Shan Ng, Patricia A. D'Amore, David T. Shima, Anthony P. Adamis

Ophthalmology and Visual Science Faculty Publications

Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted. During pathological neovascularization, both the absolute and relative expression levels for VEGF₁₆₄ increased to a greater degree than during physiological neovascularization. Furthermore, extensive leukocyte adhesion was observed at the leading edge of pathological, but not physiological, neovascularization. When a VEGF₁₆₄-specific neutralizing aptamer was administered, it potently suppressed the leukocyte adhesion and pathological neovascularization, whereas it had little or no effect on physiological neovascularization. In parallel experiments, genetically altered VEGF_{164 …}

Group Therapy For Incarcerated Women Who Experienced Interpersonal Violence: A Pilot Study, Rebekah G. Bradley, Diane R. Follingstad

CRVAW Faculty Journal Articles

This study evaluated effectiveness of group therapy for incarcerated women with histories of childhood sexual and/or physical abuse. The intervention was based on a two-stage model of trauma treatment and included Dialectical Behavior Therapy skills and writing assignments. We randomly assigned 24 participants to group treatment (13 completed) and 25 to a no-contact comparison condition (18 completed). We evaluated treatment effects, using the Beck Depression Inventory, Inventory of Interpersonal Problems, and Trauma Symptom Inventory. The data demonstrate significant reductions in PTSD, mood, and interpersonal symptoms in the treatment group.

Polymethylmethacrylate Augmented With Carbon Nanotubes, David A. Pienkowski, Rodney J. Andrews

Center for Applied Energy Research Faculty Patents

An augmented synthetic resin is provided. That resin includes carbon nanotubes dispersed in a polymethylmethacrylate matrix. The method of preparing this synthetic resin includes the mixing and disaggregating of the carbon nanotubes.

While Working, Don't Take The Fall!, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Falls

To prevent falls while working:

• Always use appropriate fall protection systems.
• Conduct a thorough assessment in and around the work area to identify existing and potential fall hazards.
• Both employers and subcontractors should provide comprehensive fall protection training for their employees, that is site specific.
• Place warning signs in front of work areas and around perimeters where fall hazards have been identified.
• Don’t place yourself in a potentially hazardous situation. Workers should always stay alert.

Mientras Trabaja, No Se Caiga!, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Falls

Para prevenir caídas durante en trabajo:

• Siempre use el sistema apropiado de caídas. Hacer una evaluación meticulosa dentro y alrededor del área de trabajo, para identificar los riesgos existentes y potenciales de caídas.
• Los empleadores y los subcontratistas deben proveer de un entrenamiento de protección de caídas a sus empleados, en un lugar en especifico.
• Poner señales de alerta enfrente del área de trabajo y alrededor de los perímetros donde el riesgo ha sido identificado.
• No se ubique en una situación de potencialmente riesgoso. Los trabajadores siempre necesitan estar alerta.

Drivers And Riders Need To Work Safely While In And Around Refuse Collection Vehicles, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Motor Vehicle

To prevent refuse collection injuries:

• Employers should provide comprehensive employee safety training programs including identification of hazards posed by other motor vehicles in the area, and by riding on or working near moving refuse collection vehicles.
• Employers and employees should have routine maintenance programs for refuse collection vehicles including proper condition of tires.
• Don’t place yourself in a potentially hazardous situation. Workers should always stay alert.

Tanto Conductores Como Recolectores Necesitan Trabajar Con Seguridad Al Situarse Cerca O Dentro De Vehículos De Recolección De Basura, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Motor Vehicle

Para prevenir lesiones en la labor de recolección de residuos:

Los empleadores deberán proporcionar programas de entrenamiento de seguridad adaptados a la labor de sus empleados que incluyan la identificación de los riesgos que suponen otros automotores movilizándose en el área, así como el desplazamiento sobre o cerca de vehículos de recolección de residuos en movimiento.

Tanto empleadores como empleados deben asistir a programas de recolección de residuos, con cursos que incluyan el mantenimiento apropiado de las llantas.

Evite exponerse usted mismo a situaciones potencialmente riesgosas. Los trabajadores siempre deben estar atentos.

Exit Routes From Welfare: Examining Barriers To Employment, Demographic And Human Capital Factors, Colleen Heflin

University of Kentucky Center for Poverty Research Discussion Paper Series

This paper investigates how barriers to employment, human capital, and demographic characteristics affect women’s exit routes off welfare. Specifically, I address two questions. First, what are the avenues through which women leave welfare? Second, are mental and physical health problems, domestic violence, and lack of access to transportation, characteristics that have been ignored in other studies of welfare dynamics, associated with different welfare exit routes? Using multinomial logistic regression and data from the Women’s Employment Survey, this project examines the specific exit route chosen in detail and goes beyond general dynamics associated with welfare exit in order to capture the …

Adiponectin Expression From Human Adipose Tissue: Relation To Obesity, Insulin Resistance, And Tumor Necrosis Factor-Α Expression, Philip A. Kern, Gina B. Di Gregorio, Tong Lu, Negah Rassouli, Gouri Ranganathan

Clinical and Translational Science Faculty Publications

Adiponectin is a 29-kDa adipocyte protein that has been linked to the insulin resistance of obesity and lipodystrophy. To better understand the regulation of adiponectin expression, we measured plasma adiponectin and adipose tissue adiponectin mRNA levels in nondiabetic subjects with varying degrees of obesity and insulin resistance. Plasma adiponectin and adiponectin mRNA levels were highly correlated with each other (r = 0.80, P < 0.001), and obese subjects expressed significantly lower levels of adiponectin. However, a significant sex difference in adiponectin expression was observed, especially in relatively lean subjects. When men and women with a BMI2were compared, women had a twofold higher percent body fat, yet their plasma adiponectin levels were 65% higher (8.6 ± 1.1 and 14.2 ± 1.6 μg/ml in men and women, respectively; P < 0.02). Plasma adiponectin had a strong association with insulin sensitivity index (S_I) (r = 0.67, P < 0.0001, n = 51) that was not affected by sex, but no relation with insulin secretion. To separate the effects of obesity (BMI) from S_I, subjects who were discordant for S_I were matched for BMI, age, and sex. Using this approach, insulin-sensitive subjects demonstrated a twofold higher plasma level of …

Psychosocial Stress And Cervical Neoplasia Risk, Ann L. Coker, Sharon M. Bond, Margaret M. Madeleine, Kathryn J. Luchok, Lucia Pirisi

CRVAW Faculty Journal Articles

OBJECTIVE: We assessed the association between psychosocial stress and preinvasive cervical neoplasia development controlling for HR-HPV infection.

METHODS: This case-control study enrolled low-income women receiving family planning services at health department clinics. There were 59 cases with biopsy confirmed HSIL and 163 with low-grade SIL and 160 controls with normal cervical cytology. A modified SLE scale was used to measure stressful events and the perceived impact of the event in the prior 5 years. Unconditional logistic regression was used to assess SIL risk and stressful events scores and by subscales.

RESULTS: After adjusting for age, HR-HPV infection, and lifetime number …

Adolescent Violence Prevention: A Case Presentation, Hatim A. Omar, Joan Griffith

Pediatrics Faculty Publications

Violence in adolescence has seen an increase since the 1990s with dramatic statistics on violent death and risk behaviors. School violence has been focused upon by a huge media coverage of especially violent cases that could have had some endemic consequences worldwide. We present a case of a 14 year old white male with change in school behavior, strategies for the case investigation, its results, and long term prevention. Other research has shown that preventive measures during pregnancy, infancy and childhood can prevent adolescent and adult delinquency.

41 Year-Old Male Dies After Being Struck In The Head With An Auger, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On October 23, 2002, a 41 year-old male (decedent) died after he was hit in the head with the handle of an auger. He was part of a four-member work crew tying water lines of private residences into a municipal water line. He was injured while backing the auger out of the hole and the handle became tangled with the rotating auger bit which caused the handle to flip up and strike him in the head, twice. After being struck, with co-workers following him trying to convince him to sit down, he walked away from the site until emergency rescue …

21 Year-Old Male Dies When Struck In The Head With A Track Hoe Bucket, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On November 22, 2002, a 21-year-old male laborer died after being hit in the head with the bucket of a track hoe. He was wearing a safety helmet at the time of the incident. There were six to seven workers at the job site when the incident occurred. The work crew was pouring the footing for a retaining wall as part of a bridge for a private runway being built. The concrete form collapsed, trapping one worker and almost trapping two others. The decedent had left to retrieve a shovel to help free the trapped co-worker. As he retrieved the …

Hispanic Worker Dies In Tractor Rollover, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

On May 31, 2002, a 25 year-old Hispanic worker (decedent) died when the gasoline-powered tractor he was operating overturned. The incident occurred when the decedent mowed a steep embankment along a rural roadside which caused the tractor to flip over a 3-strand, barbed wire fence, pinning the operator under the seat and tire. A passing motorist noticed the overturned tractor and notified 911, emergency services. Local police and fire departments arrived at the scene, as did a local ambulance. The coroner arrived and declared the tractor operator dead due to asphyxiation and crushing injuries to the chest.

• Tractors should be …

Neuronal Cell Model And Methods Of Use Thereof, Craig S. Miller, Robert J. Jacob, Robert J. Danaher

Microbiology, Immunology and Molecular Genetics Faculty Patents

We previously described a novel in vitro model of a non-productive herpes simplex virus type 1 (HSV-1) infection in neurally-differentiated (ND)-PC12 cells that allows for inducible virus replication upon forskolin and heat stress (HS) treatment. In this research, we further characterized the model with respect to HSV-2 strain 333. We found that: (i) ND-PC12 cells are non-permissive to HSV-2 replication; (ii) HSV-2 can establish a quiescent infection, like HSV-1, in ND-PC12 cells with the transient use of acycloguanosine (ACV); however unlike HSV-1, anti-viral conditions are not obligatory to establish and maintain a quiescent state; (iii) the quiescent state is maintained …

Kentucky River Basin: Unified Long-Range Water Resources Plan. Executive Summary, Lindell E. Ormsbee, Malissa Mcalister

KWRRI Research Reports

No abstract provided.

Development Of Procedures For Identifying High-Crash Locations And Prioritizing Safety Improvements, Kenneth R. Agent, Lenahan O'Connell, Eric R. Green, Doug Kreis, Jerry G. Pigman, Neil Tollner, Eric C. Thompson

Kentucky Transportation Center Research Report

The objectives of this study were to review and analyze the current procedures for identifying high-crash locations and evaluating and prioritizing roadway safety improvements at high-crash locations, and to recommend improved methods. Several tasks were undertaken to accomplish these objectives, including the following:

• Review of program guidelines and procedures used by other states to prioritize improvements at high-crash locations
• Review and documentation of Kentucky’s current procedures
• Update of Kentucky’s Crash Buildup Program software to be compatible with the 2000 crash report form
• Development of new software to assist in estimating the benefits and costs of potential projects for inclusion in …

Synthases, Joe Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.

Transdemal Delivery Of Opioid Antagonist Prodrugs, Audra L. Stinchcomb, Peter W. Swaan

Pharmaceutical Sciences Faculty Patents

A composition, a method and an apparatus for transdermally delivering an effective amount of opioid antagonists derived from prodrugs for treatment of eating disorders, narcotic dependence and alcoholism. In addition, the present invention relates to a composition, a method and an apparatus for transdermally delivering an effective amount of an opioid and opioid antagonist derived from an opioid agonist and one of an opioid antagonist and a prodrug for treatment of pain.

Synthases, Joe Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.

Forage News [2003-05], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Losses and Drying Rates of Different Conditioners
• UK Robinson Station Host All Commodity Field Day
• Impact of Alfalfa Cutting Height on Yield and Quality
• Kentucky Plays Prominent Role at National Level
• Cool Season Pastures and Meat Goat Interaction
• Relationship Between Yield and Quality
• Upcoming Events

Assessment And Modeling Of Stream Mitigation Procedures [2003], Bernadette S. Dupont, Sudhir Palle

Kentucky Transportation Center Research Report

As population increases, so does the need to improve and augment the road network. Construction of new roadways or modification of existing roads often requires diversion or modification of streams. If a stream is disturbed, government regulations require mitigation or compensatory replacement of the affected area in a similar environment. Stream mitigation is of particular importance in Kentucky, as Kentucky ranks second in the United States for having the most miles of waterways. Consequently, stream mitigation has become a significant factor in roadway construction costs. To date, no studies have been made to assess the execution of the mitigation plans …