Digital Commons Network^™

Method Of Inhibiting Alu Rna And Therapeutic Uses Thereof, Jayakrishna Ambati

Ophthalmology and Visual Science Faculty Patents

The presently-disclosed subject matter includes methods of identifying an Alu RNA inhibitor, and methods and compo sitions for inhibiting Alu RNA. Methods and compositions can be used for the treatment of geographic atrophy and other conditions of interest.

Similar Promotion Of Abeta1-42 Fibrillogenesis By Native Apolipoprotein E Epsilon3 And Epsilon4 Isoforms, David Sweeney, Ralph Martins, Harry Levine, Jonathan D. Smith, Sam Gandy

Sanders-Brown Center on Aging Faculty Publications

The apolipoprotein E epsilon4 allele contributes to the genetic susceptibility underlying a large proportion (~40-60%) of typical, sporadic Alzheimer disease. Apolipoprotein E deficient mice made transgenic for human apolipoprotein E epsilon4 accumulate excess cerebral amyloid when compared to similarly prepared mice expressing human apolipoprotein E epsilon3. Therefore, it is important to search for relevant interactions(s) between apolipoprotein E epsilon4 and Abeta in order to clarify the biological role for apolipoprotein E epsilon4 in Alzheimer disease. Using a thioflavine T (ThT)-based assay, we have investigated the effects of native human apolipoprotein E isoforms on the kinetics of Abeta fibrillogenesis. No obvious …

From Biomedicine To Natural History Research: Est Resources For Ambystomatid Aalamanders, Srikrishna Putta, Jeramiah J. Smith, John A. Walker, Mathieu Rondet, David W. Weisrock, James Monaghan, Amy K. Samuels, D. Kevin Kump, David C. King, Nicholas J. Maness, Bianca Habermann, Elly Tanaka, Susan V. Bryant, David M. Gardiner, David M. Parichy, S. Randal Voss

Biology Faculty Publications

BACKGROUND: Establishing genomic resources for closely related species will provide comparative insights that are crucial for understanding diversity and variability at multiple levels of biological organization. We developed ESTs for Mexican axolotl (Ambystoma mexicanum) and Eastern tiger salamander (A. tigrinum tigrinum), species with deep and diverse research histories.

RESULTS: Approximately 40,000 quality cDNA sequences were isolated for these species from various tissues, including regenerating limb and tail. These sequences and an existing set of 16,030 cDNA sequences for A. mexicanum were processed to yield 35,413 and 20,599 high quality ESTs for A. mexicanum and A. t. tigrinum, respectively. Because the …

Forage News [2004-08], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Warren Thompson Receives International Recognition
• Forage Website
• 5^TH Kentucky Grazing Conference
• Forage Spokesman Needed
• Advances in Forage-Beef Programs Resulting from Agriculture Development Funds
• Alfalfa Acreage Up Other Hay Down
• Transition from Toxic Tall Fescue to Non-Toxic Novel Endophyte Tall Fescue
• Effect of Alfalfa Seeding Rate on Stand Longevity
• Forage Yield and Quality of Winter Hardy Cereals and Winter Sensitive Species for Grazing
• Forage Production and Forage Mixture Complexity
• Upcoming Events

Homicides In The Workplace, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Other

To prevent workplace violence:

• Assessment for workplace violence risks should be done in all workplaces.
• Workplaces should have policies that clearly delineate that violence is not appropriate during any workplace interaction and violence policies should mirror other workplace policies in terms of strategies for reporting and investigation of incidents, and progressive discipline.
• A clear and consistent reporting system for workplace violence should be in place and every worker should understand how it works.
• Safety training should be attended by employers, supervisors, and employees.
• Policy, training, and employee assistance for domestic violence should be implemented in collaboration with community service providers.

Homicidios En El Lugar De Trabajo, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Other

Para prevenir la violencia ocupacional:

Una valoración de los riesgos de violencia ocupacional deberá ser llevada a cabo en todos los lugares de trabajo.

Los lugares de trabajo deben implementar políticas que aclaren que la violencia no es apropiada durante ninguna interacción laboral; de igual forma las políticas sobre violencia deberán reflejar los procedimientos del lugar de trabajo en términos de estrategias para reportar e investigar los casos y la progresión de la disciplina.

Un sistema de reporte de la violencia laboral claro y consistente deberá ser implementado en el lugar de trabajo, y cada trabajador deberá comprender como funciona. …

Il-5 Links Adaptive And Natural Immunity In Reducing Atherosclerotic Disease, Alan Daugherty, Debra L. Rateri, Victoria L. King

Gill Heart & Vascular Institute Faculty Publications

Oxidized LDL induces changes in several facets of the immune system, although the relationships between these facets and their contributions to atherogenesis have yet to be fully elucidated. A report in this issue of the JCI provides a novel demonstration of the adaptive immune system influencing the production of natural antibodies. The results demonstrate that injection of malondialdehyde-modified LDL promotes a Th2 response that in turn increases the titers of the natural antibody T15/EO6, which recognizes the oxidized phospholipid POVPC. Atherosclerotic lesion size in LDL receptor–deficient mice is reduced as a consequence of the increase in natural antibody titers, and …

"Competing Conceptions Of Globalization" Revisited: Relocating The Tension Between World-Systems Analysis And Globalization Analysis, Thomas Clayton

Linguistics Faculty Publications

No abstract provided.

Permeable, Water Soluble, Non-Irritating Prodrugs Of Chemotherapeutic Agents With Oxaalkanoic Acids, Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, Paul Ashton

Pharmaceutical Sciences Faculty Patents

The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof.

Long-Term Evaluation Of The Use Of The Transdermal Contraceptive Patch In Adolescents, Stephanie Logsdon, Jessica Richards, Hatim A. Omar

Pediatrics Faculty Publications

The transdermal contraceptive patch, Ortho Evra™, was approved in December 2001 and released on the market in June 2002. In this study, we reviewed clinical data of young women who started the patch between June 2002 and December 2003 in the adolescent medicine clinic at a university-based outpatient center. A total of 62 patients started the patch in that period and two of them were lost to follow-up. Mean age of patients was 17.9 years and mean length of use was 10 cycles. Only 10 patients (16.7%) discontinued use. Reasons for discontinuation were moderate to severe skin irritation (3 patients, …

Clinical Profiles, Occurrence, And Management Of Adolescent Patients With Hair-An Syndrome, Hatim A. Omar, Stephanie Logsdon, Jessica Richards

Pediatrics Faculty Publications

The syndrome of hyperandrogenism, insulin resistance, and acanthosis nigricans (HAIR-AN) is a subphenotype of the polycystic ovary syndrome. It is one of the most common causes of menstrual problems, hyperandrogenic symptoms, and insulin resistance among young women. Review of clinical data in an outpatient adolescent clinic showed that of the 1,002 young women (ages 10-21 years) attending the clinic over a 2-year period, 50 (5%) were diagnosed with HAIR-AN syndrome. Mean age of the patients was 15.5, initial mean weight at diagnosis was 94.5 kg, and the mean BMI was 33.33 kg/m2. Patients were treated with a weight-stabilization and -reduction …

Social Support Protects Against The Negative Effects Of Partner Violence On Mental Health, Ann L. Coker, Paige H. Smith, Martie P. Thompson, Robert E. Mckeown, Lesa Bethea, Keith E. Davis

CRVAW Faculty Journal Articles

Objectives: Social support for abused women may reduce the impact of abuse on mental health, yet few studies have addressed this issue. We wish to determine associations between intimate partner violence (IPV) and mental health outcomes and to assess the protective role of abuse disclosure and support on mental health among abused women.

Methods: A cross-sectional survey was conducted of 1152 women, ages 18–65, recruited from family practice clinics from 1997 through 1999. They were screened for IPV during a brief in-clinic interview, and physical and mental health status was assessed in a follow-up interview.

Results: IPV, defined as sexual, …

The New Promised Land: Black-White Convergence In The American South, 1940-2000, Jacob L. Vigdor

University of Kentucky Center for Poverty Research Discussion Paper Series

The black-white earnings gap has historically been larger in the South than in other regions of the United States. This paper shows that this regional gap has closed over time, and in fact reversed during the last decades of the twentieth century. Three proposed explanations for this trend focus on changing patterns of selective migration, reduced discrimination in Southern labor markets, and lower levels of school segregation and school resource disparities in the modern South relative to the North. Evidence suggests that reductions in Southern labor market discrimination explain rapid regional convergence in racial wage gaps between 1960 and 1980. …

The Rise Of Low-Skill Immigration In The South, George J. Borjas

University of Kentucky Center for Poverty Research Discussion Paper Series

The 1990s witnessed a significant geographic redistribution of immigration away from the traditional immigrant-receiving states, mainly California, and towards other parts of the country, mainly the Southern states that have not historically been immigrant-receiving states. This paper documents the impact of this change in immigrant settlement patterns on the skill endowment of the workforce in Southern states. The empirical analysis indicates that the recent change in immigrant settlement patterns led to the rise of a sizable foreign-born low-skill workforce in the South, particularly outside Florida and Texas. This workforce developed both as a result of increased settlement of many newly …

Forage News [2004-07], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Warren Thompson Retires From ABI
• Seeded Bermudagrass: Filling in the Summer Slump
• Bill Talley Receives AFGC Merit Award
• Kentucky Students Win First AFGC Forage Bowl
• KFGC Field Day
• Yield and Persistence of Bolting-Resistant Cultivars of Chicory in Forage Plots
• Management of Beef Cattle to Alleviate Fescue Toxicosis
• Comparison of Three Tall Fescues Containing Novel Endophytes for Stocker Cattle Weight Gain
• Persistence of HiMag Tall Fescue Inoculated with Nontoxic Endophytes
• Upcoming Events

Southeastern Law Librarian Summer 2004, Seaall

Newsletters

No abstract provided.

Methods For Increasing Leptin Levels Using Nicotinic Acid Compounds, Elaine L. Jacobson, Myron Jacobson, Hyuntae Kim

Graduate Center for Nutritional Sciences Faculty Patents

The invention relates to the use of nicotinic acid and nicotinic acid esters, such as nicotinic acid alkyl esters, to increase the amount of leptin in a subject. As a result, one can treat conditions, such as conditions characterized by wounds, by administering sufficient amounts of nicotinic acid or nicotinic acid ester to increase leptin levels to alleviating amounts. Various conditions and modes of treatment are disclosed.

Forage News [2004-06], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• KFGC Field Day
• AFGC to Meet In Roanoke, Virginia June 12-16
• Forage Species and Spatial Effects on the Dietary Intake of Goats
• Kentucky Ranks High in Beef
• Forage-Animal Production Research Unit: Most Recent Agriculture Research Service Location
• Calibrating Seeders
• Upcoming Events

9th Biennial Employment Law Institute, Office Of Continuing Legal Education At The University Of Kentucky College Of Law

Continuing Legal Education Materials

Materials from the 9th Biennial Employment Law Institute held by UK/CLE in June 2004.

Influence Of Varied, Controlled Distances From The Crank Axis On Peak Physiological Responses During Arm Crank Ergometry, Thomas L. Miller, Carl G. Mattacola, Mayra C. Santiago

Physical Therapy Faculty Publications

The purpose of the study was to determine the influence of varied, controlled distances from the crank axis during arm crank ergometry (ACE) on peak physiological responses and physical work capacity (PWC). Physiological responses to ACE were evaluated using three controlled distances from the crank axis based on 0°, 15°, and 30° from full extension in the elbow while at the furthest point in the crank rotation. Eleven adult, able-bodied women (age = 24.5 ± 4.7 yrs) performed graded maximal ACE tests at each of three distances from the crank axis. Data were analyzed for differences in peak physiological responses …

Master Plumber Dies When Trench Collapses, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On July 29, 2003, a 35-year-old, male master plumber died when an unshorn trench collapsed. Two employees from the contracting company were speaking with him at the time from the side of the trench. He had searched and diagnosed a water line leak when the walls of the trench collapsed. The plumber was employed by a plumbing company contracted by a commercial establishment to locate and repair a water leak. He died at the scene from asphyxia due to chest compression.

To prevent future occurrences of similar incidents, the following recommendations have been made:

Recommendation No. 1: Employers should train …

Roofing Laborer Dies After 60-Foot Fall, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Falls

At 8:00 AM on the morning of October 7, 2003, a 33-year-old laborer, working for a roofing contractor, was removing debris from a commercial building roof when he slipped and fell 60 feet to the sidewalk below. There were 2 other laborers and the contractor at the work site that morning. It was the second work day at this particular job site and the three workers were to finish discarding bags of debris from the roof. The decedent and one of the laborers accessed the roof through the building interior, up a flight of stairs to a five-step ladder which …

Methods To Impair Hematologic Cancer Progenitor Cells And Compounds Related Thereto, Craig Jordan

Internal Medicine Faculty Patents

Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML) and chronic lymphoid leukemia (CLL). Interleukin-3 receptor alpha chain (IL-3Rα or CD123) is strongly expressed on progenitor hematologic cancer cells, but is virtually undetectable on normal bone marrow cells. The present invention provides methods of impairing progenitor hematologic cancer (e.g., leukemia and lymphomic) cells by selectively targeting cells expressing CD123. These methods are useful in the detection and treatment of leukemias and malignant lymphoproliferative disorders. Also provided are compounds useful …

Food Stamp Program Participation Of Refugees And Immigrants, Christopher Bollinger, Paul Hagstrom

University of Kentucky Center for Poverty Research Discussion Paper Series

No abstract.

The Gaia Hypothesis And Ecofeminism: Culture, Reason, And Symbiosis, Serena Anderlini-D'Onofrio

disClosure: A Journal of Social Theory

No abstract provided.

Against War And The Preconditions Of War, Werner Bonefeld

disClosure: A Journal of Social Theory

No abstract provided.

Rethinking Politics, Scholarship, And Economics: Disclosure Interviews David F. Ruccio, Tina Mangieri, Matt Mccourt, Natalia Ruiz-Junco, Jeff West

disClosure: A Journal of Social Theory

No abstract provided.

Method For Identifying Regulators Of Protein-Advanced Glycation End Product (Protein-Age) Formation, Elaine L. Jacobson, Myron Jacobson, Georg T. Wondrak

Graduate Center for Nutritional Sciences Faculty Patents

The invention relates to methods for identifying compounds which affect cellular stress. In particular, the method relates to identifying compounds which inhibit protein advanced glycation end product formation, where the compounds are carbonyl scavengers which inhibit the formation. The assay involves combing the substance of interest with histone H1 and ADP-ribose, and then measuring fluorescence and protein cross linking. Various inhibitors of protein AGE glycation have been identified, using this assay.

24th Annual Conference On Legal Issues For Financial Institutions, Office Of Continuing Legal Education At The University Of Kentucky College Of Law

Continuing Legal Education Materials

Materials from the 24th Annual Conference on Legal Issues for Financial Institutions held by UK/CLE in April of 2004.

Southeastern Law Librarian Spring 2004, Seaall

Newsletters

No abstract provided.