Digital Commons Network^™

Structural Racism And The Law In America Today: An Introduction, William M. Wiecek

Kentucky Law Journal

No abstract provided.

Overcoming Structural Barriers To Integrated Housing: A Back-To-The-Future Reflection On The Fair Housing Act's "Affirmatively Further" Mandate, Robert G. Schwemm

Kentucky Law Journal

No abstract provided.

Forcing Life On The Dead: Why The Pregnancy Exemption Clause Of The Kentucky Living Will Directive Act Is Unconstitutional, Kristeena L. Johnson

Kentucky Law Journal

No abstract provided.

Granny Snatching And Personal Jurisdiction--An Argument For A New Federal Interpleader, Brittany Griffin Smith

Kentucky Law Journal

No abstract provided.

Computational Analyses Of The Uptake And Distribution Of Carbon Monoxide (Co) In Human Subjects, Kinnera Chada

University of Kentucky Doctoral Dissertations

Carbon monoxide (CO) is an odorless, colorless, tasteless gas that binds to hemoglobin with high affinity. This property underlies the use of low doses of CO to determine hemoglobin mass (M_Hb) in the fields of clinical and sports medicine. However, hemoglobin bound to CO is unable to transport oxygen and exposure to high CO concentrations is a significant environmental and occupational health concern. These contrasting aspects of CO—clinically useful in low doses but potentially lethal in higher doses—mandates a need for a quantitative understanding of the temporal profiles of the uptake and distribution of CO …

Single-Parent Families In Bangkok, Thailand: Factors Affecting Children Living In Single-Parent Families, Waruesporn Jiumpanyarach

Theses and Dissertations--Sociology

There has been a transformation in family structure in Thailand due to the changes in economic and social structures over time. Though not recorded in census data the rise in single-parent families can be expected due to a rise in divorce rates, that have been recorded, over the past decades. However, the literature on single-parent families is limited and little is known about the experiences of single-mothers and children of singlemother families in Thailand. This study examines the factors that have major impacts on the well-being of children of single-parent families in Bangkok, Thailand.

A qualitative methodology was employed to …

Rit Gtpase Signaling Mediates Oxidative Stress Resistance And Survival Of Adult Newborn Neurons After Traumatic Brain Injury, Weikang Cai

Theses and Dissertations--Molecular and Cellular Biochemistry

The small GTPases function as molecular switches to control diverse signaling cascades. The mammalian Rit and Rin, along with Drosophila Ric, comprise an evolutionarily conserved subfamily of the Ras-related GTPases. Previous studies using cultured cell models suggested that Rit was involved in the control of cell proliferation, transformation, neuronal differentiation, morphogenesis, and cell survival, but the principal physiological function of Rit remained uncharacterized.

To address this outstanding question, we employed a genetic approach, engineering a Rit knockout mouse. Using this animal model, we demonstrate a central role of Rit in governing cell survival in a p38-dependent fashion. Primary mouse embryonic …

Intrapsychic Predictors Of Professional Quality Of Life: Mindfulness, Empathy, And Emotional Separation, Jacky T. Thomas

University of Kentucky Doctoral Dissertations

A growing literature documents the inherently stressful nature of working with persons who are suffering or traumatized, and the potential for the development of stress disorders among social workers and other helpers. Previous studies of compassion fatigue and burnout have provided important information about professional and workplace variables that might influence risk, but little attention has been given to studying intrapersonal skills/abilities that might reduce risk and/or increase resilience and work satisfaction among helping professionals. This exploratory study asked whether levels of mindfulness, empathy, and emotional separation would influence professional quality of life, including compassion fatigue, burnout, and compassion satisfaction. …

The Role Of Co-Infection In The Spread Of Hiv In Sub-Saharan Africa, Diego Fernando Cuadros

Theses and Dissertations--Biology

The cause of the high HIV prevalence in sub-Saharan Africa is incompletely understood, with heterosexual penile-vaginal transmission proposed as the main mechanism. Heterosexual HIV transmission has a very low probability; further, a single estimation of heterosexual probability of HIV transmission fails to reproduce the variation associated with important biological cofactors. In particular, studies of HIV incidence suggest that co-infection with other infectious diseases influence the HIV transmission, and therefore might substantially vary the pattern of the spread of the infection. To assess the effect of co-infection on the spread of HIV, I developed and analyzed several mathematical and statistical models …

Trichloroethylene Exposure And Traumatic Brain Injury Interact And Produce Dual Injury Based Pathology And Pioglitazone Can Attenuate Deficits Following Traumatic Brain Injury, Andrew David Sauerbeck

University of Kentucky Doctoral Dissertations

The development of Parkinson's disease (PD) in humans has been linked to genetic and environmental factors for many years. However, finding common single insults which can produce pathology in humans has proved difficult. Exposure to trichloroethylene (TCE) or traumatic brain injury (TBI) has been shown to be linked to PD and it has also been proposed that multiple insults may be needed for disease development.

The present studies show that exposure to TCE prior to a TBI can result in pathology similar to early PD and that the interaction of both insults is required for impairment in behavioral function, and …

Assessing The Perceptions Of Environmental Pollutants, Health And Nutrition Behavior To Improve Risk Communications In Kentucky, Elizabeth Virginia Willett

University of Kentucky Master's Theses

Nutrition interventions are an effective way to improve the dietary habits and lifestyle choices and reduce the risk of chronic disease. The Researchers in the UK-SRP Community Engagement Core develop nutrition programs for communities affected by environmental pollutants. Risk communication is a discipline that can be used to develop targeted nutrition interventions that will yield positive behavior change. The purpose of this study was to examine knowledge, risk perception, and actions concerning environmental pollutants and nutrition behavior. Data was collected using a modified survey instrument based on the validated Environmental Health Engagement Profile (EHEP). Survey participants from diverse regions of …

The Effects Of New Media On Alumni Engagement Among Millennials: A Case Study Of The University Of Kentucky College Of Health Sciences Alumni, Allison M. Horseman

University of Kentucky Master's Theses

This thesis explores the effects of new media, specifically the Internet and the popular social networking site Facebook, on alumni engagement among Millennials in the University of Kentucky College of Health Sciences. Millennials are defined as those born in or after 1982. Alumni engagement is defined as part of the larger social science term of social capital and is defined here as consisting of volunteerism and financial giving. To explore this topic, a survey was constructed and sent electronically to all Millennial alumni from the UK College of Health Sciences. Data reveal Millennial alumni from the College of Health Sciences …

Developing A Time And Motion Study For A Lean Healthcare Environment, Michael Winston Patton Jr.

University of Kentucky Master's Theses

This thesis outlines the development of a standard methodology for performing a time and motion study in a lean healthcare environment. Time and motion studies have been used in healthcare environments in the past, however they have nearly all been exclusive to a particular healthcare enterprise. To develop the time and motion study methodology, a study was designed to examine how resident doctors spend their time. This study was performed in response to coming changes in the work hours for all residents. Once the methodology was developed, trial observations were conducted. The data from these observations was analyzed to determine …

The Association Between Emotional Intelligence, Body Mass Index And Eating Behaviors Among College Students, Feai-Voon Wong

University of Kentucky Master's Theses

Available research has shown a relationship between emotional intelligence (EI) and health behaviors. However, the link between EI and eating behaviors has not been well explained. Thus, the purpose of this study was to investigate the correlations among EI, eating behaviors, as measured by the Dutch Eating Behavior Questionnaire (DEBQ), and body mass index (BMI) in college students. One hundred and eighty four students (118 (64%) female, 66 (36%) male, average BMI = 23.8kg/m²) were recruited to complete an online survey. The survey consisted of basic demographic questions, academic information with grade point average (GPA), ACT and SAT …

Healing Healthcare Design For Adolescent Patients: Promoting Holistic Quality Of Life, Eun Young Kim

University of Kentucky Master's Theses

This study examined environmental preferences for adolescent patients in hospital patient rooms and activity rooms to determine age-appropriate healing design elements. The health-related quality of life (HRQOL) concept was adapted to this study as a theoretical framework. In order to develop an age-appropriate healing design, a comprehensive understanding of adolescents‘ cognitive developmental stages and their expectations in hospital settings needs to be recognized. Thirty-two adolescent outpatients aged 15 to 18 participated in the survey. Data collection consisted of three different instruments: Emotional state survey with demographics, Photo analysis with semantic differentials, and environmental preference value survey. Comfort, sadness and stress …

Factors Affecting Rural Kentucky Patients Hospital Choice And Bypass Behavior, Xiao He

University of Kentucky Master's Theses

This study examines the underutilization of rural hospitals in Kentucky. The authors study hospital and patient characteristics to determine why and how rural patients bypass local rural hospitals and how they make their decision in the hospital choice. A Health Care Service Survey conducted in rural Kentucky and hospital data drew from American Hospital Directory are used. A binary probit model and a conditional logit model are applied. The results suggest that the hospital quality, prior experiences and the satisfaction of the local hospital, along with patients’ value of hospital size, reputation and patients’ insurance coverage influence rural patients’ hospital …

Participation In Agricultural Governmental Cost Share Programs In The Kentucky River Watershed, Pedro Miguel Fernandes Da Costa

University of Kentucky Master's Theses

The purpose of this study is to review existing literature of factors that influence farmers’ decision to participate in conservation programs. This study is also intended to collect county data and information on conservation programs and participation in the Kentucky River watershed region, which can be analyzed and used to draw differences in characteristics of the region that would suggest willingness to participate in a trading scheme for improvements in water quality.

The results suggest that more participation in a trading scheme from some counties than others should be expected. Counties with more farms and larger farms will probably have …

Practice And Application Of Knowledge By Nutrition Students, Jennifer Kristin Boyee

University of Kentucky Master's Theses

Practice and knowledge of upper‐level human nutrition and dietetics students (juniors and seniors, n=96) attending a midwestern university were compared to their comprehension and application of the Scope of Dietetics Practice. The sample consisted of 96 students, primarily (72%) in the 21 – 23 age category; females made up 83% and males comprised the remaining 17% of the sample. In this sample, 70% of the participants reported dietetics as their current major, and 30% stated that their major was human nutrition. Overall, students majoring in human nutrition responded neutrally to the questions concerning comprehension, knowledge, and implementation of the Scope …

A Qualitative Inquiry Into Understanding The Experience Of Wilderness Family Therapists, Lauren W. Smith

University of Kentucky Master's Theses

Wilderness therapy is a unique approach to therapy that incorporates nature and experiential learning as a part of the therapeutic process. Wilderness therapy has proven to be a successful means of treatment, but research suggests the importance of family involvement for sustainable change post-wilderness therapy treatment. Wilderness family therapy was created as a result of this research; however, limited research reflects the experience and outcomes of wilderness therapy that includes more intense family involvement. Moreover, research lacks data collected from the therapists within the wilderness family therapy programs. Because the therapist plays an integral role in the success of treatment, …

A Comparison Of Leadership Traits Across Countries: Taiwan And United States, Chi-Shou Justin Yang

University of Kentucky Master's Theses

With the rise of new technologies, geographical and political boundaries between companies are disappearing. Managers within multinational organizations are faced with the challenge of adapting to new paradigms of leadership while leading employees who may share different backgrounds. With businesses becoming more globalized, it is important to know and understand how to lead and interact with people from other cultures. The purpose of the study is to explore and describe similarities or differences with managers from the United States and managers from Taiwan in relation to the 29 leadership traits overall as well as at individual management levels. As a …

An Evidence-Based Toolkit For Human Papillomavirus Vaccine Education Of Female Adolescents In The School Setting, Nancy R. Kloha

DNP Projects

A new vaccine to prevent human papillomavirus infection was approved in 2006 in the United States (U.S.). Uptake of the vaccine has been less than optimal (CDC, 2010c). New venues for promoting vaccine acceptance are needed (Middleman & Tung, 2010). The goal of this capstone clinical project is to create an evidence based toolkit for use by school nurses in educating female adolescents, parents, communities and other healthcare providers about the HPV vaccine.

Schools nurses have daily access to young people in the target group for HPV immunization. A vital component of vaccine acceptance is education of those who are …

A Systematic Approach To Manage Clinical Deterioration On Inpatient Units In The Health Care System, Colleen H. Swartz

DNP Projects

The transformation of health care delivery in the United States is accelerating at unbelievable speed. The acceleration is a result of many variables including health care reform as well as the covariation occurring with adjustments in regulations related to resident work hours. The evolving care delivery model has exposed a vulnerability of the health system, specifically in academic medical centers of the United States. Academic medical centers have established a care delivery model grounded and predicated in resident presence and performance. With changes in resident work expectations and reduced time spent in hospitals, an urgent need exists to evaluate and …

Methionine-35 Of Aβ(1-42): Importance For Oxidative Stress In Alzheimer Disease, D. Allan Butterfield, Rukhsana Sultana

Chemistry Faculty Publications

Alzheimer disease (AD) is an age-related progressive neurodegenerative disorder. This devastating disease is characterized by the presence of senile plaques (SP), neurofibrillary tangles (NFTs), and loss of synapses. Amyloid beta-peptide 1–42 (Aβ(1–42)) is the main component of SP and is pivotal to AD pathogenesis. Brain of subjects with AD and arguably its earliest manifestation, mild cognitive impairment (MCI), demonstrate increased levels of oxidative stress markers. Our laboratory combined these two aspects of AD and MCI and proposed the Aβ(1–42)-associated free radical oxidative stress hypothesis to explain oxidative stress under which the MCI and AD brain exist …

Distal Radioulnar Joint Biomechanics And Forearm Muscle Activity, Joseph Scott Bader

University of Kentucky Doctoral Dissertations

Optimal management of fractures, post-traumatic arthritis and instability of the distal radioulnar joint (DRUJ) requires an understanding of the forces existing across this joint as a function of the activities of daily living. However, such knowledge is currently incomplete. The goal of this research was to quantify the loads that occur at the DRUJ during forearm rotation and to determine the effect that individual muscles have on those loads.

Human and cadaver studies were used to analyze the shear (A-P), transverse (M-L) and resultant forces at the DRUJ and to determine the role that 15 individual muscles had on those …

Microsurgical Reconstruction Of Large, Locally Advanced Cutaneous Malignancy Of The Head And Neck, Joseph L. Hill, Brian Rinker

Surgery Faculty Publications

Large, locally advanced cutaneous malignancy of the head and neck region is rare. However, when present, they impart a significant reconstructive challenge. These cancers have a tendency to invade peripheral tissues covering a large surface area as well as expose deeper structures such as skull, dura, orbit, and sinus after resection. Complicating the reconstructive dilemma is the high incidence of individuals who have undergone previous surgery in the region as well as adjuvant radiation therapy, which may preclude the use of local flaps or skin graft. Free tissue transfer provides a reconstructive surgeon the ability to provide well-vascularized tissue with …

Stability Of Affinity Based Layer-By-Layer Polymeric Self-Assemblies For Oral Wound Applications, Sundar Prasanth Authimoolam

Theses and Dissertations--Chemical and Materials Engineering

Oral mucositis is a painful and debilitating chronic inflammatory condition that can result from chemo and/or radiotherapy. While current treatment strategies which provide temporary relief exist, there is still an unmet clinical need for a robust long active barrier strategy which can simultaneously provide protection and release drug to enhance the wound healing response. It is proposed that an affinity based layer-by-layer self-assembled barrier administered as a series of mouth rinses can allow for wound specific drug delivery, providing an effective regenerative therapy.

In this work, biotinylated poly(acrylic acid) is used to develop LBL assemblies based upon biotin-streptavidin affinity interactions. …

Cell And Protein-Based Sensing Systems For The Detection Of Environmentally And Physiologically Relevant Molecules, Kendrick Bruce Turner

Theses and Dissertations--Chemistry

The detection of small molecules in complex sample matrices such as environmental (surface and ground water, sediment, etc.) and biological (blood, serum, plasma, etc.) samples is of paramount importance for monitoring the distribution of environmental pollutants and their patterns of exposure within the population as well as diagnosing and managing diseases. Biosensors have demonstrated a singular ability to sensitively and selectively detect analytes in complex samples without the need for extensive sample preparation and pretreatment. Nature has demonstrated myriad examples of exquisite selectivity in spite of complexity and we seek to take advantage of that attribute in the development of …

Opioid Codrugs For Pain Management, Ujjwal Chakraborty

Theses and Dissertations--Chemistry

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissus damage or described in terms of such damage. Opioids are effective in treating moderate to severe pain, but opioid alone therapy is associated with several adverse effects, development of tolerance and addiction potential. One way to solve these problems is to administer opioids with adjuvant drugs. In this project several opioid molecules were combined with other adjuvant drugs in a single chemical entity to form a codrug.

A series of codrugs were prepared by conjugation of an opioid with S-(-)-nornicotine, ketamine, norketamine and gabapentin. Several …

Prisoners Serving Sentences Of Life Without Parole: A Qualitative Study And Survey, Glenn J. Abraham

University of Kentucky Doctoral Dissertations

This mixed methods exploratory study examined how adult male prisoners serving sentences of life without parole adapt to the probability that they will be incarcerated for the remainder of their lives. As a second element, state prison wardens were surveyed about their support for the provision of certain amenities to those serving life without parole and the extent to which they believed those prisoners presented a risk of future dangerousness. Qualitative interviews were conducted with 24 inmates serving sentences of life without parole at a high security prison in Ohio. Informants identified factors that made adjustment more difficult or which …

Sibling Conflict Resolution Styles And Marital Conflict Resolution Styles, Fatimah Shalash

University of Kentucky Master's Theses

This study used qualitative methods to examine if there was a connection between conflict resolution styles used with siblings in adolescence and conflict resolution styles utilized in current romantic committed relationships. The Conflict Resolution Behavior Questionnaire (Reese-Weber, & Bartle-Haring, 2003) and Gottman‟s (1994a, 1994b) couple-conflict types as adapted by Holman and Jarvis (2003) were administered to 144 participants through an online questionnaire. Analysis of the CRBQ using a multiple regression indicated participant‟s self-rating of compromise, attack, and avoidant conflict resolution styles used with siblings when an adolescent predicted current self-ratings of compromise, attack, and avoidant conflict resolution styles utilized in …