Digital Commons Network^™

Ruminative Thought In Individuals With Borderline Personality Features, Brian Thomas Upton

University of Kentucky Master's Theses

Borderline personality disorder (BPD) is characterized by patterns of intense negative affect, interpersonal difficulties, and maladaptive impulsive behaviors, and is associated with impairments in social and occupational functioning. Rumination is a maladaptive form of repetitive thought that maintains and intensifies emotional disturbance and is associated with behavioral dysregulation. This study tested several hypotheses about relationships between rumination and borderline personality features. This study included 117 college student participants, 88 female students and 29 male students, most of whom (84%) identified themselves as Caucasian. Participants completed a series of measures which included a writing sample to sample repetitive thought. Findings consistently …

Development And Characterization Of Novel Monoclonal Antibodies For Studying Prion Pathogenesis, Chu-Chun Weng

University of Kentucky Master's Theses

Monoclonal antibodies (mAbs) recognizing different regions of PrP are potential tools in the study of prion diseases and immunotherapy. We used shuffled recombinant prion protein containing elk and mouse PrP as antigen to produce monoclonal antibodies in mice. We found that mAb 5C6 mapped to a discontinuous epitope comprised of amino acid 132 and 158 (mouse numbering). Monoclonal anibody 9E9 which maps to a unique N-terminal epitope at amino acid preferentially recognized cervid PrP. In contrast, the epitope of mAb 9H9 is located in the C-terminus and only reacted with mouse and hamster. The epitope for mAb 7H11 appears to …

“Obtuse Women”: Venereal Disease Control Policies And Maintaining A “Fit” Nation, 1920-1945, Evelyn Ashley Sorrell

University of Kentucky Master's Theses

Public health officials and social reformers grew concerned over the prevalence of gonorrhea and syphilis following World War I. The initiatives put in place by authorities to control the spread of venereal disease lacked any concern for women’s health and sought to control their newly found independence and mobility. This thesis examines public health policies related to venereal disease control from 1920-1945 and how these regulations affected women in the United States. Laws and social reform measures such as pre-marital blood tests, the Sheppard-Towner Maternity and Infancy Act, and the use of quarantining prostitutes during World War I and World …

Deaf Or Hearing: A Hearing Impaired Individual’S Navigation Between Two Worlds, Brittany Nicole Lash

University of Kentucky Master's Theses

identity play an important role in how they communicate and interact with other individuals. One group in which identity construction and navigation is a difficult process is the hearing impaired population. In an effort to understand how these individuals construct their identity and navigate their hearing impairment, this study utilizes Communication Theory of Identity. Through the use of interactive interviews, the researcher was able to examine how 11 participants manage their identity as hearing impaired individuals. The interviews provided insight into the four layers of identity proposed by CTI – personal, relational, enacted, and communal – in the hearing impaired …

Cultivating Miracle Perceptions: Cultivation Theory And Medical Dramas, Rachael A. Record

University of Kentucky Master's Theses

This thesis reports the results of a study designed to investigate the influence of exposure to televised medical dramas on perceptions of medical miracles. Four hundred and eighty-one college students participated in a survey in which they responded to different questions about their medical drama viewership and their different beliefs with regard to medical miracles. Results found that heavy medical drama viewers perceived belief in medical miracles to be less normal than non-viewers. Similarly, heavy viewers perceived medical miracles to occur less often than non-viewers. Interestingly, heavy viewers perceived medical dramas to be less credible than non-viewers. In addition, this …

Combinatorial Biosynthetic Derivatization Of The Antitumoral Agent Gilvocarcin V, Micah Douglas Shepherd

University of Kentucky Doctoral Dissertations

Gilvocarcin V (GV), the principal product of Streptomyces griseoflavus Gö 3592 and other Streptomyces spp., is the most prominent member of a distinct class of antitumor antibiotics that share a polyketide derived coumarin-based aromatic core. GV and other members of this class including polycarcin V from Streptomyces polyformus, often referred to as gilvocarcin-like aryl C-glycosides, are particularly interesting because of their potent bactericidal, virucidal and antitumor activities at low concentrations while maintaining low in vivo toxicity. Although the precise molecular mechanism of GV bioactivity is unknown, gilvocarcin V has been shown to undergo a photoactivated [2+2] cycloaddition of …

T-Phylloplanin And Cis-Abienol, Two Natural Products From Tobacco Have Broad Spectrum, Anti-Fungal Activities, Brian Christopher King

University of Kentucky Doctoral Dissertations

Tobacco phylloplanins (T-phylloplanin) are a group of closely-related glycoproteins that are formed and disposed at the interface between the plant aerial surface (the phylloplane) and the atmosphere. They are synthesized in short procumbent trichomes and are secreted to aerial surfaces where they are thought to serve the plant as a first line of defense against fungal pathogens. Here it is shown using in vitro and in planta assays that tobacco and sunflower phylloplanins have broad-spectrum antifungal activities against spores - and also hyphae for two species - of several true fungi. Field tests show that T-phylloplanin reduces diseases caused by …

Computer Simulation Of A Hollow-Fiber Bioreactor: Heparan Regulated Growth Factors-Receptors Binding And Dissociation Analysis, Changjiang Zhang

University of Kentucky Doctoral Dissertations

This thesis demonstrates the use of numerical simulation in predicting the behavior of proteins in a flow environment.

A novel convection-diffusion-reaction computational model is first introduced to simulate fibroblast growth factor (FGF-2) binding to its receptor (FGFR) on cell surfaces and regulated by heparan sulfate proteoglycan (HSPG) under flow in a bioreactor. The model includes three parts: (1) the flow of medium using incompressible Navier-Stokes equations; (2) the mass transport of FGF-2 using convection-diffusion equations; and (3) the cell surface binding using chemical kinetics. The model consists of a set of coupled nonlinear partial differential equations (PDEs) for flow and …

Effect Of Azithromycin On Macrophage Phenotype During Pulmonary Infections And Cystic Fibrosis, Theodore James Cory

University of Kentucky Doctoral Dissertations

Azithromycin improves clinical outcomes in patients with cystic fibrosis (CF), specifically in patients infected with Pseudomonas aeruginosa. Azithromycin shifts macrophage programming away from a pro-inflammatory classical (M1) phenotype, and towards an anti-inflammatory alternative (M2) phenotype; however, little is known about this mechanism, nor of its impact upon immune response to pulmonary infection. We set out to determine the mechanism by which azithromycin is able to alter macrophage phenotype, and assess the effect of azithromycin induced macrophage polarization on inflammation during pulmonary infections.

Utilizing macrophage cell culture, we found that azithromycin increased IKKβ, a signaling molecule in the NFκB pathway, which …

Bayesian Semiparametric Generalizations Of Linear Models Using Polya Trees, Angela Schoergendorfer

University of Kentucky Doctoral Dissertations

In a Bayesian framework, prior distributions on a space of nonparametric continuous distributions may be defined using Polya trees. This dissertation addresses statistical problems for which the Polya tree idea can be utilized to provide efficient and practical methodological solutions.

One problem considered is the estimation of risks, odds ratios, or other similar measures that are derived by specifying a threshold for an observed continuous variable. It has been previously shown that fitting a linear model to the continuous outcome under the assumption of a logistic error distribution leads to more efficient odds ratio estimates. We will show that deviations …

Knowledge And Acknowledgement Of Posttraumatic Stress Disorder And Effects On Military Couples, Laura M. Compton

University of Kentucky Master's Theses

This study used mixed methods to examine the impact of service-members‟ knowledge and acknowledgement of Posttraumatic Stress Disorder (PTSD) on relationship satisfaction of both the service-members and their spouses. Family stress theory was used to conceptualize the relationship between the occurrence of PTSD and relationship satisfaction. Forty individuals (i.e., 20 couples) completed questionnaires containing self-report measures of knowledge of PTSD, experience of PTSD symptoms, severity of PTSD symptoms, and relationship satisfaction. Participants also completed semi-structured interviews concerning PTSD symptoms, impact of PTSD symptoms on their relationship, and attitudes observed about PTSD. No significant links were found between knowledge, acknowledgement, and …

Should Pseudoephedrine (Pse) Be Moved From Behind The Counter To Prescription-Only? An Analysis Of Pse As An Otc Medication And A Precursor For Methamphetamine Production, Jerry Dillon

MPA/MPP/MPFM Capstone Projects

Kentucky State Senator Tom Jensen recently sponsored Senate Bill 45, which would change pseudoephedrine (PSE) from an over-the-counter to a schedule V prescription-only drug. The bill failed, but the debate continues as to whether Kentucky should make PSE, a precursor required to manufacture illicit methamphetamine, a controlled drug that is available by prescription only.

Methamphetamine abuse has been increasing in Kentucky as well as in the rest of the country, despite efforts to control the sale of PSE through federal and state legislation. The Combat Methamphetamine Epidemic Act (CMEA) of 2006 and Kentucky’s initiative to electronically monitor the sales of …

Predictors Of Food Bank Usage Among Those With Low Food Security: Analysis Of The Current Population Survey Food Supplement Data, Sarah Mcqueen

MPA/MPP/MPFM Capstone Projects

Food insecurity is defined as the “access…at all times to the food needed for a healthy life” (Powledge 2010). According to the U.S. Census Bureau, approximately 15 percent of all Americans have experienced some measure of food insecurity. The issue is not new, but one that is ongoing and very complex and has impacts on individuals, households and society. In order to better understand the breadth and depth of the nation’s struggle with food sufficiency, an annual Food Supplement was attached to the Current Population Survey (CPS), a national labor force survey instrument. The CPS Food Supplement gathers information on …

An Analysis Of Bachelor's Degree Production By Kentucky Public 4-Year Universities: Before And After The Kentucky Postsecondary Education Improvement Act Of 1997, Jonathan Pruitt

MPA/MPP/MPFM Capstone Projects

With the passage of the Postsecondary Education Improvement Act of 1997, Governor Paul Patton and the Kentucky General Assembly sought to improve the standard of living and quality of life in the state through increasing the educational attainment of its citizens. The production of bachelor’s degrees by the state’s public four-year universities is a key driver in increasing educational attainment and, therefore, meeting the goals of the legislation. This paper uses interrupted time series regression analysis to evaluate whether Kentucky public four-year universities have increased the rate at which bachelor’s degrees are produced in the period of time since the …

An Analysis Of Quality Of Life Findings Among Money Follows The Person Program Beneficiaries, Mitch F. Ruscitti

MPA/MPP/MPFM Capstone Projects

This study will examine the quality of life survey findings of 154 recipients of services provided through the Kentucky Money Follows the Person program. In order to accomplish this, the term „quality of life‟ must first be defined and examined from the viewpoint of its role in the provision of health related services. Also, as a point of reference, a brief background concerning the Money Follows the Person program and its development will be provided. Lastly, after „quality of life‟ is defined for the purposes of this study, 183 surveys (154 baseline and 29 follow up) will be statistically analyzed …

U.S. State Employee Pension Systems: An Investigation Into The Causes Of Unfunded Liabilities, Chuck Truesdell

MPA/MPP/MPFM Capstone Projects

Defined benefit retirement plans for state employees have come under fire, both financially and politically, following recent market volatility and subsequent losses in pension investments. Asset losses matched with liabilities that are set years in advance translate to pressures on state policymakers and plan administrators to either find ways to improve the finances of these pension systems or transition to defined contribution plans that put the financial risk on individual employees rather than the state government. Because most states are legally and contractually obligated to pay retiree benefits regardless of the pension system’s financial condition — even to the point …

The Incidence Of Hip Fracture Associated With Proton Pump Inhibitor (Ppi) And/Or H2 Receptor Antagonist (H2ra) Use In The Kentucky Medicaid Population, Timothy C. Umeh

MPA/MPP/MPFM Capstone Projects

No executive summary.

An Examination Of Compressed Natural Gas For Use In Municipal Fleets: Would Cng Work For Lexington, Ky?, Robert Kahne

MPA/MPP/MPFM Capstone Projects

Compressed Natural Gas (CNG) is an alternative fuel source which could replace diesel as a fuel for municipal fleets. This paper seeks to examine the viability of CNG and its potential to power Lexington-Fayette Urban County Government’s fleet of waste removal trucks. This paper takes into account financial and environmental factors in determining CNG’s potential, but gives priority to financial considerations. The results of this analysis are mixed—under some future scenarios, compressed natural gas would be a favorable option for the fleet, but given other future scenarios, CNG would not be viable. In terms of environmental benefits, a switch to …

Local E-Government Trends: Evaluating The Adoption And Sophistication Of Kentucky City Websites, Kevin Klosterboer

MPA/MPP/MPFM Capstone Projects

With the prevalence of internet technologies and e-commerce, citizens’ expectations for online e-government services are growing. Numerous studies have been conducted on the worldwide adoption and sophistication of national governments’ e-government websites and state websites in the United States, but previous studies of local governments have been limited to looking at nationwide samples of the largest cities. By presenting a statewide analysis of all Kentucky city websites, I expect that my findings will provide valuable information about how cities of all sizes are using web-technologies to provide services to their citizens. I examine which types of cities, organized along several …

Local Economic Development: Researching Clusters In Woodford County, Kentucky, Tom Middleton

MPA/MPP/MPFM Capstone Projects

Woodford Tomorrow, a citizen economic development planning group in Woodford County, is interested in promoting cluster development. Clusters are a geographic concentration of businesses and institutions which interact and collaborate within a particular economic sector. This report provides quantitative analysis of three clusters: (1) health, (2) agriculture, and (3) arts, entertainment, and tourism. The majority of this data comes from the consulting firm Economic Modeling Specialists Inc.

The agriculture cluster has many industries, specifically in the crop and animal production and manufacturing sectors, which appear to be potential industries to target. The hotel and motel industry seems to be an …

U.S. Development Aid, Its Objectives And Lower-Middle Income Countries, Nazar Muhammad

MPA/MPP/MPFM Capstone Projects

The U.S. is investing billions of dollars in developing countries. U.S. development aid is an essential part of U.S. foreign policy. The objectives laid down by the architects of development aid are wide and range from strategic, economic and social uplift of poor countries to humanitarian assistance to alleviate the suffering of residents. There is a tense political and academic debate about the impacts of development aid funded by the U.S. There are many who believe funds support dictators, while others consider aid to be a real help to fragile economies.

Pakistan is one of the biggest recipients of U.S. …

What Makes People Generally Satisfied With Mental Health Services? Findings Of 2010 Consumer Satisfaction Survey In Kentucky Community Mental Health Centers, Minji Sohn

MPA/MPP/MPFM Capstone Projects

Problem: In 2010, the Kentucky Cabinet for Health and Family Services, Department for Behavioral Health Developmental and Intellectual Disabilities (BHDID) conducted a survey to evaluate consumers’ satisfaction with services delivered at the Community Mental Health Centers (CMHCs) in Kentucky. The purpose of this study is to identify factors that predict clients’ perception on General Satisfaction using responses of the survey.

Research Design: Two separate logistic regression analysis were performed for adult and youth survey respondents, respectively. For the Adult survey, respondents’ characteristics and their responses about several aspects of services were included as potential explanatory variables. For the Youth survey, …

Dental Service Utilization In An Academic Setting: An Analysis For Improved Oral Health, Paula R. Sandford

MPA/MPP/MPFM Capstone Projects

The National Oral Health Surveillance System (NOHSS) is the result of a collaborative effort between the Centers for Disease Control and Prevention and the Association of State and Territorial Dental Directors which is designed to monitor aspects of oral health and disease on both a national and state level. The NOHSS ranks Kentucky at or near the bottom in most oral health indicators. The primary message of the Surgeon General’s May 2000 report on Oral Health in America was to emphasize the link between oral health and overall health including the effect on day‐to‐day activities such as work and school …

Establishing Long-Term Cost Effectiveness Of Fema Buyouts: A Loss Avoidance Study Of The Acquisition/Demolition Of 22 Properties In Shepherdsville, Kentucky, Esther White

MPA/MPP/MPFM Capstone Projects

Kentucky has 1500 square miles of surface water and 1500 miles of navigable waterways. Fifty-one of the 120 county seats are located on rivers, and over 25 percent of the state’s population lives along waterways. Not surprisingly, flooding is the most common natural hazard in Kentucky, and many structures have been built over the years in floodplain areas. Although many local ordinances have been enacted across the State in recent years to limit new construction in these areas, existing structures still experience frequent flood damages. These structures are required by the federal government to maintain flood insurance, and the National …

Graduate School Choice And Recruitment: An Assessment Of The Martin School Applicant Data System And Its Utility For Supporting Administrative Decisions, Leslie A. Curtis

MPA/MPP/MPFM Capstone Projects

Student recruitment and retention are issues of importance for both graduate schools and graduate programs alike. Administrative decisions must be made, regarding these topics, which will best benefit the school or program. Within the Martin School of Public Policy and Administration, those decisions can be influenced by data collected on current and past students. Analysis of data obtained from the student admissions application and a survey sent to students accepted into the Martin School can inform these management decisions. The information developed can highlight areas of recruiting concern such as attracting a higher number of high-quality in-state applicants, increasing diversity, …

Educational Advancement: Decision Influences Regarding Attendance And Level Of Post-Secondary Education, William Spears

MPA/MPP/MPFM Capstone Projects

The intent of this study was to determine which characteristics from a group of student, teacher, and school characteristics had a significant influence in affecting enrollment in education beyond high school. There are social benefits from having a more educated populace, the Kentucky political system has highlighted intentions to increase enrollment in institutions, and Kentucky has lagged behind the nation and most states in its ability to continue educating the populace beyond high school. Most of the previous efforts to examine postsecondary attendance decisions have focused on the demographics of students with the implication that those student characteristics are the …

Understanding Non-Profit Organizations In States With Appalachian Counties: Where They Locate And The Missions They Serve, Rebecca E. Tucker

MPA/MPP/MPFM Capstone Projects

No executive summary.

The Federalization Of The Duty Of Loyalty Governing Charity Fiduciaries Under United States Tax Law, Johnny Rex Buckles

Kentucky Law Journal

No abstract provided.

Choking Out Local Community Service Organizations: Rising Federal Tax Regulation And Its Impact On Small Nonprofit Entities, Nicole S. Dandridge

Kentucky Law Journal

No abstract provided.

The "Federalization" Problem And Nonprofit Self- Regulation: Some Initial Thoughts, Mark Sidel

Kentucky Law Journal

No abstract provided.