Digital Commons Network^™

Anabolic Properties Of The Progestin Altrenogest And Its Regulation As An Environmental Substance In Horse Racing – Review And Analysis, Andreas F. Lehner, Levent Dirikolu, Sarah Jacob, Kimberly Brewer, Abelardo Morales Briceñoe, Robert Holland, George Maylin, Clara Fenger, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Altrenogest is a progestogen substance used in equine medicine for the synchronization of ovulation during the spring breeding season and the control of estrus in mares. It accomplishes its actions by down-regulation of endometrial progesterone receptors and repression of estrogen receptor transcriptional activation. However, various groups have also measured androgen receptor binding activity for altrenogest in vitro; these findings combined with androgenic and anabolic properties roughly 1/20 in potency of testosterone and its structural similarity to the anabolic steroid trenbolone have created concerns among racing authorities of altrenogest’s potential abilities to alter the outcome of equine athletic performance, even though …

Listening To Cursive: The Roles Of Regional Identity And Folk Beliefs In Perceptual Cue-Weighting, Stella Takvoryan

Theses and Dissertations--Linguistics

Listeners use knowledge acquired from experiences to weight phonetic-level cues to phonological contrasts. Phonetic knowledge is imbued with expectations about the contexts in which cues covary, speakers of a variety, and identity categories or constructs, so it can be challenging to distinguish expectations about variation from expectations about speakers. This study aims to explore the extent that expectations about iconic vowel quality variation in Southern American Englishes can drive cue-weighting. Listeners categorized stimuli with vowel qualities synthesized from an [ɛ]-[eɪ] continuum from a Southern and a non-Southern talker, with duration manipulated in tandem. Half of the participants saw a label …

Common Law Executive Privilege(S), Jonathan Shaub

Law Faculty Scholarly Articles

There are few Supreme Court cases that enjoy as much widespread support as the unanimous decision in United States v. Nixon. The recent pitched battles between Congress and the executive branch have made apparent the vast disagreement between the two branches over access to information. But that disagreement does not extend to Nixon, the unquestioned jurisprudential foundation for the doctrine of executive privilege. Closer inspection shows, however, that this foundation is not a stable one, but one constructed from unnecessary, ill-considered dicta.

As this Article demonstrates, Nixon conflated the constitutional question about one branch’s power vis-à-vis another branch with an …

Visual Legal Rhetoric In The Age Of Generative Ai And Deepfakes: Renaissance Or Dark Ages?, Michael D. Murray

Law Faculty Scholarly Articles

The paradoxical development of visual generative AI tools, such as OpenAI’s DALL-E 3, Midjourney, and Stable Diffusion, simultaneously signals a renaissance and a potential dark age in visual rhetoric and communication. On the one hand, these tools democratize the creation of visual content, empowering attorneys and others to become artists and illustrators of their legal communications without needing to learn how to draw. These AI systems can simplify complex legal concepts, bridge language barriers, and enhance advocacy. But on the other hand, the proliferation of deepfakes presents significant challenges for visual rhetoric. Deepfakes can quickly and easily create realistic but …

Framing Large Language Models: Teaching Foundational Concepts Of Generative Ai And Information Literacy For Critical Student Engagement, Isaac Wink, Jennifer Hootman

Library Faculty and Staff Publications

This chapter situates the emerging scholarly conversation around AI literacy within the established Association for College and Research Libraries (ACRL) Framework for Information Literacy for Higher Education. We apply three frames in particular: 1) Authority Is Constructed and Contextual, 2) Information Creation as a Process, and 3) Research as Inquiry, considering competencies relevant to students encountering generative AI applications in educational contexts and addressing ways that both students and instructors may seek to engage productively with such tools.

This chapter primarily focuses on tools such as ChatGPT that are built atop large language models (LLMs)—systems trained on massive text corpora—rather …

Quieting The Cacophony: How To Reduce Greenwashing And Environmental Damage From The Food Industry, Alex Woodward

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

In this article, Alex G. Woodward addresses the problem of greenwashing and environmental harm caused by industrial agriculture and misleading food labeling. Woodward explains that while agriculture is essential to feeding a growing global population, its large-scale, profit-driven practices cause significant environmental damage. Woodward argues for a strategy that compels transparency through warning labels and expanding credible certification frameworks. Woodward proposes that the USDA implement a tiered labeling system under its Organic Program and require factual, noncontroversial disclosures about environmental harms on food packaging, with the goal of informing consumers, restoring trust, and incentivizing environmentally responsible agricultural practices.

This Land Is Our Land: Addressing Foreign Ownership Of Agricultural Land In The United States, Will Miller

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

In this note, Will Miller examines the rapid increase in foreign ownership of U.S. agricultural land and the national security and food security risks it creates. He explains that the Agricultural Foreign Investment Disclosure Act (AFIDA) only requires reporting of foreign ownership but imposes no restrictions, leaving regulation largely to a patchwork of state laws. Miller argues for federal oversight, contending that matters of foreign affairs and national security are best handled at the national level. He proposes a comprehensive federal regulatory scheme which would set nationwide minimum standards such as prohibiting ownership by foreign adversaries and capping total foreign-held …

The Impact Of Veterinary Stewardship Program Implementations On Backyard Chicken Farming In Rural Georgia, Lauren Ashley Herrin

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

In this article, Lauren Ashley Herrin examines the impacts of new FDA veterinary stewardship regulations on backyard chicken farming in rural Georgia. She explains that requiring prescriptions for previously over-the-counter antibiotics disproportionately harms low-income and rural communities by limiting access to affordable veterinary care, worsening risks of disease spread and public health threats. Herrin argues for policy approaches that balance antimicrobial resistance concerns with the realities of rural accessibility. She proposes solutions such as telehealth veterinary consultations, scholarship programs to encourage rural veterinary practice, and expanding prescriptive authority for veterinary technicians to ensure sustainable animal health care in underserved areas

When Breathing Becomes Wheezing: Why Kentucky Should Require Schools To Conduct Radon Testing, Abbey Norvell

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

In this note, Abbey Norvell analyzes the dangers of radon exposure in Kentucky schools, highlighting the state’s nation-leading lung cancer rates and the heightened risks for children. She explains that Kentucky has no law requiring schools to test for or mitigate radon levels, leaving students vulnerable. Norvell argues for mandatory radon testing and remediation in Kentucky schools. She proposes legislation modeled on other states requiring testing in both public and private schools within five years, and remediation within two years if levels exceed EPA standards.

Pesticide Lies! A Call For Epa Action As Recent Judicial Decisions Reveal The Harmful Truth Resulting From Exposure, Stevi Whitman

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

In this note, Stevi Whitman analyzes the dangers of weak pesticide regulation in the United States. Whitman explains that the EPA’s reliance on the vague “unreasonable adverse effects” standard under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) allows harmful products like Roundup to remain on the market despite strong evidence of health risks. Whitman argues for strengthening U.S. pesticide laws to match the European Union’s stricter safety threshold. She proposes amending FIFRA to require proactive bans on hazardous pesticides and greater accountability from manufacturers to better protect public health and the environment.

Simpson's Tachytely Or Bradytely? The Importance Of Quantifying Rate Uncertainty, Rosana Zenil-Ferguson, Lee Hsiang Liow

Biology Faculty Publications

The spectacular variation in species forms and richness across space and time can be explored using sophisticated and powerful tools recently developed by evolutionary modellers. In this contribution, we ask if the classic ‘Simpsonian’ view of tachytelic (fast), horotelic (standard) and bradytelic (slow) diversification rates can be distinguished with currently available tools and data. A neglected topic here is the role that the uncertainty of diversification rate estimates plays, where the lack of in-depth uncertainty measures could hinder our ability to confidently suggest differences in speciation or extinction rates in any given comparison. We propose quantifying the relative uncertainty of …

“I Just Don’T Find It Interesting”, Jennifer L. Osterhage, Utku Caybas, Jaeyun Han, Ellen L. Usher

Biology Faculty Publications

Situated expectancy-value theory (SEVT) posits that students’ expectancies for success, task values, and perceived costs affect their performance in STEM courses. Less is known about how students’ majors and timing of course completion affect motivational processes. Using the SEVT framework, this study utilised a convergent mixed methods approach to investigate academic motivation among students (N = 646) who enrolled in introductory biology at a large public university. Survey data revealed that students majoring in Biology were more motivated than students from other majors, although academic major was not directly associated with final grade. Upper-level students reported significantly lower competence-related beliefs …

Seasonal Divergence In Reproductive Timing On The Verge Of Spring, Devraj Singh, Adam M. Fudickar, Ellen D. Ketterson

Biology Faculty Publications

Every year as spring approaches and day length increases, many birds begin to reproduce, an annual expression of seasonal phenology that requires physiological preparation. In species distributed over a broad geographic range, populations that breed at higher latitudes are often migratory and delay reproduction until later in the year as compared to those breeding at lower latitudes. Dark-eyed Juncos serve as an excellent model for understanding the timing mechanisms regulating population-level variation in seasonal reproductive responses. We compared two seasonally sympatric dark-eyed junco populations in early spring. One migrates (Junco hyemalis hyemalis) and breeds in Alaska and Canada, while the …

Effect Of The Communities That Heal Intervention On Overdose Education And Naloxone Distribution, Patricia R. Freeman, Alexander Y. Walley, T. John Winhusen, Emmanuel A. Oga, Jennifer Villani, Timothy Hunt, Redonna K. Chandler, Douglas R. Oyler, Brittni Reilly, Kitty Gelberg, Christian Douglas, Michael S. Lyons, Ja Nae Holloway, Nathan A. Vandergrift, Joella W. Adams, Katherine Asman, Trevor J. Baker, Candace J. Brancato, Debbie M. Cheng, Janet E. Childerhose, James L. David, Daniel J. Feaster, Louisa Gilbert, La Shawn M. Glasgow, Dawn A. Goddard-Eckrich, Charles Knott, Hannah K. Knudsen, Michelle R. Lofwall

Sociology Faculty Publications

Objectives. To determine whether the Communities That HEAL (CTH) intervention is effective in increasing naloxone distribution compared with usual care. Methods. The HEALing (Helping to End Addiction Long-Term) Communities Study (HCS) is a clusterrandomized, parallel-arm, wait-list controlled implementation science trial testing the impact of the CTH intervention on increasing the use of evidence-based practices to lower opioid-related overdose deaths. Communities (n567) highly impacted by opioid overdose in Kentucky, Massachusetts, New York, and Ohio were allocated to CTH intervention (n534) or wait-list comparison (usual care; n533) arms. The primary outcome for this study was the number of naloxone units distributed in …

A Large Electroencephalogram Database Of Freewill Reaching And Grasping Tasks For Brain Machine Interfaces, Bhoj Raj Thapa, John Boggess, Jihye Bae

Electrical and Computer Engineering Faculty Publications

Brain machine interfaces (BMIs) offer great potential to improve the quality of life for individuals with neurological disorders or severe motor impairments. Among various neural recording modalities, electroencephalogram (EEG) is particularly favorable for BMIs due to its noninvasive nature, portability, and high temporal resolution. Existing EEG datasets for BMIs are often limited to experimental settings that fail to address subjects’ freewill in decision making. We present a large EEG dataset, containing a total of 6808 trials, recorded from 23 healthy young adults (eight females and 15 males with an age range from 18 to 24 years) while performing reaching and …

Speed Variation Based Power Regulation Concept For Dynamic Wireless Charging, Donovin D. Lewis, Sudarshan T. Harave, Omer Onar, Mostak Mohammad, Veda Prakash Galigekere, Gui-Jia Su, Dan Ionel

Electrical and Computer Engineering Graduate Research

On-road wireless charging of electric vehicles (EVs) in-motion could potentially reduce range anxiety or battery size with wide-spread deployment. The planning and implementation of such systems are greatly complicated due to their susceptibility to load variation inherent to traffic flow. This paper proposes a method for derisking the potential for traffic slowdowns by compensating for reduced vehicle speed and investigates how implementation may affect system performance. A load modeling case study is presented at 200kW for a mile of high-speed roadway employing speed-based power regulation with results indicating average power usage and maximum car hosting capability can be reduced by …

Fault-Tolerant High-Power Two-Phase Coreless Afpm Motor-Drive System Concept, Yaser Chulaee, Ali Mohammadi, Matin Vatani, Aaron M. Cramer, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper proposes a fault-tolerant, high-power two-phase coreless axial flux permanent magnet (AFPM) motor drive system concept. Initially, the performance of a two-phase variant of the coreless AFPM machine is compared with that of its three-phase counterpart using both 3D finite element analysis (FEA) and experiments. Thanks to the intrinsic unique features of coreless AFPM machines, the analysis of the results demonstrates that the two-phase configuration has comparable power density (kW/kg) and efficiency. In terms of fault tolerance, the two-phase configuration exhibits superior performance, as the mutual inductance between phases is zero, resulting in an electric machine with magnetically decoupled …

Ai In Newsrooms: Assessing Perception, Challenges And Possibilities In Bangladesh’S Media Landscape, Nadia Rahman

Theses and Dissertations--Communication

With the relentless progression of technological advancements, artificial intelligence (AI) has become a transformative force across various sectors, and newsrooms are no exception. Developed nations have already integrated AI into journalistic practices, showcasing its versatility in different news functions. However, the developing nations, including Bangladesh, a south Asian nation faces challenges in catching up, marked by technological and economic disparities. As an emerging economic force Bangladesh encounters different obstacles in the adoption of AI in its media landscape. Despite the expansiveness of its media industry, the country grapples with limited technological support and inadequate training opportunities. These challenges bring up …

Cybersecurity Training As Risk Communication: A Theory-Informed Model Of Employee Learning And Behavior Change, Daniel Chaney

Theses and Dissertations--Communication

Cybersecurity threats like phishing remain a persistent and costly challenge for organizations. Despite widespread corporate cybersecurity training (CCT) programs, many fail to produce lasting behavior change. This dissertation introduces the Training Knowledge Flow (TKF) Model to assess why such efforts often fall short. Grounded in communication theory, risk messaging, and adult learning principles, the TKF Model conceptualizes cybersecurity training as a staged process of learning, application, and behavioral adaptation. The model includes three phases: (1) Employee as Learner, focusing on message clarity and cognitive engagement; (2) Employee as Practitioner, assessing workplace transfer and training relevance; and (3) Employee …

"The Lgbtq Community, That's My New Church": An Examination Of Lgbtq+ Former Church Members' Experiences Of Religious Exit, Samantha N. Pfeiffer

Theses and Dissertations--Communication

This study examines the experiences of LGBTQ+ individuals who previously attended Independent Fundamentalist Baptist (IFB) churches, considering their experiences of being in the church, leaving the church, and rebuilding outside of the church. It also examines sermons from IFB churches that addressed topics related to the LGBTQ+ community to examine the teachings these individuals received while in the church. My examination of this topic was based in scholarly literature addressing the rhetoric of church sermons, the process and experience of religious disaffiliation, and Weick’s (1995) theory of organizational sensemaking. I used multiple qualitative methods in this study, including qualitative content …

Crystal Structures And Low-Affinity Complex Formation Of Halogenase Ctcp And Fad Reductase Ctcq From The Chlortetracycline Biosynthetic Pathway, Caixia Hou, Sylvie Garneau-Tsodikova, Oleg V. Tsodikov

Pharmaceutical Sciences Faculty Publications

Enzymatic halogenation in natural products has been intensely investigated due to its potential utility as a tool to improve pharmacological and pharmaceutical properties of drug leads. Chlortetracycline (CTC), the first tetracycline (TC) antibiotic discovered nearly eight decades ago, contains a chlorine group. This chlorine is installed enzymatically by the flavin adenine dinucleotide (FAD)-dependent halogenase CtcP. CtcP and the FAD reductase CtcQ, which is also encoded in the CTC biosynthetic gene cluster, function as a two-component system. Structural information on CtcP and CtcQ has been lacking. In this study, we determined crystal structures of CtcP from Kitasatospora aureofaciens in a complex …

Effects Of Biased Analogues Of The Kappa Opioid Receptor Agonist, U50,488, In Preclinical Models Of Pain And Side Effects, Ross Van De Wetering, Loan Y. Vu, Lindsay D. Kornberger, Dan Luo, Brittany Scouller, Sheein Hong, Kelly F. Paton, Thomas E. Prisinzano, Bronwyn M. Kivell

Pharmaceutical Sciences Faculty Publications

Kappa opioid receptor (KOR) agonists have well-established antinociceptive effects. However, many KOR agonists have negative side effects, which limit their therapeutic potential. Some researchers have suggested that the development of biased agonists that preferentially stimulate KOR G-protein pathways over β-arrestin pathways may yield drugs with fewer adverse side effects. This was investigated in the current study. We describe the synthesis and characterization of three U50,488 analogues, 1, 2, and 3. We evaluated the acute and chronic antinociceptive effects of these compounds in mice using the warm-water tail flick assay and in a paclitaxel-induced neuropathic pain model. Side …

Effects Of Fentanyl-Adulterated Methamphetamine On Circulating Ghrelin In Rats, Huimei Wei, Elise C. Maul, Shawn Park, Kaniz Fatema, Daniel J. Peter, Chang-Guo Zhan, Fang Zheng

Pharmaceutical Sciences Faculty Publications

The appetite hormone ghrelin influences biological processes that are responsible for substance use disorder, which is related to alcohol and most abused drugs including cocaine, methamphetamine, nicotine, etc. In general, upregulation of the ghrelin system enhances drug cravings and substance use. Studies reported in the literature consistently demonstrated that the ghrelin system is associated with stimulants. However, research on opioids in combination with methamphetamine has not been reported. In this study, we examined the relationship of circulating ghrelin with the polydrug use of fentanyl and methamphetamine in male Sprague-Dawley rats, demonstrating for the first time that concurrent use of fentanyl …

Koszulity, Supersolvability And Stirling Representations, Ayah Almousa, Victor Reiner, Sheila Sundaram

Mathematics Faculty Publications

Supersolvable hyperplane arrangements and matroids are known to give rise to certain Koszul algebras, namely their Orlik–Solomon algebras and graded Varchenko–Gel’fand algebras. We explore how this interacts with group actions, particularly for the braid arrangement and the action of the symmetric group, where the Hilbert functions of the algebras and their Koszul duals are given by Stirling numbers of the first and second kinds, respectively. The corresponding symmetric group representations exhibit branching rules that interpret Stirling number recurrences, which are shown to apply to all supersolvable arrangements. They also enjoy representation stability properties that follow from Koszul duality.

Image Processing And Machine Learning Using Lidar And 360 Camera In Underground Mines, Ana Fabiola Patricia Tejada Peralta

Theses and Dissertations--Mining Engineering

Underground mining environments present several safety challenges due to low visibility, poor lighting, and the absence of GPS coverage. These factors hinder situational awareness and delay hazard detection, particularly during post-disaster conditions. This research introduces an integrated framework that combines image processing and machine learning techniques applied to 360-degree camera and LiDAR data to enable automated object detection and remote monitoring in underground mines.

The study was divided into two main stages: 2D object detection and 3D object detection. The 2D component employed images captured with a Ricoh Theta Z1 360° camera and utilized YOLO-based deep learning models for object …

Development Of A Stable Isotope Method To Measure Protein Fractional Synthesis Rate In Equine Skeletal Muscle, Antoinette E. Foliart

Theses and Dissertations--Animal and Food Sciences

Muscle mass is regulated by the balance between muscle protein synthesis and degradation. Previous research in horses has shown that the signaling pathway that regulates protein synthesis is upregulated with increasing protein intake; however, whether this corresponds to an increase in muscle protein synthesis rates had not been previously explored. The objective of this study was to develop an isotopic method to measure muscle protein fractional synthesis rate (FSR) in horses following graded protein intake. Eight mature Thoroughbred horses were studied using a randomized cross-over design. Horses consumed meals containing 0 (No), 0.125 (Low), 0.25 (Med), or 0.5 (High) g …

Regulation Of Human Dna Mismatch Repair, Breanna Knicely

Theses and Dissertations--Toxicology and Cancer Biology

The DNA mismatch repair (MMR) pathway identifies and corrects misincorporations that arise during DNA replication. MMR is a pathway that is critical for maintaining genomic stability. Mutations within the MMR pathway, both germline and somatic, lead to the development of cancer. There are a variety of mechanisms that regulate the MMR pathway including protein-protein interactions, DNA damage response, and post-translational modifications. In this study, we aim to dive deeper into each of these mechanisms to obtain novel information regarding the mechanisms and regulation of human DNA MMR. In this study we generated hExo1 constructs mutating Exo1’s interactions with MSH2 and …

The Paradox Of Survival: Gendered Food Insecurity, Labor Inequalities, And Coping Strategies During The 2023/4 Drought In Eastern Ethiopia, Meron E. Lemma

Theses and Dissertations--Geography

In drought-prone regions of Eastern Ethiopia, recurring droughts profoundly reshape everyday life in ways that deepen existing gendered inequalities. Drawing on fieldwork conducted in Fedis district, including semi-structured interviews with women, project implementers, and government officials, as well as group discussions with community members, this study explores how women experience, navigate, and resist the gendered impacts of drought. By attending to the sociopolitical dynamics of drought and the development interventions that accompany it, I analyze how these forces restructure labor, land, food systems, and authority in ways that reproduce and exacerbate existing inequalities. Women’s coping strategies, ranging from begging and …

Body Mass Index, Sleep, And Food Insecurity Predict Prevalence Of Anxiety And Depression In College Students, Makenzie Barr-Porter, Amelia Sullivan, Jade Mcnamara

Dietetics and Human Nutrition Faculty Publications

This study aimed to assess the relationship between mental health, health behaviors, and food security in young adults in a university environment. Young adults (N = 536) at two United States universities completed a survey assessing health behaviors and characteristics. Logistic regression determined the odds of anxiety and/or depression based on gender identity, body mass index (BMI), food security status (FSS), and sleep restfulness. Over one-third of students were food insecure (36.7%), and almost all reported anxiety (57%) and/or depression (39.1%). Students who identified as female, reported very low FSS, poor sleep, and had higher BMI were at greater odds …

A Case Study In Program Evaluation, Kaitlyn E. Lee

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

This capstone project evaluates a fictious online MRSA education program developed by the Lexington-Fayette County Health Department and Fayette County Public Schools after a suspected outbreak among student athletes. Using the CDC’s 6-Step Framework for Program Evaluation, the project focuses on how stakeholders were engaged, how the program was described and mapped, how the evaluation questions were developed, what evidence was collected, and how conclusions were formed. The goal of the evaluation is to understand whether the program’s structure, delivery, and implementation support clear infection-control education for the different school personnel who use it. This project emphasizes the overall evaluation …