Forage News [2025-04], University Of Kentucky

Forage News

No abstract provided.

Current Practices In Training Paraeducators: A Literature Review, Rebekah Pearson

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

I conducted a brief literature review to examine current practices for training paraeducators in school settings. I reviewed literature published after 2010 using an online database. Using an author-made inclusion criterion, 13 articles were considered for review. Findings suggest that behavior skills training (BST), brief performance feedback, didactic training, and a strategy instruction framework are currently being used to train paraeducators. These trainings have yielded positive results in increasing desired paraeducator behaviors. I conclude by discussing the limitations and directions for future research.

Influence Of Naturalistic Language Intervention On Child Communication And Engagement, Olivia R. Abate

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

The purpose of this study is to parallel naturalistic instructional contexts that often occur during caregiver-child interactions (e.g., one-to-one arrangement during play) to learn more about how children respond when prompting is introduced compared to responsive interaction strategies alone or with environmental arrangement strategies. This exploratory study was designed to evaluate the potential differential effects within an ATD, comparing RI alone, RI + EA, and RI + MP on joint engagement, communication acts, and interfering behaviors. This study is ongoing and lacks results for communication acts. Preliminary results supported and contradicted aspects of the hypothesis: joint engagement would occur at …

Portable Multi-Parametric Microscopy For Noninvasive Metabolic And Vascular Imaging Of Orthotopic Tongue Cancer Models In Vivo, Pranto Soumik Saha, Jing Yan, Caigang Zhu

Markey Cancer Center Faculty Publications

Significance: Precise imaging of tumor metabolism with its vascular microenvironment becomes emerging critical for cancer research because increasing evidence shows that the key attribute that allows a tumor to survive therapies is metabolic and vascular reprogramming. However, there are surprisingly few imaging techniques available to provide a systems-level view of tumor metabolism and vasculature in vivo on small animals for cancer discoveries.

Aim: We aim to develop a new multi-parametric microscope that can faithfully recapitulate in vivo metabolic and vascular changes with a wide field of view and microscope-level resolution to advance cancer-related investigations. To maximize the ease and accessibility …

Discovering My Sonic Identity Through Intent And Self-Belief: A Portfolio Of Compositions, Addison J. Bird

Theses and Dissertations--Music

An analysis and overview of a master’s degree electroacoustic composition portfolio. These works represent significant benchmarks in terms of musical development and composer intent. Each piece is analyzed for its musical methods and inspirations as well as the non-musical ideas surrounding them. The pieces covered are a mixture of fixed media electroacoustic works and live electronic works incorporating popular and folk music influences.

Astrovascular Decoupling In Awake 5×Fad Mice Is Associated With Reduced Astrocytic Calcium, Ruei-Lung Lin, Sophiya L. Sims, Nicholas A. Wright, Léopoldine B. Galopin, Blaine Weiss, Susan D. Kraner, Jacquelyn E. Rhinehart, Ting-Hsuan Lu, Pradoldej Sompol, Christopher M. Norris, Olivier Thibault

Pharmacology and Nutritional Sciences Faculty Publications

INTRODUCTION

Evidence points to dysregulated Ca²⁺ in neurons and astrocytes in models of amyloidosis. While most of these data were obtained in vitro or in vivo under anesthesia, less work has investigated these variables in awake ambulating mice.

METHODS

Astrocytic Ca²⁺ fluctuations (GCaMP8f) were imaged concomitantly with vasoreactivity in S1 on a two-photon microscope during rest and ambulation. Single-cell resolution variables were extracted using continuous wavelet transform and traditional ΔF/F measures.

RESULTS

Along with increases in amyloid beta (Aβ) accumulation, we found significant reductions in measures of astrocyte functional connectivity, pairwise correlations, and network synchronicity in older 5×FAD …

A Framework For Ai Implementation In Construction: Use Cases, Challenges, And Benefits For Contractors, Jaqueline De Aquino Leite Gomes

Theses and Dissertations--Civil Engineering

The construction industry is one of the most important sectors that contribute to the economy worldwide, but it has been very slow in adopting digital transformation. Artificial Intelligence is the backbone of digital innovation, and it can help solve inefficiencies, improve safety, and enhance decision-making in construction. This thesis reviews 85 academic papers, identifies 354 AI use-cases, 180 benefits, and 173 challenges. Key findings have looked at the role of AI in safety monitoring, design optimization, and operational efficiency, while barriers involve data scarcity, high costs, and readiness of the workforce.

All of these challenges have one very handy framework …

Description Of Implementing A Mail-Based Overdose Education And Naloxone Distribution Program In Community Supervision Settings During Covid-19, Carrie B. Oser, Margaret Louise Mcgladrey, Douglas Oyler, Hannah K. Knudsen, Sharon L. Walsh, Susannah Stitzer, Michael Goetz, Marisa Booty, Erica Hargis, Sarah Johnson, Michele Staton, Patricia R. Freeman

Behavioral Science Faculty Publications

Introduction: This study uses the Exploration, Preparation, Implementation , and Sustainment (EPIS) model to retrospectively describe the mail-based overdose education and naloxone distribution (OEND) program developed in collaboration with the Kentucky Department of Corrections (DOC) for use in the HEALing Communities Study in Kentucky (HCS-KY) and details the reach of this innovative delivery model.

Methods: HCS-KY is a community-engaged cluster-randomized trial assessing the effects of implementing evidence-based practices, including OEND, on overdose death reduction across 16 communities highly impacted by the opioid epidemic in Kentucky. ⁶ The study launch coincided with the COVID-19 pandemic. All coalitions in the 16 HCS-KY …

Multi-Scale Computational Mechanical Modeling Of Complex Multi-Phase Materials Systems, Naji Al-Mashrafi

Theses and Dissertations--Chemical and Materials Engineering

This thesis employs finite-element–based computational methods to investigate how microstructural features and material heterogeneity govern mechanical behavior across three distinct complex systems. First, the elastic response of open-cell metallic foams is analyzed using large ensembles of model RVEs generated with the Kentucky Random Structures Toolkit (KRaSTk); finite-element homogenization reveals that effective stiffness is not dictated by relative density alone, as the skewness of ligament-length distributions—captured by the second Pearson’s coefficient—exerts a strong and previously unrecognized influence, with structures enriched in short load-bearing ligaments exhibiting consistently higher stiffness even at fixed density and connectivity. The second study examines heterogeneous polycrystalline solids …

An Investigation Into The Feasibility And Efficacy Of Stereotactic Radiosurgery For 1–3 Cm Single Brain Lesions On The Ring-Mounted Halcyon Linac, Kristin J. Hazelwood, Shane Mccarthy, Josh Misa, David Castelvetere, William St. Clair, Damodar Pokhrel

Radiation Medicine Faculty Publications

Purpose: An evaluation of the accuracy, safety, and efficiency of the Halcyon ring delivery system (RDS) for stereotactic radiosurgery (SRS) treatment to relatively small (1–3 cm) brain lesions.

Methods: After completing the extensive in-house quality assurance checks including Winston–Lutz test and independent dose verification via MD Anderson IROC SRS head phantom irradiation on Halcyon, fifteen brain SRS patients previously treated with a single dose of 20 Gy on TrueBeam (6MV-FFF) with HyperArc geometry were retrospectively replanned on Halcyon (6MV-FFF). Plan quality metrics including conformity index (CI), gradient index (GI), gradient distance (GD), PTV coverage, gross tumor volume (GTV) dose, heterogeneity …

Feasibility Of Treatment Planning With Hyperarc Stereotactic Radiosurgery Methods For Ocular Tumors, Chase Cochran, Shane Mccarthy, William St. Clair, Damodar Pokhrel

Radiation Medicine Faculty Publications

Purpose/objectives

Currently, ocular disease is primarily managed with COMS plaque brachytherapy. Various stereotactic radiosurgery (SRS) platforms have also been employed, yet widespread access remains a challenge. Herein, we demonstrate the feasibility of using the HyperArc SRS system to provide an additional platform for the treatment of ocular malignancies.

Materials/methods

Twenty previously treated COMS patients with ocular melanoma were selected for a retrospective HyperArc SRS planning study. The average gross tumor volume (GTV) derived from MRI was 1.19 ± 0.60 cc. Planning target volumes (PTV) were generated from a 2 mm expansion of the GTVs. HyperArc plans were created for a …

Ex Vivo Single-Molecule Analysis Of Ryanodine Receptor 2 Assembly In Cardiac And Neuronal Tissue, Qianye Yin, Christopher I. Richards

Chemistry Faculty Publications

Understanding receptor assembly is critical for elucidating the mechanisms underlying their function and regulation in physiological processes. While traditional in vitro single-molecule studies rely on isolating proteins from heterologous expression systems, they often fail to capture the in vivo physiological complexity involved in the organization and assembly of cell surface proteins. This protocol employs Total Internal Reflection Fluorescence Microscopy (TIRFM) to study GFP-tagged Ryanodine Receptor 2 (RyR2) molecules encapsulated within nanoscale vesicles. These vesicles, generated from organs rapidly extracted from the animal, effectively provide a snapshot of the receptor's assembly state at the time of extraction, enabling detailed analysis of …

Incarceration Reimagined: A Diversionary Option For Serious Felony Offenders, Jane Mitchell

Kentucky Law Journal

No abstract provided.

Converting “Nonlesional” Imaging Occult Epilepsy Into A Focal Lesional Entity Using Advanced Imaging Techniques: Illustrative Case, Muhammad Usman Khalid, Flavius D. Raslau, Valentinos Zachariou, David Powell, Zachary Winder, Ryan Cloyd, Sarah Helen Thomas, John Kuipers, Rachel Ward Mitchell, Riham H. El Khouli, Timothy J. Ainger, Sally Mathias, Farhan A. Mirza

Neurosurgery Faculty Publications

BACKGROUND To achieve the best possible outcome in surgical refractory epilepsy, the seizure onset zone must be accurately identified prior to treatment.

OBSERVATIONS A 38-year-old man presented with tonic-clonic and focal seizures 2–3 times per month, refractory to antiseizure medications. Scalp EEG, MRI, PET, ictal SPECT, magnetoencephalography, and stereo-EEG (SEEG) did not provide conclusive seizure onset zone localization. Subsequently, the patient was included in the authors’ ongoing postictal arterial spin labeling (ASL) study and additional postprocessing was performed with a morphometric analysis program (MAP) and texture analysis. Using these results, the authors reexamined the original structural MR images, with attention …

Exploring Early Childhood Educators’ Perceptions Of Lockdown Drills: Preparedness, Training Needs, And The Balance With Social-Emotional Development, Juniper Alaska Brewer

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

The purpose of this study was to evaluate early childhood educators’ perceptions of lockdown drills. It assessed feelings of preparedness, perceived training needs, and balancing safety protocols with children's social-emotional development. A multi-methods online survey was distributed to 13 early childhood educators and students in the Interdisciplinary Early Childhood Education (IECE) field, collecting both quantitative and qualitative responses via Qualtrics.

Survey data showed educators strongly agreed drills prepare them for emergencies (average 4.46/5) and generally agreed drills prepare children (4.08/5), though responses were more neutral about reducing educator anxiety (3.77/5). Only one participant reported occasional training; most (7 of 13) …

Exploiting Artificial Intelligence And Optimization For Smart Agriculture, Jackson K. Butcher

Theses and Dissertations--Computer Science

Dynamic integration of Cyber-Physical Systems (CPS) and Artificial Intelligence (AI) has become a vital component for unlocking the potential of smart agriculture. Currently, limitations such as limited computational resources, poor network connectivity, and rigid treatment strategies stifle optimal agricultural outcomes. This creates a challenge of leveraging the capabilities of modern artificial intelligence to combat the natural and artificial constraints of the smart agriculture environment. The primary contribution of this thesis is the development of frameworks to alleviate the overhead data and computational demand for AI within smart agriculture settings. The first framework, iCrop+, utilizes TinyML and LoRa to guarantee high-precision …

Biomedical Relation Extraction In The Era Of (Large) Language Models, Yuhang Jiang

Theses and Dissertations--Computer Science

Biomedical relation extraction is a key task in information extraction supporting downstream applications such as knowledge discovery, information retrieval, and question answering. As such, improvements in relation extraction (RE) are expected to have major implications for other information needs in biomedicine. In this dis- sertation, we pursue biomedical relation extraction in several advanced settings with recent advances in large language models (LLMs) and retrieval augmented generation (RAG). First, we address an important slot filling task on social media that arose during the Covid-19 pandemic, using the idea of continuous prompts with encoder models. Next, we handle a tricky dynamic n-ary …

Assessing Generalization Along Side Acquisition Using System Of Least Prompts Versus Video Modeling Plus System Of Least Prompts Of Simulated Vocational Tasks, Victoria B. Shafer

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

The purpose of this study was to assess if system of least prompts alone or video modeling plus system of least prompts was more effective when teaching a student with a moderate intellectual disability three simulated vocational tasks using paper materials. Additionally, generalization was assessed using real-world materials. An adapted alternating treatment design was used to compare conditions. The results indicated that system of least prompts alone was more effective than video modeling plus system of least prompts. There was no demonstration of generalization.

Efficacy Of Deferoxamine Mesylate In Serum And Serum-Free Media: Adult Ventral Root Schwann Cell Survival Following Hydrogen Peroxide-Induced Cell Death, Yee Hang Ethan Ma, Abhinay R. Putta, Cyrus H. H. Chan, Stephen R. Vidman, Paula V. Monje, Giles W. Plant

Neurosurgery Faculty Publications

Schwann cell (SC) transplantation shows promise in treating spinal cord injury as a pro-regenerative agent to allow host endogenous neurons to bridge over the lesion. However, SC transplants face significant oxidative stress facilitated by ROS in the lesion, leading to poor survival. deferoxamine mesylate (DFO) is a neuroprotective agent shown to reduce H₂O₂-induced cell death in serum-containing conditions. Here we show that DFO is not necessary to induce neuroprotection under serum-free conditions by cell survival quantification and phenotypic analysis via immunohistochemistry, Hif1α and collagen IV quantification via whole cell corrected total cell fluorescence, and cell death …

Comparison Of Video Modeling And Naturalistic Time Delay For Children With Autism In Preschool Classrooms, Makenna A. Briggs

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

This study presents findings from an alternating adapted treatments design (AATD) that compared the use of video modeling and naturalistic time delay to teach language targets to children with autism. The research included two U.S. preschool students with a provisional diagnosis of autism spectrum disorder (ASD). Both participants met criterion with time delay.

Including Black Farmers, Excluding Pests: Perspectives On Participation In The Cooperative Extension Service, Briana Bazile

Theses and Dissertations--Entomology

In recent years, the U.S. Department of Agriculture has faced renewed scrutiny for documented discrimination against Black farmers, yet far less attention has focused on its century-old partner in public service delivery, the Cooperative Extension Service (CES). This gap is especially notable considering 1) federal parity mandates extant since 1972 in response to significant disparities between Black and White constituents and staff,2) public commitments to Diversity, Equity & Inclusion in 2020 and, 3) the contributions of Black leaders at the origins of CES, at Tuskegee University in the late nineteenth century. Using the Kentucky Cooperative Extension Service (KYCES) as a …

Understanding Assessments For Adult English Learners: A Case Study Of Second Language Acquisition And Development, Chi Ma

Theses and Dissertations--Education Sciences

While standardized tests have become the norm for assessing language proficiency, they may not effectively capture the diversity of adult immigrants, including their backgrounds, experiences, and varying levels of language proficiency. Grounded in experiential learning theory, sociocultural theory on second language acquisition, and concepts of identity, motivation, and investment, this study explored how the Adult English Learning (AEL) program utilized different types of assessments, what the needs and goals of AEL students were in learning English, and how various stakeholders, including teachers, students, and program coordinator, perceived current assessments reflecting students’ needs and goals.

The findings of the study reveals …

Seasonal Variation Of The Stream’S Autogenic Sediment Transport Regime, Melissa Beckman

Theses and Dissertations--Civil Engineering

This thesis investigates the autogenic sediment transport regime in a low-gradient stream system in the inner bluegrass region of central Kentucky, USA The seasonality of sediment transport seasonality was not well addressed in prior research for baseflow and low flow periods, to our knowledge, due to the assumption that low flows do not account for considerable fluid transport capacity to move sediment. The hypothesis is that during the autogenic regime the sediment transport in the low-gradient system is being driven by geophysical, biogeochemical, and biological processes. We hypothesize that crayfish are one mechanical driver of sediment transport during these periods. …

The Effects Of System Of Least Prompts To Promote Indpendence For A Student With Autism, Misty L. Brown

Theses and Dissertations--Education Sciences

This study examined the effects of a System of Least Prompts (SLP) intervention on the independent skills, such as completing a daily schedule, setting alarms on a personal device, and transitioning into set activities, for a high-school student diagnosed with autism spectrum disorder (ASD) and multiple co-occurring diagnoses. LB was a 15-year-old student who attended a specialized non-profit school for individuals with ASD and severe behaviors and was in the process of transitioning back into public school. He required support in self-management and choice making skills. The purpose of this intervention was to increase LB’s ability to evaluate his day …

Measurement Of Two-Point Energy Correlators Within Jets In P+P Collisions At Sqrt[S]=200  Gev, Star Collaboration

Physics and Astronomy Faculty Publications

Hard-scattered partons ejected from high-energy proton-proton collisions undergo parton shower and hadronization, resulting in collimated collections of particles that are clustered into jets. A substructure observable that highlights the transition between the perturbative and nonperturbative regimes of jet evolution in terms of the angle between two particles is the two-point energy correlator (EEC). In this Letter, the first measurement of the EEC at RHIC is presented, using data taken from 200 GeV p þ p collisions by the STAR experiment. The EEC is measured both for all the pairs of particles in jets and separately for pairs with like and …

Crop Insurance And Weather Risk: Decision Tools And The Effects Of Rising Temperatures In Kentucky, Enil Serrano

Theses and Dissertations--Agricultural Economics

This thesis investigates how rising temperatures and climate variability affect crop insurance decisions and premium rates for corn and soybean farmers in Kentucky. It introduces a new decision-support tool, the "Crop Insurance Decision Maker" (CIDM), which helps producers evaluate the financial trade-offs of various crop insurance products under different risk preferences. The first chapter details the tool’s development, function, and potential to improve farmer understanding of insurance options. The second chapter quantifies how +1°C and +2°C warming scenarios impact yield risk and crop insurance premium rates using 73 years of corn yield data, 51 years for soybean yield, and weather …

The Impact Of A Geriatric Trauma Unit On Patient Outcomes, Shannon E. Johnson

DNP Projects

Abstract

Background: Traumatic injuries in the geriatric (> 65) patient population can have devastating effects. Only a small percentage of these patients return to independent ambulation and living. As the population continues to age and life expectancy continues to increase, the incidence of traumatic injuries in geriatric patients will continue to increase. Geriatric friendly hospital wards in several disciplines have been shown to reduce length of stay and improve patient outcomes. However, there has been no research surrounding geriatric trauma wards specifically.

Purpose: The purpose of this quality improvement project was to evaluate the impact of admitting geriatric trauma patients …

Trace Level Identifications Of N-Ethylnicotinamide In Racing Horses Associated With A Vitamin B3 Supplement: Case Reports And Analysis, Clara Fenger, Kimberly Brewer, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Nikethamide, N,N-diethyl-3-pyridinecarboxamide (Coramine®) is a central nervous system stimulant at one time used therapeutically in human medicine but no longer marketed in the US. Nikethamide is classified a Drug Class 1, Penalty Class A substance by the Association of Racing Commissioners International (ARCI) and as a Horseracing Integrity and Safety Authority (HISA) SO or banned Stimulant that lacks FDA approval. Identifications of Nikethamide or its metabolite N-Ethylnicotinamide in racing samples can result in significant penalties in horse racing. Nikethamide is rapidly metabolized to N-Ethylnicotinamide, which remains detectable in plasma and urine leading to its use as a regulatory “marker” of …

Serious Bacterial Infections And Hepatitis C Virus Among People Who Inject Drugs, Thomas J. Stopka, Robin M. Nance, L. Sarah Mixson, Hunter Spencer, Judith I. Tsui, Judith M. Leahy, Mai T. Pho, Jean Dejace, Judith Feinberg, April M. Young, Wei Teng Yang, Amelia Baltes, Eric Romo, Randall T. Brown, Kerry Nolte, William C. Miller, William A. Zule, Wiley D. Jenkins, Joseph A. Delaney, Peter D. Friedmann

Epidemiology and Environmental Health Faculty Publications

Limited research has examined the possible synergistic interrelationships between serious bacterial infections (SBIs) of the heart (i.e., endocarditis), bone, spine, brain, or joints (e.g., osteomylelitis) and hepatitis C virus (HCV) infections. We examined whether syndemic interactions existed between SBI, HCV, and substance-use-related factors in rural communities, hypothesizing that injection-mediated risks elevated the likelihood for both SBIs and HCV infections, which could be exacerbated by synergistic biological–biological or biological and social interactions. We calculated the prevalence ratios (PRs) of past-year SBI associated with each risk factor in separate models. Effect modification among significant risk factors was assessed using multiplicative interaction. Among …

Viral Transcript And Tumor Immune Microenvironment-Based Transcriptomic Profiling Of Hpv-Associated Head And Neck Squamous Cell Carcinoma Identifies Subtypes Associated With Prognosis, Anastasiia Nikitina, Daria Kiriy, Andrey Tyshevich, Dmitry Tychinin, Zoya Antysheva, Anastasya Sobol, Vladimir Kushnarev, Nara Shin, Jessica H. Brown, James Lewis, Krystle A. Lang Kuhs, Robert Ferris, Lori Wirth, Nikita Kotlov, Daniel L. Faden

Epidemiology and Environmental Health Faculty Publications

Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HPV-positive HNSCC) has distinct biological characteristics from HPV-negative HNSCC. Using an AI-based analytical platform on meta cohorts, we profiled expression patterns of viral transcripts and HPV viral genome integration, and classified the tumor microenvironment (TME). Unsupervised clustering analysis revealed five distinct and novel TME subtypes across patients (immune-enriched, highly immune and B-cell enriched, fibrotic, immune-desert, and immune-enriched luminal). These TME subtypes were highly correlated with patient prognosis. In order to understand specific factors associated with prognosis, we used the unsupervised clustering of an HPV-positive HNSCC cohort from The Cancer Genome Atlas …