Digital Commons Network^™

Spectral Properties And The Behavior Of The Current-Current Correlation Measure For The Luttinger-Sy Model, Jonathan Benoit

Theses and Dissertations--Mathematics

The Luttinger-Sy Model, sometimes referred to as the Pieces Model, is a Random Schrodinger Operator on L²(R) which is characterized in part by "pieces" whose endpoints are chosen by a Poisson Point Process. The Hamiltonian in this setting is then given as a direct sum of Laplacians with Dirchlet boundary conditions on each piece. In this work, we show several spectral properties of the Luttinger-Sy Model, including proving the deterministic spectrum is [0,infinity) and that a Wegner-type and Minami-type estimate both hold. Additionally, we show that the finite-volume Current-Current Correlation Measure is singular continuous with respect …

A Major Update And Improved Validation Functionality In The Mwtab Python Library And The Metabolomics Workbench File Status Website, P. Travis Thompson, Hunter N. B. Moseley

Markey Cancer Center Faculty Publications

Background: The Metabolomics Workbench (MW) is a public scientific data repository consisting of experimental data and metadata from metabolomics studies collected with mass spectroscopy (MS) and nuclear magnetic resonance (NMR) analyses. Although not as rapidly as in the past, MW has steadily evolved, updating its mwTab and JSON deposition text file formats and its web-based infrastructure. However, the growth of MW has been exponential since its inception in 2013 and continues to be exponential, with the number of datasets hosted on the repository increasing by 50% since April 2024. As part of regular maintenance to keep up with changes to …

Mental Health Needs Of Families Of Patients In Intensive Care Units And The Role Of Mobile Health: Survey Study, Anthony Faiola, Saira Soroya, Zhonglin Hao, Reinhold Munker

Markey Cancer Center Faculty Publications

Background: The experiences of patients with COVID-19 and their families manifested the most devastating effects of family separation since the 1918 Spanish influenza pandemic and, with it, a call for solutions to patient isolation and its effect on family mental health.

Objective: This study examined the recent experiences of families of critical care (intensive care unit; ICU) patients related to anxiety and depression (AD), satisfaction with clinician-family communication, and counseling from mental health and social services. This study explored correlations between these factors and family interest in mobile health (mHealth) designed to improve information flow and communication from patient bedside …

Case Report: Prostate Adenocarcinoma With Peritoneal Carcinomatosis And Elevated Cea Mimicking Colorectal Cancer: A Diagnostic Dilemma, Hala Majeed, Nathan R. Shelman, Jitesh A. Patel, Janeesh S. Veedu, Insija I. Selene, Ashlyn Whitesell, Zin W. Myint

Markey Cancer Center Faculty Publications

This case report describes an exceptionally rare manifestation of prostate adenocarcinoma presenting with peritoneal carcinomatosis, rectal obstruction, and markedly elevated carcinoembryonic antigen (CEA), closely mimicking colorectal cancer. A 65-year-old man with localized high-grade prostate adenocarcinoma (Gleason 4 + 4) underwent robotic prostatectomy in November 2020, followed by salvage radiation and stereotactic body radiation therapy for early biochemical recurrence. He achieved an excellent response to androgen deprivation therapy (ADT) combined with abiraterone and prednisone, maintaining an undetectable prostate-specific antigen (PSA) level for over 2 years. In late 2024, the patient developed hematochezia, narrow stools, and abdominal pain. Imaging revealed a rectal …

Robotizing Complex Welding Processes Through Imitation Learning And Generative Models From Human Demonstration, Yue Cao

Theses and Dissertations--Electrical and Computer Engineering

Arc welding processes demand real-time adaptive control that current robotic systems cannot achieve autonomously. This dissertation develops a systematic framework to robotize complex welding by learning from human demonstration, integrating generative modeling, physics-informed reconstruction, and model-based imitation learning. First, human--robot collaboration systems are established for both Gas Tungsten Arc Welding (GTAW) and Double-Electrode Gas Metal Arc Welding, combining robotic teleoperation with virtual reality interfaces to capture high-quality operator demonstrations. Second, a physics-informed neural network framework reconstructs complete molten pool flow fields from high-speed imaging, enriching process understanding beyond direct sensor observation. Third, generative models, including a hybrid latent variational autoencoder …

Challenges And Applications Of Fine-Grained Temporal Action Understanding: Modeling Temporal Granularity And Data Efficiency, Halil I. Helvaci

Theses and Dissertations--Electrical and Computer Engineering

Fine-grained Temporal Action Segmentation (TAS) has become a cornerstone of video understanding, offering dense frame-level predictions essential for clinical assessment, surgical skill evaluation, and human-computer interaction. While TAS methods have delivered strong results on coarse-grained benchmarks, two fundamental challenges persist: (1) global attention mechanisms dilute boundary information critical for subsecond precision, a phenomenon we term the temporal granularity bottleneck, and (2) dense frame-level annotation remains prohibitively expensive, with most datasets requiring exhaustive labeling of lengthy untrimmed videos. These challenges are particularly pronounced in medical domains, where sub-second primitives define clinical outcomes while expert annotation remains scarce. In this dissertation, we …

Learning-Enabled Methods For Optimal, Constrained, And Fault-Tolerant Robot Motion Planning, Charles L. Clark

Theses and Dissertations--Electrical and Computer Engineering

Safe and efficient motion planning is a core requirement for robots operating in complex real-world environments, yet traditional model-based approaches struggle to simultaneously achieve computational efficiency, solution optimality, and the ability to handle complex constraints and potential hardware failures. This dissertation investigates how neural networks, as general purpose function approximators, can be leveraged in both traditional and novel ways to overcome these limitations and advance beyond what purely model-based methods can offer. Three distinct contributions are presented. First, a new motion planner is developed that uses ReLU neural networks to decompose the configuration space into linear cost regions, enabling existing …

Advancing Edge Intelligence: Strategies For Improving Machine Learning On Embedded Devices, Prakash Dhungana

Theses and Dissertations--Electrical and Computer Engineering

Artificial intelligence (AI) has demonstrated tremendous success in handling complex tasks across multiple domains, a leap largely attributed to complex deep neural network (DNN) architectures. However, the increasing demand for real-time processing, low latency, limited connectivity, and enhanced privacy necessitates edge intelligence, where computation is performed directly on resource-constrained embedded devices rather than relying on cloud infrastructures. While optimized TinyML techniques such as pruning, quantization, and neural architecture search (NAS) have made edge deployment feasible by significantly reducing computation and memory demands, achievable performance remains severely limited by hardware constraints. Furthermore, models deployed in highly dynamic real-world environments suffer from …

Making Sense Of Membership: Organizational Socialization Of African Immigrant Employees In U.S. Workplaces, Ikeola J. Bodunde

Theses and Dissertations--Communication

This dissertation examines how African immigrant employees make sense of organizational socialization in U.S. workplaces. As global mobility reshapes the labor force, nearly one in five U.S. workers is foreign-born, making organizational socialization an increasingly complex communicative process. Classic socialization models assume linear, uniform adjustment, yet international employees often face ambiguity, cultural mismatch, and racialized expectations that complicate early workplace experiences. Guided by sensemaking theory, this study conceptualizes socialization as an ongoing, nonlinear process through which newcomers notice cues, construct interpretations, act on provisional understandings, and revise meanings as contexts shift. Using a qualitative, interpretive design, I conducted semi-structured interviews …

Enhancing Tray Integrity: A Quality Improvement Project To Reduce Central Sterile Processing Defects, Ashley Conn

DNP Projects

Background: Instrument tray defects contribute to surgical delays, workflow disruptions, rework in sterile processing, inefficient instrument utilization, and patient safety risks.

Purpose: The purpose of this quality improvement project was to reduce orthopedic instrument tray defects through targeted education and standardized tray audits with double-check verification in a large academic medical center.

Methods: A quasi-experimental pre-post design was utilized to evaluate the impact of the intervention. Tray errors were captured using a standardized binary indicator. Staff satisfaction and confidence surveys were measured using Likert-scale surveys.

Results: Orthopedic trays were analyzed before (n=1,017) and after (n=941) implementation. Post-implementation, tray errors decreased …

Evaluation Of A Nicotine Prevention Program In A Third Grade Classroom, Jennifer A. Pile

DNP Projects

Purpose: The purpose of this project was to increase knowledge of nicotine products and promote negative perceptions of nicotine use among third-grade students through early prevention education.

Background: Prevention is key and to prevent nicotine use, there must be an educational program with that aim in a much younger population. Third grade encompasses 8-, 9-, and 10-year-olds. This group is in the middle childhood stage and begin more complex thinking and problem-solving skills. There is physical and emotional development among this group.

Methods: This is a quasi-experimental study among third grade students in Breckinridge County Kentucky with pretest and …

Improving Compliance With Preoperative Antibiotic Protocols For Cardiac Implanted Electronic Devices: A Quality Improvement Project, James Kaup

DNP Projects

Abstract

Background

Cardiac implantable electronic device infections remain a serious complication of permanent pacemaker implantation despite evidence-based infection prevention guidelines.

Local Problem

An academic electrophysiology laboratory identified inconsistent guideline-concordant antibiotic selection despite consistently high compliance with recommended antibiotic timing.

Methods

A nurse-led, quasi-experimental pre-post quality improvement project evaluated implementation of a standardized preoperative antibiotic prophylaxis protocol. Data from 36 permanent pacemaker implantations (16 pre-intervention, 20 postintervention) were analyzed.

Interventions

The intervention included a standardized antibiotic protocol, multidisciplinary staff education, and performance feedback.

Results

Guideline-concordant antibiotic selection improved from 37.5% to 95.0% (χ² = 11.27, P = .001). Antibiotic timing remained …

Impact Of Land Use On Soil Properties, Clay Mineralogy, And Behavior Of Ammonium Across A Precipitation Gradient, Isabel Delamater

Theses and Dissertations--Plant and Soil Sciences

Like soil texture, clay mineralogy is considered a permanent or inherent characteristic of soils reflecting the influence of soil forming factors over long periods of time. Despite the importance of clay mineralogy in providing ecosystem services, much remains unknown about whether land use (native grassland sod versus no-tillage) can modify clay mineralogy under short periods of time. Furthermore, in no-tillage agroecosystems, lower crop yields are often ascribed to immobilization of added N fertilizer where inorganic nitrogen (such as ammonium) is converted to organic nitrogen. The possible role of clay mineralogy in retaining added ammonium has been overlooked in no-tillage systems. …

Enhanced Photostability Through Rapid Exciton Decay In Desymmetrized Cyclopentannulated Acenes With Strong Face-To-Face Pi Stacking, Chad D. Cruz, Karl J. Thorley, Zachary J. Knepp, Jared Wahlstrand, Gil M. Repa, John C. Stephenson, Sean Parkin, Lisa A. Fredin, John E. Anthony, Emily G. Bittle

Chemistry Faculty Publications

The photophysics of organic semiconductors impacts their efficiency in optoelectronic devices where exciton transitions, including singlet fission, intersystem crossing and the formation of charge transfer states influence the ability to convert between bright and dark states and to dissociate into free charges. Unfortunately, photodegradation and spurious signals often confound the results of optical studies, especially of important triplet states. Here four asymmetric cyclopentannulated acenes are synthesized and studied. This system represents an extreme in photophysics achieved via molecular design to fully quench the photoluminescence and bypass triplet formation allowing for comparative studies with other highly absorbing acenes. Rapid molecular exciton …

Investigation Of Succinylated Zwitterionic Polyethylenimine/Dna Complexes: Performance In Serum, Internalization, And Intracellular Fate, Levi Lampe

Theses and Dissertations--Chemical and Materials Engineering

Gene therapy has promised to revolutionize medicine since the earliest clinical trials, but a lack of delivery methods that are both safe and efficient has hampered progress. Gene therapy with viral vectors is effective at delivering nucleic acids to cells, but is associated with dangerous immunogenic responses and cancer-causing insertions into the genome. Viral vectors are also among the most prohibitively costly therapeutics in medicine. Polymeric vectors avoid these dangers and are made from inexpensive, off-the- shelf materials, but have been hindered by poor efficiency compared to viral vectors.

A benchmark polymer for in vitro nucleic acid delivery has been …

Utilizing Coal For Mesophase Pitch-Based Carbon Fiber Production: Precursors, Processes, And Progress, Christina M. Thompson

Theses and Dissertations--Chemistry

Graphitic materials possess unique properties due to the unique combination of layered crystalline structure and carbon’s low atomic weight. High performance carbon fiber is one such example, displaying exceptional strength-to-weight ratios, stiffness, and thermal and chemical resistance. These properties render high performance carbon fiber a critical structural reinforcement material in the manufacture of composites across various industries, such as for automotive and aerospace applications. However, balancing fiber performance with precursor and processing costs remains a challenge. As alternative carbonaceous feedstocks are explored, coal has gained interest for utilization in graphitic products as a relatively abundant and low-cost source of aromatic …

Elucidating The Impacts Of Non-Covalent Interactions In Organic Materials Through A Multiscale Computational Approach, Sashen A. Ruhunage

Theses and Dissertations--Chemistry

Noncovalent interactions (NCIs) in π-conjugated organic materials serve as tunable levers that influence molecular structure and intermolecular interactions in the condensed phase and, in turn, impact the electronic, optical, and mechanical properties of these materials. NCIs include attractive dispersion, electrostatic, and induction interactions, as well as repulsive exchange interactions. However, how to design materials with NCI considerations remains an open question across many fields. Here, we seek to provide an electronic and atomistic perspective on these interactions through multiscale simulations to aid materials design, processing, and performance optimization. In this study, we investigate NCIs and their effects across various systems …

Student Familiarity With The Periodic Table Of The Elements: Results From Cued-Recall And Eye-Tracking Assessments On Memory, Victor A. Okuo

Theses and Dissertations--Chemistry

Learning element symbol–name associations and the spatial organization of elements on the periodic table is a foundational step in learning chemistry, supporting later understanding of chemical formulas, equations, bonding, and stoichiometry. Although students often rely on memorization strategies to learn periodic table content, this task is challenging due to the large number of elements and the apparent ambiguity in matching some element symbols to their names.

This study explores students’ recall of element names when given element symbols as cues and their knowledge of element locations on the periodic table when given element names as cues. The study also examines …

Amustaline/Glutathione Pathogen-Reduced Red Cell Hemoglobin Utilization In Complex Cardiac Surgery, Ian J. Welsby, Michael E. Sekela, Edward L. Snyder, James D. Gorham, John S. Mcneil, Kathy Liu, Stanley Bentow, Thomas Gniadek, Laurence Corash, Nina Mufti, Richard J. Benjamin

Surgery Faculty Publications

Background: The ReCePI randomized, controlled trial compared amustaline/glutathione pathogen-reduced (PR) and conventional red blood cell (RBC) transfusions in cardiac surgery. Study design and methods: We performed a post-hoc analysis of hemoglobin (Hb) utilization and safety outcomes. Hb content of study RBCs was measured at manufacture. Subject Hb levels, estimated blood loss and blood product use were recorded during and for 7 days post-surgery. Acute kidney injury (AKI) incidence was graded over 7 days, and adverse events were assessed for 28 days. Results: PR-RBCs contained 5.2% less Hb (mean [SD] Test 58.1 [6.5] g; Control 61.5 [6.8] g Hb, p <.001) due to manufacturing volume losses. Four hundred fifty-six PR- and 524 conventional RBCs were transfused to 159 Test and 162 Control subjects, respectively. Mean subject baseline and post-surgery Hb levels, and blood loss were not different between groups. Test subjects tended to require fewer total RBCs (3.5 [2.7] Test vs. 4.0 [3.5] Control, p =.08) resulting in 17.6% significantly less mean total Hb transfused (Test 203.2 g; Control 246.8 g Hb, p =.01). The proportions of subjects transfused with, and the number of platelet and cryoprecipitate units transfused were not different. Test subjects received less plasma (2.3 [1.8] units Test vs. 3.5 [3.8] Control, p =.03). Overall incidence of adverse events and AKI were not clinically different. Imbalances in AKI severity (Grade III Test 15/159 [9.4%]; Control 7/162 [4.3%], p =.07) may suggest under-transfusion in the highest-risk Test subjects. Discussion: Test patients required less transfused Hb than control subjects to maintain equivalent daily hemoglobin levels following similar blood loss.

Brief Exposure Therapy With Exercise For Ptsd: A Pilot Study Using Single Case Experimental Design, Troy J.J. Hubert

Theses and Dissertations--Psychology

Posttraumatic stress disorder (PTSD) is a common and often disabling psychiatric disorder associated with an increased risk of multiple mental and physical health conditions. Exposure therapy is a gold standard treatment for PTSD, but attrition rates and treatment response are notable limitations. Animal and human research collectively indicate that aerobic exercise can enhance preclinical and experimental models of exposure by improving consolidation of fear-extinction memories. To date, only one clinical trial has attempted to translate exercise augmented exposure therapy for PTSD. The current study is an open-label pilot clinical trial aiming at gauging the effectiveness of a brief eight-session PTSD …

Effect Of Substrate Dispersion Method And Particle Size On In Vitro Digestibility, Gas Production Kinetics And Composition, And Fermentation Characteristics In Different Feed Types, Luiz C. O. Sousa, Ellem M. A. Matos, Ronald J. Trotta, Edenio Detmann, David L. Harmon

Animal and Food Sciences Faculty Publications

Our objective was to evaluate the influence of substrate dispersion method and particle size on in vitro digestibility, gas production kinetics and composition, and fermentation characteristics of different feed types. Alfalfa hay, tall fescue hay, ground corn, soybean meal, and a total mixed ration (TMR) were used as substrates. Treatments were designed according to a 2 × 2 × 5 factorial arrangement: two substrate dispersion methods (loose substrate and in filter bags), two particle sizes (1 mm and 2 mm), and five feeds. Filter bags decreased (P ≤ 0.001) digestibility and gas production compared with loose samples. Filter bags decreased …

Soybean Meal Mitigates Vasoconstriction And Serotonin Suppression During Fescue Toxicosis In Beef Cattle, Luiz C.O. Sousa, Brittany E. Davis, David L. Harmon, Ronald J. Trotta

Animal and Food Sciences Faculty Publications

Legume supplementation has been shown to mitigate fescue toxicosis in beef cattle. However, no studies have directly compared the use of soybean-based feeds to alleviate symptoms of fescue toxicosis under controlled environmental heat and equalized feed intake. The objectives were to evaluate the effects of soybean hulls, whole soybeans, or soybean meal (SBM) supplementation on the mitigation of vasoconstriction, heat stress, and inflammatory responses in beef cattle during fescue toxicosis. Ten ruminally-cannulated Angus × Holstein steers were used in a 5 × 10 Latin rectangle design. Five treatments were evaluated: 1) non-toxic endophyte-infected tall fescue seed (NTE), 2) toxic endophyte-infected …

Menstrual Cycle Phase Effects On Alcohol-Impaired Driving Performance And Risk Awareness, Annie K. Griffith

Theses and Dissertations--Psychology

Growing evidence indicates that risky behavior among women is elevated during the late follicular phase of the menstrual cycle, likely due to increased estradiol levels. Furthermore, alcohol-induced impairment of women’s inhibitory control is significantly greater during the late versus early follicular phase. Consequently, cycle phase may influence outcomes of poor inhibitory control while intoxicated, such as alcohol-impaired driving. Alcohol-impaired driving risk manifests in two ways: risk-taking while driving, and risk awareness regarding the decision to drive. This dissertation tested the hypothesis that alcohol-induced increases in driver risk-taking and decreases in risk awareness would be exacerbated during the late versus early …

Relative Utility Governs Working Memory For Drug-Associated Stimuli In A Novel Translational Paradigm, Maxwell E. Boileau

Theses and Dissertations--Psychology

Substance use disorder (SUD) remains a prevalent health concern, partially characterized by continued drug use despite aversive consequences. Contrary to accounts emphasizing cognitive deficits, drug versus non-drug choice data reflect sensitivity to reinforcement dimensions, with preference shifting systematically as a function of magnitude and probability. The present study tested whether another cognitive system, working memory, is similarly affected by relative utility. Preclinical studies have demonstrated sensitivity of working memory to reinforcement dimensions, but these are often attributed to the differential outcomes effect. Generalized matching models were fit to allomorphic choice data, allowing estimation of exchange rate parameters. A concurrent solid- …

Working Memory In The Pigeon: An Alternative Paradigm, Daniel Peng

Theses and Dissertations--Psychology

One of the most widely used measures of working memory in non-human animals is the delayed matching to sample (DMTS) design. While this design can assess for duration of working memory, alternative accounts can be made to explain decrements in retention. In addition, DMTS does not assess capacity of working memory in terms of number of items able to be held. The works in this dissertation aims to design a paradigm to measure capacity of number of items held in memory for non-human animals by asking animals to make a specific response after presentation of a random spatial sequence. While …

Next-Day Effects Of Binge Drinking On Inhibitory Control In Laboratory And Naturalistic Settings, Justin Verlinden

Theses and Dissertations--Psychology

Binge drinking occurs at an alarmingly high rate, despite its negative consequences on behavior, health, and cognition. One acute cognitive consequence of binge drinking is the impairment of inhibitory control, or the ability to stop oneself from engaging in maladaptive or inappropriate behaviors. Specifically, during a binge episode, individuals display impaired inhibitory control while completing Go/NoGo or Stop Signal Tasks (SST). This impairment has been shown to be maintained for up to five hours post-drinking, even as breath alcohol concentration (BrAC) approaches zero. Evidence also suggests that binge drinking results in next-day deficits in attention, memory, and psychomotor speed. However, …

Effects Of Transcranial Direct Current Stimulation On Urge During Cue-Exposure To Body-Focused Repetitive Behaviors, Hannah Rebecca Wild

Theses and Dissertations--Psychology

Body-focused repetitive behaviors (BFRBs) are unnecessary, repetitive grooming behaviors linked to abnormalities in sensory and reward processing, as well as top-down inhibition. The left dorsolateral prefrontal cortex (dlPFC) is implicated in these processes and plays a key role in cravings among individuals facing addiction. Transcranial direct current stimulation (tDCS) targeting the left dlPFC shows promise in reducing craving for addictive substances. Despite phenomenological similarities between BFRBs and addictive disorders, no controlled studies have examined tDCS’s effect on BFRBs. This study used a randomized, double-blind design to examine whether a single session of anodal multifocal tDCS targeting the left dlPFC reduced …

Comparing Domain- And Facet-Based Models Of Personality Disorder: Incremental Predictive Validity And Model Fit, Alexandra Hines

Theses and Dissertations--Psychology

Personality disorders (PDs) have historically been conferred using a categorical diagnostic framework (i.e., present versus absent). However, recent research supports a transition toward dimensional models of PDs wherein personality traits are measured along a continuum. Some dimensional models contain personality domains only, whereas other models contain both personality domains and facets of each of those domains. The leading models of each type are the PD model in the eleventh edition of the International Classification of Diseases (ICD-11) and the Alternative Model of Personality Disorders (AMPD) in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), respectively. …

A Mixed Method Investigation On The Effects Of Information And Motivation On Self-Regulation Skills And Fruit And Vegetable Consumption, Kristen Buford

Theses and Dissertations--Psychology

Introduction: The purpose of this research study is to understand the interplay between health information and health motivation on eating behaviors in African American emerging adults. Greater knowledge of nutrition is linked to healthier eating outcomes, but the motivations that individuals possess about their ability to improve their health also play a pivotal role. However, the joint effect of such constructs (i.e., information and motivation) on eating behaviors is unknown. Emerging adults are still developing their capacities to exercise their health autonomy, and this developmental period represents an opportunity to intervene before the onset of age-related chronic diseases in middle …

Numerical Modeling Of Multi-Scale Jet Feedback In Seyfert Galaxies, Julianne Goddard

Theses and Dissertations--Physics and Astronomy

We present a suite of high-resolution cosmological zoom-in simulations investigating the impact of mechanical and thermal feedback from low-luminosity jets launched from supermassive black holes (SMBHs) on Seyfert galaxy evolution from early cosmic times to the present (z ≤ 10). Our models follow the formation of central galaxies within identical dark matter halos of logMhalo/M⊙ ∼ 11.8 at z = 0, seeded with ∼ 10^6M⊙ SMBHs at z ∼ 9.1 and z ∼ 3.7. Feedback from active galactic nuclei (AGN) is implemented in the form of bipolar jets launched along the SMBH spin axis, with jet powers spanning Ljet ∼ …