Studies Toward The Development Of An Improved Countermeasure For Synthetic Opioid Overdose, Sidnee L. Hedrick

Theses and Dissertations--Pharmacy

One of the most prominent opioid analgesics in the United States is the high potency agonist fentanyl. It is used in the treatment of acute and chronic pain and as an anesthetic adjuvant. When used inappropriately, however, ingestion of just a few milligrams of fentanyl or other synthetic opioid can cause opioid-induced respiratory depression (OIRD), often leading to death. Currently, the treatment of choice for OIRD is the opioid receptor antagonist naloxone. Recent reports, however, suggest that higher doses or repeated dosing of naloxone (due to recurrence of respiratory depression) may be required to fully reverse fentanyl-induced respiratory depression, rendering …

Investigating The Physical Stability Of Amorphous Pharmaceutical Formulations, Travis W. Jarrells

Theses and Dissertations--Pharmacy

Amorphous formulations, including amorphous solid dispersions (ASDs), consisting of the active pharmaceutical ingredient (API) intimately mixed in a polymeric matrix, are an attractive formulation approach to improve drug delivery, dissolution, and solubility. However, an amorphous API in an ASD is in a higher energy state compared to the crystalline drug and results in most ASDs being inherently unstable. The polymer helps to stabilize the amorphous drug against crystallization such that the resulting homogenous mixture maintains its solubility advantage relative to the crystalline form. One challenge of ASDs is that the presence of impurities including crystals or residual solvent, variations in …

The Relative Contribution Of Liver And Intestine In Reverse Cholesterol Transport, Rupinder Kaur

Theses and Dissertations--Pharmacy

Despite decades of advances in research, death due to cardiometabolic disease remains the largest contributor to mortality in the US. While present therapies oppose “forward cholesterol transport,” and atherosclerotic plaque progression, they do not remove cholesterol from established atherosclerotic plaques. Reverse cholesterol transport (RCT) is the active process of mobilizing peripheral cholesterol for excretion through the hepatobiliary (transhepatic cholesterol elimination, THCE) or intestinal (transintestinal cholesterol elimination, TICE) pathways. Currently, there are no clinically approved therapeutics that target RCT. Elucidation of the mechanisms that govern RCT and TICE, and the subsequent identification of novel targets is of importance. The present work …

Development Of Accurate And Efficient Computational Methodologies For Predicting Protein-Ligand And Protein-Protein Binding Free Energies, Alexander Hamilton Williams

Theses and Dissertations--Pharmacy

Computational modeling is an invaluable tool in the drug discovery process either for small ligand or protein therapeutics. The widespread availability of protein X-Ray Crystal and Cryo-Electron Microscopy (Cryo-EM) structures has allowed for more accurate molecular dynamics (MD) simulations that are not reliant on methods such as homology modeling, which may produce structures that require significant computational time to demonstrate their stability. In this thesis we describe several novel methodologies for the computationally efficient modeling of protein/ligand and protein/protein complexes that may be employed within both large-scale virtual screenings and lead compound optimization. These methodologies may also be utilized in …

Addressing Ascertainment Bias In The Study Of Cardiovascular Disease Burden In Opioid Use Disorders - Application Of Natural Language Processing Of Electronic Health Records, Jade Huang Singleton

Theses and Dissertations--Epidemiology and Biostatistics

In the United States, the prevalence of long-term exposure to opioid drugs, for both medically and nonmedically indicated purposes, has increased considerably since the mid-1990’s. Concerns have emerged about the potential health effects of opioid use. There is also growing interest in other possible connections with opioid use including cardiovascular disease. Electronic health records (EHR) contain information about patient care in the form of structured codes and unstructured notes. Natural language processing (NLP) provides a tool for processing unstructured textual data in EHR clinical notes and extracts useful information for research with structured formats. The purpose of this dissertation was …

The Influence Of Distance Learning On Undergraduate Social Work Competency: An Exploratory Study At A Private University, Christine K. Fulmer

Theses and Dissertations--Social Work

This is an exploratory study of undergraduate social work education at a private faith-based university. The university offers both online and residential program options. The purpose of the study was to examine the influence of distance education and program option on the educational outcomes of graduates in a newly developed social work program. The program started in 2015 with its first graduating class in 2017. The sample (N = 262) consists of students graduating in 2017, 2018, and 2019. Students could take classes across program options and each student in the sample completed both traditional and online social work courses. …

Laptop Recycling Case Study: Estimating The Contained Value And Value Recovery Process Feasibility Of End-Of-Life Consumer Electronics, Zebulon Hart

Theses and Dissertations--Mining Engineering

Work has been done to establish, through the development and use of novel assay techniques and analysis metrics, the contained value of a sampling of laptop computers (as an analog for myriad e-waste sources). This work has conceptualized e-waste as an alternative to geologic-origin complex metallic ores and has likewise evaluated the feasibility of value recovery from e-waste sources in a similar manner to an ore. The application of conventional and novel mineral separation techniques to e-waste recycling processes has been evaluated and positive results are demonstrated. Further, this work has demonstrated the ability to identify the presence of base …

Numerical Investigation Of An Oxyacetylene Torch With Regards To An Ablative Material, Luke Fortner

Theses and Dissertations--Mechanical and Aerospace Engineering

A computational fluid dynamic (CFD) software is used to model an oxyacetylene torch used as a screening facility for high temperature material testing. First, a published test-case is used to verify the CFD approach. The model that was produced falls within 5% of the Marra et al. [15] work in regards to heat flux and front face temperature, with a one step reaction mechanism that is computationally cheap. Then, the approach is used to model an existing experimental facility.

A Decoupled Engineering Methodology For Accurate Prediction Of Ablative Surface Boundary Conditions In Thermal Protection Systems, Justin Cooper

Theses and Dissertations--Mechanical and Aerospace Engineering

The main objective of the present work is to demonstrate a method for prediction of aerothermal environments in the engineering design of hypersonic vehicles as an alternative to the current heritage method. Flat plate and stagnation point boundary layer theory require multiple assumptions to establish the current engineering paradigm. Chief among these assumptions is the similarity between mass and heat transfer. Origins of these assumptions are demonstrated and their relationship to conservative engineering design is analyzed, as well as conditions where they possibly break down. An alternative approach for assessing aerothermal environments from the fluid domain is presented, which permits …

The Effects Of Reference-Command Preview On The Strategies That Humans Use In Command-Following Tasks, Amelia J. S. Sheffler

Theses and Dissertations--Mechanical and Aerospace Engineering

This thesis presents results from an experiment in which 22 human subjects each interact with a dynamic system 40 times over a one-week period. For each interaction, a subject performs a command-following task, where the reference command is the same for all 22 subjects but different on each trial. The subjects are divided into 2 groups of 11 subjects. One group performs the command-following task without reference-command preview. The other group is provided with 1-s preview of the reference command. The experimental results are used to examine the effects of reference-command preview. For the group with 1-s reference-command preview, the …

Kentucky Re-Entry Universal Payload System (Krups): Hypersonic Re-Entry Flight, John Daniel Schmidt

Theses and Dissertations--Mechanical and Aerospace Engineering

The Kentucky Re-entry Universal Payload System (KRUPS) is a small capsule designed as a technology testbed for re-entry experiments. For its first incarnation, KRUPS has been designed to test Thermal Protection Systems (TPS) and instruments in re-entry flights. Because of the unique environment a vehicle undergoes during re-entry, there is a high-demand for experimental data from re-entry experiments. KRUPS has been developed at the University of Kentucky (UK) over the past seven years to meet this demand. After completing sub-orbital campaigns, the first KRUPS hypersonic re-entry mission was attempted. The mission involved building three 11-inch diameter capsules each outfitted with …

Numerical And Scaling Study On Application Of Inkjet Technology To Automotive Coating, Masoud Arabghahestani Dr.

Theses and Dissertations--Mechanical and Aerospace Engineering

A thorough literature review identified lack of precision control over quality of droplets generated by the currently available industrial sprayers and a growing need for higher quality droplets in the coating industry. Particularly, lack of knowledge and understanding in continuous inkjets (CIJ) and drop-on-demand (DOD) technologies is identified as significant. Motivated by these needs, this dissertation is dedicated to computational fluid dynamics (CFD) and scaling studies to improve existing inkjet technologies and develop new designs of efficient coating with single and/or multiple piezoelectric sensors to produce on-demand droplets. This dissertation study aims at developing a new DOD type coating technology, …

In-Situ Characterization Of Burr Formation In Finish Machining Of Inconel 718, Hamzah M. Zannoun

Theses and Dissertations--Mechanical and Aerospace Engineering

One of the undesirable byproducts that occur during the machining process is the development of burrs, which are defined as rough excess material that forms around the geometric discontinuities of a part. Burrs are especially problematic because they have negative impacts across the triple bottom line: economic, environmental, societal. For one, they are expensive to remove because the deburring process is entirely manual and requires skill. Further, burr material is typically discarded which is adding to the already mounting waste generated from machining such as in coolant and chip disposal. Lastly, there are many societal implications, such as operator injury …

Formation Control With Collision Avoidance For Fixed-Wing Unmanned Air Vehicles With Speed Constraints, Christopher Heintz

Theses and Dissertations--Mechanical and Aerospace Engineering

Advances in the miniaturization of powerful electronic components and motors, the democratization of global navigation satellite systems (GNSS), and improvements in the performance, safety, and cost in lithium batteries has led to the proliferation of small and relatively inexpensive unmanned aerial vehicles (UAVs). Many of these UAVs are of the multi-rotor design, however, fixed-wing designs are often more efficient than rotary-wing aircraft, leading to a reduction in the power required for a UAV of a given mass to stay airborne. Autonomous cooperation between multiple UAVs would enable them to complete objectives that would be difficult or impossible for a single …

Art Education In Medical Education: Benefits And Challenges, Sara K. Brown

Theses and Dissertations--Art and Visual Studies

Humanity is synergistic with art and medicine. Likewise, art education can be impactful throughout medical education. Art as a tool to develop the next generation of healthcare differs from the clinical goals of creative art therapies. Over the prior decade, many medical schools now provide curricular offerings in the arts and humanities. Less is known about the application in postgraduate medical settings. The focus of this thesis is to review the pairing of artist-educators with postgraduate medical training programs.

One such program is ArtsCAFE (Arts Connect Around Food and Enrichment), an intercollegiate project fusing experienced arts educators with medical educators …

A Study Of The Analysis Of Hemp-Derived Oil Products: Development Of A Method For The Analysis Of Phytocannabinoids In Medicinal Products, Erin Johnson

Theses and Dissertations--Pharmacology and Nutritional Sciences

Human interactions with cannabis have a history spanning millennia as a source of fiber, food, and medicine. The plant came across Asia, Europe, and Africa with the movements of people and travelers eventually coming to the Americas with European explorers. In colonizing North America, cannabis fiber was key to the production of canvas and ropes for ships. Although fiber was the driver for cannabis production in the United States, medicinal uses were prevalent and propelled the eventual regulations. The Pure Food and Drug Act of 1906 mandated accurate labeling on drugs such as cannabis followed by the Marihuana Tax Act …

Farmers’ Market Incentive Program As An Intervention For Improving Behavior Regarding Fruit And Vegetable Consumption In Children And Adolescents, Madison Blades

Theses and Dissertations--Nutrition and Food Systems

Background: Previous research shows that there is low consumption of fruits and vegetables in children and adolescents, specifically those residing in the state of Kentucky which is ranked the lowest of all states in fruit and vegetable (F/V) consumption. The lack of F/V in a diet of someone during their developmental ages can result in negative health outcomes in the future.

Objective: To determine if the use of a farmers’ market incentive program as a nutritional intervention affects the consumption of F/V in children and adolescents.

Methods: 261 children and adolescents, ages 3-14, from 160 families participated in a 10-week …

Family And Consumer Sciences Extension Agents Perception Of A Sustainable Eating Curriculum For Kentuckians, Lindley Barker

Theses and Dissertations--Nutrition and Food Systems

The population is rapidly increasing all over the world. As foods are produced for us to consume, the food system generates negative environmental impacts at each step. The extent of damage generated by food production depends on the amount of land, water, and energy depleted. These environmental impacts can result in reduced quantities of food produced, damages to the land and water used to grow/produce food, pollution of food, and food waste. All of which impact the amount of product produced. Thereby, shifting food-related behaviors of consumers toward sustainable eating may be a way to promote the health of people …

An Examination Of Organic Options In Tomato Systems And Their Use As Alternatives To Copper-Based Products, Erica Ann Fealko

Theses and Dissertations--Plant Pathology

Organic farming is an ever-increasing segment of tomato production. Currently, limited information is available which directly compares conventional to organic treatment programs for disease control in tomato production. Furthermore, many methods available rely on the use of copper products which may be contribute to high Cu levels in agricultural soils. In this study, the efficacies of current conventional and organic methods were compared. In addition, newer disease-control programs, with and without copper were examined, which potentially could reduce over-reliance on copper products.

Standard organic and conventional spray programs were conducted over a four year period targeting two pathogens, Alternaria tomatophila …

The Microbiome Of The Equine Roundworm, Parascaris Spp., Jennifer Lynn Cain

Theses and Dissertations--Veterinary Science

Parasitic nematodes, including the large roundworms colloquially known as ascarids, affect the health and well-being of livestock animals worldwide. The equine ascarid, Parascaris spp., was the first ascarid parasite to develop wide-spread anthelmintic drug resistance, with other species slowly following suit. There are no new classes of anthelmintics currently in development, and a solution to the ever-increasing prevalence of resistance is desperately needed. The microbiome has been shown to be an important factor in the fitness and health of many organisms and changes to microbiome composition have been associated with a plethora of diseases. The microbiome is also important to …

Evaluating Restoration Outcomes: Red Spruce Reforestation In The West Virginia Highlands, Benjamin Rhodes

Theses and Dissertations--Forestry and Natural Resources

Red spruce (Picea rubens) is the keystone species of the red spruce-northern hardwood forest, a unique high-elevation plant community that supports hundreds of animal species in the Central Appalachians. These forests were devastated by the Industrial Logging Era of the late 1800s and early 1900s, and they remain in a degraded and fragmented state. Current restoration efforts include red spruce plantings on old field sites and reclaimed coal mines. This project seeks to aid those efforts by evaluating restoration outcomes for vegetation and soils along a ten-year chronosequence. Specifically, the study aims to determine whether restoration site soils …

Spatial Ecology Of Rocky Mountain Elk (Cervus Canadensis Nelsoni) Cows In Southeastern Kentucky, Nathan Dennis Hooven

Theses and Dissertations--Forestry and Natural Resources

The elk (Cervus canadensis) was extirpated from its range in eastern North America by the end of the 1800s, prompting several U.S. states and Canadian provinces to begin translocation programs with the goal of reestablishing elk populations. While eastern elk managers have relied on information from western herds to guide population and habitat management, there is a need for region-specific research on the spatial ecology and habitat associations of translocated elk given the stark differences in landscape, climate, predator communities, and harvest regimes across the continent. While the Kentucky elk reintroduction is one of the best documented programs …

Bat Activity On West Virginia Mined Lands Restored Via The Forestry Reclamation Approach, Briana C. Snyder

Theses and Dissertations--Forestry and Natural Resources

The Forestry Reclamation Approach (FRA) is a practical guide to reforesting surface mined lands. Bats, as a unique group of species with declining populations, could benefit from this reforestation. In order to determine if the FRA is providing suitable bat foraging habitat, I surveyed bat activity at created depressional wetlands on 1-year old and 8-year old FRA restored lands (FRA1; FRA8), as well as at naturally formed wetlands in regenerating forest on traditionally reclaimed mined land (~40 years old; REGEN) and wetlands in mature forest not previously mined (MAT). I passively recorded echolocation calls for 12 nights across sixteen sites …

The Response Of Beef Cattle To Disturbances From Unmanned Aerial Vehicles (Uavs), Gabriel Abdulai

Theses and Dissertations--Biosystems and Agricultural Engineering

Unmanned aerial vehicles (UAVs) are increasingly becoming common in animal agriculture. However, research regarding the impact of UAV disturbance on animal wellbeing is lacking or limited. The goal of this study was to investigate the effect of UAV flights on beef cattle by measuring cattle heart and movement rate when introduced to single or multiple UAV flights. A total of 16 -18 crossbred beef heifers were introduced to different flights patterns at between 5 and 9 m above ground level (AGL) at approximately 1 to 2 m/s horizontal velocity for 4 weeks with flights repeated 3 days per week. Results …

Classifying And Mapping Aquatic Vegetation In Heterogeneous Stream Ecosystems Using Visible And Multispectral Uav Imagery, Rozalia Agioutanti

Theses and Dissertations--Biosystems and Agricultural Engineering

The need for assessment and management of aquatic vegetation in stream ecosystems is recognized given the importance in impacting water quality, hydrodynamics, and aquatic biota. However, existing approaches to monitor are laborious and its currently not feasible to track spatial and temporal differences at broad scales. The objective of this study was therefore to map and classify aquatic vegetation of a shallow stream with heterogenous mixtures of emergent and submerged aquatic vegetation. Data was collected in the Camden Creek watershed within the Inner Bluegrass Region of central Kentucky. The use of unmanned aerial vehicles (UAVs) was employed and both visible …

Assessing Machine Learning Utility In Predicting Hydrologic And Nitrate Dynamics In Karst Agroecosystems, Timothy Mcgill

Theses and Dissertations--Biosystems and Agricultural Engineering

Seasonal hypoxia in the Gulf of Mexico and harmful algal blooms experienced in many inland freshwater bodies is partially driven due to excessive nitrogen loading seen from agricultural watersheds. Within the Mississippi/Atchafalaya River Basin, many areas are underlain with karst features, and efforts to reduce nitrogen contributions from these areas have had varying success, due to lacking a complete understanding of nutrient dynamics in karst agricultural systems. To improve the understanding of nitrogen cycling in these systems, 35 months of high resolution in situ water quality and atmospheric data were collected and fed into a two-hidden layer extreme learning machine …

Trauma-Sensitive Leadership In Multidisciplinary Settings, Jennifer Griswold Withrow

DSW Capstone Projects

As the social work profession continues to expand into more diversified areas of practice, such as politics, environmental justice, governmental work, and international crisis work, it is critical to ensure that social workers have the tools necessary to be successful leaders in these extended areas. Utilizing Trauma-Sensitive Leadership is an important concept to incorporate into multidisciplinary teams to ensure employees and communities feel supported and understood. By implementing these concepts which are ingrained into the social work profession into expanded areas of practice, social workers can feel empowered to lead multidisciplinary teams and provide support and understanding to the staff …

Patient Transitions Between Acute And Post-Acute Care Organizations: Can Nursing Communication Prevent Patient Readmission?, Penny Gilbert

DNP Projects

Preventing Patient Readmission

Background and Review of Literature: Communication is the foundation of patient safety. As patients move from the acute to post-acute care setting, risk for insufficient communication rises. Research demonstrates a vast array of communication hand-off tools currently exist for and between different care arenas. No one tool has been standardized for patients transitioning from acute to post-acute care settings. The Institute of Medicine (IOM) and The Joint Commission (TJC) have published multiple documents discussing communication plagues within health care resulting in readmission.

Purpose: The purpose of this project is multifaceted: 1) identifying current nursing communication practices between …

Utilizing A Video-Based Intervention To Improve Medicine Adherence And Retention Of Hiv Care In A Hiv Clinic., Robert Currie

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Memphis, Tennessee has higher rates of black men who have sex with men living with human immunodeficiency (BMSMLWH) compared to state and national levels. ART has been shown to be effective in keeping people living with HIV virally suppressed and unable to transmit HIV through sex. However, BMSMLWH are disproportionately affected by HIV than other races in Memphis, Tennesee. The proposed program relies on evidence-based data that demonstrates the effectiveness of video-based intervention in improving medication adherence and HIV retention of care. Taking Care of Me is a video-based intervention that promotes HIV treatment initiation, ART adherence, and retention in …

Bending The Elbow During Shoulder Flexion Facilitates Greater Scapular Upward Rotation And A More Favorable Scapular Muscle Activation Pattern, Alon Rabin, Brakha R. Tabi, Timothy L. Uhl, Zvi Kozol

Physical Therapy Faculty Publications

Context: Decreased scapular upward rotation (UR) and diminished activation of the serratus anterior (SA) and lower trapezius (LT) are often observed among patients with subacromial impingement syndrome. Maintaining the elbow fully flexed during shoulder flexion may limit glenohumeral motion due to passive insufficiency of the triceps brachii and therefore facilitate greater scapular UR and increased scapular muscle activation. Objectives: To compare scapular UR, SA, upper trapezius (UT), middle trapezius, and LT activation levels between shoulder flexion with the elbow extended (Flexion-EE) to shoulder flexion with the elbow fully flexed (Flexion-EF). This study hypothesized that Flexion-EF would result in …