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Estrogen Regulation Of Daily Metabolic Rhythms In Female Mice, Oluwabukola Omotola

Theses and Dissertations--Biology

Circadian rhythms are approximately 24-hour cycles of behavior, physiology, and gene expression. In mammals, these circadian rhythms are generated by clocks located in nearly every tissue in the body. The function of circadian clocks is to synchronize physiology and behavior with environmental cycles such as the light-dark cycle. After menopause, when circulating levels of estrogens are very low, women are more susceptible to obesity comorbidities such as metabolic syndrome and cardiovascular disease, suggesting that estrogens regulate these processes. Estrogens could protect females from metabolic dysfunction by regulating circadian rhythms. Consumption of diets that are high in fat contribute to obesity. …

Distribution Of Particulate Organic Carbon – Fluxes And Inventories – In Growth-Faulted Coastal Wetlands, Samuel Joel Whitehead

Theses and Dissertations--Earth and Environmental Sciences

Coastal wetlands along the Northern Gulf of Mexico (NGOMx) are critically important but threatened environments which provide significant and diverse economic, social, and environmental value. These environments are essential components to the global carbon cycle, serving as one of the most efficient terrestrial carbon sinks. Since onset of the Industrial Revolution increasing rates of coastal wetland loss have been documented due to a variety of anthropogenic activities, neotectonic processes, subsidence, and rising sea-levels. This research utilized an array of methods and sedimentological analyses to test the hypothesis that growth-fault induced changes at Earth’s surface affects the delivery to, and storage …

Deformation Of Wall Rocks And Overburden Sequences Proximal To Salt Diapirs In Salt Valley, Utah: Implications For Predicting Subseismic Damage In Salt Tectonic Systems, William Swanger

Theses and Dissertations--Earth and Environmental Sciences

Although deformation related to salt tectonics is generally considered to be an ancillary field of structural geology, owing to its relatively limited occurrence in the geologic record, the preponderance of salt-involved systems in multiple hydrocarbon-rich basins around the world (e.g., Gulf of Mexico, Atlantic passive margins, Iran, etc.) creates a necessity for understanding salt-related deformation. Traditionally, salt was considered to be relatively weak and thus was mostly unable to drive deformation of adjacent wall rocks and cover sequences. However, a number of recent numerical modeling studies have shown that mobilized and pressurized salt may have the ability to actively pierce …

Tryptophan-Like Fluorescence And Non-Point Source Pollution In Karst Basins, Inner Bluegrass Region, Kentucky, Ryan Dapkus

Theses and Dissertations--Earth and Environmental Sciences

Typically, the degree of fecal contamination of water is assessed by the concentration of thermotolerant coliforms, like E. coli. This method is time-consuming, taking > 18 hours between the start of incubation and subsequent enumeration. The current study examines the utility of monitoring tryptophan-like fluorescence (TLF) using in-situ fluorometers as a proxy for fecal contamination, particularly E. coli. Relative timing of discharge peaks and TLF peaks is considered, as well as differences in E. coli concentrations and major anion concentrations between two different basins that were monitored weekly. Results indicate that TLF is somewhat useful in the prediction of …

Syn- To Post-Orogenic Evolution Of Collisional Mountain Systems: Investigating The Potential For Crustal Flow Using Thermochronology And Numerical Models, Brandon Spencer

Theses and Dissertations--Earth and Environmental Sciences

This dissertation is composed of three distinct manuscripts which collectively investigate processes that contribute to the late evolution of collisional mountain systems —specifically, the ancient Appalachian-Caledonian system. In the first paper, ⁴⁰Ar/³⁹Ar thermochronological data are used to constrain the timing of exhumation of the Scandian orogenic wedge of northern Scotland. Muscovite and amphibole samples yield dates of ca. 420-411 Ma, consistent with cooling after peak orogenesis. During this cooling phase, dates from both systems in individual thrust sheets show an increase in cooling rate in the later stage of exhumation; in the orogenic core, the cooling rate …

The Role Of Sox4 In Ocular Morphogenesis And Retinal Differentiation, Rebecca Petersen

Theses and Dissertations--Biology

Visual impairment ranges from mild forms that can be corrected with glasses to more severe cases that result in permanent loss of vision. Microphthalmia, anophthalmia, and coloboma (collectively referred to as MAC) account for 11% of cases of pediatric blindness and are a result of improper ocular morphogenesis. Retinitis Pigmentosa (RP) is a retinal degenerative disease that affects 1 in 3000 people worldwide. It is a progressive disorder that initially begins with loss of vision in low light settings due to rod photoreceptor degeneration but progresses to complete blindness upon loss of cone photoreceptors. Currently, there is no cure for …

Affective Registers Of Displacement: Eviction And Gentrification In Post-Earthquake Mexico City, Jess Linz

Theses and Dissertations--Geography

This dissertation contributes to understandings of the affective and emotional register of urban politics by analyzing how affective dynamics influence struggles over displacement in Mexico City amid rapid gentrification and in the wake of the 2017 earthquake. Drawing primarily on feminist and queer/cuir theory and trauma studies, I aim to show the relevance of an often-overlooked dimension of urban political struggles. This dissertation is based on data collected through ethnographic methods over the course of 2018-2021. The primary source of data is long-form semi-structured interviews, supported by participant observation in meetings, protests, and WhatsApp groups. The dissertation studies the following …

Reading Comprehension Constrains Word Reading: A Tongue Twister Study By Moderating Attentional Control, Xueying Wang

Theses and Dissertations--Linguistics

Numerous research studies show word reading performance influences reading comprehension. Few studies investigate how reading comprehension influences word reading. The current study explores whether alleviating the attention required for reading comprehension correlates with a better word reading performance. Three types of tongue twister reading tasks that involve recall (RR), semantic priming (PP), and instructional focus on the phonological information (PF) all have a high demand for attention on word reading. Differently, the attention demanded by PP tasks on reading comprehension is smaller than RR and RF tasks. Numbers of speech errors are used to manifest the variability of these three …

A Corpus Study Of The Development Of The Adjective Phrase In French Children, Avery Elizabeth Baggett

Theses and Dissertations--Linguistics

In this thesis I attempt to answer three questions:

H1) Do children use proportionally more prenominal or post-nominal placement of adjectives than adults?

H2) Are children more conservative or more creative in their behavior in alternating prenominal and post-nominal placement of adjectives?

H3) If colored terms are more frequent in child speech will they pattern more like prenominal adjectives or more like post nominal adjectives, as in adult speech?

To do this, I examine two general semantic viewpoints, opting to use Scontras & Goodman (2017) subjectivity hypothesis. Next, I provide a general overview of First Language Acquisition research and then …

"Not Just Whites In Appalachia": The Black Appalachian Commission, Regional Black Power Politics, And The War On Poverty, 1965-1975, Jillean Mccommons

Theses and Dissertations--History

During the Black Power era of the late 1960s and 1970s, Black activists in Appalachia used the opening of the War on Poverty to wage a regional war against institutional and environmental racism. Through the Black Appalachian Commission, a grassroots organization created in 1969, Black activists worked to expose racism in local and federal policy as the root cause of poverty for Black Appalachians, who they argued were the poorest in the region. Their outward self-definition as Black and Appalachian was a political strategy to garner power over resources earmarked for Appalachians. The term “Black Appalachian'' was more than a …

Geometric Properties Of Weighted Projective Space Simplices, Derek Hanely

Theses and Dissertations--Mathematics

A long-standing conjecture in geometric combinatorics entails the interplay between three properties of lattice polytopes: reflexivity, the integer decomposition property (IDP), and the unimodality of Ehrhart h*-vectors. Motivated by this conjecture, this dissertation explores geometric properties of weighted projective space simplices, a class of lattice simplices related to weighted projective spaces.

In the first part of this dissertation, we are interested in which IDP reflexive lattice polytopes admit regular unimodular triangulations. Let Delta_(1,q)denote the simplex corresponding to the associated weighted projective space whose weights are given by the vector (1,q). Focusing on the case where Delta …

Batch Normalization Preconditioning For Neural Network Training, Susanna Luisa Gertrude Lange

Theses and Dissertations--Mathematics

Batch normalization (BN) is a popular and ubiquitous method in deep learning that has been shown to decrease training time and improve generalization performance of neural networks. Despite its success, BN is not theoretically well understood. It is not suitable for use with very small mini-batch sizes or online learning. In this work, we propose a new method called Batch Normalization Preconditioning (BNP). Instead of applying normalization explicitly through a batch normalization layer as is done in BN, BNP applies normalization by conditioning the parameter gradients directly during training. This is designed to improve the Hessian matrix of the loss …

The V1-Periodic Region In Complex Motivic Ext And A Real Motivic V1-Selfmap, Ang Li

Theses and Dissertations--Mathematics

My thesis work consists of two main projects with some connections. In the first project we establish a v₁ periodicity theorem in Ext over the complex motivic Steenrod algebra. The element h₁ of Ext, which detects the homotopy class \eta in the motivic Adams spectral sequence, is non-nilpotent and therefore generates h₁-towers. Our result is that, apart from these h₁-towers, v₁ periodicity operators give isomorphisms in a range near the top of the Adams chart. This result generalizes well-known classical behavior.

In the second project we consider a nontrivial action of C_{2 …}

The Role Of Sexual Difference In Plato's Timaeus, Mary Cunningham

Theses and Dissertations--Philosophy

My dissertation is a reading of Plato’s Timaeus that centers sexual difference and in particular femininity. I analyze the role of sexual difference in the framing of the dialogue as well as its accounts of body in the first and second discourse and its account of health in the third discourse. I argue that sexual difference, and, in particular, sexual reproduction, serves as a guiding paradigm of Timaeus’ entire project. I argue in each part of my dissertation that various aspects of the Timaeus depend on a certain notion of sexual difference—even aspects which are seemingly causally prior to the …

The Ideal Religious Community: Articulating The Possibility Of Collaborative Community Within Religious Contexts, Kayla Bohannon

Theses and Dissertations--Philosophy

This dissertation seeks to explain a certain instability that characterizes many contemporary religious communities. Why are people abandoning organized religion at an unprecedented rate? And why do so many religious people behave in vicious ways, even as they claim to preach a message of love? These phenomena are related, and they are both usually explained on epistemological grounds. According to many of religion’s recent critics, religious belief requires the suspension of rational thought, and those who abandon it have simply seen the light of reason. Meanwhile, those who remain religious do so despite the testimony of their reason, and the …

Safety In The Woods: Studying The Effectiveness Of The Kentucky Master Logger Program, Austin Winn Leake

Theses and Dissertations--Community & Leadership Development

Logging is a dangerous field; in this study the researcher looks to see the knowledge both before and after professional loggers participate in the Kentucky Master Logger Program. This information was used to see the overall effectiveness of the Kentucky Master Logger Program. The researcher found an overall improvement in logging professionals’ perceptions and understanding of logging safety. The researcher recommends creating an emphasis on a safe work culture through safety incentives and a greater focus on less used personal protective equipment such as insecticide

Significant Life Experiences Of Kentucky Youth Climate Activists, Jeri Katherine Howell

Theses and Dissertations--Community & Leadership Development

The purpose of this study is to better understand Kentucky youth climate activism. The research questions explore how youth define their climate activism in Kentucky, their Significant Life Experiences (SLE) that motivated them to commit to climate activism, and what challenges and sustains their involvement. This qualitative study utilizes a blended framework of social/environmental positionality and political ecology to analyze 7 semi-structured interviews with participants between the ages 18 to 24 years old who are acting to address climate change in Kentucky. New contributions to the existing body of SLE literature are discussed.

The Youth - Adult Partnership Between Secondary Agriculture Educators And Native American Youth: A Qualitative Case Study, Hunter Anne Julian

Theses and Dissertations--Community & Leadership Development

This case study examines the connection made between secondary agriculture educators through Youth-Adult Partnerships (YAP). This study provides insight into the elements of YAP and contributes to the limited body of research surrounding Youth-Adult Partnership in secondary agriculture education and in the Native American community. Data was collected through qualitative interviews of six agriculture educators teaching on Native American reservations. The findings of this study indicate that YAP is present in secondary agriculture education programs and offers insight into how agriculture educators form connections with the Native American communities they teach in.

Membrane Palmitoylated Protein Magu-3 Regulates The C. Elegans Locomotor Circuit Via Modulation Of Cholinergic Activity, Henry Richburg

Theses and Dissertations--Medical Sciences

Precise coordination of the activity and transmission in excitatory and inhibitory neural circuits is essential for healthy information flow. Synaptic scaffolding proteins play a key role in the regulation of circuit activity through the localization and organization of receptors, channels, and other synaptic machinery to facilitate signal transduction. Using the C. elegans motor circuit which has both cholinergic (excitatory) and GABAergic (inhibitory) inputs onto muscles, we revealed an unexplored role of a family of scaffolding molecules known as membrane palmitoylated proteins (MPPs). Here, we examined magu-3, a C. elegans ortholog within the membrane palmitoylated protein family, using GFP tagging …

Classification And Effect Of Correctors On Sitosterolemia-Associated Mutants In Abcg8, Brittney Poole

Theses and Dissertations--Medical Sciences

Objective: To classify mutants of ABCG8 identified in subjects with clinically confirmed Sitosterolemia, a rare form of Familial Hypercholesterolemia distinguished by the accumulation of phytosterols in plasma and tissues and determine the effects of correctors and/or regulators of proteostasis on maturation of the ABCG5/ABCG8 sterol transporter.

Methods: Disease-causing missense mutants within the cytosolic domain of ABCG8 were generated through site-directed mutagenesis. Normal and mutant proteins were expressed in human hepatocytes. Cellular proteins were prepared, and maturation was assessed by SDS-PAGE and immunoblotting. Formation of the higher molecular weight, mature form of glycoproteins was used as a bioassay for trafficking the …

Evaluating The Microbiome To Boost Recovery From Stroke: The Embrs Study, Tyler Hammond

Theses and Dissertations--Neuroscience

Accumulating evidence suggests that gut microbes modulate brain plasticity via the bidirectional gut-brain axis and may play a role in stroke rehabilitation. A severely imbalanced microbial community has been shown to occur following stroke, causing a systemic flood of neuro- and immunomodulatory substances due to increased gut permeability and decreased gut motility. Here we measure post-stroke increased gut dysbiosis and how it correlates with gut permeability and subsequent cognitive impairment.

We recruited 12 participants with acute stroke, 12 healthy control participants, and 18 participants who had risk factors for stroke, but had not had a stroke. We measured the gut …

Evaluating The Role Of Mmp9 In Hyperhomocysteinemia Induced Cerebrovascular Pathology, Alexandria Linton

Theses and Dissertations--Neuroscience

Vascular contributions to cognitive impairment and dementia (VCID) is one of the leading causes of dementia, along with Alzheimer’s disease (AD), and often manifests as a comorbidity of AD. Elevated plasma homocysteine, known as hyperhomocysteinemia (HHcy), is a risk factor for VCID; however, the mechanism underlying the connection between HHcy and development of VCID pathology remains elusive. Understanding this mechanism would reveal novel therapeutic targets with the potential to be disease modifying, which are a critical need for a disease that lacks any approved treatment. Previous studies from our lab have strongly associated neuroinflammation and blood brain barrier (BBB) dysregulation …

Peripheral And Central Glucose Flux In Type I Diabetes, Jelena Anna Juras

Theses and Dissertations--Neuroscience

Diabetes is a complex metabolic disorder, of which high blood glucose concentration is the primary hallmark. Type I diabetes mellitus (T1DM) is characterized by the lack of insulin production, due to a poorly understood autoinflammatory cascade. In the words of historian Barnett “Diabetes may no longer be a death sentence, but for more and more people in the 21st century, it will become a life sentence”, making it the focal point of many research groups. It is estimated that around 20 million individuals worldwide live with T1DM.

Effects of long-term chronically elevated blood glucose are not only seen in micro/macro-vascular …

Interleukin-1 Receptor 1 Signaling In Mild Tbi: Do Endothelial Cells Play A Major Role?, Colleen N. Bodnar

Theses and Dissertations--Neuroscience

Across the world, over 69 million people sustain a traumatic brain injury (TBI) per year making TBI a major health concern worldwide. Of all the TBIs that occur each year, it is suggested that up to 90 percent are mild in nature. Even a mild TBI causes both physical damages to the cells of the brain and activation of a variety of biochemical cascades. Inflammation is an extremely common pathology seen in the brains of TBI survivors of all severities. Chronic inflammation can cause detrimental effects within the brain including neurodegeneration. A major pro-inflammatory cytokine, interleukin-1 (IL-1), is upregulated within …

Three Essays On The Economic Implications Of Oil Shocks, Ryan Hanson

Theses and Dissertations--Economics

My dissertation consists of three papers on the response of various economic indicators to crude oil shocks. In the first paper, I investigate the Western Australian gasoline market for asymmetric responses in gasoline prices to changes in input costs, otherwise known as the rockets and feathers hypothesis. This theory states that after a positive cost shock, firms will swiftly increase their retail prices to consumers; after a decrease in input costs, however, they take longer to adjust and lower prices. Using daily, establishment level data, I estimate a multi-stage error correction model and find evidence of asymmetric price adjustment in …

Multivariate Statistical Modeling For Radio-Genomics Study, Tiantian Zeng

Theses and Dissertations--Statistics

Radiogenomics is a new direction in cancer research that focuses on the associations among radiomics, genomics and clinical outcome. Currently, the major challenge for Radiogenomics lies in the effective integration of genomics and imaging data for promising clinical outcome prediction. Herein, we propose a multivariate joint model that can integrate imaging and genomic data for better predicting the clinical outcome. Specifically, we jointly consider two multivariate group lasso models, one regresses imaging features on genomic features, and the other regresses patient’s clinical outcome on genomic features. An L1 penalty term is introduced for each variable, and weight in the penalty …

Statistical Theory For Specialized Linear Regression Adjustment Methods Compared To Multiple Linear Regression In The Presence And Absence Of Interaction Effects, Leon Su

Theses and Dissertations--Statistics

When building models to investigate outcomes and variables of interest, researchers often want to adjust for other variables. There is a variety of ways that these adjustments are performed. In this work, we will consider four approaches to adjustment utilized by researchers in various fields. We will compare the efficacy of these methods to what we call the ”true model method”, fitting a multiple linear regression model in which adjustment variables are model covariates. Our goal is to show that these adjustment methods have inferior performance to the true model method by comparing model parameter estimates, power, type I error, …

Deriving The Distributions And Developing Methods Of Inference For R2-Type Measures, With Applications To Big Data Analysis, Gregory S. Hawk

Theses and Dissertations--Statistics

As computing capabilities and cloud-enhanced data sharing has accelerated exponentially in the 21st century, our access to Big Data has revolutionized the way we see data around the world, from healthcare to investments to manufacturing to retail and supply-chain. In many areas of research, however, the cost of obtaining each data point makes more than just a few observations impossible. While machine learning and artificial intelligence (AI) are improving our ability to make predictions from datasets, we need better statistical methods to improve our ability to understand and translate models into meaningful and actionable insights.

A central goal in the …

Describing And Predicting Preprocedural Anxiety In Patients Scheduled For Advanced Gastrointestinal Endoscopy During The Covid-19 Pandemic, Dawn Profit

Theses and Dissertations--Nursing

Advanced gastrointestinal endoscopy includes a group of specialized procedures and interventions that are being performed more frequently with little attention given to a patient’s preprocedural anxiety issues. Preprocedural anxiety is an anticipated problem with any surgery or invasive procedure and if sustained or experienced excessively, is associated with negative clinical factors and complications.

In the beginning of 2020, the United States was met with a global pandemic caused by the coronavirus SARS-CoV-2, termed COVID-19. There were recommendations to decrease medical procedural case volume in order to slow the spread of the virus, protect staff and patients from getting the virus, …

Building Tools For Improved Modulation Of The Human Gabaa Receptor, A Central Nervous System Target For The Treatment Of Anxiety, Garrett Edward Zinck

Theses and Dissertations--Pharmacy

In the U.S., anxiety is recognized as an increasing range of mentally and physically debilitating psychiatric health disorders with significant economic repercussions. Over the last 20 years, several novel anti-anxiety therapies have entered the drug development pipeline, but none have made it to market.

The work in this dissertation focused on structurally modifying valerenic acid (VA), a structurally unique carboxylated sesquiterpene acid found in Valeriana officinalis. VA is putatively reported to have allosteric modulatory activity of the human GABA_A receptor, a ligand-gated ion channel responsible for attenuating neurotransmissions. Structural modeling of VA’s GABA_A receptor interaction suggests that …