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Innovating A Crustacean Embryo Toxicity (Cet) Assay For Screening Environmental Contaminants, Irina A. Polunina-Proulx

Graduate Doctoral Dissertations

Environmental pollutants can disrupt normal developmental processes, leading to neurobehavioral and developmental abnormalities. Toxicity tests are important for evaluating environmental contaminants; however, standard assays are often time- and cost-intensive and typically require large numbers of vertebrate animals. These limitations highlight the need to reduce reliance on vertebrate testing and to develop New Approach Methodologies that provide comparable results while improving efficiency and cost-effectiveness. This research utilizes a novel screening assay to evaluate developmental toxicity using Hyalella azteca. H. azteca is a freshwater amphipod widely used as a model organism for sediment toxicity in ecotoxicology, yet its embryos have been minimally …

Writing Together, Writing Differently: Collective Authorship As Reflective Practice, Thanh Thao Le, Trut Thuy Pham

The Qualitative Report

This article examines collective authorship as a reflective and ethical research practice within a sustained program of co-authored qualitative, post-qualitative, linguistic, and reflective inquiries into teacher reflection, professional learning, language, silence, and recognition. It offers an oral-history-informed reflective methodological account of a writing collective and asks how collective authorship became a methodological practice through our collaborative writing process. The primary materials were shared drafts, margin comments, revisions, silences, version histories, short reflective notes, and remembered writing encounters. Teacher-reflection texts and related professional writing materials from our broader research program formed the secondary materials around which the writing process unfolded. Analytically, …

Modeling Kinetics Of 5-Aminolevulinic Acid-Induced Protoporphyrin Ix Accumulation For Optimal Photodynamic Therapy, Priscilla Melebor

Graduate Masters Theses

Photodynamic therapy (PDT) is a minimally invasive treatment that uses light-activated photosensitizers to selectively destroy diseased tissue through the generation of reactive oxygen species. However, conventional in vitro models often fail to accurately reproduce the pharmacokinetics of photosensitizer accumulation and clearance observed in vivo. This study investigated protoporphyrin IX (PpIX) accumulation following 5-aminolevulinic acid (ALA) exposure under physiologically relevant conditions using two-dimensional (2D) monolayers and three-dimensional (3D) spheroids. By comparing continuous ALA exposure with transient exposure followed by ALA washout, this work provides a more biologically relevant framework for studying PpIX kinetics and optimizing photodynamic therapy.

Crosstalk Between Upr And Mitochondria: The Triad Of Er-Mitochondria Contacts, Ca²⁺, And Ros, Ester Zito, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Endoplasmic reticulum (ER) stress is triggered by several cellular perturbations causing protein misfolding, and activates the unfolded protein response (UPR), an initially adaptive signaling network that aims to restore ER and cellular homeostasis. Growing evidence indicates that UPR signaling extends beyond ER proteostasis, influencing mitochondrial function and bioenergetics through ER-mitochondria contact sites (ERMCs). The CHOP-ERO1A-IP3R axis has a primary role in recruiting mitochondria to adaptive UPR. However, its sustained activation renders UPR signaling maladaptive, leading to mitochondrial dysfunction through both outer mitochondrial membrane permeabilization (OMMP) and mitochondrial permeability transition pore (mPTP) opening, ultimately contributing to irreversible cell injury and disease …

How Do Governments Combat Jihad Online?, Noah Cook

Honors College Theses

Since the September 11th, 2001 attacks, jihadist groups like ISIS, al-Qaeda, and al-Shabaab have used the internet as a tool for recruitment, radicalization, and propaganda dissemination. Since then, governments, non-governmental organizations, and private companies have developed strategies to combat jihadism on the internet. This paper examines how these actors have worked to mitigate the digital jihadist footprint and its effects by analyzing three main approaches to countering violent Islamist extremism on the internet: counter narrative initiatives, awareness-raising programs, and content removals. This paper finds that each of these methods has its own strengths and weaknesses. Counter narrative campaigns show the …

Relationship Between Financial Performance And Healthcare Quality Outcomes, Ela C. Lena

Walden Dissertations and Doctoral Studies

Hospital leaders face increasing pressure to improve quality outcomes while controlling costs. The evidence is limited on whether hospital financial performance predicts overall quality star ratings. Grounded in the general contingency theory, this quantitative, correlational project examined the predictive relationship between operating margin, current ratio, and a composite of quality metrics represented by the overall hospital Quality Star Rating (QSR). Data included the population of acute care hospitals in Massachusetts with 25 or more beds, yielding a final analytic sample of 54. Four year-specific multiple linear regression models were performed from 2021 through 2024. The analyses did not indicate a …

Staff Education On Standardized Suicide Risk Assessment In An Outpatient Clinic For Behavioral Health, Fanta Haja Cabah

Walden Dissertations and Doctoral Studies

Suicide risk assessment is a high-priority nursing safety responsibility in outpatient behavioral health. The practice gap was a variation in nurses’ knowledge of validated suicide screening, direct inquiry, risk escalation, referral, and related documentation expectations working in an outpatient behavioral health clinic located on the Eastern Atlantic Coast. To address this problem, I developed, implemented, and evaluated a staff education program on a standardized suicide risk assessment. The practice question focused on whether staff knowledge increased following participation in the education program. Ten nursing staff members participated in a 60-minute education program. Pretest and posttest questionnaires included 20 multiple-choice questions. …

Staff Education On Teach- Back Communication Method For Psychiatric Nursing Staff, Adanma Violet Ebere

Walden Dissertations and Doctoral Studies

Summary Patient education delivered without a standardized communication protocol for patients with serious mental illness (SMI), especially for those who face disproportionate health literacy deficits, cognitive challenges, and stigma, may increase the risk of medication misunderstanding and non-adherence. An outpatient psychiatric practice lacked a standardized patient education protocol. This quality improvement staff education initiative equipped all clinical nursing staff with the 5Ts for Teach Back framework, an evidence-based, five-step method endorsed by the Agency for Healthcare Research and Quality (AHRQ), The Joint Commission (TJC), and the American Hospital Association (AHA), and grounded with evidence in 13 sources at Levels I …

Adverse Drug Reaction Reporting In Dental Practice And The Importance Of Pharmacovigilance In Dental Education, Radhakrishna Lagishetty, Lakshmi Ramya T, Kvr Barath Raju, Mohan Kumar Pasupuleti

Journal of Dentistry Indonesia

Background: Adverse drug reactions (ADRs) are a critical component of patient safety; however, ADR monitoring remains underutilized in dentistry. This study aimed to assess knowledge, attitudes, and practices regarding ADR reporting among undergraduate and postgraduate students and practicing dentists.

Methods: A cross-sectional observational study was conducted using a structured, validated 19-item questionnaire covering socio-demographics, knowledge (6 items), attitude (4 items), and practice (5 items), which was distributed both in person and online. A total of 258 complete responses were analyzed out of 300 individuals contacted (response rate: 86%). Descriptive statistics and Chi-square tests were applied, with p < 0.05 considered statistically significant.

Results …

Investigation Of Patients' Use Of Non-Pharmacological Substances In Dental Pain Management, Neslihan Yılmaz Çırakoğlu, Özgenur Kaya

Journal of Dentistry Indonesia

Background: Dental pain is a complex condition influenced by biological, biochemical, environmental, and psychological factors. Before seeking professional care, many patients attempt to relieve dental pain using self-administered, non-medical agents. This study aimed to investigate patients’ use of non-pharmacological substances in dental pain management and to identify factors influencing these practices.

Methods: The questionnaire consisted of four sections addressing demographic characteristics, oral hygiene habits, pain characteristics, and pain-relief agents. Categorical variables were analyzed using Pearson’s chi-square test. Categorical data are presented as frequencies and percentages, while continuous data are expressed as mean ± standard deviation and median values. …

Orthodontic Camouflage Treatment Of A Severe Class Iii Skeletal Pattern With Anterior Open Bite: A Case Report, Dikeledi Maureen Letsholo, Mandla Dominic Nyakale, Mosimane Peter Silas Sethusa

Journal of Dentistry Indonesia

Background: Class III malocclusion combined with anterior open bite (AOB) is one of the most challenging occlusal problems to treat. The objective of this article was to report a case of an adult female patient diagnosed with Class III malocclusion combined with an anterior open bite and a hyperdivergent facial pattern.

Case Report: Camouflage orthodontic treatment with the extraction of maxillary and mandibular first premolars was used to treat the patient. Anterior teeth were retracted maximally against the Nance holding arch and fixed lingual arch appliances, and box elastics were used to close AOB. At the end of …

Evaluation Of Antibiotic Use Using The Gyssens Method On Clinical Outcomes In Ischemic Stroke Patients, Juniarto Mende, Graciano A. Maturbongs, Yohana K. A. Mbulang

Pharmacology and Clinical Pharmacy Research

Ischemic stroke is a health problem that causes death and neurovascular disability worldwide. The inflammatory response due to infection can increase ischemic stroke and increase brain damage through changes in blood pressure, coagulation, immune response, and endothelial function. This study aims to evaluate the rationality of antibiotic use on clinical outcomes in ischemic stroke patients. This study used a cross-sectional design. Retrospective data were taken from the medical records of Jayapura Regional Hospital for the period January 1, 2023, to May 31, 2025. The study subjects were all patients who suffered ischemic stroke and received antibiotics. Evaluation of the rationality …

Staff Education To Increase Knowledge And Awareness Of Sexually Transmitted Diseases, Alie Sholola Sahid

Walden Dissertations and Doctoral Studies

Background STIs or sexually transmitted diseases (STDs) are consequential public health emergencies that affect millions of people globally and have long-term health implications (Garcia et al., 2024). STIs are infections that are passed from one person to another through sexual contact with the most common types of STIs include chlamydia, trichomoniasis, general herpes, and human papillomavirus (HPV). It is estimated that each year, more than 20% of the U.S. population has had an STI, with around 26.2 million cases per year (Centers for Disease Control and Prevention [CDC], 2024a). The common types of STIs include chlamydia, trichomoniasis, general herpes, and …

Optimizing Advanced Ehr And Enhanced Data-Sharing And Reporting In Rural Health Clinics, Adaeze Honesta Duru

Walden Dissertations and Doctoral Studies

Rural clinics continue to face several barriers in utilizing advanced electronic health record (EHR) features, including interoperability, data sharing, and care coordination. The purpose of this integrative review was to investigate strategies to overcome barriers to the use of advanced EHRs and enhance data-sharing and reporting capabilities in rural clinics. The review question emphasized viable strategies for overcoming barriers to advanced EHR utilization and enhancing data-sharing and reporting capabilities in rural clinics. The consolidated framework for implementation research provided a conceptual model for understanding the various facets of EHR optimization. A literature search initially resulted in 135 relevant articles. After …

Truly Blown Away — Humanistic Lens Looking At Glassblowers’ Creative Thinking: A Qualitative Case Study, Yugant Patra

The Qualitative Report

This study examines how emotional and cognitive engagement shape glassblowing artists’ decision-making and artistic outcomes throughout the creative process. Using a qualitative case study methodology, the study examines how glassblowing artists conceptualize, execute, and refine their work by balancing their artistic vision with the medium's technical demands through a humanistic lens. Five themes emerge, which are discussed: the identification with self – confronting the demons, I belong here, claiming the molten as my own, the reign of glass and from it fractures rising anew, and having a conversation with glass. The study closes with the need for continued research on …

Community-Based Research: Key Considerations For Researchers And Community Partners When Collaborating, Bothwell Piason, Kathleen A. Fox

The Qualitative Report

Community-based research (CBR) is a research orientation that emphasizes equitable engagement in the process of knowledge production, though researchers and community partners may navigate collaborative partnerships with differing expectations, priorities, and understandings of success. Extant research has demonstrated that successful CBR partnerships can benefit both researchers and community partners, yet little is known about how both groups simultaneously conceptualize successful collaboration across diverse partnership contexts. In this study, we ask: What considerations do researchers and community partners identify as important when engaging in community-based research partnerships? Drawing on semi-structured interviews with 10 university researchers and 10 community partners engaged in …

Moralized Indulgence In The Age Of Inflation: How “Better-For-You” Dessert Brands Reframe Pleasure As Self-Care, Dariya Savrukova

Honors College Theses

In the modern U.S. food landscape, the line between indulgence and wellness has nearly disappeared. The booming “better-for-you” dessert industry, owned primarily by multinational giants such as Mondelēz International, PepsiCo, and Mars Inc., reframes high-sugar, high-calorie treats as acts of self-discipline or self-care. This phenomenon is often referred to as “healthwashing” (Tufts Health & Nutrition Letter, 2022), when through verbal and visual language, these companies transform indulgence into moral consumption, inviting consumers to feel virtuous through consumption. Many consumers crave stability and health, but navigate an environment saturated with manipulative design and ambiguous claims. “Better-for-you” branding exploits this gap by …

Exposing And Addressing Machine Learning Brittleness Through Constraint Solving, Muyeed Ahmed

Dissertations

Machine Learning (ML) implementations are fundamentally brittle: nondeterministic, inconsistent, and prone to overfitting; however, constraint solving can be used to systematically expose, quantify, and address this brittleness.

This dissertation first establishes that widely-used implementations of popular ML algorithms are nondeterministic (producing different outputs on the same input, across different runs) and inconsistent (different implementations of the same algorithm producing different outputs on the same input). This is more prevalent in Unsupervised Learning (UL) implementations where, due to the lack of a ground truth, subtle execution errors can go unnoticed and are difficult to verify. Nondeterminism and inconsistency also introduce security …

Development Of Ultrafast Protein Digestion And Standards Free Quantitation Methods For Mass Spectrometric Analysis, Praneeth Ivan Joel Fnu

Dissertations

A wide variety of biologically important molecules, such as enzymes, antibodies, hormones, transporters and receptors are proteins by composition and they play key roles in biological functions such as cellular regulation, communication, metabolism and physiological function. Protein dysfunctions and abnormalities are associated with numerous diseases, making proteins critical targets for understanding disease mechanisms and developing therapeutic interventions. Protein-based therapeutics such as monoclonal antibodies, hormones and vaccines gained popularity due to their high specificity, efficacy, and ability to treat complex diseases that are often difficult to address with small-molecule drugs.

Given the important role of proteins in a variety of biological …

Geographic And Environmnetal Influences On Color Pattern Similarity Between Coral Snakes (Genus: Micrurus) And Their Lookalikes, Anthony Sena

Dissertations

Venomous coral snakes and their lookalikes are often regarded as a classic example of Batesian mimicry, whereby a harmless species imitates a harmful species. The existing literature regarding coral snake resemblance presents a divisive stance on whether Batesian mimicry is the primary driver of shared color patterns or if alternative factors are responsible. While recent literature largely favors the Batesian hypothesis, empirical support remains inconsistent, and the specific geographic and interpretation of the conditions required for mimicry lacks consensus within the scientific community.

To evaluate the mechanisms maintaining these phenotypes, a quantitative, multivariate framework was utilized to analyze 400 museum …

Tracking Towards Zero: Implementing A Picc Team Tracker To Prevent Clabsis, Carolina Maria Gerodias Cayetano

Master's Projects and Capstones

Background: Central line-associated bloodstream infections (CLABSIs) remain among the most serious and costly healthcare-associated infections in acute care settings, with each event associated with significant excess mortality, prolonged hospital stays, and avoidable healthcare costs. At Hospital A, a 239-bed acute care facility, two of six total CLABSI events over a 12-month period were associated with peripherally inserted central catheters (PICCs), representing 33% of all facility CLABSIs and exposing a critical gap in standardized PICC line surveillance and maintenance bundle monitoring.

Problem: The PICC team lacked a systematic, real-time tracking mechanism to monitor central line maintenance bundle adherence across seven adult …

Comm 11 Fundamentals Of Interpersonal Communication Textbook, Teresa A. Fisher

Open Educational Resources

A survey of interpersonal communication.

Autoethnography: Understandings, Evolution, And The Influence Of Genai, Prokopis Christou

The Qualitative Report

Autoethnography occupies a central place within qualitative research because of its focus on lived experience, reflexivity, and meaning-making. In this paper, I critically examine the implications of generative artificial intelligence (GenAI) for autoethnographic inquiry through a reflexive and theoretically informed discussion situated within the contemporary AI-mediated era. By revisiting key understandings and developments of autoethnography while drawing on technological mediation theory, I explore how GenAI extends beyond a mere tool to become a mediating mechanism capable of profoundly shaping autoethnographic practice. Attention is given to how seemingly minor AI-generated alterations may transform lived experience into more polished, coherent, and emotionally …

Searching The Druggable Genome Using Large Language Models, Lars Schimmelpfennig, Matthew Cannon, Quentin Cody, Joshua Mcmichael, Adam C Coffman, Susanna Kiwala, Kilannin Krysiak, Alex H Wagner, Malachi Griffith, Obi L Griffith

2020-Current year OA Pubs

SUMMARY: The druggable genome encompasses the genes that are known or predicted to interact with drugs. The Drug-Gene Interaction Database (DGIdb) provides an integrated resource for discovering and contextualizing these interactions, supporting a broad range of research and clinical applications. DGIdb is currently accessed through structured web interfaces and API calls, requiring users to translate natural-language questions into database-specific query patterns. To allow for the use of DGIdb through natural language, we developed the DGIdb Model Context Protocol (MCP) server, which allows large language models (LLMs) access to up-to-date information through the DGIdb API. We demonstrate that the MCP server …

With Students, As A Student: Using Reflexive Autoethnography To Make Sense Of Navigating Student–Researcher Liminality In A Ph.D., Melody Bishop

The Qualitative Report

Postgraduate researchers (PGRs) are increasingly encouraged to practice reflexivity. But there is a lack of PGR-authored literature about what it means to negotiate multiple identities, particularly for student–researchers doing research with students. This paper explores challenges experienced during a longitudinal Ph.D. project involving undergraduate students with long-term health conditions. I present outcomes of a reflexive autoethnographic analysis of a diary kept making sense of research challenges, including holding dual positions as a student–researcher at the same institution. Drawing on the notion of liminality, I argue that the boundaries between my student–researcher identities, and between myself and participants, have been consistently …

Plaza Off The Park, Hdfc V. Mcgowan

All Decisions

Court dismissed holdover against proprietary lessee in HDFC because petition failed to accurately describe the regulatory status of the unit and tenancy as required by RPAPL § 741(4). Court held that respondent's ability to independently discover the correct regulatory status does not obviate the landlord's burden to describe the premises accurately in the petition from the start.

Association Between Athletic Trainers And Frequency Of Pediatric Orthopedic Visits, Abaigeal Field, James M. Mensch, Courtney Meyer, Susan W. Yeargin

Clinical Practice in Athletic Training

Context: There is sparse research on the relationship between athletic trainer (AT) employment and the number of athletes presenting to orthopedic clinics with sports-related injuries. The purpose of this study is to determine if athletic training services are associated with the frequency of first-time orthopedic office visits for sports-related injuries.

Methods: A retrospective chart review collected injuries between January 1, 2018 and December 31, 2020 from the electronic health records system for a hospital network in the Southeast United States with 6 orthopedic clinics and included 48 high schools hosting 20 sports with at least 1 AT per school. Patients …

Development And Uncertainty Assessment Of Secondary Method For Ph Measurement In Physicochemical Measurements, Sarvar Rakhmatullaev, Dostonbek Xujakulov, Mohinur Nigmatova

Chemical Technology, Control and Management

In physicochemical measurements across various industries, laboratory analyses commonly require the determination of pH as an indicator of hydrogen ion activity in aqueous solutions. Ensuring the accuracy and reliability of these measurements, obtaining precise readings from pH measuring instruments, and maintaining overall measurement quality represent critical challenges in guaranteeing the safety of both products and processes. This requires constant monitoring, accuracy assessment, calibration, metrological verification, and control of measuring instruments. In this case, it should be carried out not with solutions prepared in any laboratory, but with certified reference materials (СRM) with appropriate regulatory framework, ensuring metrological observation. …

Robust-Adaptive Estimation Of Unmeasurable States And External Disturbances Of A Dynamic Object Based On An Augmented Kalman Filter, Husan Igamberdiev, Uktam Farkhodovich Mamirov, Lu Liu, Bohong Wang, Bunyod Buronov

Chemical Technology, Control and Management

The paper addresses the problem of joint estimation of the directly unmeasurable states of a dynamic object and of external disturbances when information is available only on the control inputs and on the measured output signals. To solve this problem, a robust-adaptive algorithm based on an augmented Kalman filter is proposed, in which the external disturbance is included in the extended state vector. Two operating modes of the algorithm are considered. For slowly varying disturbances, a random-walk model with a constant process-noise covariance is used, whereas for rapidly varying inputs a signal adaptation  driven by the normalized innovation is proposed. …

Re: Comment Letter For Butte Priority Soils Operable Unit (Bpsou) Draft Diggings East Dewatering Treatability Study Pre-Design Investigation Work Plan (Pdiwp) (Dated August 24, 2026) And The 2026 Draft Diggings East Dewatering Treatability Study Quality Assurance Project Plan (Qapp) (Dated August 24, 2026), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.